Dr. Sunil J. Wimalawansa

Professor
Cardio Metabolic Institute, USA

Highest Degree
Ph.D. in Endocrine Pathology from University of London, UK

My URL
https://livedna.org/1.14107

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Area of Interest:

Biomedical Sciences
Cadiovascular Sciences
Drug Formulation
Osteopososis
Cell Biology

Selected Publications

  1. Wimalawansa, S.J., 2016. Vitamin D deficiency is a surrogate marker for visceral fat content, metabolic syndrome, type 2 diabetes and future metabolic complications. J. Diabetes Metab. Disorders Control, 3: 1-10.

  2. Wimalawansa, S.J., 2016. Vitamin D adequacy and improvements of comorbidities in persons with intellectual developmental disabilities. J. Childhood Dev. Disorders, Vol. 2. 10.4172/2472-1786.100030.
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  3. Wimalawansa, S.J., 2016. The role of ions, heavy metals, fluoride and agrochemicals: Critical evaluation of potential aetiological factors of chronic kidney disease of multifactorial origin (CKDmfo/CKDu) and recommendations for its eradication. Environ. Geochem. Health, 38: 639-678.
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  4. Wimalawansa, S.J., 2016. Optimum duration and safety of long-term use of potent anti-resorptive medications in osteoporosis. Expert Rev. Endocrinol. Metab., 11: 329-348.
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  5. Wimalawansa, S.J., 2016. Non-musculoskeletal benefits of vitamin D. J. Steroid Biochem. Mol. Biol., 10.1016/j.jsbmb.2016.09.016.
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  6. Wimalawansa, S.J., 2016. Extra-Skeletal benefits, Endocrine Functions and Toxicity of Vitamin. J. Endocrinol. Diabetes, 3: 1-5.

  7. Wimalawansa, S.J., 2016. Endocrinological mechanisms of depressive disorders and ill health. Expert Rev. Endocrinol. Metab., 11: 3-6.
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  8. Wimalawansa, S.J., 2016. Effect of water hardness on non-communicable diseases, including chronic kidney disease of multifactorial origin (CKDmfo/CKDuo). J. Environ. Health Sci., 2: 1-11.
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  9. Wimalawansa, S.J., 2016. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes and metabolic syndrome. J. Steroid Biochem. Mol. Biol., 10.1016/j.jsbmb.2016.09.017.
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  10. Wimalawansa, S.A. and S.J. Wimalawansa, 2016. Environmentally induced, occupational diseases with emphasis on chronic kidney disease of multifactorial origin affecting tropical countries. Ann. Occup. Environ. Med., Vol. 28. 10.1186/s40557-016-0119-y.
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  11. Smith, G., S.J. Wimalawansa, A. Laillou, P. Sophonneary and S. Un et al., 2016. High prevalence of vitamin D deficiency in Cambodian women: A common deficiency in a sunny country. Nutrients, Vol. 8. 10.3390/nu8050290.
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  12. Haq, A., S.J. Wimalawansa, P. Pludowski and F. Al Anouti, 2016. Clinical practice guidelines for vitamin D in the United Arab Emirates. J. Steroid Biochem. Mol. Biol., 10.1016/j.jsbmb.2016.09.021.
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  13. Camacho, P.M., S.M. Petak, N.C. Binkley, T. Harris and M. Kleerekoper et al., 2016. American associationof clinical endocrinologists and American college of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2016-executive summary. Endocr. Pract., 22: 1111-1118.
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  14. Wimalawansa, S.J., 2015. Strategic framework for managing non-communicable diseases: Preventing chronic kidney disease of multi-factorial origin (CKDmfo / CKDu) as an example. Chronic Dis. Int., 2: 1-8.

  15. Wimalawansa, S.J., 2015. Preventing long-term complications of obesity, type 2 diabetes and metabolic syndrome. Endocrinol. Metab. Syndrome, Vol. 4. 10.4172/2161-1017.1000206.
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  16. Wimalawansa, S.J., 2015. Obesity and type 2 diabetes: Preventing complications. J. Diabetes Metab. Disorders Control, 2: 47-50.
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  17. Wimalawansa, S.J., 2015. In the era of budgetary constraints, cost-effective management of metabolic syndrome, type 2 diabetes and obesity is essential. Curr. Res. Diabetes Obesity J., Vol. 1. .
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  18. Wimalawansa, S.J., 2015. Escalating chronic kidney diseases of multi-factorial origin (CKD-mfo) in Sri Lanka: causes, solutions and recommendations: Update and responses. Environ. Health Prev. Med., 20: 152-157.
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  19. Wimalawansa, S.J., 2015. Agrochemicals and chronic kidney disease of multifactorial origin: Environmentally induced occupational exposure disease. Int. J. Nephrol. Kidney Fail., 1: 1-9.

  20. Wimalawansa, S.A. and S.J. Wimalawansa, 2015. Clean water, healthy environment and preservation of watersheds: Correct, enforceable policies are essential. Jacobs J. Hydrol., 1: 3-15.

  21. Wimalawansa, S.A. and S.J. Wimalawansa, 2015. Chronic kidney disease of multifactorial origin (CKDmfo/CKDu): Escalating incidence and long-term survival estimates. J. Urol. Nephrol. Res., 2: 1-15.

  22. Wimalawansa, S. and S.J. Wimalawansa, 2015. Protection of watersheds and control of fertilisers to prevent phosphate eutrophication of reservoirs in Sri Lanka. Int. J. Res. Environ. Sci., 1: 1-18.
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  23. Weeraratne, S. and S.J. Wimalawansa, 2015. A major irrigation project (accelerated mahaweli programme) and the chronic kidney disease of multifactorial origin in Sri Lanka. Int. J. Environ. Agric. Res., 1: 16-27.
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  24. Smith, G. and S.J. Wimalawansa, 2015. Reconciling the irreconcilable: Micronutrients in clinical nutrition and public health. Vitamins Minerals, Vol. 4. 10.4172/2376-1318.1000e136.
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  25. Naser, K.A. and S.J. Wimalawansa, 2015. Diabetes diet: Is glycemic index still relevant in medical nutrition therapy? SLR Diabetes Metab., 1: 1-4.
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  26. Grant, W.B., S.J. Wimalawansa, M.F. Holick, J.J. Cannell and P. Pludowski et al., 2015. Emphasizing the health benefits of vitamin D for those with neurodevelopmental disorders and intellectual disabilities. Nutrients, 7: 1538-1564.
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  27. Grant, W.B., S.J. Wimalawansa and M.F. Holick, 2015. Vitamin D supplements and reasonable solar UVB should be recommended to prevent escalating incidence of chronic diseases. Br. Med. J, Vol. 350. .
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  28. Wimalawansa, S.J., 2014. Stigma of obesity: A major barrier to overcome. J. Clin. Transl. Endocrinol., 1: 73-76.
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  29. Wimalawansa, S.J., 2014. Mechanisms of developing post-traumatic stress disorder: New targets for drug development and other potential interventions. CNS Neurol. Disorders Drug Targets, 13: 807-816.
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  30. Wimalawansa, S.J., 2014. Escalating chronic kidney diseases of multi-factorial origin in Sri Lanka: Causes, solutions and recommendations. Environ. Health Prev. Med., 19: 375-394.
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  31. Wimalawansa, S.J., 2014. Controlling obesity and its complications by elimination of causes and adopting healthy habits. Adv. Med. Sci., 3: 1-15.

  32. Wimalawansa, S.J., 2014. Causes and risk factors for posttraumatic stress disorder: The importance of right diagnosis and treatment. Asian J. Med. Sci., 5: 1-13.
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  33. Wimalawansa, S.A. and S.J. Wimalawansa, 2014. Changing agricultural practices in dry zonal areas and escalating incidences of chronic kidney disease of multi-factorial origin. Wudpecker J. Agric. Environ., 3: 110-124.

  34. Wimalawansa, S.A. and S.J. Wimalawansa, 2014. Agrochemical-related environmental pollution: Effects on human health. Global J. Biol. Agric. Health Sci., 3: 72-83.
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  35. Wimalawansa, S.J., 2013. Visceral adiposity and cardiometabolic risks: Epidemic of abdominal obesity in north America. Res. Rep. Endocr. Disorder, 3: 17-30.
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  36. Wimalawansa, S.J., 2013. Thermogenesis based interventions for treatment for obesity and type 2 diabetes mellitus. Expert Rev. Endocrinol. Metab., 8: 275-288.

  37. Wimalawansa, S.J., 2013. Rational food fortification programs to alleviate micronutrient deficiencies. J. Food Process. Technol., 4: 257-267.
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  38. Wimalawansa, S.J., 2013. Purification of contaminated water with reverse osmosis: Effective solution of providing clean water for human needs in developing countries. J. Emerging Technol. Adv. Eng., 3: 75-89.
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  39. Wimalawansa, S.J., 2013. Post-traumatic stress disorder: An under-diagnosed and under-treated entity. Compr. Res. J. Med. Med. Sci., 1: 1-12.
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  40. Wimalawansa, S.J., 2013. Pathophysiology of obesity: Focused, cause-driven approach to control the epidemic. Global Adv. Res. J. Pharm. Pharmacol., 2: 2-12.
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  41. Wimalawansa, S.J., 2012. Vitamin D: What clinicians would like to know. Sri Lanka J. Diabetes Endocrinol. Metab., 2: 73-88.

  42. Wimalawansa, S.J., 2012. Vitamin D in the new millennium. Curr. Osteoporosis Rep., 10: 4-15.
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  43. Wimalawansa, S.J., 2011. Vitamin D: An essential component for skeletal health. Ann. N.Y. Acad. Sci., Vol. 1240. 10.1111/j.1749-6632.2011.06374.x.
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  44. Wimalawansa, S.J., 2010. Nitric oxide and bone. Ann. N.Y. Acad. Sci., 1192: 391-403.
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  45. Watts, N.B., J.P. Bilezikian, P.M. Camacho, S.L. Greenspan and S.T. Harris et al., 2010. American association of clinical endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr. Pract., 16: 1-37.
    PubMed  |  Direct Link  |  

  46. Wimalawansa, S.J., J.P. Grimes, A.C. Wilson and D.R. Hoover, 2009. Transdermal nitroglycerin therapy may not prevent early postmenopausal bone loss. J. Clin. Endocrinol. Metab., 94: 3356-3364.
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  47. Wimalawansa, S.J., 2008. Nitric oxide: Novel therapy for osteoporosis. Expert Opin. Pharmacother., 9: 3025-3044.
    PubMed  |  

  48. Wimalawansa, S.J., 2008. Nitric oxide: New evidence for novel therapeutic indications. Expert Opin. Pharmacother., 9: 1935-1954.
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  49. Wimalawansa, S.J., 2008. Insight into bisphosphonate-associated osteomyelitis of the jaw: Pathophysiology, mechanisms and clinical management. Expert Opin. Drug Saf., 7: 491-512.
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  50. Wimalawansa, S., 2008. Bisphosphonate-associated osteomyelitis of the jaw: Guidelines for practicing clinicians. Endocr. Pract., 14: 1150-1168.
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  51. Wimalawansa, S.J., 2007. Rationale for using nitric oxide donor therapy for prevention of bone loss and treatment of osteoporosis in humans. Ann. N.Y. Acad. Sci., 1117: 283-297.
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  52. Margolis, R.N. and S.J. Wimalawansa, 2006. Novel targets and therapeutics for bone loss. Ann. N.Y. Acad. Sci., 1068: 402-409.
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  53. Liebschner, M.A., R. Muller, S.J. Wimalawansa, C.S. Rajapakse and G.H. Gunaratne, 2005. Testing two predictions for fracture load using computer models of trabecular bone. Biophys. J., 89: 759-767.
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  54. Klein, G.L., S.J. Wimalawansa, G. Kulkarni, D.J. Sherrard, A.P. Sanford and D.N. Herndon, 2005. The efficacy of acute administration of pamidronate on the conservation of bone mass following severe burn injury in children: A double-blind, randomized, controlled study. Osteoporosis Int., 16: 631-635.
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  55. Yallampalli, C., S.B. Kondapaka, P. Lanlua, S.J. Wimalawansa and P.R.R. Gangula, 2004. Female sex steroid hormones and pregnancy regulate receptors for calcitonin gene-related peptide in rat mesenteric arteries, but not in aorta. Biol. Reprod., 70: 1055-1062.
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  56. Rajapakse, C.S., J.S. Thomsen, J.S.E. Ortiz, S.J. Wimalawansa, E.N. Ebbesen, L. Mosekilde and G.H. Gunaratne, 2004. An expression relating breaking stress and density of trabecular bone. J. Biomech., 37: 1241-1249.
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  57. Penchalaneni, J., S.J. Wimalawansa and C. Yallampalli, 2004. Adrenomedullin antagonist treatment during early gestation in rats causes fetoplacental growth restriction through apoptosis. Biol. Reprod., 71: 1475-1483.
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  58. Gangula, P.R.R., P. Lanlua, R.D. Bukoski, S.J. Wimalawansa and C. Yallampalli, 2004. Mesenteric arterial relaxation to calcitonin gene-related peptide is increased during pregnancy and by sex steroid hormones. Biol. Reprod., 71: 1739-1745.
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  59. Chauhan, M., P.R.R. Gangula, S.J. Wimalawansa and C. Yallampalli, 2004. Studies on the effects of the n-terminal domain antibodies of calcitoninreceptor-like receptor and receptor activity-modifying protein 1 on calcitoningene-related peptide-induced vasorelaxation in rat uterine artery. Biol. Reprod., 70: 1658-1663.
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  60. Witlin, A.G., P.R. Gangula, S.J. Wimalawansa, M. Grafe, J.J. Grady and C. Yallampalli, 2003. Adrenomedullin requires an intact nitric oxide system to function as an endogenous vasodilator in rat gestation. Hypertens. Pregnancy, 22: 9-24.
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  61. Vandevska-Radunovic, V., I. Fristad, S.J. Wimalawansa and I.H. Kvinnsland, 2003. CGRP1 and NK1 receptors in postnatal, developing rat dental tissues. Eur. J. Oral Sci., 111: 497-502.
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  62. Qing, X., S.J. Wimalawansa and I.M. Keith, 2003. Specific N-terminal CGRP fragments mitigate chronic hypoxic pulmonary hypertension in rats. Regul. Pept., 110: 93-99.
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  63. Grimes, J.P. and S.J. Wimalawansa, 2003. Breast-feeding and postmenopausal osteoporosis. Current Women's Health Rep., 3: 193-198.

  64. Gangula, P.R.R., C. Thota, S.J. Wimalawansa, R.D. Bukoski and C. Yallampalli, 2003. Mechanisms involved in calcitonin gene-related peptide-induced relaxation in pregnant rat uterine artery. Biol. Reprod., 69: 1635-1641.
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  65. Fristad, I., V. Vandevska-Radunovic, K. Fjeld, S.J. Wimalawansa and I.H. Kvinnsland, 2003. NK1, NK2, NK3 and CGRP1 receptors identified in rat oral soft tissues and in bone and dental hard tissue cells. Cell Tissue Res., 311: 383-391.
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  66. Dong, Y.L., S. Wimalawansa and C. Yallampalli, 2003. Effects of steroid hormones on calcitonin gene-related peptide receptors in cultured human myometrium. Am. J. Obstetrics Gynecology, 188: 466-472.
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  67. Chauhan, M., C.S. Thota, S.B. Kondapaka, S.J. Wimalawansa and C. Yallampalli, 2003. CGRP receptor heterogeneity: A role for receptor component protein? Trends Endocrinol. Metab., 14: 4-6.
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  68. Chauhan, M., C.S. Thota, S. Kondapaka, S. Wimalawansa and C. Yallampalli, 2003. Evidence for the existence of a new receptor for CGRP, which is not CRLR. Peptides, 24: 65-71.
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  69. Advani, S. and S.J. Wimalawansa, 2003. Bones and nutrition: Common sense supplementation for osteoporosis. Curr. Womens Health Rep., 3: 187-192.
    PubMed  |  

  70. Yallampalli, C., M. Chauhan, C.S. Thota, S. Kondapaka and S.J. Wimalawansa, 2002. Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity. Trends Endocrinol. Metab., 13: 263-269.
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  71. Witlin, A.G., Z.Y. Li, S.J. Wimalawansa, J.J. Grady, M.R. Grafe and C. Yallampalli, 2002. Placental and fetal growth and development in late rat gestation is dependent on adrenomedullin. Biol. Reprod., 67: 1025-1031.
    CrossRef  |  PubMed  |  Direct Link  |  

  72. Lanlua, P., R.D. Bukoski, S.J. Wimalawansa and C. Yallampalli, 2002. Effects of pregnancy and female sex steroid hormones on calcitonin gene-related peptide content of mesenteric artery in rats. Biol. Reprod., 67: 1430-1434.
    CrossRef  |  PubMed  |  Direct Link  |  

  73. Gunaratne, G.H., K.K. Mohanty and S.J. Wimalawansa, 2002. A model of trabecular bone and an application to osteoporosis. Phys. A Stat. Mech. Applic., 315: 98-104.
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  74. Gunaratne, G.H., C.S. Rajapaksa, K.E. Bassler, K.K. Mohanty and S.J. Wimalawansa, 2002. Model for bone strength and osteoporotic fractures. Phys. Rev. Lett., Vol. 88. 10.1103/PhysRevLett.88.068101.
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  75. Gangula, P.R.R., Y.L. Dong, S.J. Wimalawansa and C. Yallampalli, 2002. Infusion of pregnant rats with calcitonin gene-related peptide (CGRP) 8-37, a CGRP receptor antagonist, increases blood pressure and fetal mortality and decreases fetal growth. Biol. Reprod., 67: 624-629.
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  76. Gangula, P.R.R., S.J. Wimalawansa and C. Yallampalli, 2002. Sex steroid hormones enhance hypotensive effects of calcitonin gene-related peptide in aged female rats. Biol. Reprod., 67: 1881-1887.
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  77. Dong, Y.L., S. Vegiraju, P.R. Gangula, S.B. Kondapaka, S.J. Wimalawansa and C. Yallampalli, 2002. Expression and regulation of calcitonin gene-related peptide receptor in rat placentas. Biol. Reprod., 67: 1321-1326.
    PubMed  |  Direct Link  |  

  78. Zhang, L., A.O. Hoff, S.J. Wimalawansa, G.J. Cote, R.F. Gagel and K.N. Westlund, 2001. Arthritic calcitonin/α calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity. Pain, 89: 265-273.
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  79. Halhali, A., S.J. Wimalawansa, V. Berentsen, E. Avila, C.S. Thota and F. Larrea, 2001. Calcitonin gene- and parathyroid hormone-related peptides in preeclampsia: Effects of magnesium sulfate. Obstetrics Gynecology, 97: 893-897.
    PubMed  |  Direct Link  |  

  80. Gangula, P.R.R., H. Zhao, S.J. Wimalawansa, S.C. Supowit, D.J. DiPette and C. Yallampalli, 2001. Pregnancy and steroid hormones enhance the systemic and regional hemodynamic effects of calcitonin gene-related peptide in rats. Biol. Reprod., 64: 1776-1783.
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  81. D'este, L., S.J. Wimalawansa and T.G. Renda, 2001. Distribution of amylin-immunoreactive neurons in the monkey hypothalamus and their relationships with the histaminergic system. Arch. Histol. Cytol., 64: 295-303.
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  82. Classey, J.D., M.P. Lasalandra, Y.K. Knight, S.J. Wimalawansa and P.J. Goadsby, 2001. Immunohistochemical comparison of CGRP and substance P (peptides and receptors) and NMDAR1 and GLUR1 receptor distribution in the cat trigeminocervical complex. Cephalalgia Int. J. Headache, 21: 351-367.

  83. Yallampalli, C. and S.J. Wimalawansa, 2000. Calcitonin Gene-Related Peptide and Pregnancy. In: The CGRP Family: Calcitonin Gene-Related Peptide, Amylin and Adrenomedullin. Poyner, D., I. Marshall and S.D. Brain (Ed.). RG Landes Co., Texas, USA., pp: 229-238..

  84. Wimalawansa, S.M., V.S. Shankar, D.J. Simmins and S.J. Wimalawansa, 2000. The mechanism of bone resorption by cyclosporin: Involvement of the NO-cGMP pathway. J. Musculoskelet Neuronal Interact., 1: 141-143.
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  85. Wimalawansa, S.M. and S.J. Wimalawansa, 2000. A novel pharmacological approach of musculoskeletal losses associated with simulated microgravity. J. Musculoskel Neuron Interact., 11: 34-41.
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  86. Wimalawansa, S.J., 2000. Restoration of ovariectomy-induced osteopenia by nitroglycerin. Calcified Tissue Int., 66: 56-60.
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  87. Wimalawansa, S.J., 2000. Prevention and treatment of osteoporosis: Efficacy of combination of hormone replacement therapy with other antiresorptive agents. J. Clin. Densitometry, 3: 187-201.
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  88. Wimalawansa, S.J., 2000. Nitroglycerin therapy is as efficacious as standard estrogen replacement therapy (premarin) in prevention of oophorectomy-induced bone loss: A human pilot clinical study. J. Bone Mineral Res., 15: 2240-2244.
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  89. Wimalawansa, S., T. Chapa, L. Fang, C. Yallampalli, D. Simmons and S. Wimalawansa, 2000. Frequency-dependent effect of nitric oxide donor nitroglycerin on bone. J. Bone Mineral Res., 15: 1119-1125.
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  90. Morara, S., A. Rosina, L. Provini, G. Forloni, A. Caretti and S.J. Wimalawansa, 2000. Calcitonin gene-related peptide receptor expression in the neurons and glia of developing rat cerebellum: An autoradiographic and immunohistochemical analysis. Neurosci., 100: 381-391.
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  91. Gangula, P.R.R., S.J. Wimalawansa and C. Yallampalli, 2000. Pregnancy and sex steroid hormones enhance circulating calcitonin gene-related peptide concentrations in rats. Hum. Reprod., 15: 949-953.
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  92. Gangula, P.R.R., P. Lanlua, S. Wimalawansa, S. Supowit, D. DiPette and C. Yallampalli, 2000. Regulation of calcitonin gene-related peptide expression in dorsal root ganglia of rats by female sex steroid hormones. Biol. Reprod., 62: 1033-1039.
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  93. Gangula, P.R., H. Zhao, S.C. Supowit, S.J. Wimalawansa and D.J. Dipette et al., 2000. Increased blood pressure in α-calcitonin gene-related peptide/calcitonin gene knockout mice. Hypertens., 35: 470-475.
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  94. D'Este, L., A. Casini, S.J. Wimalawansa and T.G. Renda, 2000. Immunohistochemical localization of amylin in rat brainstem. Peptides, 21: 1743-1749.
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