Dr. Ramachandra S. Hosmane


University of South Florida, USA

Highest Degree
Ph.D. in Chemistry from University of South Florida, USA

My URL
https://livedna.org/1.28093

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Area of Interest:

Chemistry
Organic Chemistry
Molecular Chemistry
Chemistry Analytics
Chemistry Pohosphorus

Selected Publications

  1. Bol, G.M., F. Vesuna, M. Xie, J. Zeng and K. Aziz et al., 2015. Targeting DDX3 with a small molecule inhibitor for lung cancer therapy. EMBO Mol. Med., 7: 648-669.
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  2. Zhang, N., P. Zhang, A. Baier, L. Cova and R. S. Hosmane, 2014. Dual inhibition of HCV and HIV by ring-expanded nucleosides containing the 5:7-fused imidazo[4,5-e][1,3]diazepine ring system. In vitro results and implications. Bioorg. Med. Chem. Lett., 24: 1154-1157.
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  3. Tantravedi, S., S. Chakraborty, J.C. Fishbein and R.S. Hosmane, 2013. Analogs of Iso-azepinomycin as potential transition-state analog inhibitors of guanase: Synthesis, biochemical screening and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines. Bioorg. Med. Chem., 21: 4893-4903.
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  4. Kondaskar, A., S. Kondaskar, J.C. Fishbein, B.A. Carter-Cooper and R.G. Lapidus et al., 2013. Structure-based drug design and potent anti-cancer activity of tricyclic 5:7:5-fused diimidazo[4,5-d:4',5'-f][1,3]diazepines. Bioorg. Med. Chem., 21: 618-631.
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  5. Chakraborty, S., N.H. Shah, J.C. Fishbein and R.S. Hosmane, 2012. Investigations into specificity of azepinomycin for inhibition of guanase: Discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues. Bioorg. Med. Chem. Lett., 22: 7214-7218.
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  6. Kondaskar, A., S. Kondaskar, R. Kumar, N. Muvarak and R.G. Lapidus et al., 2011. Novel, broad spectrum anti-cancer agents containing the tricyclic 5:7:5-fused diimidazodiazepine ring system. ACS Med. Chem. Lett., 2: 252-256.
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  7. Chakraborty, S., N.H. Shah, J.C. Fishbein and R.S. Hosmane, 2011. A novel transition state analog inhibitor of guanase based on azepinomycin ring structure: Synthesis and biochemical assessment of enzyme inhibition. Bioorg. Med. Chem. Lett., 21: 756-759.
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  8. Xie, M., R.K. Ujjinamatada, M. Sadowska, R.G. Lapidus, M.J. Edelman and R.S. Hosmane, 2010. A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system. Bioorg. Med. Chem. Lett., 20: 4386-4389.
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  9. Watashi, K., M.L. Yeung, M.F. Starost, R.S. Hosmane and K.T. Jeang, 2010. Identification of small molecules that suppress microRNA function and reverse tumorigenesis. J. Biol. Chem., 285: 24707-24716.
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  10. Cai, H., T.A. Roach, M. Dabek, K.S. Somerville, S. Acharya and R.S. Hosmane, 2010. Bis[2-(3-carboxyphenoxy)carbonylethyl]phosphinic acid (m-BCCEP): A novel affinity cross-linking reagent for the β-cleft modification of human hemoglobin. Bioconjugate Chem., 21: 1494-1507.
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  11. Hosmane, R.S., 2009. Ring-expanded (‘Fat’‘) purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics. Progr. Heterocyclic Chem., 21: 35-68.
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  12. Hosmane, R.S. and J.F. Liebman, 2009. Paradoxes and paradigms: Why is quinoline less basic than pyridine or isoquinoline? A classical organic chemical perspective. Struct. Chem., 20: 693-697.
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  13. Yedavalli, V., N. Zhang, H. Cai, K.T. Jeang and R.S. Hosmane, 2008. Ring-expanded nucleosides (RENs) exhibit potent in vitro anti-HIV activity with little or no toxicity in ex vivo cell culture and in vivo in mice. Synthesis and mechanistic explorations. J. Med. Chem., 51: 5043-5051.

  14. Ujjinamatada, R.K., P. Phatak, A.M. Burger and R.S. Hosmane, 2008. Inhibition of adenosine deaminase by analogues of adenosine and inosine incorporating a common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one. J. Med. Chem., 51: 694-698.

  15. Kumar, R., R.K. Ujjinamatada and R.S. Hosmane, 2008. The first synthesis of a novel 5:7:5-fused diimidazodiazepine ring system and some of its chemical properties. Org. Lett., 10: 4681-4684.
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  16. Zhang, P., N. Zhang, V. Buckwold and R.S. Hosmane, 2007. Chemical and biological effects of substitution of the 2-position of ring-expanded (“fat”) nucleosides containing the imidazo[4,5-e][1,3] diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic bond stability and anti-HCV activity. Bioorg. Med. Chem., 15: 4933-4955.
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  17. Zhang, P., N. Zhang, B.E. Korba and R.S. Hosmane, 2007. Structure-activity relationship studies on anti-HCV activity of ring-expanded (fat) nucleobase analogues containing the imidazo[4, 5-e][1, 3] diazepine-4,8-dione ring system. Bioorg. Med. Chem. Lett., 17: 2225-2228.
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  18. Ujjinamatada, R.K., A. Baier, P. Borowski and R.S. Hosmane, 2007. An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5-(4,6 diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-ß-D-ribofuranoside. Bioorg. Med. Chem. Lett., 17: 2285-2288.

  19. Ujjinamatada, R.K., Y.S. Agasimundin, P. Borowski and R.S. Hosmane, 2006. Reactions of guanidine with vinylogous ester-aldehydes: Synthesis and anti-west nile virus activity of a novel imidazole nucleoside containing a diaminodihydro-s-triazine as a Substituent: 147. Antiviral Res., 65: A68-A69.
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  20. Ujjinamatada, R.K., R.L. Paulman, R.G. Ptak and R.S. Hosmane, 2006. Nucleosides with Self- complementary hydrogen-bonding motifs: Synthesis and base-pairing studies of two nucleosides containing the imidazo[4,5-d]pyridazine ring system. Bioorg. Med. Chem., 14: 6359-6367.
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  21. Ujjinamatada, R.K., A. Bhan and R.S. Hosmane, 2006. Design of inhibitors against guanase: Synthesis and biochemical evaluation of analogues of azepinomycin. Bioorg. Med. Chem. Lett., 16: 5551-5554.
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  22. Zhang, P., N. Zhang, B.E. Korba and R.S. Hosmane, 2005. Synthesis and in vitro anti-hepatitis B and C virus activities of ring-expanded (fat) nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system. Bioorg. Med. Chem. Lett., 15: 5397-5401.
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  23. Ujjinamatada, R.K., Y.S. Agasimundin, P. Zhang, V. Koch and H. Schmitz et al., 2005. A novel imidazole nucleoside containing a diaminodihydro-s-triazine as a substituent and an inhibitory activity against the West Nile Virus NTPase/helicase. Nucleosides Nucleotides Nucleic Acids, 24: 1775-1788.
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  24. Ujjinamatada, R.K. and R.S. Hosmane, 2005. Selective functional group transformation using guanidine: The conversion of an ester group into an amide in vinylogous ester-aldehydes of imidazole. Tetrahedron Lett., 46: 6005-6009.
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  25. Roach, T.A., V.W. Macdonald and R.S. Hosmane, 2004. A novel site-directed affinity reagent for cross-linking human hemoglobin: bis[2-(4-phosphonooxyphenoxy)carbonylethyl]phosphinic acid. J. Med. Chem., 47: 5847-5859.
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  26. Reayi, A. and R.S. Hosmane, 2004. Inhibitors of adenosine deaminase: continued studies of structure‐activity relationships in analogues of coformycin. Nucleosides Nucleotides Nucleic Acids, 23: 263-271.
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  27. Reayi, A. and R.S. Hosmane, 2004. Inhibition of adenosine deaminase by novel 5:7-fused heterocycles containing the imidazo[4,5-e][1,2,4]triazepine ring system: A structure-activity relationship study. J. Med. Chem., 47: 1044-1050.

  28. Hosmane, R.S., 2004. Antiviral Agents. In: Kirk-Othmer Encyclopedia of Chemical Technology, Kirk-Othmer (Ed.). 5th Edn., John Wiley & Sons, New York, ISBN: 978-0-471-48518-6, pp: 135-182.

  29. Hosmane, R.S. and J.F. Liebman, 2004. Resonance stabilization in diazophenoxides. Struct. Chem., 15: 253-255.

  30. Gunther, S., M. Asper, C. Roser, L.K. Luna and C. Drosten et al., 2004. Application of real-time PCR for testing antiviral compounds against Lassa virus, SARS coronavirus and Ebola virus in vitro. Antiviral Res., 63: 209-215.
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  31. Zhang, N., H.M. Chen, V. Koch, H. Schmitz and M. Minczuk et al., 2003. Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded (“fat”) nucleoside analogues. J. Med. Chem., 46: 4776-4789.
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  32. Zhang, N., H.M. Chen, V. Koch, CL. Liao and M. Bretner et al., 2003. Ring-expanded (“fat”) nucleoside and nucleotide analogues exhibit potent in vitro activity against Flaviviridae NTPases/helicases, including those of the West Nile Virus (WNV), Hepatitis C Virus (HCV) and Japanese Encephalitis Virus (JEV). J. Med. Chem., 46: 4149-4164.
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  33. Zhang, N., H.M. Chen, R. Sood, K. Kalicharran and A.I. Fattom et al., 2002. In vitro inhibition of measles virus replication by novel ring-expanded (“Fat”) nucleoside analogues containing the imidazo[4,5-e][1,3]diazepine ring system. Bioorg. Med. Chem. Lett., 12: 3391-3394.

  34. Sood, R.K., V.S. Bhadti, A.I. Fattom, R.B. Naso and B.E. Korba et al., 2002. Novel ring-expanded nucleoside analogs exhibit potent and selective inhibition of hepatitis B virus replication in cultured human hepatoblastoma cells. Antiviral Res., 53: 159-164.
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  35. Roux, M.V., M. Temprado, J.Z. Davalos, P. Jimenez, R.S. Hosmane and J.F. Liebman, 2002. Enthalpy of formation of methyl benzoate: Calorimetry and consequences. Phys. Chem. Chem. Phys., 4: 3611-3613.
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  36. Hosmane, R.S., 2002. Ring-Expanded ("Fat") Nucleosides as Broad-Spectrum Anticancer and Antiviral Agents. In: Current Topics in Medicinal Chemistry: Recent Developments in Antiviral Nucleosides, Nucleotides and Oligonucleotides Hosmane, R.S. (Ed.). Bentham Science Publishers, USA., pp: 1093-1109.

  37. Hosmane, R.S., 2002. Coformycin and Analogues as Inhibitors of Adenosine Deaminase. In: Modified Nucleosides, Synthesis and Applications, Loakes, D. (Ed.). Transworld Research Network, Trivendrum, pp: 133-151.

  38. Hosmane, R.S. and J.F. Liebman, 2002. Diazomethane and ethyl diazoacetate: The role of substituent effects on stability. Struct. Chem., 5-6: 501-503.

  39. Burnett, F.N. and R.S. Hosmane, 2002. Synthesis of a novel ring-expanded purine analogue containing a 5:8-fused Imidazo[4,5-e][1,2,4]triazocine ring system amidst opportunistic rearrangements and ring ransformations. Tetrahedron, 58: 9567-9578.
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  40. Borowski, P., M. Lang, A. Haag, H. Schmitz, J. Choe, H.M. Chen and R.S. Hosmane, 2002. Characterization of imidazo [4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: Evidence for activity on the level of substrate and/or enzyme. Antimicrob. Agents Chemother., 46: 1231-1239.
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  41. Borowski, P., A. Niebuhr, H. Schmitz, R.S. Hosmane, M. Bretner, M.A. Siwecka and T. Kulikowski, 2002. NTPase/helicase of flaviviridae: Inhibitors and inhibition of the enzyme. Acta Biochem. Polon., 49: 597-614.

  42. Sun, Z. and R.S. Hosmane, 2001. An improved synthesis of 9-benzyladenine: A model for adenosine and its analogues. Synth. Commun., 32: 549-554.

  43. Sood, R.K., V.S. Bhadti, H.M. Chen and R.S. Hosmane, 2001. 6-Amino-1-(2'-deoxy-b-D-ribofuranosyl)-4,5-dihydro-8H-imidazo[4,5-e][1,3]diazepine-4,8-dione. Molecules, Vol. 6. 10.3390/M264.
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  44. Gill, J., M. Bretner, R. Newman, N. Kyprianou and R.S. Hosmane, 2001. Synthesis, anticancer activity and in vitro mechanistic investigations of several "fat" nucleosides containing the imidazo[4,5-e][1,3] diazepine ring system. Nucleosides Nucleotides, 20: 1043-1045.

  45. Chen, H.M. and R.S. Hosmane, 2001. Synthesis of a novel ring‐expanded (“fat”) nucleotide analogue of phosphonomethoxyethylguanine (PMEG) containing the imidazo[4,5‐e][1,3]diazepine ring system. J. Heterocycl. Chem., 38: 1313-1315.
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  46. Chen, H.M. and R.S. Hosmane, 2001. Acyclic nucleoside/nucleotide analogues bearing an imidazole ring skeleton. Nucleosides Nucleotides, 20: 1599-1614.

  47. Chen, H.M. and R. Hosmane, 2001. Synthesis of 1-(2'-O-Methyl-ß-D-ribofuranosyl)-1H-imidazo[4,5-d] pyridazine-4,7(5H, 6H)-dione: An attractive building block for antisense and triple-helical applications. Molecules, 6: 203-207.
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  48. Sun, Z., R.S. Hosmane and M. Tadros, 2000. Photochromic fulgides: Transformation of the non‐photochromic (Z)‐isomer of a fulgide into a highly photochromic (E)‐isomer via structural modification involving enhanced conjugation. J. Heterocyclic Chem., 37: 1439-1441.
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  49. Siddiqui, S. and R. Hosmane, 2000. Synthetic analogue of stilbene containing an imidazole nucleus. Molecules, 5: 856-863.
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  50. Rajappan, V. and R.S. Hosmane, 2000. A model study for a novel synthetic approach to 2-carboxyinosines. Tetrahedron Lett., 41: 9713-9717.
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  51. Chen, H.M., R.S. Hosmane and D.M. Baldisseri, 2000. Synthesis of a novel ring‐expanded nucleoside analogue containing the imidazo [4, 5‐e][1, 3] diazepine ring system with a guanidinocarbamoyl‐substituted cyclopropylidene group in place of a sugar moiety. J. Heterocyclic Chem., 37: 951-953.
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  52. Chen, H.M. and R. S. Hosmane, 2000. 6-Amino-2-phenylimidazo[4,5-e][1,3]diazepine-4,8(1H,5H)-dione. Molecules, Vol. 6. 10.3390/M164.
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  53. Chen, H.M. and R. Hosmane, 2000. Synthesis of 1-(2'-Deoxy-β-D-ribofuranosyl)-1H-imidazo [4, 5-d]-pyridazine-4, 7 (5H, 6H)-dione: A potential building block for antisense applications. Molecules, 5: 1187-1193.
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  54. Rajappan, V.P. and R.S. Hosmane, 1999. Investigations into biochemical mode of inhibition of guanase by azepinomycin: Synthesis and biochemical screening of several analogues of azepinomycin. Nucleosides Nucleotides, 18: 835-836.
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  55. Peri, S.P., V.S. Bhadti, K.S. Somervffle-Armstrong, R. Liang, V.W. Macdonald and R.S. Hosmane, 1999. Affinity reagents for cross-linking hemoglobin: Bis (phenoxycarbonylethyl) phosphinic acid (BPCEP) and bis (3-nitrophenoxycarbonylethyl) phosphinic acid (BNCEP). Hemoglobin, 23: 1-20.
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  56. Davalos, J.Z., H. Flores, P. Jimenez, R. Notario and M.V. Roux et al., 1999. Calorimetric, computational (G2 (MP2) and G3) and conceptual study of the energetics of the isomeric 1, 3-and 1, 4-dithianes. J. Org. Chem., 64: 9328-9336.
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  57. Chen, H., R. Sood and R.S. Hosmane, 1999. An efficient, short synthesis of 6-Imino-6-H-1-β-D-ribofuranosyl-4,5,7,8- tetrahydroimidazo[4,5-e]diazepine-4,8-dione: A novel ring-expanded purine nucleoside analogue containing a 5:7-fused, planar, aromatic, heterocyclic ring system. Nucleosides Nucleotides, 18: 331-335.

  58. Bretner, M., D. Beckett, R. Sood and R.S. Hosmane, 1999. Inhibition of bacteriophage T7 RNA polymerase by the 5'- triphosphate derivative of a ring-expanded ("Fat") nucleoside possessing a potent anti-hepatitis B viral activity. Bioorg. Med. Chem., 7: 2931-2936.

  59. Bretner, M., D. Beckett and R.S. Hosmane, 1999. Potent anti-hepatitis B viral activity and inhibition of bacteriophage T7 RNA polymerase by a "Fat" nucleoside and its 5'-triphosphate derivative: Synthetic, biochemical and biological studies of 4, 8-Diamino-6-imino-6 h-1-β-D-ribofuranosylimidazo [4, 5-E][1, 3] diazepine-5'-triphosphate. Nucleosides Nucleotides, 18: 837-838.
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  60. Skancke, A., R.S. Hosmane and J.F. Liebman, 1998. Unification of some literature models of aromaticity: Calculational and conceptual study of a set of one-ring species. Acta Chem. Scandinavica, 52: 967-974.
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  61. Rajappan, V.P. and R.S. Hosmane, 1998. Pentafluorophenol: A superior reagent for condensations in heterocyclic chemistry. Synth. Commun., 28: 753-764.
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  62. Rajappan, V.P. and R.S. Hosmane, 1998. Analogues of azepinomycin as inhibitors of guanase. Nucleosides Nucleotides, 17: 1141-1151.
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  63. Rajappan, V. and R.S. Hosmane, 1998. Synthesis and guanase inhibition studies of a novel ring-expanded purine analogue containing a 5: 7-fused, planar, aromatic heterocyclic ring system. Bioorg. Med. Chem. Lett., 8: 3649-3652.
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  64. Hosmane, R.S., S.P. Peri, V.S. Bhadti and V.W. Macdonald, 1998. Bis [2-(4-carboxyphenoxy) carbonylethyl] phosphinic acid (BCCEP): A novel affinity reagent for the β-cleft modification of human hemoglobin. Bioorg. Med. Chem., 6: 767-783.
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  65. Agasimundin, Y.S., M.W. Mumper and R.S. Hosmane, 1998. Inhibitors of glycogen phosphorylase B: Synthesis, biochemical screening and molecular modeling studies of novel analogues of hydantocidin. Bioorg. Med. Chem., 6: 911-923.
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  66. Roux, M.V., P. Jimenez, M.A. Martin-Luengo, J.Z. Davalos, Z. Sun, R.S. Hosmane and J.F. Liebman, 1997. The elusive antiaromaticity of maleimides and maleic anhydride: Enthalpies of formation of N-methylmaleimide, N-methylsuccinimide, N-methylphthalimide and N-benzoyl-N-methylbenzamide. J. Org. Chem., 62: 2732-2737.
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  67. Peri, S.P., V.S. Bhadti, R.S. Hosmane and V.W. Macdonald, 1997. Bis [2-(4-carboxyphenoxy) carbonylethyl] phosphinic acid (BCCEP): A new reagent for hemoglobin modification. Artif. Cells Blood Substitutes Biotechnol., 25: 511-520.
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  68. Hosmane, R.S. and M. Hong, 1997. How important is theN-3 sugar moiety in the tight-binding interaction of coformycin with adenosine deaminase? Biochem. Biophys. Res. Commun., 236: 88-93.
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  69. Hong, M. and R.S. Hosmane, 1997. Irreversible, tight-binding inhibition of adenosine deaminase by coformycins: Inhibitor structural features that contribute to the mode of enzyme inhibition. Nucleosides Nucleotides Nucleic Acids, 16: 1053-1057.
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  70. Burnett, F.N. and R.S. Hosmane, 1997. Imidazo [4, 5-e][1, 2, 4] triazocine: a novel 5: 8-fused ring system riddled with rearrangements. Heterocycles, 5: 857-861.
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  71. Bhadti, V.S., S.P. Peri and R.S. Hosmane, 1996. A novel organic reagent for biomacromolecular modification: Bis(Phenoxycarbonylethyl)phosphinic acid. Bioorg. Med. Chem. Lett., 6: 879-882.

  72. Sun, Z., R.S. Hosmane, M. Tadros, S. Guha, W. Chen and J.M. Chen, 1995. Photochromism of fulgides and stereoelectronic factors: Synthesis of (E)‐4 (3)‐adamantyhdene‐(5)‐dicyanomethylene‐3 (4)‐[1‐(2, 5‐dimethylfuryl) ethylidene] tetrahydrofuran‐2‐one 4 and 4a and (E)‐4‐adamantylidene‐3‐[2, 6‐dimethyl‐3, 5‐bis (p‐diethyl‐aminostyryl) benzylidene] tetrahydrofuran‐2, 5‐dione 10. J. Heterocyclic Chem., 32: 1819-1828.

  73. Sun, Z., R.S. Hosmane and M. Tadros, 1995. Fulgides and photochromism. Synthesis of 5-Dicyanomethylene-4- dicyclopropylmethylene 3-(2,5-dimethyl-3-furylethylidene) tetrahydrofuran-2-one. Tetrahedron Lett., 36: 3453-3456.

  74. Rao, P.R., S. Jones, Z. Sun, R.S. Hosmane, O. Abugo and J. Rifkind, 1995. Aspirin analogues and flow of erythrocytes through narrow capillaries. Clin. Hemorheol. Microcircul., 15: 877-887.
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  75. Pou, S., A. Bhan, V.S. Bhadti, S.Y. Wu, R.S. Hosmane and G.M. Rosen, 1995. The use of fluorophore-containing spin traps as potential probes to localize free radicals in cells with fluorescence imaging methods. FASEB J., 9: 1085-1090.
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  76. Burnett, F.N. and R.S. Hosmane, 1995. Synthetic approaches to 5: 8-fused heterocyclic systems. A novel rearrangement during the synthesis of imidazo [4, 5-e][1, 2, 4] triazocine ring system. Nucleosides Nucleotides Nucleic Acids, 14: 325-328.
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  77. Bhan, A., R.S. Hosmane, H. Zhang and N.S. Hosmane, 1995. A diaminomalonate synthon useful for building novel heterocycles. Synth. Commun., 25: 2723-2737.

  78. Bhan, A. and R.S. Hosmane, 1995. Analogues of Azepinomycin: Inhibitors of Guanase. Nucleosides Nucleotides Nucleic Acids, 14: 455-458.
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  79. Wang, L., A. Bhan, R.S. Hosmane and R.D. Guiles, 1994. A short synthesis of a novel ring-expanded purine and its nucleoside analogue containing the imidazo [4, 5-e][1, 3] diazepine ring skeleton with multiple amino substituents attached to the 7-membered ring. Nucleosides Nucleotides Nucleic Acids, 13: 2307-2320.
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  80. Mumper, M.W., C. Aurenge and R.S. Hosmane, 1994. "Slim" nucleosides and nucleotides. I. Synthetic, structural and biophysical investigations of showdomycins. J. Biomol. Struct. Dynamics, 11: 1107-1131.
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  81. Bhan, A., R.S. Hosmane, H. Zhang and N.S. Hosmane, 1994. Ring closure of diethyl 2-methoxy-2-[N-(5-amino-1-benzylimidazolyl-4-carbonyl) amino] malonate: Product structures and pathways of product formation. Struct. Chem., 5: 375-381.
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  82. Bhan, A. and R.S. Hosmane, 1994. Novel inhibitors of guanase. Tetrahedron Lett., 35: 6831-6834.
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  83. Bertha, C.M., R.S. Hosmane, H. Zhang and N.S. Hosmane, 1994. Reagents for bioorganic synthesis. 6. The design and synthesis of two novel polyfunctional organic reagents for biomacromolecular modification. J. Biomol. Struct. Dynamics, 12: 413-437.
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  84. Vaidya, V.P., R.S. Hosmane, U.Siriwardane, H. Zhang and N.S. Hosmane, 1993. Unequivocal structural assignment of the product of methylation of 4-nitro-5-styrylimidazole. Struct. Chem., 4: 339-343.
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  85. Pou, S., A. Bhan, V.S. Bhadti, S.Y. Wu, R.S. Hosmane and G.M. Rosen, 1993. Synthesis of fluorophore containing nitroxides for detecting superoxide and hydroxyl radical generated by stimulated neutrophils. Anal. Biochem., 212: 85-90.

  86. Mumper, M.W., C. Aurenge and R.S. Hosmane, 1993. A short, convenient synthesis of 2'-deoxyshowdomycin. Bioorg. Med. Chem. Lett., 3: 2847-2850.
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  87. Bhan, A. and R.S. Hosmane, 1993. Reactions of ring‐expanded xanthines containing the imidazo [4, 5‐e][1, 4] diazepine ring system. J. Heterocyclic Chem., 30: 1453-1462.
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  88. Hosmane, R.S. and J.F. Liebman, 1992. Aromaticity of five-membered heterocycles: An experimentally convenient theoretical model for prediction of relative aromaticity. Tetrahedron Lett., 33: 2303-2306.
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  89. Bhan, A. and R.S. Hosmane, 1992. The synthesis, structure and conformation of 2'-Deoxy analogues of "Fat" Xanthine nucleosides, containing the imidazo [4, 5-e][1, 4] diazepine ring system. Nucleosides Nucleotides, 11: 1175-1200.
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  90. Bhadti, V.S., A. Bhan, R.S. Hosmane and M. Hulce, 1992. The synthesis of novel regioisomeric ring-expanded xanthine nucleosides containing the 5: 7-Fused imidazo [4, 5-e][1, 2, 4] triazepine ring system. Nucleosides Nucleotides, 11: 1137-1149.
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  91. Bertha, C.M., R.S. Hosmane, H. Zhang and N.S. Hosmane, 1992. Reagents for bioorganic synthesis. 5. The synthesis of two potential cross-linking reagents: 2, 2'-sulfonylbis [3-(benzylamino)-(E, E)-N-(2-oxoethyl) propenamide](SBBOP) and 2, 2'-sulfonylbis [3-(benzylamino)-(E, E)-N-(2-chloroethyl) propenamide](SBBCP). J. Org. Chem., 57: 5868-5873.
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  92. Bertha, C.M. and R.S. Hosmane, 1992. The synthesis of a potential cross-linking reagent: 2,2'-Sulfonylbis[3-benzylamino- (E,E)-N-(2-oxoethyl)propenamide. Tetrahedron Lett., 33: 3425-3428.
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  93. Hosmane, R.S., V.P. Vaidya, M.K. Chung, U. Siriwardane, H. Zhang and N.S. Hosmane, 1991. Synthesis of ring-expanded xanthines and xanthosines containing the imidazo [4, 5-d][1, 3] diazepine ring system. Nucleosides Nucleotides Nucleic Acids, 10: 1693-1706.
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  94. Hosmane, R.S., A. Bhan, M. Hulce, H. Zhang and N.S. Hosmane, 1991. Synthetic, structural and conformational studies of methylated ring-expanded nucleosides containing the ihidazo [4, 5-e][1, 4] diazepine ring system. Nucleosides Nucleotides, 10: 819-836.
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  95. Hosmane, R.S. and J.F. Liebman, 1991. Aromaticity of heterocycles: Experimental realization of dewar-breslow definition of aromaticity. Tetrahedron Lett., 32: 3949-3952.
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  96. Hosmane, R.S. and B.B. Lim, 1991. The synthesis and structure of 1,2,3,4-Tetrahydro-8-nitroimidazo[1,5-d][1,2,4]triazin-1-one, C8H11N5O3: A heterocycle with a rare ring system. J. Cryst. Spectr. Res., 21: 353-356.

  97. Hosmane, R.S., V.S. Bhadti and B.B. Lim, 1990. Synthesis of a novel ring-expanded xanthine analogue and several methyl or benzyl derivatives containing the 5:7-fused imidazo [4,5-e][1,2,4]triazepine ring system. Synthesis, 11: 1095-1100.
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  98. Hosmane, R.S., C.M. Bertha, U. Siriwardane and N.S. Hosmane, 1990. Reagents for bioorganic synthesis. 4. A novel bifunctional crosslinking reagent. Preparation, structure, properties, and reactions of 2,2'-sulfonylbis[3-methoxy-(E,E)-2-propenenitrile]. J. Org. Chem., 55: 5206-5216.
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  99. Hosmane, R.S., A. Bhan, R.L. Karpel, U. Siriwardane and N.S. Hosmane, 1990. The synthesis and biophysical investigations of novel ring-expanded nucleosides, nucleotides and homopolymers containing the 5: 7-fused heterocyclic ring system, imidazo [4, 5-e][1, 4] diazepine. J. Org. Chem., 55: 5882-5890.
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  100. Hosmane, R.S. and C.M. Bertha, 1990. A versatile, highly reactive, cross-linking reagent: 2,2′-sulfonylbis[3-methoxy-(E,E)-2-propenenitrile]. Biochem. Biophys. Res. Commun., 166: 567-573.
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  101. Hosmane, R.S. and A. Bhan, 1990. The synthesis of two novel ring-expanded xanthine nucleosides containing the imidazo[4,5-e][1,4]diazepine ring system. Nucleosides Nucleotides, 9: 913-922.
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  102. Hosmane, R.S. and A. Bhan, 1990. The synthesis of ring‐expanded analogues of xanthine containing the imidazo [4, 5‐e][1, 4] diazepine ring system. J. Heterocyclic Chem., 27: 2189-2196.
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  103. Hosmane, R.S. and A. Bhan, 1989. Conformational studies of two isomeric ring-expanded purine nucleosides and their 5′-mono- and-diphosphate derivatives. Biochem. Biophys. Res. Commun., 165: 106-113.
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  104. Siriwardane, U., S.S. Chu, N.S. Hosmane, C.M. Bertha and R.S. Hosmane, 1988. Structure of a potential cross-linking reagent: 2,2'-bis(methoxymethylene)-2,2-sulfonyldiacetonitrile (MMSBA). Acta Crystallogr. Sect. C: Cryst. Struct. Commun., 44: 104-107.
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  105. Hosmane, R.S., B.B. Lim, M.F. Summers, U. Siriwardane, N.S. Hosmane and S.S.C. Chu, 1988. Rearrangements in heterocyclic synthesis. 2. Novel transformations of 2-aminonicotinonitrile and anthranilonitrile. J. Org. Chem., 53: 5309-5315.
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  106. Hosmane, R.S., B.B. Lim and F.N. Burnett, 1988. Rearrangements in heterocyclic synthesis: A novel translocation of an (N-amino-N-methylamino)methylene group from a heterocyclic N-amino-N-methylformamidine side chain to the vinylogous nitrile function. J. Org. Chem., 53: 382-386.
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  107. Hosmane, R.S. and C.M. Bertha, 1988. A novel bifunctional reagent: 2,2′-bis(methoxymethylene)-2,2′-sulfonyldiacetonitrile. Tetrahedron Lett., 29: 5847-5850.
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  108. Hosmane, R.S. and B.B. Lim, 1988. Chemistry of the 5:7-fused heteroaromatic systems: A novel rearrangement involving the imidao[4,5-e][1,3,4]triazepine and pyrazolo[3,4-e][1,3,4]triazapine systems. Heterocycles, 27: 31-34.
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  109. Hosmane, R.S. and B.B. Lim, 1988. A novel method for the synthesis of 9-benzyl-6-(2-methylhydrazino)purine and 1-methyl-4-(2-methylhydrazino)-1H-pyrazolo[3,4-d]pyrimidine. Synthesis, 3: 242-244.
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  110. Siriwardane, U., S.S. Chu, N.S. Hosmane, C.M. Bertha and R.S. Hosmane, 1987. Structure of a bifunctional organic reagent: 2,2'-bis(dimethylaminomethylene)-2,2'-sulfonyldiacetonitrile. Acta Crystallogr. Sect. C: Cryst. Struct. Commun., 43: 1823-1826.
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  111. Siriwardane, U., N.S. Hosmane and S.S. Chu, 1987. 1-(2,2'-Bipyridyl)-2-methyl-3-(trimethylsilyl)-2,3-dicarba-1-stanna-closo-heptaborane(6). Acta Crystallogr. Sect. C: Cryst. Struct. Commun., 43: 1067-1069.
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  112. Afshar, C., H.M. Berman, P. Sawzik, L. Lessinger, B.B. Lim and R.S. Hosmane, 1987. Structure of a rearrangement product: 1-methyl-3-(5-amino-1-benzylimidazol-4-yl)-1,2,4-triazole, C13H14N6. J. Crystallogr. Spectrosc. Res., 17: 533-543.
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  113. Hosmane, R.S., A. Bhan and M.E. Rauser, 1986. Models for “fat” nucleosides and nucleotides: Syntheses of “fat” xanthine (fX), “fat” guanine (fG) and “fat” hypoxanthene (fHx) analogues of the imidazo[4,5-e][1,4]diazepine system. Heterocycles, 24: 2743-2748.
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  114. Lim, B.B. and R.S. Hosmane, 1985. Reagents for bioorganic synthesis. 2. Methyl N-(dicarbomethoxymethyl)methanimidate. J. Org. Chem., 50: 5111-5115.
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  115. Hosmane, R.S., A. Bhan and M.E. Rauser, 1985. Facile conversion of 4(5)-nitro-5(4)-methylimidazoles into 4(5)-nitro-5(4)-cyanoimidazoles. J. Org. Chem., 50: 5892-5895.
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  116. Hosmane, R.S. and B.B. Lim, 1985. On the mechanism of the one-pot conversion of 4-Carbomethoxy-5-hydroxyimidazoles into 5-amino-4-carbamoylimidazoles. Heterocycles, 23: 2247-2250.
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  117. Hosmane, R.S. and B.B. Lim, 1985. A general method for the synthesis of 1-substituted (or unsubstituted)-4-carbomethoxy-2-imidazolin-5-ones. Tetrahedron Lett., 26: 1915-1918.
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  118. Shahbaz, M., S. Urano, P.L. LeBreton, M.A. Rossman, R.S. Hosmane and N.J. Leonard, 1984. Synthesis, chemical behavior and spectroscopic and theoretical probes of valence orbital structure. J. Am. Chem. Soc., 106: 2805-2811.

  119. Schneller, S.W., J.K. Luo, R.S. Hosmane, E. de Clercq and J.D. Stoeckler et al., 1984. Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine). J. Med. Chem., 27: 1737-1739.
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  120. Schneller, S.W., J.K. Luo, R.S. Hosmane and R.H. Durrfeld, 1984. The synthesis of 1-substituted 6-amino-1H-pyrrolo-[3,2-c] pyridine-4(5H)-ones. J. Heterocycl. Chem., 21: 1153-1155.
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  121. Leonard, N.J., R.S. Hosmane, Y.S. Agasimundin, L.J. Kostuba and F.T. Oakes, 1984. Chemical modification of nucleic acid components: Conversion of guanosine by methyl N-cyanomethanimidate to a tricyclic, fluorescent analog of adenosine. J. Am. Chem. Soc., 106: 6847-6848.
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  122. Hosmane, R.S., F.N. Burnett and M.S. Albert, 1984. Reagents for bioorganic synthesis: Preparation, properties and reactions of ethyl and methyl N-(cyanomethyl) methanimidates. J. Org. Chem., 49: 1212-1215.
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  123. Hosmane, R.S., 1984. Imidates in organic synthesis: Methyl N-cyanomethylmethanimidate. Tetrahedron Lett., 25: 363-366.
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  124. Hosmane, R.S., 1984. An efficient, one-step synthesis of 2-imidazolin-4(5)-one. Liebigs Annalen der Chemie, 4: 831-834.
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  125. Halpern, A.M., M.A. Rossman, R.S. Hosmane and N.J. Leonard, 1984. Photophysics of the S1 ↔ S0 transition in tri-s-triazine. J. Phys. Chem., 88: 4324-4326.
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  126. Balicki, R., R.S. Hosmane and N.J. Leonard, 1983. Translocative rearrangements. Generality of the formamidine-induced rearrangement of 4-substituted 5-amino-4-cyano-4H-imidazoles. J. Org. Chem., 48: 3-7.
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  127. Hosmane, R.S., V. Bakthavachalam and N.J. Leonard, 1982. 5-Methyladenine: A transient intermediate in a translocative rearrangement. J. Am. Chem. Soc., 104: 235-239.
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  128. Hosmane, R.S., M.A. Rossman and N.J. Leonard, 1982. Synthesis and structure of tri-s-triazine. J. Am. Chem. Soc., 104: 5497-5499.
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  129. Hosmane, R.S. and N.J. Leonard, 1981. Simple convenient synthesis of 1-methylcytosine. Synthesis, 2: 118-119.
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  130. Hosmane, R.S. and N.J. Leonard, 1981. Chemical modification of nucleic acid components: Reactions of cytosine, cytidine, isocytosine and adenine with methyl N-cyanomethanimidate. J. Org. Chem., 46: 1457-1465.
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  131. Helfer, D.L., R.S. Hosmane and N.J. Leonard, 1981. Selective alkylation and aralkylation of cytosine at the 1-position. J. Org. Chem., 46: 4803-4804.
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  132. Schneller, S.W., J.K. Luo and R.S. Hosmane, 1980. 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine). Tetrahedron Lett., 21: 3135-3138.
    CrossRef  |  Direct Link  |  

  133. Schneller, S.W., R.S. Hosmane, L.B. MacCartney and D.A. Hessinger, 1978. Synthesis and xanthine oxidase inhibitory analysis of 1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)-dione (3,7-dideazaxanthine) and two of its derivatives. J. Med. Chem., 21: 990-993.
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  134. Schneller, S.W. and R.S. Hosmane, 1978. Ring-opening reactions of 1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)-dione (3,7-dideazaxanthine) and two of its derivatives. J. Org. Chem., 43: 4487-4491.
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  135. Schneller, S.W. and R.S. Hosmane, 1978. Pyrrolo[3,2-c]Pyridin-4,6(5H,7H)-Dione (3,7-Dideazaxanthine). In: Nucleic Acid Chemistry: Improved and New Synthetic Procedures, Methods and Techniques, Part 1, Townsend, L.B. and R.S. Tipson (Eds.). John Wiley & Sons, New York, USA., ISBN: 0-471-88090-6, pp: 137.

  136. Schneller, S.W. and R.S. Hosmane, 1978. Chlorination of 1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)dione (3,7-dideazaxanthine) and its 5-methyl derivative. J. Heterocycl. Chem., 15: 325-326.
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  137. Schneller, S.W. and R.S. Hosmane, 1978. 4-Amino-6-hydroxy-1H-pyrrolo[3,2-c] pyridine (3,7-dideazaisoguanine). J. Heterocycl. Chem., 15: 1505-1506.
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  138. Schneller, S.W. and R.S. Hosmane, 1977. 1H-pyrrolo[3,2-c]pyridine-4,6(5H,7H)dione(3,7-dideazaxanthine). J. Heterocycl. Chem., 14: 1291-1292.
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  139. Hosmane, R.S., S.P. Hiremath and S.W. Schneller, 1974. Synthesis of tryptamine analogs of 3H-benz[e]- and 1H-benz[g]indole. Indian J. Chem., 12: 1009-1011.

  140. Hosmane, R.S., S.P. Hiremath and S.W. Schneller, 1974. Synthesis of benz[e]indole and benz[g]indole carboxaldehydes. J. Heterocycl. Chem., 11: 29-32.
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  141. Hosmane, R.S., S.P. Hiremath and S.W. Schneller, 1973. Synthesis of indoles and carbazoles: Diels-Alder reactions of nitrovinyl-pyrroles and-benzindoles. J. Chem. Soc. Perkin Trans. 1, 1973: 2450-2453.
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  142. Hiremath, S.P. and R.S. Hosmane, 1973. Applications of nuclear magnetic resonance spectroscopy to heterocyclic chemistry: Indole and its derivatives. Adv. Heterocycl. Chem., 15: 277-324.
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  143. Hiremath, S.P. and R.S. Hosmane, 1969. Use of physical methods in heterocyclic chemistry-part I. Nuclear magnetic resonance spectroscopy. J. Karnatak Univ. (Sci.), 14: 202-226.
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