Dr. Jennifer M. Loftis
ProfessorVeterans Affairs Medical Center, United State of America
Highest Degree
Ph.D. in Neuroscience and Behavior from Oregon Health & Science University, United States
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Area of Interest:
Selected Publications
- Wardzala, C., C. Murchison, J.M. Loftis, K.J. Schenning and N. Mattek et al., 2018. Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians. Psychopharmacology, 235: 761-770.
CrossRef | Direct Link | - Walcott, A.T., M.L. Smith, J.M. Loftis and A.E. Ryabinin, 2018. Social transfer of alcohol withdrawal-induced hyperalgesia in female prairie voles. Soc. Neurosci. 10.1080/17470919.2018.1456957.
CrossRef | - Loftis, J.M., J. Valerio, J. Taylor, E. Huang and R. Hudson et al., 2018. S100B and inflammatory cytokine levels in blood as potential markers of blood–brain barrier damage and psychiatric impairment in comorbid hepatitis C viral infection and alcohol use disorder. Alcoholism: Clin. Exp. Res. 10.1111/acer.13796.
CrossRef | - Kohno, M., J.M. Loftis, M. Huckans, L.E. Dennis, H. McCready and W.F. Hoffman, 2018. The relationship between interleukin-6 and functional connectivity in methamphetamine users. Neurosci. Lett., 677: 49-54.
CrossRef | Direct Link | - Gustafsson, H.C., E.L. Sullivan, E.K. Nousen, C.A. Sullivan and E. Huang et al., 2018. Maternal prenatal depression predicts infant negative affect via maternal inflammatory cytokine levels. Brain Behav. Immunity. 10.1016/j.bbi.2018.06.011.
CrossRef | - Zaccari, B., W. Layne, J. Loftis and P. Penn, 2017. The participant's voice: A mixed-method evaluation of a mixed-gender seeking safety group. Alcoholism Treat. Quarterly, 35: 213-231.
CrossRef | Direct Link | - Wilhelm, C.J., B.E. Fuller, M. Huckans and J.M. Loftis, 2017. Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory. Drug Alcohol Dependence, 176: 71-78.
CrossRef | Direct Link | - Huckans, M., C.J. Wilhelm, T.J. Phillips, E.T. Huang, R. Hudson and J.M. Loftis, 2017. Parallel effects of methamphetamine on anxiety and CCL3 in humans and a genetic mouse model of high methamphetamine intake. Neuropsychobiology, 75: 169-177.
CrossRef | Direct Link | - Loftis, J.M., J. Taylor, H.P. Raue, M.K. Slifka and E. Huang, 2016. Alcohol intake alters immune responses and promotes CNS viral persistence in mice. Behav. Brain Res., 312: 1-8.
CrossRef | Direct Link | - Loftis, J.M. and M.M. Lim, 2016. Sleep disturbance in substance use disorders and comorbid chronic viral infections. Addiction, 111: 1093-1094.
CrossRef | Direct Link | - Ellis, C., W. Hoffman, S. Jaehnert, J. Plagge, J.M. Loftis, D. Schwartz and M. Huckans, 2016. Everyday problems with executive dysfunction and impulsivity in adults recovering from methamphetamine addiction. Addictive Disorders Treat., 15: 1-5.
CrossRef | Direct Link | - Loftis, J.M., 2015. Commentary: Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection. Frontiers Microbiol., Vol. 6. 10.3389/fmicb.2015.00793.
CrossRef | - Huckans, M., B.E. Fuller, A.L. Chalker, M. Adams and J.M. Loftis, 2015. Plasma inflammatory factors are associated with anxiety, depression and cognitive problems in adults with and without methamphetamine dependence: An exploratory protein array study. Frontiers Psychiatry, Vol. 6. 10.3389/fpsyt.2015.00178.
CrossRef | - Huckans, M., B. Fuller, V. Wheaton, S. Jaehnert and C. Ellis et al., 2015. A longitudinal study evaluating the effects of interferon-alpha therapy on cognitive and psychiatric function in adults with chronic hepatitis C. J. Psychosomatic Res., 78: 184-192.
CrossRef | Direct Link | - Loftis, J.M. and A. Janowsky, 2014. Neuroimmune Basis of Methamphetamine Toxicity. In: Review of Neurobiology: Neuroimmune Signaling in Drug Actions and Addictions, Cui, C., D. Shurtleff and R.A. Harris (Eds.). Elsevier, Oxford, UK., pp: 165-197.
- Huckans, M., B.E. Fuller, H. Olavarria, A.W. Sasaki and M. Chang et al., 2014. Multi‐analyte profile analysis of plasma immune proteins: Altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection. Brain Behav., 4: 123-142.
CrossRef | Direct Link | - Downey, L.A. and J.M. Loftis, 2014. Altered energy production, lowered antioxidant potential, and inflammatory processes mediate CNS damage associated with abuse of the psychostimulants MDMA and methamphetamine. Eur. J. Pharmacol., 727: 125-129.
CrossRef | Direct Link | - Anacker, A.M., T.H. Ahern, C.M. Hostetler, B.D. Dufour and M.L. Smith et al., 2014. Drinking alcohol has sex-dependent effects on pair bond formation in prairie voles. Proc. Nat. Acad. Sci. 10.1073/pnas.1320879111.
CrossRef | - Wilhelm, C.J., D. Choi, M. Huckans, L. Manthe and J.M. Loftis, 2013. Adipocytokine signaling is altered in Flinders sensitive line rats and adiponectin correlates in humans with some symptoms of depression. Pharmacol. Biochem. Behav., 103: 643-651.
CrossRef | Direct Link | - Sakamoto, M., S.P. Woods, M. Kolessar, D. Kriz and J.R. Anderson et al., 2013. Protective effects of higher cognitive reserve for neuropsychological and daily functioning among individuals infected with hepatitis C. J. Neurovirol., 19: 442-451.
CrossRef | Direct Link | - Loftis, J.M., M. Huckans and S.P. Woods, 2013. Substance Abuse and Infectious Disease. In: Neuropsychological Aspects of Substance Use Disorders: Evidence-Based Perspectives, Allen, D.N. and S.P. Woods (Eds.)., Oxford University Press, New York.
- Loftis, J.M., C.J. Wilhelm, A.A. Vandenbark and M. Huckans, 2013. Partial MHC/neuroantigen peptide constructs: A potential neuroimmune-based treatment for methamphetamine addiction. PloS One, Vol. 8. 10.1371/journal.pone.0056306.
CrossRef | - Loftis, J.M., C.J. Wilhelm and M. Huckans, 2013. Effect of epigallocatechin gallate supplementation in schizophrenia and bipolar disorder: An 8-week, randomized, double-blind, placebo-controlled study. Therapeutic Adv. Psychopharmacol., 3: 21-27.
CrossRef | Direct Link | - Loftis, J.M., A.L. Patterson, C.J. Wilhelm, H. McNett and B.J. Morasco et al., 2013. Vulnerability to somatic symptoms of depression during interferon-alpha therapy for hepatitis C: A 16-week prospective study. J. Psychosomatic Res., 74: 57-63.
CrossRef | Direct Link | - Loftis, J.M., 2013. Indolamine 2, 3-dioxygenase regulation and neuropsychiatric symptoms. Psychoneuroendocrinology, 38: 1829-1830.
CrossRef | Direct Link | - Loftis, J.M. and P. Hauser, 2013. Pain and opioid use in chronic liver disease: Optimal treatment must address the mental health care needs of the patient. Digestive Dis. Sci., 58: 2753-2755.
CrossRef | Direct Link | - Loftis, J.M. and M. Huckans, 2013. Substance use disorders: Psychoneuroimmunological mechanisms and new targets for therapy. Pharmacol. Therapeutics, 139: 289-300.
CrossRef | Direct Link | - Wilhelm, C.J., A. Murphpy-Crews, D.J. Menasco, M. Huckans and J.M. Loftis, 2012. CRF1 receptor antagonism alters the biochemical, but not behavioral effects of repeated interleukin-1β treatment. Neuropharmacology, 62: 313-321.
CrossRef | - Hostetler, C.M., A.M. Anacker, J.M. Loftis and A.E. Ryabinin, 2012. Social housing and alcohol drinking in male-female pairs of prairie voles (Microtus ochrogaster). Psychopharmacology, 224: 121-132.
CrossRef | Direct Link | - Patterson, A.L., B.J. Morasco, B.E. Fuller, D.W. Indest, J.M. Loftis and P. Hauser, 2011. Screening for depression in patients with hepatitis C using the beck depression inventory-II: Do somatic symptoms compromise validity? Gen. Hospital Psychiatry, 33: 354-362.
CrossRef | Direct Link | - Lotrich, F.E., J.M. Loftis, R.E. Ferrell, M. Rabinovitz and P. Hauser, 2011. IL28B polymorphism is associated with both side effects and clearance of hepatitis C during interferon-alpha therapy. J. Interferon Cytokine Res., 31: 331-336.
CrossRef | - Loftis, J.M., D. Choi, W. Hoffman and M.S. Huckans, 2011. Methamphetamine causes persistent immune dysregulation: A cross-species, translational report. Neurotoxicity Res., 20: 59-68.
CrossRef | Direct Link | - Loftis, J.M., B.J. Morasco and P. Hauser, 2011. Depression and antiviral response to interferon‐based therapy for hepatitis C virus infection. Hepatology, 53: 1413-1414.
- Loftis, J.M., 2011. Sertoli cell therapy: A novel possible treatment strategy for treatment-resistant major depressive disorder. Med. Hypotheses, 77: 35-42.
CrossRef | Direct Link | - Loftis, J.M. and M. Huckans, 2011. Cognitive enhancement in combination with ‘brain repair’may be optimal for the treatment of stimulant addiction. Addiction, 106: 1021-1022.
CrossRef | Direct Link | - Huckans, M., A. Seelye, J. Woodhouse, T. Parcel and L. Mull et al., 2011. Discounting of delayed rewards and executive dysfunction in individuals infected with hepatitis C. J. Clin. Exp. Neuropsychol., 33: 176-186.
CrossRef | Direct Link | - Huckans, M. and J.M. Loftis, 2011. Handbook of medical neuropsychology: Add it to your library. J. Clin. Exp. Neuropsychol., 24: 1-3.
- Anacker, A.M., J.M. Loftis, S. Kaur and A.E. Ryabinin, 2011. Prairie voles as a novel model of socially facilitated excessive drinking. Addiction Biol., 16: 92-107.
CrossRef | Direct Link | - Anacker, A.M., J.M. Loftis and A.E. Ryabinin, 2011. Alcohol intake in prairie voles is influenced by the drinking level of a peer. Alcoholism: Clin. Exp. Res., 35: 1884-1890.
CrossRef | Direct Link | - Morasco, B.J., M. Huckans, J.M. Loftis, J. Woodhouse, A. Seelye, D.C. Turk and P. Hauser, 2010. Predictors of pain intensity and pain functioning in patients with the hepatitis C virus. Gen. Hospital Psychiatry, 32: 413-418.
CrossRef | Direct Link | - Morasco, B.J., J.M. Loftis, D.W. Indest, S. Ruimy, J.W. Davison, B. Felker and P. Hauser, 2010. Prophylactic antidepressant treatment in patients with hepatitis C on antiviral therapy: A double-blind, placebo-controlled trial. Psychosomatics, 51: 401-408.
CrossRef | Direct Link | - Loftis, J.M., M. Huckans and B.J. Morasco, 2010. Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies. Neurobiol. Dis., 37: 519-533.
CrossRef | Direct Link | - Loftis, J.M., B.J. Morasco, D. Menasco, D. Fuchs, M. Strater and P. Hauser, 2010. Serum serotonin levels are associated with antiviral therapy outcomes in patients with chronic hepatitis C. Open Infect. Dis. J., 4: 132-141.
Direct Link | - Loftis, J.M. and E.H. Turner, 2010. Novel treatment strategies for depression in patients with hepatitis C. Psychosomatics, 51: 357-358.
CrossRef | Direct Link | - Huckans, M., A. Mitchell, S. Pavawalla, B. Morasco and S. Ruimy et al., 2010. The influence of antiviral therapy on psychiatry symptoms among hepatitis C patients with schizophrenia. Antiviral Therapy, 15: 111-119.
- Mansour, H.A., M.E. Talkowski, J. Wood, K.V. Chowdari and L. McClain et al., 2009. Association study of twenty-one circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Bipolar Disorders, 11: 701-710.
- Huckans, M., A. Seelye, T. Parcel, L. Mull and J. Woodhouse et al., 2009. The cognitive effects of hepatitis C in the presence and absence of a history of substance use disorder. J. Int. Neuropsychol. Soc., 15: 69-82.
CrossRef | - Hauser, P., B.J. Morasco, A. Linke, D. Bjornson and S. Ruimy et al., 2009. Antiviral completion rates and sustained viral response in hepatitis C patients with and without preexisting major depressive disorder. Psychosomatics, 50: 500-505.
CrossRef | Direct Link | - Fuller, B.E., J.M. Loftis, V.L. Rodriguez, M.J. McQuesten and P. Hauser, 2009. Psychiatric and substance use disorders comorbidities in veterans with hepatitis C virus and HIV coinfection. Curr. Opinion Psychiatry, 22: 401-408.
CrossRef | Direct Link | - Nelligan, J.A., J.M. Loftis, A.M. Matthews, B.L. Zucker, A.M. Linke and P. Hauser, 2008. Depression comorbidity and antidepressant use in veterans with chronic hepatitis C: Results from a retrospective chart review. J. Clin. Psychiatry, 69: 810-816.
CrossRef | Direct Link | - Loftis, J.M., M. Huckans, S. Ruimy, D.J. Hinrichs and P. Hauser, 2008. Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α. Neurosci. Lett., 430: 264-268.
CrossRef | Direct Link | - Loftis, J.M. and P. Hauser, 2008. Risk and protective factors in interferon-induced depression: treatment strategies and clinical outcomes. Directions Psychiatry, 28: 227-242.
- Loftis, J.M. and P. Hauser, 2008. Prevalence of psychiatric and substance use disorder comorbidities in patients with hepatitis C. Psychiatry, 28: 211-225.
- Huckans, M., A. Mitchell, S. Ruimy, J. Loftis and P. Hauser, 2008. Antiviral therapy completion and response rates among hepatitis C patients with and without schizophrenia. Schizophrenia Bull., 36: 165-172.
CrossRef | Direct Link | - Morasco, B.J., M.A. Rifai, J.M. Loftis, D.W. Indest, J.K. Moles and P. Hauser, 2007. A randomized trial of paroxetine to prevent interferon-α-induced depression in patients with hepatitis C. J. Affective Disorders, 103: 83-90.
CrossRef | Direct Link | - Huckans, M.S., J.M. Loftis, A.D. Blackwell and P. Hauser, 2007. Interferon-based therapy for hepatitis C: Treatment response and completion rates among patients with schizophrenia, schizoaffective disorder and substance use disorder. Substance Abuse Treat. Prevention Policy, 12: 2-4.
- Turner, E.H., J.M. Loftis and A.D. Blackwell, 2006. Serotonin a la carte: Supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacol. Therapeutics, 109: 325-338.
CrossRef | Direct Link | - Rifai, M.A., J.M. Loftis and P. Hauser, 2006. Hepatitis C treatment of veterans with psychiatric illness. Am. J. Gastroenterol., 101: 673-674.
Direct Link | - Rifai, M.A., D. Indest, J. Loftis and P. Hauser, 2006. Psychiatric management of the hepatitis C patient. Curr. Treat. Options Gastroenterol., 9: 508-519.
CrossRef | Direct Link | - Loftis, J.M., P. Hauser, T.A. Macey and J.D. Lowe, 2006. Can rodents be used to model interferon-α-induced depressive symptoms? Progr. Neuropsychopharmacol. Biol. Psychiatry, 7: 1364-1365.
- Loftis, J.M., J.M. Wall, R.L. Pagel and P. Hauser, 2006. Administration of pegylated interferon-does not induce sickness behavior in Lewis rats. Psychoneuroendocrinology, 31: 1289-1294.
- Loftis, J.M., A.M. Matthews and P. Hauser, 2006. Psychiatric and substance use disorders in individuals with hepatitis C. Drugs, 66: 155-174.
CrossRef | Direct Link | - Rifai, M.A., J.M. Loftis and P. Hauser, 2005. Interferon-treatment of patients with hepatitis C: The role of a comprehensive risk-benefit assessment. CNS Drugs, 19: 719-721.
- Mansour, H.A., M.E. Talkowski, J. Wood, L. Pless and M. Bamne et al., 2005. Serotonin gene polymorphisms and bipolar I disorder: Focus on the serotonin transporter. Ann. Med., 37: 590-602.
CrossRef | Direct Link | - Loftis, J.M., M.A. Rifai and P. Hauser, 2005. The association between viral clearance and depression in patients with hepatitis C receiving interferon-alpha and ribavirin. Brain Behav. Immunity, 19: 271-272.
CrossRef | - Loftis, J.M. and P. Hauser, 2005. Letter to the editor re: The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complication in chronic hepatitis C. Hum. Psychopharmacol.: Clin. Exp., 20: 211-212.
- Sylvestre, D.L., J.M. Loftis, P. Hauser, S. Genser and H. Cesari et al., 2004. Co-occurring hepatitis C, substance use, and psychiatric illness: Treatment issues and developing integrated models of care. J. Urban Health, 81: 719-734.
CrossRef | Direct Link | - Loftis, J.M., R.E. Socherman, C.D. Howell, A.J. Whitehead, J.A. Hill, J.A. Dominitz and P. Hauser, 2004. Association of interferon-α-induced depression and improved treatment response in patients with hepatitis C. Neurosci. Lett., 365: 87-91.
CrossRef | Direct Link | - Loftis, J.M., J.M. Wall, E. Linardatos, S. Benvenga and P. Hauser, 2004. A quantitative assessment of depression and thyroid dysfunction secondary to antiviral therapy in patients with hepatitis C. J. Endocrinol. Invest., 27: RC16-RC20.
- Loftis, J.M. and P. Hauser, 2004. The phenomenology and treatment of interferon-induced depression. J. Affective Disorders, 82: 175-190.
CrossRef | Direct Link | - Hauser, P., J.M. Loftis, E. Dieperink, G. Garcia-Tsao, M. Rigsby and M. Willenbring, 2004. Depression and substance use disorders in chronic hepatitis C: Implications of new guidelines and experience in the VA health care system. Federal Practitioner, 21: 90-102.
- Loftis, J.M. and P. Hauser, 2003. Safety considerations for the treatment of interferon-induced depression. Psychosomatics, 44: 524-526.
- Loftis, J.M. and P. Hauser, 2003. Hepatitis C in patients with psychiatric disease and substance abuse: Screening strategies and comanagement models of care. Curr. Hepatitis Rep., 2: 93-100.
CrossRef | Direct Link | - Loftis, J.M. and P. Hauser, 2003. Co-management of depression and HCV treatment. Psychiatric Ann., 33: 385-391.
- Loftis, J.M. and A. Janowsky, 2003. Review of the NMDA receptor, NR2B: localization, functional properties, regulation and clinical implications. Pharmacol. Therapeutics, 97: 55-85.
- Loftis, J.M. and A. Janowsky, 2002. Cocaine-withdrawal induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit. Psychopharmacology, 164: 349-359.
- Mason, J.N., A.J. Eshleman, J.K. Belknap, J.C. Crabbe, J.M. Loftis, T.A. Macey and A. Janowsky, 2001. NMDA receptor subunit mRNA and protein expression in ethanol‐withdrawal seizure‐prone and‐resistant mice. Alcoholism: Clin. Exp. Res., 25: 651-660.
CrossRef | Direct Link | - Loftis, J.M. and A. Janowsky, 2000. Regulation of NMDA receptor subunits and nitric oxide synthase expression during cocaine withdrawal. J. Neurochem., 75: 2040-2050.
CrossRef | Direct Link | - Fridlund, A.J. and J.M. Loftis, 1990. Relationship between tickling and humorous laughter. Biol. Psychol., 30: 141-150.