Dr. Gerald W. Zamponi

Professor and Senior Associate Dean
University of Calgary, Canada

Highest Degree
Ph.D. in Neurosciences from University of Calgary, Calgary, Canada

My URL
https://livedna.org/1.1314

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Area of Interest:

Physics
Neurosciences
Biophysics
Engineering Physics
Biological Chemistry

Selected Publications

  1. Zamponi, G.W., 2011. Antiallodynic effects of a confused α-conotoxin: Vc1.1 relieves neuropathic pain via off target actions on GABAB receptors and N-type channels. Pain, 152: 241-242.
    CrossRef  |  PubMed  |  Direct Link  |  

  2. Altier, C., A. Garcia-Caballero, B. Simms, H. You and L. Chen et al., 2011. The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels. Nat. Neurosci., 14: 173-180.
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  3. Zamponi, G.W., P. Lory and E. Perez-Reyes, 2010. Role of voltage-gated calcium channels in epilepsy. Pflugers Arch. Eur. J. Physiol., 460: 395-403.
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  4. You, H., C. Altier and G.W. Zamponi, 2010. CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels. Mol. Pharmacol., 77: 211-217.
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  5. Weiss, N., C. Legrand, S. Pouvreau, B. Allard, G.W. Zamponi, M. De Waard and V. Jacquemond, 2010. In vivo expression of G-protein β1γ2 dimer in adult mouse skeletal muscle alters L-type calcium current and excitation-contraction coupling. J. Physiol., 588: 2945-2960.
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  6. Vergnolle, N., N. Cenac, C. Altier, K. Chapman and G.W. Zamponi et al., 2010. A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. Br. J. Pharmacol., 151: 1161-1173.
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  7. Pina-Crespo, J., M. Talantova, I. Micu, B. States and H.S. Chen et al., 2010. Excitatory glycine responses of CNS myelin mediated by NR1/NR3 NMDA receptor subunits. J. Neurosci., 30: 11501-11505.
    CrossRef  |  PubMed  |  Direct Link  |  

  8. Pajouhesh, H., Z.P. Feng, Y. Ding, L. Zhang and H. Pajouhesh et al., 2010. Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorg. Med. Chem. Lett., 20: 1378-1383.
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  9. Flynn, R. and G.W. Zamponi, 2010. Regulation of calcium channels by RGK proteins. Channels, 4: 434-439.
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  10. Evans, R.M., H. You, S. Hameed, C. Altier, A. Mezghrani, E. Bourinet and G.W. Zamponi, 2010. Heterodimerization of ORL1 and opioid receptors and its consequences for N-type calcium channel regulation. J. Biol. Chem., 285: 1032-1040.
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  11. Cenac, N., C. Altier, J.P. Motta, S. Galeano, G.W. Zamponi and N. Vergnolle, 2010. Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity. Gut, 59: 481-488.
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  12. Anderson, D., R. Rehak, S. Hameed, W.H. Mehaffey, G.W. Zamponi and R.W. Turner, 2010. Regulation of the KV4.2 complex by CaV3.1 calcium channels. Channels, 4: 1-5.
    Direct Link  |  

  13. Anderson, D., H. Mehaffey, M. Iftinca, R. Rehak and J.D.T. Engbers et al., 2010. Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes. Nat. Neurosci., 13: 333-337.
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  14. Zamponi, G.W., Z.P. Feng, L. Zhang, D. Dolphin and L.A. Mitcher et al., 2009. Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg. Med. Chem. Lett., 19: 6467-6472.
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  15. Zamponi, G.W., R.J. Lewis, S. Todorovic, S. Arneric and T.P. Snutch, 2009. Role of voltage-gated calcium channels in ascending pain pathways. Brain Res. Rev., 60: 84-89.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Zamponi, G.W. and P.K. Stys, 2009. Role of prions in neuroprotection and neurodegeneration-a mechanism involving glutamate receptors. Prion, 3: 187-189.
    CrossRef  |  PubMed  |  Direct Link  |  

  17. Ouardouz, M., E. Coderre, G.W. Zamponi, S. Hameed, X. Yin, B.D. Trapp and P.K. Stys, 2009. Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors. Ann. Neurol., 65: 160-166.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Ouardouz, M., E. Coderre, A. Basak, A. Chen and G.W. Zamponi et al., 2009. Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors. Ann. Neurol., 65: 151-159.
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  19. Dale, C.S., C. Altier, N. Cenac, M.A. Juliano and L. Juliano et al., 2009. Analgesic properties of S100A9 C-terminal domain: A mechanism dependent on calcium channel inhibition. Fundam. Clin. Pharmacol., 23: 427-438.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Sun, H., D. Varela, D. Chartier, P.C. Ruben, S. Nattel, G.W. Zamponi and N. Leblanc, 2008. Differential interactions of Na+ channel toxins with T-type Ca2+ channels. J. Gen. Physiol., 132: 101-113.
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  21. Rajapaksha, W.R.A.K.J.S., D. Wang, J. Davies, L. Chen, G.W. Zamponi and T.E. Fisher, 2008. Novel splice variants of rat Cav2.1 that lack much of the synaptic protein interaction site are expressed in neuroendocrine cells. J. Biol. Chem., 283: 15997-16003.
    CrossRef  |  PubMed  |  Direct Link  |  

  22. McRory, J.E., R. Rehak, B. Simms, C.J. Doering and L. Chen et al., 2008. Syntaxin 1A is required for normal in utero development. Biochem. Biophys. Res. Comm., 375: 372-377.
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  23. Kisilevsky, A.E., S. Mulligan, C. Altier, M.C. Iftinca and D. Varela et al., 2008. D1 receptors physically interact with N-type calcium channels to regulate channel distribution and dendritic calcium entry. Neuron, 58: 557-570.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Kisilevsky, A.E. and G.W. Zamponi, 2008. D2 dopamine receptors interact directly with N-type calcium channels and regulate channel surface expression levels. Channels, 2: 269-277.
    CrossRef  |  PubMed  |  Direct Link  |  

  25. Khosravani, H., Y. Zhang, S. Tsutsui, S. Hameed and J. Hamid et al., 2008. Prion protein attenuates excitotoxicity by inhibiting NMDA receptors. J. Cell. Biol., 181: 551-565.
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  26. Khosravani, H., Y. Zhang and G.W. Zamponi, 2008. Cellular prion protein null mice display normal AMPA receptor mediated long term depression. Prion, 2: 48-50.
    CrossRef  |  PubMed  |  Direct Link  |  

  27. Flynn, R., S. Hameed, L. Chen, J.D. Spafford and G.W. Zamponi, 2008. Molecular determinants of Rem2 regulation of N-type calcium channels. Biochem. Biophys. Res. Commun., 368: 827-831.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Davies, J.N. and G.W. Zamponi, 2008. Old proteins, developing roles: The regulation of calcium channels by synaptic proteins. Channels, 2: 130-138.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Chee, M., K. Morl, K. Linder, N. Merten and G.W. Zamponi et al., 2008. The third intracellular loop stabilizes the inactive state of the Neuropeptide Y1 receptor. J. Biol. Chem., 283: 33337-33346.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Altier, C. and G.W. Zamponi, 2008. Signaling complexes of voltage-gated calcium channels and G protein-coupled receptors. J. Recept. Signal Transduction, 28: 71-81.
    CrossRef  |  Direct Link  |  

  31. Varela, D. and G.W. Zamponi, 2007. Use 'em and lose 'em-activity-induced removal of calcium channels from the plasma membrane. Neuron, 55: 539-541.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. Jarvis, S.E. and G.W. Zamponi, 2007. Trafficking and regulation of neuronal voltage-gated calcium channels. Curr. Opin. Cell Biol., 19: 474-482.
    CrossRef  |  PubMed  |  Direct Link  |  

  33. Iftinca, M.C., J. Hamid, L. Chen, D. Varela and R. Tadayonnejad et al., 2007. Regulation of T-type calcium channels by Rho-associated kinase. Nat. Neurosci., 10: 854-860.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Hildebrand, M.E., L.S. David, J. Hamid, K. Mulatz, E. Garcia, G.W. Zamponi and T.P. Snutch, 2007. Selective inhibition of Cav3.3 T-type calcium channels by Gαq/11-coupled muscarinic acetylcholine receptors. J. Biol. Chem., 282: 21043-21055.
    CrossRef  |  PubMed  |  Direct Link  |  

  35. Heron, S.E., H. Khosravani, D. Varela, C. Bladen and T.C. Williams et al., 2007. Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants. Ann. Neurol., 62: 560-568.
    CrossRef  |  PubMed  |  Direct Link  |  

  36. Grant, A.D., G.S. Cottrell, S. Amadesi, M. Trevisani and P. Nicoletti et al., 2007. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J. Physiol., 578: 715-733.
    CrossRef  |  PubMed  |  Direct Link  |  

  37. Asfaha, S., N. Cenac, S. Houle, C. Altier and M.D. Papez et al., 2007. Protease-activated receptor-4: A novel mechanism of inflammatory pain modulation. Br. J. Pharmacol., 150: 176-185.
    CrossRef  |  PubMed  |  Direct Link  |  

  38. Altier, C., C.S. Dale, A.E. Kisilevsky, K. Chapman and A.J. Castiglioni et al., 2007. Differential role of N-type calcium channel splice isoforms in pain. J. Neurosci., 27: 6363-6373.
    CrossRef  |  Direct Link  |  

  39. Tedford, H.W., A.E. Kisilevsky, J.B. Peloquin and G.W. Zamponi, 2006. Scanning mutagenesis reveals a role for serine 189 of the heterotrimeric G-protein beta 1 subunit in the inhibition of N-type calcium channels. J. Neurophysiol., 96: 465-470.
    CrossRef  |  PubMed  |  Direct Link  |  

  40. Szabo, Z., G.J. Obermair, C.B. Cooper, G.W. Zamponi and B.E. Flucher, 2006. Role of the synprint site in presynaptic targeting of the calcium channel Cav2.2 in hippocampal neurons. Eur. J. Neurosci., 24: 709-718.
    CrossRef  |  PubMed  |  Direct Link  |  

  41. Schroeder, C.I., C.J. Doering, G.W. Zamponi and R.J. Lewis, 2006. N-type Calcium channel blockers: Novel therapeutics for the treatment of pain. Med. Chem., 2: 535-543.
    CrossRef  |  PubMed  |  

  42. Schenning, M., D.T. Proctor, L. Ragnarsson, J. Barbier and M.A. Lavisis et al., 2006. Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons. J. Neurochem., 98: 894-904.
    CrossRef  |  Direct Link  |  

  43. Molineux, M.L., J.E. McRory, B.E. McKay, H. Mehaffey, J. Hamid et al., 2006. Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons. Proc. Natl. Acad. Sci. USA. 103: 5555-5560.
    Direct Link  |  

  44. Micu, I., Q. Jiang, E. Coderre, A. Ridsdale and L. Zhang et al., 2006. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature, 439: 988-992.
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  45. McLeod, G.T., L. Chen, S. Karunanithi, J.B. Peloquin and H.L. Atwood et al., 2006. The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation. Eur. J. Neurosci., 23: 3230-3244.
    CrossRef  |  PubMed  |  Direct Link  |  

  46. Khosravani, H. and G.W. Zamponi, 2006. Voltage-gated calcium channels and idiopathic generalized epilepsies. Physiol. Rev., 86: 941-966.
    CrossRef  |  PubMed  |  Direct Link  |  

  47. Iftinca, M., B.E. McKay, T.P. Snutch, J.E. McRory, R.W. Turner and G.W. Zamponi, 2006. Temperature dependence of T-type calcium channel gating. Neuroscience, 142: 1031-1042.
    CrossRef  |  PubMed  |  Direct Link  |  

  48. Hamid, J., J.B. Peloquin, A. Monteil and G.W. Zamponi, 2006. Determinants of the differential gating properties of Cav3.1 and Cav3.3 T-type channels: a role of domain IV. Neuroscience, 143: 717-728.
    CrossRef  |  PubMed  |  Direct Link  |  

  49. Gui, P., X. Wu, S. Ling, S.C. Stotz and R.J. Winkfein et al., 2006. Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-src and Protein kinase A pathways. J. Biol. Chem., 281: 14015-14025.
    CrossRef  |  PubMed  |  Direct Link  |  

  50. Evans, R.M. and G.W. Zamponi, 2006. Presynaptic Ca2+ channels-integration centers for neuronal signaling pathways. Trends Neurosci., 29: 617-624.
    CrossRef  |  PubMed  |  Direct Link  |  

  51. Altier, C. and G.W. Zamponi, 2006. Opioid, cheating on its receptors, exacerbates pain. Nature Neurosci., 9: 1465-1467.
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