Dr. Dennis Robert Grayson

Researcher
University of Illinois at Chicago, USA

Highest Degree
PostDoc. in Cell Biology from Rockefeller University, New York, USA

My URL
https://livedna.org/1.1402

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Area of Interest:

Pharmacology and Toxicology
Neuropharmacology
Neuroscience
Neuropsychopharmacology
Molecular Pharamcology

Selected Publications

  1. Sharma, R.P., D.P. Gavin and D.R. Grayson, 2010. CpG methylation in neurons: Message, memory, or mask. Neuropsychopharmacol, 35: 2009-2020.
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  2. Grayson, D.R., M. Kundakovic and R.P. Sharma, 2010. Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders. Mol. Pharmacol., 77: 126-135.
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  3. Grayson, D.R., 2010. Schizophrenia and the epigenetic hypothesis. Epigenomics, 2: 341-344.
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  4. Dong, E., Y. Chen, D.P. Gavin, D.R. Grayson and A. Guidotti, 2010. Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics, 5: 730-735.
    CrossRef  |  PubMed  |  Direct Link  |  

  5. Kundakovic, M., Y. Chen, A. Guidotti and D.R. Grayson, 2009. The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes. Mol. Pharm., 75: 342-354.
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  6. Guidotti, A., E. Dong, M. Kundakovic, R. Satta, D.R. Grayson and E. Costa, 2009. Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends Pharmacol. Sci., 30: 55-60.
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  7. Grayson, D.R., Y. Chen, E. Dong, M. Kundakovic and A. Guidotti, 2009. From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia. Epigenetics, 4: 144-149.
    PubMed  |  Direct Link  |  

  8. Gavin, D.P., C. Rosen, K. Chase, D.R. Grayson, N. Tun and R.P. Sharma, 2009. Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. J. Psychiatry Neurosci., 34: 232-237.
    PubMed  |  Direct Link  |  

  9. Costa, E., Y. Chen, E. Dong, D.R. Grayson and M. Kundakovic et al., 2009. GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert Rev. Neurother., 9: 87-98.
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  10. Sharma, R.P., N. Tun and D.R. Grayson, 2008. Depolarization induces downregulation of DNMT1 and DNMT3 in primary cortical cultures. Epigenetics, 3: 74-80.
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  11. Sharma, R.P., D.R. Grayson and D.P. Gavin, 2008. Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects; analysis of the National Brain Databank microarray collection. Schiophrenia Res., 98: 111-117.
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  12. Kharlamov, E.A., K.L. Downey, P.I. Jukkola, D.R. Grayson and K.M. Kelly, 2008. Expression of GABAA receptor α1 subunit mRNA and protein in rat neocortex following photothrombotic infarction. Brain Res., 1210: 29-38.
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  13. Gavin, D.P., S. Kartan, K. Chase, D.R. Grayson and R.P. Sharma, 2008. Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. Schizophrenia Res., 103: 330-332.
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  14. Dong, E., M. Nelson, D.R. Grayson, E. Costa and A. Guidotti, 2008. Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation. Proc. Natl. Acad. Sci., 105: 13614-13619.
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  15. Ruzika, W., A. Zhubi, M. Veldic, D.R. Grayson, E. Costa and A. Guidotti, 2007. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Mol. Psychiatry, 12: 385-397.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Kundakovic, M., Y. Chen, E. Costa and D.R. Grayson, 2007. DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol. Pharmacol., 71: 644-653.
    CrossRef  |  PubMed  |  Direct Link  |  

  17. Dong, E., A. Guidotti, D.R. Grayson and E. Costa, 2007. Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters. Proc. Natl. Acad. Sci. USA., 104: 4676-4681.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Costa, E., E. Dong, D.R. Grayson, A. Guidotti, W. Ruzicka and M. Veldic, 2007. Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics, 2: 29-36.
    CrossRef  |  PubMed  |  Direct Link  |  

  19. Chen, Y., M. Kundakovic, R.C. Agis-Balboa, G. Pinna and D.R. Grayson, 2007. Induction of the reelin promoter by retinoic acid is mediated by Sp1. J. Neurochem., 103: 650-665.
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  20. Sharma, R.P., C. Rosen, S. Kartan, A. Guidotti, E. Costa, D.R. Grayson and K. Chase, 2006. Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: Preliminary results from a clinical population. Schizophrenia Res., 88: 227-231.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Pinna, G., R.C. Agis-Balboa, A. Zhubi, K. Matsumoto, D.R. Grayson, E. Costa and A. Guidotti, 2006. Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proc. Natl. Acad. Sci. USA., 103: 4275-4280.
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  22. Guidotti, A., W. Ruzicka, D.R. Grayson, M. Veldic, G. Pinna, J.M. Davis and E. Costa, 2006. S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis. Neuroreport, 18: 57-60.
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  23. Grayson, D.R., Y. Chen, E. Costa, E. Dong, A. Guidotti, M. Kundakovic and R.P. Sharma, 2006. The human reelin gene: Transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia. Pharmacol. Ther., 111: 272-286.
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  24. Costa, E., E. Dong, D.R. Grayson, W. Ruzicka, M.V. Simonini, M. Veldic and A. Guidotti, 2006. Epigenetic targets in GABAergic neurons to treat schizophrenia. Adv. Pharmacol., 54: 95-117.
    PubMed  |  

  25. Tremolizzo, L., M.S. Doueiri, E. Dong, D.R. Grayson and G. Pinna et al., 2005. Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry, 57: 500-509.
    CrossRef  |  PubMed  |  Direct Link  |  

  26. Sharma, R.P., D.R. Grayson, A. Guidotti, E. Costa, 2005. Chromatin, DNA methylation and neuron gene regulation-the purpose of the package. J. Psychiatry Neurosci., 30: 257-263.
    PubMed  |  Direct Link  |  

  27. Mitchell, C.P., Y. Chen, M. Kundakovic, E. Costa and D.R. Grayson, 2005. Histone deacetylase inhibitors decrease reelin promoter methylation in vitro. J. Neurochem., 93: 483-492.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Guidotti, A., J. Auta, J.M. Davis, E. Dong and D.R. Grayson et al., 2005. GABAergic dysfunction in schizophrenia: New treatment strategies on the horizon. Psychopharmacology, 180: 191-205.
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  29. Grayson, D.R., X. Jia, Y. Chen, R.P. Sharma, C.P. Mitchell, A. Guidotti and E. Costa, 2005. Reelin promoter hypermethylation in schizophrenia. Proc. Natl. Acad. Sci. USA., 102: 9341-9346.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Gibbons, R.D., D.K. Bhaumik, D.R. Cox, D.R. Grayson, J.M. Davis and R.P. Sharma, 2005. Sequential prediction bounds for identifying differentially expressed genes in replicated microarray experiments. J. Stat. Plann. Inference, 129: 19-37.
    CrossRef  |  Direct Link  |  

  31. Dong, E., R.C. Agis-Balboa, M.V. Simonini, D.R. Grayson, E. Costa and A. Guidotti, 2005. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc. Natl. Acad. Sci. USA., 102: 12578-12583.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. Veldic, M., H.M. Caruncho, W.S. Liu, J. Davis and R. Satta et al., 2004. DNA-Methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. Proc. Natl. Acad. Sci. USA., 101: 348-353.
    CrossRef  |  PubMed  |  Direct Link  |  

  33. Noh, J.S., R.P. Sharma, M. Veldic, A.A. Salvacion and X. Jia et al., 2004. DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures. Proc. Natl. Acad. Sci. USA., 102: 1749-1754.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Costa, E., J. Davis, E. Dong, D.R. Grayson, A. Guidotti, L. Tremolizzo and M. Veldic, 2004. A GABAergic cortical deficit dominates schizophrenia pathophysiology. Crit. Rev. Neurobiol., 16: 1-23.
    CrossRef  |  PubMed  |  Direct Link  |  

  35. Costa, E., D.R. Grayson, C.P. Mitchell, L. Tremolizzo, M. Veldic and A. Guidotti, 2003. GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability. Crit. Rev. Neurobiol., 15: 121-142.
    PubMed  |  
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