Dr. Muniswamy Madesh

Associate Professor
Temple University School of Medicine, USA

Highest Degree
Ph.D. in Biomedical Sciences from The Wellcome Trust Laboratory, United Kingdom

My URL
https://livedna.org/1.11045

Share this Profile

Biography

Dr. Muniswamy Madesh is currently working as Associate Professor at Department of Biochemistry and Center for Translational Medicine, Temple University School of Medicine. He has completed his Ph.D. in Biomedical Sciences from The Wellcome Trust Laboratory, United Kingdom. Previously he was appointed as Assistant Professor at University of Pennsylvania. He is member of American Association for the Advancement of Science, American Society for Microbiology, American Society for Biochemistry and Molecular Biology, and American Society of Cell Biology. He has 87 publications in journals contributed as author/co-author. His main area of research interest focuses on the Biochemical Signaling Cascade Components participating in the Decoding of Mitochondrial Ca2+ influx into ATP and ROS, Subcellular Bioenergetic Sensor and Regulatory Molecules of Ca2+, ROS, and ATP, and Evolutionary Divergence and Convergence from yeast to humans in Mitochondrial Biology.

Area of Interest:

Molecular Sciences
Biochemical Signaling
Subcellular Bioenergetic Sensor
Regulatory Molecules
Evolutionary Divergence

Selected Publications

  1. Sharma, V.D., J. Lees, N.E. Hoffman, E. Brailoiu, M. Madesh, S.L. Wunder and M.A. Ilies, 2014. Modulation of pyridinium cationic lipid-DNA complex properties by pyridinium gemini surfactants and its impact on lipoplex transfection properties. Mol. Pharmaceutics, 11: 545-559.
    CrossRef  |  Direct Link  |  

  2. Miller, B.A., N.E. Hoffman, S. Merali, X.Q. Zhang and J.F. Wang et al., 2014. TRPM2 Channels Protect Against Cardiac Ischemia-Reperfusion Injury: Role of Mitochondria. J. Biol. Chem., 289: 7615-7629.
    CrossRef  |  Direct Link  |  

  3. Hoffman, N.E., H.C. Chandramoorthy, S. Santhanam, X. Zhang and S. Vallem et al., 2014. SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Mol. Biol. Cell, 25: 934-947.
    CrossRef  |  Direct Link  |  

  4. Bansaghi, S., T. Golenar, M. Madesh, G. Csordas and S. RamachandraRao, et al., 2014. Isoform-and species-specific control of IP3 receptors by reactive oxygen species. J. Biol. Chem., 289: 8170-8181.

  5. Pan, J.A., Y. Fan, R. Kumar, M. Madesh and W.X. Zong, 2013. Hyperactivation of the mammalian degenerin MDEG leads to intracellular activation of caspase-8 and apoptosis. J. Biol. Chem., 288: 2952-2963.

  6. Mancarella, S., S. Potireddy, Y. Wang, H. Gao and R. Gandhirajan et al., 2013. Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle. FASEB J., 27: 893-906.
    CrossRef  |  Direct Link  |  

  7. Justine, Y., E. Deliu, H.Q. Zhang, N.E. Hoffman and R.L. Carter et al., 2013. Differential Activation of Cultured Neonatal Cardiomyocytes by Plasmalemmal vs Intracellular GPR55. J. Biol. Chem., 288: 22481-22492.
    CrossRef  |  Direct Link  |  

  8. Hoffman, N.E., H.C. Chandramoorthy, S. Santhanam, X. Zhang and S. Rajan et al., 2013. MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity. Cell Rep., 26: 1576-1588.
    CrossRef  |  Direct Link  |  

  9. Gandhirajan, R.M., S. Meng, H.C. Chandramoorthy, K. Mallilankaraman and S. Mancarella et al., 2013. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J. Clin. Invest., 123: 887-902.
    CrossRef  |  Direct Link  |  

  10. Duran, J.M., C.A. Makarewich, T.E. Sharp, T. Starosta and F. Zhu et al., 2013. Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circulation Res., 113: 539-552.
    CrossRef  |  Direct Link  |  

  11. Deliu, E.G., C. Brailoiu, N.E. Hoffman, M. Madesh, W.J. Koch and E. Brailoiu, 2013. Direct evidence of intracrine angiotensin II signaling in neurons. Am. J. Physiol., 306: 736-744.
    CrossRef  |  Direct Link  |  

  12. Barrero, C.A., O. Perez-Leal, M. Aksoy, C. Moncada and Y. Lopez et al., 2013. Histone 3.3 participates in a self- sustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 188: 673-683.
    CrossRef  |  Direct Link  |  

  13. Yin, Y., J.L. Pastrana, X. Li, X. Huang and K. Mallilankaraman et al., 2012. Inflammasomes: Sensors of Metabolic Stresses for Vascular Inflammation. Front. Biosci., 18: 638-649.
    Direct Link  |  

  14. Soboloff, J., B. Rothberg, M. Madesh and D.G. Gill, 2012. STIM proteins: dynamic calcium signal transducers. Nat. Rev. Mol. Cell Biol., 13: 549-565.
    CrossRef  |  Direct Link  |  

  15. Mallilankaraman, K., P.J. Doonan, C. Cardenas, H.C. Chandramoorthy and M. Muller et al., 2012. MICU1 is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake That Regulates Cell Survival. Cell, 151: 630-644.
    CrossRef  |  Direct Link  |  

  16. Mallilankaraman, K., C. Cardenas, P.J. Doonan, K.M. Irrinki and H.C. Chandramoorthy et al., 2012. MCUR1 is an Essential Component of Mitochondrial Ca2+ Uptake that Regulates Cellular Metabolism. Nat. Cell Biol., 14: 1336-1343.
    CrossRef  |  Direct Link  |  

  17. Kato, K., E.P. Lillehoj, Y.S. Park, T. Umehara, N.E. Hoffman, M. Madesh and K.C. Kim, 2012. Membrane-tethered MUC1 Mucin is Phosphorylated by EGFR in Airway Epithelial Cells and Associates with TLR5 to Inhibit Recruitment of MyD88. J. Immunol., 188: 2014-2022.
    CrossRef  |  Direct Link  |  

  18. Deliu, E.G., C. Brailoiu, A.S. Undieh, M. Madesh, W.J. Koch and E. Brailoiu, 2012. Intracellular ETB receptor-driven Ca2+ signal elicits NO production in endothelial cells. J. Biol. Chem., 287: 41023-41031.

  19. Thapa, R.J., S.H. Basagoudanavar, K.M. Irrinki, K. Mallilankaraman, A.A. Beg, M. Madesh and S. Balachandran, 2011. NF-κB protects cells from IFN-γ-induced RIP1-dependent necroptosis. Mol. Cell. Biol., 31: 2934-2946.

  20. Soboloff, J., M. Madesh and D.G. Gill, 2011. Sensing Cellular Stress through STIM Proteins. Nat. Chem. Biol., 7: 488-492.
    CrossRef  |  Direct Link  |  

  21. Shuvaev, V.V., J. Han, K. Yu, S. Huang and B.J. Hawkins et al., 2011. PECAM-Targeted Delivery of SOD Inhibits Endothelial Inflammatory Response to Cytokines. FASEB J., 25: 348-357.
    CrossRef  |  Direct Link  |  

  22. Mancarella, S., Y. Wang, X. Deng, J.R. Panettieri, M. Madesh and D.G. Gill, 2011. Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex. J. Biol. Chem., 286: 44788-44798.
    CrossRef  |  Direct Link  |  

  23. Irrinki, K.M., K. Mallilankaraman, R.J. Thapa, F.J. Smith and N.R. Jog et al., 2011. Requirement of FADD, NEMO and BAX/BAK for aberrant mitochondrial function in TNF-induced necrosis. Mol. Cell. Biol., 31: 3745-3758.
    CrossRef  |  Direct Link  |  

  24. Cheng, Z.J., X. Jiang, W. Kruger, D. Pratico and S. Gupta et al., 2011. Hyper-homocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta-synthase deficient mice. Blood, 118: 1998-2006.

  25. Hawkins, B.J., M.D. Levin, P.J. Doonan, N.B. Petrenko, C.W. Davis, V.V. Patel and M. Madesh, 2010. Mitochondrial complex II prevents hypoxic but not calcium- and proapoptotic Bcl-2 protein-induced mitochondrial membrane potential loss. J. Biol. Chem., 285: 26494-26505.
    CrossRef  |  Direct Link  |  

  26. Hawkins, B.J., K.M. Irrinki, K. Mallilankaraman, Y.C. Lien and Y. Wang et al., 2010. S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. J. Cell Biol., 190: 391-405.
    CrossRef  |  Direct Link  |  

  27. Davis, C.W., B.J. Hawkins, S. Ramasamy, K.M. Irrinki and B.A. Cameron et al., 2010. Nitration of the Mitochondrial Complex I Subunit NDUFB8 Elicits RIP1 and 3-Mediated Necrosis. Free Radical Biol. Med., 48: 306-317.

  28. Brailoiu, G.C., B. Gurzu1, X. Gao, R. Parkesh and P.K. Aley et al., 2010. Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure. J. Biol. Chem., 285: 37133-37137.
    CrossRef  |  Direct Link  |  

  29. Roy, S.S., M. Madesh, E. Davies, B. Antonsson, N. Danial and G. Hajnoczky, 2009. Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol. Cell, 33: 377-388.

  30. Madesh, M., W.X. Zong, B.J. Hawkins, R. Subbiah and T. Venkatachalam et al., 2009. Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol. Cell. Biol., 29: 3099-3112.
    CrossRef  |  Direct Link  |  

  31. Levin, M.D., M.M. Lu, N.B. Petrenko, B.J. Hawkins and D. Lang et al., 2009. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J. Clin. Invest., 119: 3420-3436.
    CrossRef  |  Direct Link  |  

  32. Yang, H., G. Liang, B.J. Hawkins, M. Madesh, A. Pierwola and H. Wei, 2008. Inhalational Anesthetics Induce Cell Damage by Disruption of Intracellular Calcium Homeostasis with Different Potencies. Anesthesiol., 109: 243-250.
    CrossRef  |  Direct Link  |  

  33. Wei, H., G. Liang, H. Yang, Q. Wang and B.J. Hawkins et al., 2008. The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors. Anesthesiol., 108: 251-260.
    CrossRef  |  Direct Link  |  

  34. Milovanova, T., S. Chatterjee, B.J. Hawkins, N. Hong and N. Sorokina et al., 2008. Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress. Biochim Biophys Acta, 1783: 1866-1875.
    CrossRef  |  Direct Link  |  

  35. Dziubla, T.D., V.V. Shuvaev, N.K. Hong, B.J. Hawkins and M. Madesh et al., 2008. Endothelial targeting of semi-permeable stealth polymer nanocarriers for delivery of durable enzyme therapies. Biomater., 29: 215-227.
    CrossRef  |  Direct Link  |  

  36. Mukhopadhyay, P., M. Rajesh, G. Hasko, B.J. Hawkins, M. Madesh and P. Pacher, 2007. Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat. Protoc., 2: 2295-2301.
    CrossRef  |  Direct Link  |  

  37. Jones, R.G., T. Bui, C. White, M. Madesh and C.M. Krawczyk et al., 2007. Bax and Bak regulate T cell proliferation through control of ER Ca2+ homeostasis. Immun., 27: 268-280.

  38. Hawkins, B.J., M. Madesh, C.J. Kirkpatrick and A.B. Fisher, 2007. Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling. Mol. Biol. Cell 18: 2002-2012.
    CrossRef  |  Direct Link  |  

  39. Cheong, N., H. Zhang, M. Madesh, M. Zhao and K. Yu et al., 2007. ABCA3 is critical for lamellar body biogenesis in vivo. J. Biol. Chem., 282: 23811-23817.
    CrossRef  |  Direct Link  |  

  40. Muthumani, K., A.Y. Choo, W.X. Zong, M. Madesh and D.S. Hwang et al., 2006. The HIV-1 Vpr and glucocorticoid receptor complex: A gain-of-function interaction that prevents the nuclear localization of PARP-1. Nat. Cell Biol., 8: 170-179.
    CrossRef  |  Direct Link  |  

  41. Milovanova, T., S. Chatterjee, Y. Manevich, I. Kotelnikova and K. Debolt et al., 2006. Lung Endothelial Cell Proliferation with Decreased Shear Stress is Mediated by Reactive Oxygen Species. Am. J.Physiol., 290: 66-76.
    CrossRef  |  Direct Link  |  

  42. Cheong, N., M. Madesh, L.W. Gonzales, M. Zhao, K. Yu, P.L. Ballard and H. Shuman, 2006. Functional and Trafficking Defects of ABCA3 Transporter Mutants in Respiratory Distress Syndrome. J. Biol. Chem., 281: 9791-9800.

  43. White, C., C. Li, J. Yang, N.B. Petrenko, M. Madesh, C.B. Thompson and J.K. Foskett, 2005. The endoplasmic reticulum gateway to apoptosis: Bcl-XL modulation of the InsP3 receptor. Nat. Cell Biol., 7: 1021-1028.

  44. Mulugeta, S., V. Nguyen, S.J. Russo, M. Madesh and M.F. Beers, 2005. A ProSP-C BRICHOS Domain Mutation causes ER Stress, Proteosome Dysfunction, and Caspase 3 Activation. Am. J. Respir. Cell Mol. Biol., 32: 521-530.

  45. Madesh, M., B.J. Hawkins, T. Milovanova, C.D. Bhanumathy and S.K. Joseph et al., 2005. Selective role for superoxide in InsP3R-mediated mitochondrial dysfunction and endothelial apoptosis. J. Cell Biol., 170: 1079-1090.

  46. Kazerounian, S., G.M. Pitari, F.J. Shah, G.S. Frick and M. Madesh et al., 2005. Proliferative Signaling by Store- Operated Calcium Channels Opposes Colon Cancer Cell Cytostasis Induced By Bacterial Enterotoxins. J. Pharmacol. Exp. Ther., 314: 1013-1022.
    CrossRef  |  Direct Link  |  

  47. Sharma, K., L. Deelman, M. Madesh, B. Kurz and E. Ciccone et al., 2003. Involvement of Transforming Growth Factor- in Rregulation of Calcium Transients in Diabetic Vascular Smooth Muscle Cells. Am. J. Physiol., 285: 1258-1270.
    CrossRef  |  Direct Link  |  

  48. Hegde, R., S.M. Srinivasula, P. Datta, M. Madesh and R. Wassell et al., 2003. The polypeptide chain releasing factor GSPT1/eRF3 is proteolytically processed into an IAP- binding protein. J. Biol. Chem., 278: 38699-38706.
    CrossRef  |  Direct Link  |  

  49. Hajnoczky, G., E. Davies and M. Madesh, 2003. Calcium signaling and apoptosis. Biochem. Biophys. Res. Commun., 304: 445-454.
    CrossRef  |  Direct Link  |  

  50. McGowan, T.A., M. Madesh, Y. Zhu, L. Wang and M. Russo et al., 2002. TGF-Induced Calcium Influx Involves The Type III inositol 1,4,5-Triphosphate Receptor and Regulates Actin Cytoskeleton. Am. J. Physiol., 282: 910-920.

  51. Madesh, M., B. Antonsson, S.M. Srinivasula, E.S. Alnemri and G. Hajnoczky, 2002. Rapid Kinetics of tBID-Induced Cytochrome c and Smac/DIABLO Release and Mitochondrial Depolarization. J. Biol. Chem., 277: 5651-5659.
    CrossRef  |  Direct Link  |  

  52. Csordas, G., M. Madesh, B. Antonsson and G. Hajnoczky, 2002. tcBID Promotes Ca2+ Signal Propagation to The Mitochondria: Control of Ca2+ Permeation Through the Outer Mitochondrial Membrane. EMBO J., 21: 2198-2206.
    CrossRef  |  Direct Link  |  

  53. Madesh, M. and G. Hajnoczky, 2001. VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J. Cell Biol., 155: 1003-1016.
    CrossRef  |  Direct Link  |  

  54. Sharma, K., T.A McGowan, L. Wang, M. Madesh and V. Kaspar et al., 2000. Inhibition of Type I and III IP3Rs by TGF- is Associated with Impaired Calcium Release in Mesangial Cells. Am. J. Physiol., 278: 1022-1029.
    Direct Link  |  

  55. Ramachandran, A., M. Madesh and K.A. Balasubramanian, 2000. Apoptosis in the intestinal epithelium: Its relevance in normal and pathophysiological conditions. J. Gastroenterol. Hepatol., 15: 109-120.
    CrossRef  |  Direct Link  |  

  56. Madesh, M., A. Ramachandran, A. Pulimood, M. Vadranam and K.A. Balasubramanian, 2000. Attenuation of Intestinal Ischemia/Reperfusion Injury With Nitric Oxide: Studies on Mitochondrial Function and Lipid Changes. Biochimica et Biophysica Acta, 1500: 204-216.
    CrossRef  |  Direct Link  |  

  57. Hajnoczky, G., G. Csordas, M. Madesh and P. Pacher, 2000. The Machinery of Local Ca2+ Signaling Between Sarco-Endoplasmic Reticulum and Mitochondria. J. Physiol., 529: 69-81.
    CrossRef  |  Direct Link  |  

  58. Hajnoczky, G., G. Csordas, M. Madesh and P. Pacher, 2000. Control of Apoptosis by IP3 and Ryanodine Receptor Driven Calcium Signals. Cell Calcium, 28: 349-363.
Member since February, 2016