Dr. Mayson H. Alkhatib
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Dr. Mayson H. Alkhatib

Professor
Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Oman

Highest Degree
Ph.D. in Biotechnology Science and Engineering from The University of Alabama in Huntsville (UAH), Huntsville, USA

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Biography

My main research interest is studying the impact of the nano-colloidal systems on drug formulations used for cancer therapy and treating infectious diseases. Currently, my research interest concentrates on the synthesis of chitosan-nanoemulsion derivatives for water treatment and food packaging.I have more than 61 articles published in peer reviewed journals.

Area of Interest:

Biomedical Sciences
100%
Anti-Cancer Agents
62%
Anticancer Activity
90%
Anti-Microbial Properties
75%
Biochemistry
55%

Research Publications in Numbers

Books
1
Chapters
0
Articles
61
Abstracts
12

Selected Publications

  1. Bayoumi, H.M. and M.H. Alkhatib, 2022. Incorporation of topotecan into sesame oil - Nanoemulsion potentiates its cytotoxic effect in cancer cells. J. Drug Delivery Sci. Technol., Vol. 75. 10.1016/j.jddst.2022.103614.
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  2. Al-Mutairi, A.A. and M.H. Alkhatib, 2022. Antitumour effects of a solid lipid nanoparticle loaded with gemcitabine and oxaliplatin on the viability, apoptosis, autophagy, and Hsp90 of ovarian cancer cells. J. Microencapsulation, 39: 467-480.
    CrossRef  |  Direct Link  |  
  3. Bayoumi, H.M., M.H. Alkhatib and M.N. Al-Seeni, 2021. Carvacrol effect on topotecan cytotoxicity in various human cancer cells in vitro. Pharmacia, 68: 353-363.
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  4. Alkhatib, M.H., S.M. Al-Hashemi and H.M. Gashlan, 2021. Formulating etoposide in a nanoemulsion containing polyunsaturated fatty acids potentiates its anti-proliferation and anti-invasion activities against the ovarian cancer cells. Biocell., 45: 695-703.
    CrossRef  |  Direct Link  |  
  5. Alkhatib, M.H., H.M. Alkreathy, M.I.A. Omar, K.S. Balamash, F.A. 4 and A. Esmat, 2021. Doxorubicin supplemented with pravastatin in lipid nanoemulsion induces antineoplastic activity with limited hepatotoxicity and cardiotoxicity in tumor-bearing mice. Asian J. Pharm. Res. Health Care, 13: 17-29.
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  6. Alhashemi, S.M., M.H. Alkhatib and H.M. Gashlan, 2021. Inhibition of colon cancer cells proliferation and invasion by etoposide loaded on nano-suspensions containing black currant seed and evening primrose oils. Indian J. Pharm. Sci., Vol. 83. 10.36468/pharmaceutical-sciences.795.
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  7. Al-Mutairi, A.A., M.H. Alkhatib and H.M. Gashlan, 2021. Antitumor activities of co-loading gemcitabine and oxaliplatin into oleic acid-based solid lipid nanoparticle against non-small cell lung cancer cells. Biointerface Res. Appl. Chem., 12: 49-60.
    CrossRef  |  Direct Link  |  
  8. RS, B.B., M.H. Alkhatib and G.G. HM, 2020. Combination of docetaxel with thymoquinone in nanoemulsion impedes the migration of breast cancer stem cells. Int. J. Pharm. Invest., 10: 211-216.
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  9. Alkreathy, H.M., M.H. Alkhatib, M.A.H. Al-thepyani, K.S.A. Balamash and S.K. Alghamdi et al., 2020. Synergistic antitumor activity of doxorubicin and atorvastatin combination loaded nanoemulsion in mice. Int. J. Pharmacol., 16: 330-342.
    CrossRef  |  Direct Link  |  
  10. Alkhatib, M.H., R.S. Bawadud and H.M. Gashlan, 2020. Incorporation of docetaxel and thymoquinone in borage nanoemulsion potentiates their antineoplastic activity in breast cancer cells. Sci. Rep., Vol. 10. 10.1038/s41598-020-75017-5.
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  11. Alkhatib, M.H., 2020. Apoptotic effect of bleomycin formulated in cinnamon oil nanoemulsion on hela cervical cancer cells. Asian J. Pharm., Vol. 14. 10.22377/ajp.v14i03.3685.
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  12. Alkhatib, M., S. Alyamani and F. Abdu, 2020. Coconut oil nanoemulsion attenuates methotrexate-induced hepatotoxicity and nephrotoxicity in Ehrlich ascites carcinoma-bearing mice. Asian Pac. J. Trop. Biomed., 10: 540-546.
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  13. Alkreathy, H.M., M.H. Alkhatib, S.A. Al Musaddi, K.S.A. Balamash, N.N. Osman and A. Ahmad, 2019. Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma. Clin. Exp. Pharmacol. Physiol., 46: 496-505.
    CrossRef  |  Direct Link  |  
  14. Alkhatib, M.H., S.M. AlMotwaa and H.M. Alkreathy, 2019. Incorporation of ifosfamide into various essential oils-based nanoemulsions ameliorates its apoptotic effect in the cancers cells. Scient. Rep., Vol. 9. 10.1038/s41598-018-37048-x.
    CrossRef  |  Direct Link  |  
  15. Alkhatib, M.H., W.S. Alshehri and F.B. Abdu, 2018. In vivo evaluation of the anticancer activity of the gemcitabine and doxorubicin combined in a nanoemulsion. J. Pharm. BioAllied Sci., 10: 35-42.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Alkhatib, M.H., W.A. Al-Otaibi and A.N. Wali, 2018. Antineoplastic activity of mitomycin C formulated in nanoemulsions-based essential oils on HeLa cervical cancer cells. Chemico-Biol. Interact., 291: 72-80.
    CrossRef  |  Direct Link  |  
  17. Alkhatib, M.H., N.S. Alnahdi and W.S. Backer, 2018. Antitumor activity, hematoxicity and hepatotoxicity of sorafenib formulated in a nanoemulsion based on the carrot seed oil. Int. J. Life Sci. Pharma Res., 8: 50-57.
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  18. Alkhatib, M.H., A.M. Mizjaji and A.N. Wali, 2018. In vitro assessment of the antineoplastic activity of doxorubicin combined with gemcitabine in a nanoparticle. Crescent J. Med. Biol. Sci., 5: 76-82.
    Direct Link  |  
  19. Alkhaitb, M.H. and D.K. Zahim, 2018. Cytotoxicity effect of the combination of doxorubicin and pravastatin loaded in lipid nanoemulsion on MCF-7 breast cancer cells and HFS human foreskin cells. Int. J. Pharmaceut. Phytopharmacol. Res., 8: 31-39.
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  20. Al-Otaibi, W.A., M.H. Alkhatib and A.N. Wali, 2018. Cytotoxicity and apoptosis enhancement in breast and cervical cancer cells upon coadministration of mitomycin C and essential oils in nanoemulsion formulations. Biomed. Pharmacother., 106: 946-955.
    CrossRef  |  Direct Link  |  
  21. Aly, M.M., R.H. Kadi, A.M. Aldahlawi, M.H. Alkhatib and A.N. Wali, 2017. Production of the antitumor L-glutaminase enzyme from thermotolerant Streptomyces sp. D214, under submerged fermentation conditions. J. Exp. Biol. Agric. Sci., 5: 878-885.
  22. Alkhatib, M.H., S.M. Theeban and W.S. Backer, 2017. Antitumor activity of mixing gemcitabine with pravastatin in a microemulsion against a549 non-small cell lung cancer cells. Int. J. Pharma Bio Sci., 8: 41-47.
    CrossRef  |  Direct Link  |  
  23. Alkhatib, M.H., S.A. Alharbi and S.H. Mahassni, 2017. In vivo evaluation of the anticancer activity of the docetaxel incorporated into nanoemulsion based on orange oil. Pharmacophore, 8: 41-47.
    Direct Link  |  
  24. Alkhatib, M.H., M.M. Alasmari and F. Abdo, 2017. In vivo assessment of the hepatotoxicity of mixed gemcitabine and 5-fluorouracil loaded on microemulsion in mice bearing Ehrlich ascites carcinoma. Adv. Pharmacol. Pharm., 5: 44-50.
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  25. Alkhatib, M.H., D.K. Zahim and W.S. Backer, 2017. Anticancer activity of mixed doxorubicin and pravastatin in nanoemulsions against HCT 116 colon cancer cells. Int. J. Drug Deliv. Technol., 7: 63-70.
    Direct Link  |  
  26. Alkhatib, M.H., D.A. Nori and M.A. Al-Ghamdi, 2017. Cardiotoxicity and hematoxicity of sorafenib-loaded nanoemulsion in Ehrlich ascites carcinoma-bearing mice. Biosci. Biotechnol. Res. Asia, 14: 75-82.
    CrossRef  |  Direct Link  |  
  27. Alkhatib, M.H., D.A. Nori and M.A. Al-Ghamdi, 2017. Antitumor activity and hepatotoxicity effect of sorafenib incorporated into nanoemulsion formulated with flaxseed oil. Int. J. Pharmaceut. Res. Allied Sci., 6: 175-188.
    Direct Link  |  
  28. Alkhatib, M.H., D.A. Al-Saedi and W.S. Backer, 2017. Cytotoxic effect of the combination of gemcitabine and atorvastatin loaded in microemulsion on the HCT116 colon cancer cells. Int. J. Pharmaceut. Clin. Res., 9: 146-155.
    CrossRef  |  Direct Link  |  
  29. Alkhatib, M.H., B.M. Binsiddiq and W.S. Backer, 2017. In vivo evaluation of the anticancer activity of a water-in-garlic oil nanoemulsion loaded with docetaxel. Int. J. Pharmaceut. Sci. Res., 8: 5373-5379.
    CrossRef  |  Direct Link  |  
  30. Alkhatib, M.H., A.A. Al-Mutairi and A. NoorWali, 2017. Anticancer effect of gemcitabine combined with 5-flurouracil in microemulsion on the HCT-116 colon cancer cells. Int. J. Dev. Res., 7: 1790-11795.
    Direct Link  |  
  31. Alkhaitb, M.H. and D.A. Al-Saedi, 2017. Cytotoxic effect of the combination of gemcitabine and atorvastatin loaded in nanoparticle on the MCF-7 breast cancer cells and HFS human foreskin cells. Curr. Nanosci., 13: 625-633.
    CrossRef  |  Direct Link  |  
  32. Alkhatib, M.H., M.M. Aly, R.A. Rahbeni and K.S. Balamash, 2016. Antimicrobial activity of biocompatible microemulsions against Aspergillus niger and herpes simplex virus type 2. Jundishapur J. Microbiol., Vol. 9, No. 9. 10.5812/jjm.37437.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Alkhatib, M.H., M.M. Aly, O.A. Saleh and H.M. Gashlan, 2016. Antibacterial activity of a microemulsion loaded with cephalosporin. Biologia, 71: 748-756.
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  34. Alkhatib, M.H., H.M. Alkreathy, K.S. Balamash and F. Abdu, 2016. Antitumor activity of doxorubicine-loaded nanoemulsion against Ehrlich ascites carcinoma-bearing mice. Trop. J. Pharm. Res., 15: 937-943.
    CrossRef  |  Direct Link  |  
  35. Alkhatib, M.H. and N.S. Alkhayyal, 2016. The apoptotic effect of gemcitabine-loaded-microemulsion (isopropyl myristate/tween 80/span 20/water/ethanol) on A549 non-small cell lung cancer cells. Cytologia, 81: 423-429.
    CrossRef  |  Direct Link  |  
  36. Wali, A.N., M.F.E. Shal, M.H. Alkhatib and L.A. Damiati, 2015. Effect of three calmodulin antagonists on subpopulations of CD44/CD24 immunophenotypes in breast cancer cell lines. Trop. J. Pharmaceut. Res., 14: 1393-1398.
    CrossRef  |  Direct Link  |  
  37. Alkhatib, M.H. and W.A. Al-Qaidi, 2014. The antiproliferative effect of docetaxel-microemulsion formulation against HepG2 liver cancer cells. Biosci. Biotechnol. Res. Asia, 11: 1-9.
    CrossRef  |  Direct Link  |  
  38. Alkhatib, M.H. and W.A. Al-Qaidi, 2014. Cytotoxicity effect of docetaxel-loadedmicroemulsion in A549 non-small cell lung cancer and HCT116 colon cancer cells. Int. J. Pharma Bio Sci., 5: 300-315.
    Direct Link  |  
  39. Alkhatib, M.H. and W.A. Al-Qaidi, 2014. Anticancer effect of docetaxel encapsulated in a capryol 90/cremophor EL/transcutol microemulsion against MCF-7 breast cancer cells. J. Exp. Biol. Agric. Sci., 2: 1-6.
    Direct Link  |  
  40. Alkhatib, M.H. and S.S. Al-Merabi, 2014. The apoptotic effect of the microemulsion formulation of simvastatin/cremophor/transcutol/Captex355/water in A549 non-small cell lung cancer cells. Int. J. Dev. Res., 4: 753-756.
    Direct Link  |  
  41. Alkhatib, M.H. and S.S. Al-Merabi, 2014. In vitro assessment of the anticancer activity of simvastatin-loaded microemulsion in liver and colon cancer cells. J. Drug Deliv. Sci. Technol., 24: 373-379.
    CrossRef  |  Direct Link  |  
  42. Alkhatib, M.H. and N.S. Alkhayyal, 2014. Cytotoxicity of gemcitabine-loaded-microemulsions in breast and colon cancer cells. Trop. J. Pharmaceut. Res., 13: 217-224.
    CrossRef  |  Direct Link  |  
  43. Osman, N.N., M.N. Al-Seeni, M.H. Alkhatib and H.A. Al-Shreef, 2013. Modulation of radiation injury by Physalis peruviana. Life Sci. J., 4: 3403-3410.
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  44. Hayes, D.G., M.H. Alkhatib, J.G. del Rio and V.S. Urban, 2013. Physicochemical characterization of water-in-oil microemulsions formed by a binary 1,3-dioxolane alkyl ethoxylate/Aerosol-OT surfactant system. Colloids Surf. A: Physicochem. Eng. Aspects, 417: 99-110.
    CrossRef  |  
  45. Alkhatib, M.H., M.M. Aly and S. Bagabas, 2013. Antibacterial activity and mechanism of action of lipid nanoemulsions against Staphylococcus aureus. J. Pure Applied Microbiol., 7: 259-267.
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  46. Alkhatib, M.H. and H.M. AlBishi, 2013. In vitro evaluation of antitumor activity of doxorubicin-loaded nanoemulsion in MCF-7 human breast cancer cells. J. Nanopart. Res., 15: 1489-1504.
    CrossRef  |  Direct Link  |  
  47. Alkhatib, M.H., H.M. Albishi and S.H. Mahassni, 2012. Impact of nanoparticles on cancer therapy. Trop. J. Pharmaceut. Res., 11: 1001-1011.
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  48. Alkhatib, M.H., D.G. Hayes and V.S. Urban, 2009. Characterization of microemulsion systems formed by a mixed 1,3-dioxolane ethoxylate/octyl glucoside surfactant system. J. Surfactants Deterg., 12: 277-283.
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  49. Atmeh, R.F., I.M. Arafa and M. Al-Khateeb, 2007. Albumin aggregates: Hydrodynamic shape and physico-chemical properties. Jordan J. Chem., 2: 169-182.
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