Dr. Charles J. Malemud

Professor
Case Western Reserve University, USA

Highest Degree
Ph.D. in Medicine and Anatomy from George Washington University, USA

My URL
https://livedna.org/1.19973

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Area of Interest:

Pharmacology and Toxicology
Clinical Immunology
Alternative Medicine
Endocrinology
Rheumatology

Selected Publications

  1. Meszaros, E.C. and C.J. Malemud, 2017. Phosphorylation of STAT proteins by recombinant human IL-6 in immortalized human chondrocyte cell lines, T/C28a2 and C28/I2. J. Inflamm. Res., 10: 143-150.
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  2. Mandel, D.E., C.J. Malemud and A.D. Askari, 2017. Idiopathic inflammatory myopathies: A review of the classification and impact of pathogenesis. Int. J. Mol. Sci., Vol. 18. 10.3390/ijms18051084.
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  3. Mandel, D., A.D. Askari, C.J. Malemud and A. Kaso, 2017. Joint hypermobility syndrome and postural orthostatic tachycardia syndrome (HyPOTS). Biomed. Res. Clin. Pract., 2: 1-4.
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  4. Malemud, C.J., 2017. Negative regulators of JAK/STAT signaling in rheumatoid arthritis and osteoarthritis. Int. J. Mol. Sci., Vol. 18. 10.3390/ijms18030484.
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  5. Akeson, G. and C.J. Malemud, 2017. A role for soluble IL-6 receptor in osteoarthritis. J. Funct. Morphol. Kinesiol., Vol. 2. 10.3390/jfmk2030027.
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  6. Taylor, P.R., S. Roy, E.C. Meszaros, Y. Sun, S.J. Howell, C.J. Malemud and E. Pearlman, 2016. JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase and MMP9 activity. J. Leukocyte Biol., 100: 213-222.
    PubMed  |  

  7. Malemud, C.J., E.C. Meszaros, M.A. Wylie, W. Dahoud, Y. Skomorovska-Prokvolit and S. Mesiano, 2016. Matrix metalloproteinase-9 production by immortalized human chondrocyte lines. J. Clin. Cell. Immunol., Vol. 7. 10.4172/2155-9899.1000422.
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  8. Campbell, L., I. Raheem, C.J. Malemud and A.D. Askari, 2016. The relationship between NALP3 and autoinflammatory syndromes. Int. J. Mol. Sci., Vol. 17. 10.3390/ijms17050725.
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  9. Blumenthal, D.E. and C.J. Malemud, 2016. Recent strategies for drug development in fibromyalgia syndrome. Expert Rev. Neurotherapeut., 16: 1407-1411.
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  10. Amini, P., D. Michniuk, K. Kuo, L. Yi and Y. Skomorovska-Prokvolit et al., 2016. Human parturition involves phosphorylation of progesterone receptor-A at serine-345 in myometrial cells. Endocrinology, 157: 4434-4445.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Wylie, M.A., E.C. Meszaros and C.J. Malemud, 2015. The effect of interleukin-6-type cytokines and adiponectin on MAPK activation in the immortalized human chondrocyte C28/I2 line and normal human chondrocytes. J. Cell Biol. Histol., Vol. 1, No. 1. .
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  12. Meszaros, E.C., W. Dahoud, S. Mesiano and C.J. Malemud, 2015. Blockade of recombinant human IL-6 by tocilizumab suppresses matrix metalloproteinase-9 production in the C28/I2 immortalized human chondrocyte cell line. Integr. Mol. Med., 2: 304-310.
    CrossRef  |  Direct Link  |  

  13. Meszaros, E.C. and C.J. Malemud, 2015. STAT1 is constitutively activated in the T/C28a2 immortalized juvenile human chondrocyte line and stimulated by IL-6 plus soluble IL-6R. J. Clin. Cell. Immunol., Vol. 6. 10.4172/2155-9899.1000307.
    CrossRef  |  Direct Link  |  

  14. Mattar, M., B. Jandali, C.J. Malemud and A.D. Askari, 2015. Atherosclerosis and rheumatic diseases. Rheumatology, Vol. 5. 10.4172/2161-1149.1000147.
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  15. Malemud, C.J., A.C. Lewis, M.A. Wylie, E.C. Meszaros, Y. Skomorovska-Prokvolit and S. Mesiano, 2015. U0126, an inhibitor of MEK1/2, increases tumor necrosis factor-α-induced apoptosis, but not interleukin-6 induced apoptosis in C-28/I2 human chondrocytes. J. Autoimmune Disord., Vol. 1, No. 1. .
    Direct Link  |  

  16. Malemud, C.J., 2015. Vaccine development for rheumatoid arthritis. Global Vaccines Immunol., 1: 2-5.
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  17. Malemud, C.J., 2015. The biological basis of osteoarthritis: State of the evidence. Curr. Opin. Rheumatol., 27: 289-294.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Malemud, C.J., 2015. The Small Molecular Weight Inhibitor of Protein Kinase Revolution for the Treatment of Rheumatoid Arthritis. In: Drug Discovery and Development-From Molecules to Medicine, Vallisuta, O. and S. Olimat (Eds.). InTech Publishing, Rijeka, Croatia, pp: 163-179.

  19. Malemud, C.J., 2015. The PI3K/Akt/PTEN/mTOR pathway: A fruitful target for inducing cell death in rheumatoid arthritis? Future Med. Chem., 7: 1137-1147.
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  20. Malemud, C.J., 2015. Chondrocyte apoptosis in rheumatoid arthritis: Is preventive therapy possible? Immunotherapy, Vol. 1, No. 1. .
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  21. Muoh, O., C.J. Malemud and A.D. Askari, 2014. Clinical significance and implications of genetic and genomic studies in patients with osteoarthritis. Adv. Genomics Genet., 4: 193-206.
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  22. Malemud, C.J. and D.E. Blumenthal, 2014. Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical perspectives. World J. Orthopedics, 5: 496-503.
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  23. Ahmed, S., C.J. Malemud, A.E. Koch, M. Athar and D.D. Taub, 2014. Cytokines and chemokines: Disease models, mechanisms and therapies. Mediators Inflamm. 10.1155/2014/296356.
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  24. Wylie, M.A. and C.J. Malemud, 2013. Deregulation of apoptosis in arthritis by altered signal transduction. Int. J. Clin. Rheumatol., 8: 483-490.
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  25. Taherian, E., A. Rao, C.J. Malemud and A.D. Askari, 2013. The biological and clinical activity of anti-malarial drugs in autoimmune disorders. Curr. Rheumatol. Rev., 9: 45-62.
    PubMed  |  

  26. Malemud, C.J., 2013. Suppression of Pro-Inflammatory Cytokines via Targeting of STAT-Responsive Genes. In: Drug Discovery, El-Shemy, H. (Ed.). InTech Publishing, Rijeka, Croatia, pp: 373-411.

  27. Malemud, C.J., 2013. Regulation of pain in fibromyalgia by selective serotonin and serotonin norepinephrine reuptake inhibition. Int. J. Phys. Med. Rehabil., Vol. 1. 10.4172/2329-9096.1000144.
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  28. Malemud, C.J., 2013. Regulation of Chondrocyte Matrix Metalloproteinase Gene Expression. In: Role of Proteases in Cellular Dysfunction, Dhalla, N.S. and S. Chakraborti (Eds.). Springer Science, UK., pp: 63-77.

  29. Malemud, C.J., 2013. Intracellular signaling pathways in rheumatoid arthritis. J. Clin. Cell. Immunol., Vol. 4. 10.4172/2155-9899.1000160.
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  30. Meszaros, E. and C.J. Malemud, 2012. Prospects for treating osteoarthritis: Enzyme-protein interactions regulating matrix metalloproteinase activity. Therapeut. Adv. Chronic Dis., 3: 219-229.
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  31. Malemud, C.J., Y. Sun, E. Pearlman, N.M. Ginley, A. Awadallah, B.A. Wisler and J.E. Dennis, 2012. Monosodium urate and tumor necrosis factor-α increase apoptosis in human chondrocyte cultures. Rheumatol., Vol. 2. 10.4172/2161-1149.1000113.
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  32. Malemud, C.J., A. Haque, N.A. Louis and J. Wang, 2012. Immune response and apoptosis-introduction. J. Clin. Cell. Immunol., Vol. S3. 10.4172/2155-9899.S3-e001.
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  33. Malemud, C.J., 2012. Inhibitors of JAK for the treatment of rheumatoid arthritis: Rationale and clinical data. Clin. Invest., 2: 39-47.
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  34. Wisler, B.A., J.E. Dennis and C.J. Malemud, 2011. New organ-specific pharmacological strategies interfering with signaling pathways in inflammatory disorders/autoimmune disorders. Curr. Signal Transduction Ther., 6: 279-291.
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  35. Malemud, C.J., 2011. Myeloid-related protein activity in rheumatoid arthritis. Int. J. Inflamm. 10.4061/2011/580295.
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  36. Malemud, C.J., 2011. Molecular mechanisms in rheumatic diseases: Rationale for novel drug development-introduction. Anti-Inflamm. Anti-Allergy Agents Med. Chem., 10: 73-77.
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  37. Malemud, C.J., 2011. Gene Therapy Outcomes in Experimental Models of Inflammatory Arthritis. In: Gene Therapy Applications, Kang, C. (Ed.). InTech Publishing, Vienna, Austria, pp: 189-200.

  38. Malemud, C.J., 2011. Dysfunctional immune-mediated inflammation in rheumatoid arthritis dictates that development of anti-rheumatic disease drugs target multiple intracellular signaling pathways. Anti-Inflamm. Anti-Allergy Agents Med. Chem., 10: 78-84.
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  39. Malemud, C.J., 2011. Apoptosis resistance in rheumatoid arthritis synovial tissue. J. Clin. Cell. Immunol., Vol. S3. 10.4172/2155-9899.S3-006.
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  40. Lewis, A.C. and C.J. Malemud, 2011. Correction of Dysfunctional Apoptosis in Arthritis by Pharmacologic Interventions: Focus on Altering the Activity of Inhibitor of Apoptosis Protein. In: Recent Research Developments in Pharmacology, Pandalai, S.G. (Ed.). Research Signpost, Kerala, India, pp: 69-84.

  41. Malemud, C.J., 2010. Suppression of autoimmune arthritis by small molecule inhibitors of the JAK/STAT pathway. Pharmaceuticals, 3: 1446-1455.
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  42. Malemud, C.J., 2010. Differential activation of JAK enzymes in rheumatoid arthritis and autoimmune disorders by pro-inflammatory cytokines: Potential drug targets. Int. J. Interferon Cytokine Mediator Res., 2: 97-111.
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  43. Malemud, C.J., 2010. Anticytokine therapy for osteoarthritis: Evidence to date. Drugs Aging, 27: 95-115.
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  44. Torres, A., A.D. Askari and C.J. Malemud, 2009. Cardiovascular disease complications in systemic lupus erythematosus. Biomarkers Med., 3: 239-252.
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  45. Malemud, C.J., 2009. The discovery of novel experimental therapies for inflammatory arthritis. Mediators Inflamm. 10.1155/2009/698769.
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  46. Malemud, C.J., 2009. Role of Nonreceptor Tyrosine and Threonine Kinase Inhibitors. In: Molecular Biology of Cancer: Toward New Therapies, Garcia-Foncillas, J. (Ed.). Prous Science, Barcelona, Spain, pp: 537-555.

  47. Malemud, C.J., 2009. Recent advances in neutralizing the IL-6 pathway in arthritis. Open Access Rheumatol., 1: 133-150.
    PubMed  |  

  48. Malemud, C.J., 2009. Focus on pain mechanisms and pharmacotherapy in the treatment of fibromyalgia syndrome. Clin. Exp. Rheumatol., 27: S86-S91.
    Direct Link  |  

  49. Malemud, C.J. and E. Pearlman, 2009. Targeting JAK/STAT signaling pathway in inflammatory diseases. Curr. Signal Transduction Ther., 4: 201-221.
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  50. Malemud, C.J., 2008. Defining novel targets for intervention in rheumatoid arthritis: An overview. Curr. Rheumatol. Rev., 4: 214-218.
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  51. Malemud, C.J. and S.K. Reddy, 2008. Targeting cytokines, chemokines and adhesion molecules in rheumatoid arthritis. Curr. Rheumatol. Rev., 4: 219-234.
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  52. Malemud, C.J. and M.E. Schulte, 2008. Is there a final common pathway for arthritis? Future Rheumatol., 3: 253-269.

  53. Malemud, C.J. and A.H. Miller, 2008. Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs. Expert Opin. Therapeut. Targets, 12: 171-183.
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  54. Benderro, G., J.C. LaManna and C.J. Malemud, 2008. Signaling Pathways Regulating Cerebral Capillaty Remodeling in Hypoxia and Ischemia. In: New Trends in Brain Hypoxia Ischemia Research, Hamalainen, E. (Ed.). Chapter 6, Nova Science Publishers, Hauppauge, NY., USA., ISBN-13: 9781604561401, pp: 221-234.

  55. Malemud, C.J., 2007. MAP Kinases. In: OA, Inflammation and Degradation: A Continuum, Volume 70: Biomedical and Health Research, Buckwalter, J., M. Lotz and J.F. Stoltz (Eds.). IOS Press, Amsterdam, Netherlands, ISBN-13: 978-1586037734, pp: 99-117.

  56. Malemud, C.J., 2007. Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways. Curr. Opin. Pharmacol., 7: 339-343.
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  57. Malemud, C.J., 2007. Growth hormone, VEGF and FGF: Involvement in rheumatoid arthritis. Clin. Chim. Acta, 375: 10-19.
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  58. Malemud, C.J., 2007. Gene therapy for arthritis: Defining novel gene targets. Gene Ther. Mol. Biol., 11: 27-36.

  59. Gupta, K., M. Shukla, J.B. Cowland, C.J. Malemud and T.M. Haqqi, 2007. Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9. Arthritis Rheumatol., 56: 3326-3335.
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  60. Wenger, R., M.G. Hans, J.F. Welter, L.A. Solchaga, Y.R. Sheu and C.J. Malemud, 2006. Hydrostatic pressure increases apoptosis in cartilage-constructs produced from human osteoarthritic chondrocytes. Front Biosci., 11: 1690-1695.
    CrossRef  |  PubMed  |  Direct Link  |  

  61. Malemud, C.J., 2006. Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinases. Mini Rev. Med. Chem., 6: 689-698.
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  62. Malemud, C.J., 2006. Matrix metalloproteinases: Role in skeletal development and growth plate disorders. Front. Biosci., 11: 1702-1715.
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  63. Malemud, C.J., 2006. Matrix Metalloproteinases (MMPs) in health and disease: An overview. Front. Biosci., 11: 1696-1701.
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  64. Denko, C.W. and C.J. Malemud, 2006. Body mass index and blood glucose: Correlations with serum insulin, growth hormone and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH). Rheumatol. Int., 26: 292-297.
    CrossRef  |  

  65. Bertone, A.L., L.R. Bramlage, C.W. McIlwraith and C.J. Malemud, 2006. Comparison of proteoglycan and collagen in articular cartilage of horses with naturally developing osteochondrosis and healing osteochondral fragments of experimentally induced fractures. Am. J. Vet. Res., 66: 1881-1890.
    CrossRef  |  

  66. Malemud, C.J. and H.J. Gillespie, 2005. The role of apoptosis in arthritis. Curr. Rheum. Rev., 1: 131-142.
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  67. Denko, C.W. and C.J. Malemud, 2005. Serum growth hormone and insulin but not insulin-like growth factor-1 levels are elevated in patients with fibromyalgia syndrome. Rheumatol. Int., 25: 146-151.
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  68. Denko, C.W. and C.J. Malemud, 2005. Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases. Semin. Arthritis Rheum., 35: 24-34.
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  69. Ahmed, S., J. Anuntiyo, C.J. Malemud and T.M. Haqqi, 2005. Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: A review. Evidence-Based Complement. Altern. Med. 2: 301-308.
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  70. Palmer, J.L., J. Mansour, C.J. Malemud and A.L. Bertone, 2004. Effects of intra-articular hyaluronic acid on ex vivo responses by third carpal bone cartilage from horses with experimentally induced synovitis. Equine Comp. Exercise Physiol., 1: 119-129.
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  71. Malemud, C.J., 2004. Protein kinases in chondrocyte signaling and osteoarthritis. Clin. Orthopaed. Related Res., 427: S145-S151.
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  72. Malemud, C.J., 2004. Cytokines as therapeutic targets for osteoarthritis. BioDrugs, 18: 23-35.
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  73. Denko, C.W. and C.J. Malemud, 2004. The serum growth hormone to somatostatin ratio is skewed upward in rheumatoid arthritis patients. Front. Biosci., 9: 1660-1664.

  74. Denko, C.W. and C.J. Malemud, 2004. Age-related changes in serum growth hormone, insulin-like growth factor-1 and somatostatin in system lupus erythematosus. BMC Musculoskeletal Disorders, Vol. 5. 10.1186/1471-2474-5-37.
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  75. Singh, R., S. Ahmed, C.J. Malemud, V.M. Goldberg and T.M. Haqqi, 2003. Epigallocatechin-3-gallate selectively inhibits interleukin-1 β-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes. J. Orthop. Res., 21: 102-109.
    CrossRef  |  Direct Link  |  

  76. Malemud, C.J., N. Islam and T.M. Haqqi, 2003. Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies. Cells Tissues Organs, 174: 34-48.
    CrossRef  |  

  77. Kingsberg, S.A., C.J. Malemud, T. Novak, K. Cole-Kelly, M.Z. Wile, P. Spanos and T.M. Nosek, 2003. A comprehensive approach to enhancing sexual health education in the case Western reserve university school of medicine. Int. J. Impot. Res., 15: S51-S57.

  78. Denko, C.W., B. Boja and C.J. Malemud, 2003. Intra-erythrocyte deposition of growth hormone in rheumatic diseases. Rheumatol. Int., 23: 11-14.
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  79. Islam, N., T.M. Haqqi, K.J. Jepsen, M. Kraay, J.F. Welter, V.M. Goldberg and C.J. Malemud, 2002. Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-α, inducible nitric oxide synthase, p53, c-myc and bax-α and suppression of bcl-2. J. Cell. Biochem., 87: 266-278.
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  80. Denko, C.W., B. Boja and C.J. Malemud, 2002. Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH). Front. Biosci., 7: a37-a43.

  81. Islam, S., T. Kermode, D. Sultana, R.W. Moskowitz and H. Mukhtar et al., 2001. Expression profile of protein tyrosine kinase genes in human osteoarthritis chondrocytes. Osteoarthritis Cartilage, 9: 684-693.
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  82. Islam, S., N. Islam, T. Kermode, B. Johnstone and H. Mukhtar et al., 2000. Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells. Biochem. Biophys. Res. Commun., 270: 793-797.
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  83. Haqqi, T.M., D.D. Anthony and C.J. Malemud, 2000. Chondrocytes. In: Current Molecular Medicine: Principles of Molecular Rheumatology, Tsokos, G.C. (Ed.)., Humana Press, Totowa, NJ., pp: 267-277.

  84. Ah-Kim, H., X. Zhang, S. Islam, J.I. Sofi and Y. Glickberg et al., 2000. Tumour necrosis factor α enhances the expression of hydroxyl lyase, cytoplasmic antiproteinase-2 and a dual specificity kinase TTK in human chondrocyte-like cells. Cytokine, 12: 142-150.
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  85. Malemud, C.J., 1999. Fundamental pathways in osteoarthritis: An overview. Front. Biosci., 4: d659-d771.

  86. Denko, C.W. and C.J. Malemud, 1999. Metabolic disturbances and synovial joint responses in osteoarthritis. Front. Biosci., 4: D686-D693.
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  87. Palmer, J.L., A.L. Bertone, C.J. Malemud and J. Mansour, 1998. Changes in third carpal bone articular cartilage after synovectomy in normal and inflamed joints. Vet. Surg., 27: 321-330.
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  88. Hardy, J., A.L. Bertone and C.J. Malemud, 1998. Effect of synovial membrane infection in vitro on equine synoviocytes and chondrocytes. Am. J. Vet. Res., 59: 293-299.
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  89. Lillich, J.D., A.L. Bertone, C.J. Malemud, S.E. Weisbrode, A.J. Ruggles and S. Stevenson, 1997. Biochemical, histochemical and immunohistochemical characterization of distal tibial osteochondrosis in horses. Am. J. Vet. Res., 58: 89-98.
    PubMed  |  Direct Link  |  

  90. Palmer, J.L., A.L. Bertone, C.J. Malemud and J. Mansour, 1996. Biochemical and biomechanical alterations in equine articular cartilage following an experimentally-induced synovitis. Osteoarthritis Cartilage, 4: 127-137.
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  91. Malemud, C.J., R.S. Papay and T.M. Hering, 1996. Forskolin stimulates aggrecan gene expression in cultured bovine chondrocytes. Am. J. Therapeut., 3: 120-128.

  92. Palmer, J.L., A.L. Bertone, J. Mansour, B.G. Carter and C.J. Malemud, 1995. Biomechanical properties of third carpal articular cartilage in exercised and nonexercised horses. J. Orthopaedic Res., 13: 854-860.
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  93. Palmer, J.L., A.L. Bertone, C.J. Malemud, B.G. Carter, R.S. Papay and J. Mansour, 1995. Site-specific proteoglycan characteristics of third carpal articular cartilage in exercised and nonexercised horses. Am. J. Vet. Res., 56: 1570-1576.
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  94. Malemud, C.J., R.S. Papay, T.M. Hering, D. Holderbaum, V.M. Goldberg and T.M. Haqqi, 1995. Phenotypic modulation of newly synthesized proteoglycans in human cartilage and chondrocytes. Osteoarthritis Cartilage, 3: 227-238.
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  95. Malemud, C.J. and V.M. Goldberg, 1995. Synthesis of aggrecan core proteins by human cartilage and chondrocytes in vitro. J. Rheumatol., 43: 91-93.
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  96. Pelletier, J.P., J. Martel-Pelletier and C.J. Malemud, 1994. Effects of Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids on Cartilage Metabolism in Rheumatoid Arthritis and Osteoarthritis. In: Non-Steroidal Anti-Inflammatory Drugs: Mechanisms and Clinical Uses, Lewis, A.J. and D.E. Furst (Eds.)., 2nd Edn., Marcel Dekker, New York, USA., pp: 5-25.

  97. Malemud, C.J., S. Stevenson, F. Mehraban, R.S. Papay, A.F. Purchio and V.M. Goldberg, 1994. The proteoglycan synthesis repertoire of rabbit chondrocytes maintained in type II collagen gels. Osteoarthritis Cartilage, 2: 29-41.
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  98. Malemud, C.J., R.S. Papay, P. Hasler and G.M. Kammer, 1994. The effect of nonsteroidal anti-inflammatory drugs on cAMP-dependent protein kinase-mediated phosphorylation by human chondrocytes in culture. Clin. Exp. Rheumatol., 12: 149-156.
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  99. Kammer, G.M., I.U. Khan and C.J. Malemud, 1994. Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes. J. Clin. Invest., 94: 422-430.
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  100. Hoke, A., D.R. Canning, C.J. Malemud and J. Silver, 1994. Regional differences in reactive gliosis induced by substrate-bound β-amyloid. Exp. Neurol., 130: 56-66.
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  101. Ganu, V.S., S.I. Hu, R. Melton, C. Winter, V.M. Goldberg, T.M. Haqqi and C.J. Malemud, 1994. Biochemical and molecular characterization of stromelysin synthesized by human osteoarthritic chondrocytes stimulated with recombinant human interleukin-1. Clin. Exp. Rheumatol., 12: 489-496.
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  102. Malemud, C.J., 1993. The Role of growth Factors in Cartilage Metabolism. In: Rheumatic Disease Clinics of North America-Osteoarthritis Edition, Moskowitz, R.W. (Ed.)., WB Saunders, Philadelphia, pp: 569-580.

  103. Malemud, C.J., 1993. Markers of osteoarthritis and cartilage research in animal models. Curr. Opin. Rheumatol., 5: 494-502.
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  104. Kammer, G.M., T.M. Haqqi, P. Hasler and C.J. Malemud, 1993. The effect of circulating serum factors from patients with systemic lupus erythematosus on protein kinase A (PKA) activity and PKA-dependent protein phosphorylation in T lymphocytes. Clin. Immunol. Immunopathol., 67: 8-16.
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  105. Holderbaum, D., C.J. Malemud, R.W. Moskowitz and T.M. Haqqi, 1993. Human cartilage from late stage familial osteoarthritis transcribes type II collagen mRNA encoding a cysteine in position 519. Biochem. Biophys. Res. Commun., 192: 1169-1174.
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  106. Gonzalez, M.D.L., C.J. Malemud and J. Silver, 1993. Role of astroglial extracellular matrix in the formation of rat olfactory bulb glomeruli. Exp. Neurol., 123: 91-105.
    CrossRef  |  

  107. Canning, D.R., A. Hoke, C.J. Malemud and J. Silver, 1993. A potent inhibitor of neurite outgrowth that predominates in the extracellular matrix of reactive astrocytes. Int. J. Dev. Neurosci., 14: 153-175.

  108. Yoo, J.U., R.S. Papay and C.J. Malemud, 1992. Suppression of proteoglycan synthesis in chondrocyte cultures derived from canine intervertebral disc. Spine, 17: 221-224.
    Direct Link  |  

  109. Thomas, E., R.S. Papay, V.M. Goldberg and C.J. Malemud, 1992. A small proteoglycan isolated from human cartilage containing a nonfunctional hyaluronic acid binding region. Biochem. Int., 27: 165-172.
    Direct Link  |  

  110. Pelletier, J.P., J. Martel-Pelletier, F. Mehraban and C.J. Malemud, 1992. Immunological analysis of proteoglycan structural changes in the early stage of experimental osteoarthritic canine cartilage lesions. J. Orthop. Res., 10: 511-523.
    CrossRef  |  

  111. Martel-Pelletier, J., J.P. Pelletier, J.M. Cloutier, N. Rebert and C.J. Malemud, 1992. Proteoglycan structural changes in human rheumatoid articular cartilage. Clin. Exp. Rheumatol., 10: 151-159.
    Direct Link  |  

  112. Malemud, C.J. and T.M. Hering, 1992. Regulation of Chondrocytes in Osteoarthrosis. In: Biological Regulation of the Chondrocyte, Adolphe, M. (Ed.)., CRC Press, Boca Raton, pp: 295-319.

  113. Malemud, C.J. and R.S. Papay, 1992. Synthesis of low buoyant density proteoglycans by human chondrocytes in culture. Matrix, 12: 427-438.
    CrossRef  |  

  114. Goldberg, V.M., R.W. Moskowitz, C.J. Malemud and J. Mansour, 1992. Response of Articular Cartilage to Instability. In: Biology and Biomechanics of the Traumatized Synovial Joint: The Knee as a Model, Finerman, G.A.M. and F.R. Noyes (Eds.)., American Academy of Orthopaedic Surgeons, Rosemont, IL., pp: 97-109.

  115. Ratnoff, O.D., B. Everson, P. Embury, N.P. Ziats, J.M. Anderson, M.M. Emanuelson and C.J. Malemud, 1991. Inhibition of the activation of Hageman factor (factor XII) by human vascular endothelial cell culture supernates. Proc. Natl. Acad. Sci., 88: 10740-10743.
    Direct Link  |  

  116. Moskowitz, R.W., J.H. Reese, R.G. Young, D. Fein-Krantz, C.J. Malemud and A.I. Caplan, 1991. The effects of Rumalon, a glycosaminoglycan peptide complex, in a partial meniscectomy model of osteoarthritis in rabbits. J. Rheumatol., 18: 205-209.
    Direct Link  |  

  117. Malemud, C.J., W. Killeen, T.M. Hering and A.F. Purchio, 1991. Enhanced sulfated-proteoglycan core protein synthesis by incubation of rabbit chondrocytes with recombinant transforming growth factor-β1. J. Cell. Physiol., 149: 152-159.
    CrossRef  |  

  118. Malemud, C.J., 1991. Changes in proteoglycans in osteoarthritis: Biochemistry, ultrastructure and biosynthetic processing. J. Rheumatol., 18: 60-62.
    Direct Link  |  

  119. Malemud, C.J. and V.M. Goldberg, 1991. Directions for future research and treatment of osteoarthritis. Front. Biosci., 4: d762-d771.

  120. Shuckett, R. and C.J. Malemud, 1990. Distinct cartilage proteoglycan chromatographic elution patterns in advanced human hip osteoarthritis: Correlations with histologic analysis. J. Rheumatol., 17: 357-363.
    Direct Link  |  

  121. Malemud, C.J., R.S. Papay, P. Hasler and G.M. Kammer, 1990. cAMP-dependent protein kinase in chondrocyte cultures: Holoenzyme activation, phosphorylation of cellular proteins, effects of NSAIDs and possible role in proteoglycan synthesis. Semin Arthritis Rheum., 19: 10-15.

  122. Malemud, C.J., R.S. Papay and V.M. Goldberg, 1990. Proteoglycan composition and biosynthesis by human osteochondrophytic spurs of the femoral head. Biomaterials, 11: 25-27.

  123. Knowlton, R.G., P.L. Katzenstein, R.W. Moskowitz, E.J. Weaver and C.J. Malemud et al., 1990. Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia. N. Engl. J. Med., 322: 526-530.
    CrossRef  |  

  124. Katzenstein, P.L., C.J. Malemud, M.N. Pathria, J.R. Carter, R.P. Sheon and R.W. Moskowitz, 1990. Early-onset primary osteoarthritis and mild chondrodysplasia: Radiographic and pathologic studies with an analysis of proteoglycans. Arthritis Rheum., 33: 674-684.

  125. Shuckett, R., V.M. Goldberg and C.J. Malemud, 1989. Quantitation of component proteoglycans during long-term organ explant culture of human osteoarthritic hip cartilage. J. Laboratory Clin. Med., 113: 23-33.
    Direct Link  |  

  126. Shuckett, R. and C.J. Malemud, 1989. Proteoglycans synthesized by chondrocytes of human nonarthritic and osteoarthritic cartilage. Proc. Soc. Exp. Biol. Med., 190: 275-281.
    CrossRef  |  

  127. Malemud, C.J., R. Shuckett and V.M. Goldberg, 1989. Changes in osteoarthritic cartilage maintained in explant culture: Implications for understanding repair in osteoarthritis. Scand. J. Rheumatol., 77: 7-12.

  128. Yoo, J.U., T.F. Kresina, C.J. Malemud and V.M. Goldberg, 1988. Analysis of experimental immune synovitis cartilage using monoclonal antibodies reactive to rabbit proteoglycan. J. Orthopaedic Res., 6: 389-396.
    CrossRef  |  

  129. Shuckett, R. and C.J. Malemud, 1988. Qualitative changes in human osteoarthritic hip cartilage proteoglycan synthesis during long-term explant culture. Mech. Ageing Dev., 46: 33-45.
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  130. Reiner, N.E., L.A. Schultz and C.J. Malemud, 1988. Eicosanoid metabolism by Leishmania donovani-infected macrophages: Mouse strain responses in prostanoid synthesis. Am. J. Trop. Med. Hyg., 38: 59-64.
    CrossRef  |  

  131. Pelletier, J.P., J. Martel‐Pelletier and C.J. Malemud, 1988. Canine osteoarthritis: Effects of endogenous neutral metalloproteoglycanases on articular cartilage proteoglycans. J. Orthopaedic Res., 6: 379-388.
    CrossRef  |  Direct Link  |  

  132. Martel-Pelletier, J., J.P. Pelletier and C.J. Malemud, 1988. Activation of neutral metalloprotease in human osteoarthritic knee cartilage: Evidence for degradation in the core protein of sulphated proteoglycan. Ann. Rheum. Dis., 47: 801-808.
    CrossRef  |  

  133. Malemud, C.J., V.M. Goldberg and T.F. Kresina, 1988. Keratan-sulphate-containing proteoglycans in human osteochondrophytic spurs of the femoral head. Biochem. Int., 16: 25-33.
    Direct Link  |  

  134. Malemud, C.J., 1988. The Biology of Cartilage and Synovium in Animal Models of Osteoarthritis. In: Handbook of Models for Arthritis Research, Greenwald, R.A. and H. Diamond (Eds.)., CRC Press, Boca Raton, pp: 3-18.

  135. Yoo, J.U., T.F. Kresina, C.J. Malemud and V.M. Goldberg, 1987. Epitopes of proteoglycans eliciting an anti-proteoglycan response in chronic immune synovitis. Proc. Natl. Acad. Sci. USA., 84: 832-836.
    Direct Link  |  

  136. Siegel, J.N., C.J. Malemud and G.M. Kammer, 1987. Intact proteoglycan is a polyclonal activator of murine B-lymphocytes. Immunol. Lett., 15: 127-132.
    CrossRef  |  Direct Link  |  

  137. Sapolsky, S., C. Malemud and M. Sheff, 1987. The proteoglycanase from human cartilage and cultured rabbit chondrocytes and its relation to osteoarthritis. J. Rheumatol., 14: 33-35.
    PubMed  |  

  138. Pelletier, J.P., J. Martel-Pelletier and C.J. Malemud, 1987. Proteoglycans from experimental osteoarthritic cartilage: Degradation by neutral metalloproteases. J. Rheumatol., 14: 113-115.
    Direct Link  |  

  139. Martel-Pelletier, J., J.P. Pelletier, J.M. Cloutier and C.J. Malemud, 1987. Newly synthesized and endogenous proteoglycans in human osteoarthritic knee cartilage. J. Rheumatol., 14: 321-328.
    PubMed  |  

  140. Malemud, C.J., V.M. Goldberg and L.M. Miller, 1987. Synthesis of a “free” form of hyaluronic acid by articular chondrocytes in monolayer culture. Biochem. Int., 14: 987-995.
    PubMed  |  

  141. Malemud, C.J., J.U. Yoo, V.M. Goldberg and T.F. Kresina, 1987. Structural characteristics of articular cartilage proteoglycan in IgG induced experimental immune synovitis. Ann. Rheumatic Dis., 46: 520-526.
    CrossRef  |  Direct Link  |  

  142. Malemud, C.J., J. Martel-Pelletier and J.P. Pelletier, 1987. Degradation of extracellular matrix in osteoarthritis: 4 fundamental questions. J. Rheumatol., 14: 20-22.
    Direct Link  |  

  143. Malemud, C.J. and R. Shuckett, 1987. Impact Loading and Lower Extremity Disease. In: Clinical Concepts in Regional Musculoskeletal Illness, Hadler, N.M. (Ed.)., Grune and Stratton, Orlando, pp: 109-135.

  144. Shuckett, R. and C.J. Malemud, 1986. An in vitro model of ageing of human articular cartilage sulphated-proteoglycans. Mech. Ageing Dev., 34: 73-90.
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  145. Noonan, D.M., D.J. Malemud and R.J. Przybylski, 1986. Biosynthesis of heparan sulfate proteoglycans of developing chick breast skeletal muscle in vitro. Exp. Cell Res., 166: 327-339.
    CrossRef  |  Direct Link  |  

  146. Malemud, C.J., V.M. Goldberg and R.W. Moskowitz, 1986. Pathological, biochemical and experimental therapeutic studies in meniscectomy models of osteoarthritis in the rabbit-its relationship to human joint pathology. Br. J. Clin. Pract., 43: 21-31.
    PubMed  |  

  147. Malemud, C.J., T.M. Mills, R. Shuckett and R.S. Papay, 1986. Stimulation of sulfated-proteoglycan synthesis by forskolin in monolayer cultures of rabbit articular chondrocytes. J. Cell. Physiol., 129: 51-59.
    CrossRef  |  Direct Link  |  

  148. Malemud, C.J., T.M. Mills and R.S. Papay, 1986. Suppression of prostaglandin synthesis by analogues of cyclic AMP and forskolin in chondrocyte monolayer cultures. Prostaglandins, 32: 495-501.
    CrossRef  |  Direct Link  |  

  149. Malemud, C.J. and R.S. Papay, 1986. Rabbit chondrocytes maintained in serum-free medium: I. Synthesis and secretion of hydrodynamically-small proteoglycans. Exp. Cell Res., 167: 440-452.
    CrossRef  |  Direct Link  |  

  150. Kresina, T.F., C.J. Malemud and R.W. Moskowitz, 1986. Analysis of osteoarthritic cartilage using monoclonal antibodies reactive with rabbit proteoglycan. Arthritis Rheumatol., 29: 863-871.
    CrossRef  |  Direct Link  |  

  151. Kresina, T.F. and C.J. Malemud, 1986. Murine monoclonal antibodies recognizing rabbit proteoglycans. Collagen Relat. Res., 6: 15-39.
    CrossRef  |  Direct Link  |  

  152. Reiner, N.E. and C.J. Malemud, 1985. Arachidonic acid metabolism by murine peritoneal macrophages infected with Leishmania donovani: In vitro evidence for parasite-induced alterations in cyclooxygenase and lipoxygenase pathways. J. Immunol., 134: 556-563.
    Direct Link  |  

  153. Malemud, C.J., R. Shuckett, R.S. Papay, T.M. Mills and V.M. Goldberg, 1985. In vitro Culture of Human and Lapine Articular Chondrocytes: A Reliable System for the Study of Sulphated-Proteoglycans. In: Degenerative Joints, Volume 2, Verbruggen, G. and E.M. Veys (Eds.). Excerpta Medica, Amsterdam, Netherlands, pp: 211-222.

  154. Kammer, G.M., A.I. Sapolsky and C.J. Malemud, 1985. Secretion of an articular cartilage proteoglycan-degrading enzyme activity by murine T lymphocytes in vitro. J. Clin. Invest., 76: 395-402.
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  155. Webber, R.J., D.P. Norby, C.J. Malemud, V.M. Goldberg and R.W. Moskowitz, 1984. Characterization of newly synthesized proteoglycans from rabbit menisci in organ culture. Biochem. J., 221: 875-884.
    CrossRef  |  Direct Link  |  

  156. Reiner, N.E. and C.J. Malemud, 1984. Arachidonic acid metabolism in murine leishmaniasis (Donovani): Ex-vivo evidence for increased cyclooxygenase and 5-lipoxygenase activity in spleen cells. Cell. Immunol., 88: 501-510.
    CrossRef  |  Direct Link  |  

  157. Manicourt, D., D.S. Howell, R.W. Moskowitz, V. Goldberg, C. Malemud and J.C. Pita, 1984. Application of new techniques to separation of proteoglycan aggregates from normal and destabilized rabbit articular cartilages. Acta Biol. Hung., 35: 137-142.
    PubMed  |  

  158. Malemud, C.J., R.W. Moskowitz and V.M. Goldberg, 1984. Biosynthesis of sulfated proteoglycan in vitro by cells derived from human osteochondrophytic spurs of the femoral head. Connective Tissue Res., 12: 319-335.
    CrossRef  |  Direct Link  |  

  159. Malemud, C.J. and R.S. Papay, 1984. The in vitro cell culture age and cell density of articular chondrocytes alter sulfated-proteoglycan biosynthesis. J. Cell. Physiol., 121: 558-568.
    CrossRef  |  Direct Link  |  

  160. Malemud, C.J. and R.S. Papay, 1984. Stimulation of cyclic AMP in chondrocyte cultures: Effects on sulfated-proteoglycan synthesis. FEBS Lett., 167: 343-351.
    CrossRef  |  Direct Link  |  

  161. Kresina, T.F. and C.J. Malemud, 1984. Susceptibility of interstitial rabbit collagens to rabbit articular chondrocyte collagenase. Collagen Relat. Res., 4: 453-465.
    CrossRef  |  Direct Link  |  

  162. Boyd, Jr. A.D., V.M. Goldberg, L.M. Miller and C.J. Malemud, 1984. Effects of polymethylmethacrylate on rabbit articular chondrocytes in monolayer culture. Clin. Orthop. Relat. Res., 189: 279-293.
    PubMed  |  

  163. Sapolsky, A.I., M.F. Sheff, K. Matsuta, D.S. Howell and R.W. Moskowitz et al., 1983. 'Gelatinase-like' activity from articular chondrocytes in monolayer culture. Biochim. Biophys. Acta (BBA)-Mol. Cell Res., 762: 227-231.
    CrossRef  |  Direct Link  |  

  164. Rothenberg, R.J., R.W. Moskowitz and C.J. Malemud, 1983. Phospholipase C activity in plasma membranes isolated from lapine synovial cells in monolayer culture. Biochem. Biophys. Res. Commun., 115: 331-338.
    CrossRef  |  Direct Link  |  

  165. Rothenberg, R.J., R.W. Moskowitz and C.J. Malemud, 1983. Arachidonic acid metabolism by rabbit synovial cells in culture: Studies of non-cyclooxygenase pathways. Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab., 753: 257-265.
    CrossRef  |  Direct Link  |  

  166. Rosner, I.A., C.J. Malemud, A.I. Hassid, V.M. Goldberg, B.A. Boja and R.W. Moskowitz, 1983. Estradiol and tamoxifen stimulation of lapine articular chondrocyte prostaglandin synthesis. Prostaglandins, 26: 123-138.
    CrossRef  |  Direct Link  |  

  167. Rosner, I.A., B.A. Boja, C.J. Malemud, R.W. Moskowitz and V.M. Goldberg, 1983. Intraarticular hyaluronic acid injection and synovial prostaglandins in experimental immune synovitis. J. Rheumatol., 10: 71-78.
    PubMed  |  

  168. Norby, D.P., V.M. Goldberg, R.W. Moskowitz and C.J. Malemud, 1983. Buffer induced modification of 6-sulfated disaccharide in chondroitin lyase digestions. Anal. Biochem., 131: 324-332.
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  169. Keiser, H.D. and C.J. Malemud, 1983. A comparison of the proteoglycans produced by rabbit articular chondrocytes in monolyayer and spinner culture and those of bovine nasal cartilage. Connective Tissue Res., 11: 273-284.
    CrossRef  |  Direct Link  |  

  170. Goldberg, V.M., D.P. Norby, B.L. Sachs, R.W. Moskowitz and C.J. Malemud, 1983. Correlation of histopathology and sulfated proteoglycans in human osteoarthritic hip cartilage. J. Orthop. Res., 1: 302-312.
    CrossRef  |  Direct Link  |  

  171. Sachs, B.L., V.M. Goldberg, R.W. Moskowitz and C.J. Malemud, 1982. Response of articular chondrocytes to pituitary Fibroblst Growth Factor (FGF). J. Cell. Physiol., 112: 51-59.
    CrossRef  |  Direct Link  |  

  172. Sachs, B.L., V.M. Goldberg, L.L. Getzy, R.W. Moskowitz and C.J. Malemud, 1982. A histopathologic differentiation of tissue types in human osteoarthritic cartilage. J. Rheumatol., 9: 210-216.
    PubMed  |  

  173. Rosner, I.A., C.J. Malemud, V.M. Goldberg, R.S. Papay, L. Getzy and R.W. Moskowitz, 1982. Pathologic and metabolic responses of experimental osteoarthritis to estradiol and an estradiol antagonist. Clin. Orthop. Relat. Res., 171: 280-286.
    PubMed  |  

  174. Rosner, I.A., A. Manni, C.J. Malemud, B. Boja and R.W. Moskowitz, 1982. Estradiol receptors in articular chondrocytes. Biochem. Biophys. Res. Commun., 106: 1378-1382.
    CrossRef  |  Direct Link  |  

  175. Malemud, C.J., V.M. Goldberg, R.W. Moskowitz, L.L. Getzy, R.S. Papay and D.P. Norby, 1982. Biosynthesis of proteoglycan in vitro by cartilage from human osteochondrophytic spurs. Biochem. J., 206: 329-341.
    CrossRef  |  Direct Link  |  

  176. Malemud, C.J., R.W. Moskowitz and R.S. Papay, 1982. Correlation of the biosynthesis of prostaglandin and cyclic AMP in monolayer cultures of rabbit articular chondrocytes. Biochim. Biophys. Acta (BBA)-Gen. Subj., 715: 70-79.
    CrossRef  |  Direct Link  |  

  177. Malemud, C.J. and R.S. Papay, 1982. Suppression of Proteoglycan Biosynthesis by Calcium Ionophores in Chondrocyte Cultures. In: The Extracellular Matrix, Hawkes, S. and J. Wang (Eds.). Academic Press, New York, USA., pp: 277-282.

  178. Getzy, L.L., C.J. Malemud, V.M. Goldberg and R.W. Moskowitz, 1982. Factors influencing metachromatic staining in paraffin-embedded sections of rabbit and human articular cartilage: A comparison of the safranin O and toluidine blue O techniques. J. Histotechnol., 5: 111-116.
    CrossRef  |  Direct Link  |  

  179. Getzy, L.L. and C.J. Malemud, 1982. Tissue and organ culture studies of cartilage. J. Histotechnol., 5: 29-32.
    CrossRef  |  Direct Link  |  

  180. Sapolsky, A.I., C.J. Malemud, D.P. Norby, R.W. Moskowitz, K. Matsuta and D.S. Howell, 1981. Neutral proteinases from articular chondrocytes in culture. 2. Metal-dependent latent neutral proteoglycanase and inhibitory activity. Biochim. Biophys. Acta (BBA)-Enzymol., 658: 138-147.
    CrossRef  |  Direct Link  |  

  181. Moskowitz, R.W., V.M. Goldberg and C.J. Malemud, 1981. Metabolic responses of cartilage in experimentally induced osteoarthritis. Ann. Rheumatic Dis., 40: 584-592.
    CrossRef  |  Direct Link  |  

  182. Malemud, C.J., R.W. Moskowitz and A. Hassid, 1981. Prostaglandin biosynthesis by lapine articular chondrocytes in culture. Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab., 663: 480-490.
    CrossRef  |  Direct Link  |  

  183. Malemud, C.J., D.P. Norby, R.W. Moskowitz, V.M. Goldberg, A.I. Sapolsky and D.S. Howell, 1981. Neutral proteinases from articular chondrocytes in culture that degrade synthetic substrates and cartilage macromolecules. Semin. Arthritis Rheumatism, 11: 61-63.
    CrossRef  |  Direct Link  |  

  184. Malemud, C.J., D.P. Norby, A.I. Sapolsky, K. Matsuta, D.S. Howell and R.W. Moskowitz, 1981. Neutral proteinases from articular chondrocytes in culture. I. A latent collagenase that degrades human cartilage type II collagen. Biochim. Biophys. Acta (BBA)-Enzymol., 657: 517-529.
    CrossRef  |  Direct Link  |  

  185. Malemud, C.J. and R.W. Moskowitz, 1981. Physiology of articular cartilage. Clin. Rheumatic Dis., 7: 29-55.

  186. Kent, L., C.J. Malemud and R.W. Moskowitz, 1980. Differential response of articular chondrocyte populations to thromboxane B2 and analogs of prostaglandin cyclic endoperoxides. Prostaglandins, 19: 391-406.
    CrossRef  |  Direct Link  |  

  187. Malemud, C.J., G.A. Weitzman, D.P. Norby, A.I. Sapolsky and D.S. Howell, 1979. Metal-dependent neutral proteoglycanase activity from monolayer-cultured lapine articular chondrocytes. Transl. Res., 93: 1018-1030.
    Direct Link  |  

  188. Malemud, C.J., D.P. Norby and L. Sokoloff, 1978. Explant culture of human and rabbit articular chondrocytes. Connective Tissue Res., 6: 171-179.
    CrossRef  |  Direct Link  |  

  189. Malemud, C.J., 1978. Cell Culture in the Study of Mammalian Chondrocyte Metabolism. In: The Human Joint in Health and Disease, Simon, W. (Ed.). Univ. Pennsylvania Press, Philadelphia, PA., USA., pp: 43-52.

  190. Malemud, C.J. and L. Sokoloff, 1978. The effect of chondrocyte growth factor on membrane transport by articular chondrocytes in monolayer culture. Connective Tissue Res., 6: 1-9.
    CrossRef  |  Direct Link  |  

  191. Webber, R.J., C.J. Malemud and L. Sokoloff, 1977. Species differences in cell culture of mammalian articular chondrocytes. Calcified Tissue Int., 23: 61-66.
    CrossRef  |  Direct Link  |  

  192. Norby, D.P., C.J. Malemud and L. Sokoloff, 1977. Differences in the collagen types synthesized by lapine articular chondrocytes in spinner and monolayer culture. Arthritis Rheumatol., 20: 709-716.
    CrossRef  |  Direct Link  |  

  193. Malemud, C.J. and L. Sokoloff, 1977. The effect of prostaglandins on cultured lapine articular chondrocytes. Prostaglandins, 13: 845-860.
    CrossRef  |  Direct Link  |  

  194. Malemud, C.J. and D.P. Norby, 1977. Alterations in the Phenotypic Expression of Cultured Lapine Articular Chondrocytes by a Pituitary Growth Factor (CGF). In: Cell Culture and its Application, Acton, R. and J. Lynn (Eds.). Academic Press, New York, USA., pp: 481-490.

  195. Janoff, A., G. Feinstein, C.J. Malemud and J.M. Elias, 1976. Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases-a model of joint injury. I. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue. J. Clin. Invest., 57: 615-624.
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  196. Feinstein, G., C.J. Malemud and A. Janoff, 1976. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim. Biophys. Acta (BBA)-Enzymol., 429: 925-932.
    CrossRef  |  Direct Link  |  

  197. Malemud, C.J. and A. Janoff, 1975. Identification of neutral proteases in human neutrophil granules that degrade articular cartilage proteoglycan. Arthritis Rheumatol., 18: 361-368.
    CrossRef  |  Direct Link  |  

  198. Malemud, C.J. and A. Janoff, 1975. Human polymorphonuclear leukocyte elastase and cathepsin G mediate the degradation of lapine articular cartilage proteoglycan. Ann. N. Y. Acad. Sci., 256: 254-262.
    CrossRef  |  Direct Link  |  

  199. Janoff, A., J. Blondin, R.A. Sandhaus, A. Mosser and C.J. Malemud, 1975. Human Neutrophil Elastase: In vitro Effects on Natural Substrates Suggest Important Physiological and Pathological Actions. In: Proteases and Biological Control, Reich, E., D. Rifkin and E. Shaw (Eds.). Cold Spring Harbor Press, New York, USA., pp: 603-620.

  200. Srivastava, V.M.L., C.J. Malemud, A.J. Hough, J.H. Bland and L. Sokoloff, 1974. Preliminary experience with cell culture of human articular chondrocytes. Arthritis Rheumatol., 17: 165-169.
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  201. Srivastava, V.M.L., C.J. Malemud and L. Sokoloff, 1974. Chondroid expression by lapine articular chondrocytes in spinner culture following monolayer growth. Connective Tissue Res., 2: 127-136.
    CrossRef  |  Direct Link  |  

  202. Malemud, C.J. and L. Sokoloff, 1974. Some biological characteristics of a pituitary growth factor (CGF) for cultured lapine articular chondrocytes. J. Cell. Physiol., 84: 171-179.
    CrossRef  |  Direct Link  |  

  203. Malemud, C.J. and L. Sokoloff, 1972. Rumalon and serum-free culture of chondrocytes. Arthritis Rheumatol., 15: 557-557.
    CrossRef  |  Direct Link  |  

  204. Corvol, M.T., C.J. Malemud and L. Sokoloff, 1972. A pituitary growth-promoting factor for articular chondrocytes in monolayer culture. Endocrinology, 90: 262-271.
    CrossRef  |  Direct Link  |  

  205. Malemud, C.J. and L. Sokoloff, 1971. Failure of Rumalon to increase sulfate incorporation by articular chondrocytes in monolayer culture. Arthritis Rheumatol., 14: 779-780.
    CrossRef  |  Direct Link  |  

  206. Sokoloff, L., C.J. Malemud and W.T. Green, 1970. Sulfate incorporation by articular chondrocytes in monolayer culture. Arthritis Rheumatol., 13: 118-124.
    CrossRef  |  Direct Link  |  
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