Dr. Emil Martin
Associate ProfessorUniversity of Texas Medical School, USA
Highest Degree
Ph.D. in Internal Medicine from Russian Academy of Sciences, Russia
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Area of Interest:
Selected Publications
- Proinsias, K.O., D.T. Gryko, Y. Hisaeda, E. Martin, J.L. Sessler and D. Gryko, 2013. Vitamin B12 derivatives as activators of soluble guanylyl cyclase. J. Med. Chem., 55: 8943-8947.
CrossRef | - Chrominski, M., L. Banach, M. Karczewski, I. Sharina, K.O. Proinsias, D. Gryko and E. Martin, 2013. Synthesis and evaluation of bifunctional sGC regulators: Optimization of a connecting linker. J. Med Chem., 56: 7260-7277.
CrossRef | - Chrominski, M., K.O. Proinsias, E. Martin and D. Gryko, 2013. Protoporphyrin IX/cobyrinate derived hybrids-novel activators of soluble guanylyl cyclase. Eur. J. Org. Chem., 2013: 1530-1537.
CrossRef | - Tsai, A.L., V. Berka, E. Martin and J.S. Olson, 2012. A sliding-scale rule for selectivity between NO, CO and O2 by heme protein sensors. Biochemistry, 51: 172-186.
CrossRef | - Tsai, A.L., J.S. Olson, V. Berka and E. Martin, 2012. How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain and soluble guanylyl cyclase. Antiox. Redox Sign., 17: 1246-1263.
CrossRef | - Sharina, I.G., M. Sobolevsky, M.F. Doursout, D. Gryko and E. Martin, 2012. Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain. J. Pharm. Exp. Ther., 340: 723-732.
CrossRef | - Proinsias, K.O., M. Giedyk, I.G. Sharina, E. Martin and D. Gryko, 2012. Synthesis of new hydrophilic and hydrophobic cobinamides as no-independent sGC activators. Med. Chem. Lett., 3: 476-479.
CrossRef | - Martin, E., V. Berka, I.G. Sharina and A.L. Tsai, 2012. Mechanism of binding of NO to soluble guanylyl cyclase: Implication for the second NO binding to the heme proximal site. Biochemistry, 51: 2737-2746.
CrossRef | - Cote, G.J., W. Zhu, A. Thomas, E.S. Martin, F. Murad and I.G. Sharina, 2012. Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells. PLoS One, Vol. 7. 10.1371/journal.pone.0041099.
CrossRef | - Coletta, C., A. Papapetropoulos, K. Erdelyi, G. Olah and K. Modis et al., 2012. Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. Proc. Natl. Acad. Sci. USA, 109: 9161-9166.
CrossRef | Direct Link | - Chauhan, S., F. Jelen, I. Sharina and E. Martin, 2012. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase. Biochem. J., 446: 445-453.
CrossRef | - Zhu, H., J.T. Li, F. Zheng, E. Martin and A. Kots et al., 2011. Restoring sGC expression and function blocks the aggressive course of glioma. Mol. Pharm., 80: 1076-1084.
CrossRef | - Tsai, A.L., V. Berka, I. Sharina and E. Martin, 2011. Dynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization. J. Biol. Chem., 286: 43182-43192.
CrossRef | Direct Link | - Sharina, I.G., G.J. Cote, E. Martin, M.F. Doursout and F. Murad, 2011. RNA splicing in regulation of nitric oxide receptor soluble guanylyl cyclase. Nitric Oxide, 25: 265-274.
CrossRef | - Sharin, V.G., K. Mujoo, A.Y. Kots, E. Martin, F. Murad and I.G. Sharina, 2011. Nitric oxide receptor soluble guanylyl cyclase undergoes splicing regulation in differentiating human embryonic cells. Stem Cells Dec., 20: 1287-1293.
CrossRef | - Mujoo, K., V.G. Sharin, E. Martin, B.K. Choi and C. Sloan et al., 2010. Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation. Nitric Oxide, 22: 43-50.
CrossRef | - Doursout, M.F., E. Martin, I. Sharina, K. Bian and F. Murad, 2010. Hypertension: Basics concepts and the evolving role of novel treatments. Curr. Hypertens. Rev., 6: 232-237.
CrossRef | - Bui-Nguyen, T.M., S.B. Pakala, R.D. Sirigiri, E. Martin, F. Murad and R. Kumar, 2010. Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator. J. Biol. Chem., 285: 6980-6986.
CrossRef | - Sanghani, P.C., W.I. Davis, S.L. Fears, S.L. Green and L. Zhai et al., 2009. Kinetic and cellular characterization of novel inhibitors of S-nitrosoglutathione reductase. J. Biol. Chem., 84: 24354-24362.
CrossRef | - Kots, A.Y., E. Martin, I.G. Sharina and F. Murad, 2009. A short history of cGMP, guanylyl cyclases and cGMP-dependent protein kinases. Handb. Exp. Pharmacol., 191: 1-14.
CrossRef | - Sharina, I.G., F. Jelen, E.P. Bogatenkova, A. Thomas, E. Martin and F. Murad, 2008. α1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity. J. Biol Chem., 83: 15104-15113.
CrossRef | - Rayala, S.K., E. Martin, I.G. Sharina, P.R. Molli and X. Wang et al., 2007. Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics. Proc. Nat. Acad. Sci. USA., 104: 19470-19475.
PubMed | - Martin, E., K. Bian and F. Murad, 2007. Nitric Oxide Signaling in Cellular Processes. In: The Oxidative Stress: Clinical and Biomedical Implications, Matata, B.M. and M.M. Elahi (Eds.). Nova Science, Hauppauge, New York.
- Martin, E., V. Berka, E. Bogatenkova, F. Murad and A.L. Tsai, 2006. Ligand selectivity of soluble guanylyl cyclase: Effect of the hydrogen-bonding tyrosine in the distal heme pocket on binding of oxygen, nitric oxide and carbon monoxide. J. Biol. Chem., 281: 27836-27845.
Direct Link | - Rossini, L., E. Martin and M. Zhong, 2005. Nitration of inducible nitric oxide synthase tyrosine residues in RAW 264.7 macrophages. Pharmacology, 2: 1-23.
Direct Link | - Martin, E., V. Berka, A.L. Tsai and F. Murad, 2005. Soluble guanylyl cyclase: The nitric oxide receptor. Methods Enzymol., 396: 478-492.
CrossRef | - Martin, E., K. Czarnecki, V. Jayaraman, F. Murad and J. Kincaid, 2005. Resonance raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase. J. Am. Chem. Soc., 127: 4625-4631.
Direct Link | - Martin, E., I. Sharina, A. Seminara, J. Krumenacker and F. Murad, 2005. NO Cell Signaling Mediated by cGMP. In: Nitric Oxide, Cell Signaling and Gene Expression, Cadenas, E. and S. Lamas (Eds.). Marcel Dekker, New York.
- Ruiz-Stewart, I., S.R., Tiyyagura, J.E. Lin, S. Kazerounian and G.M. Pitari et al., 2004. Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism. Proc. Natl. Acad. Sci. USA, 101: 37-42.
CrossRef | - Hanafy, K., E. Martin and F. Murad, 2004. CCη, A novel soluble guanylyl cyclase-interacting protein. J. Biol. Chem., 279: 46946-46953.
CrossRef | - Sharina, I.G., E. Martin, A. Thomas, K.L. Uray and F. Murad, 2003. CCAAT-binding factor regulates expression of the β1 subunit of soluble guanylyl cyclase gene in the BE2 human neuroblastoma cell line. Proc. Natl. Acad. Sci. USA, 100: 11523-11528.
Direct Link | - Martin, E., I. Sharina, A. Kots and F. Murad, 2003. A constitutively activated mutant of human soluble guanylyl cyclase (sGC): Implication for the mechanism of sGC activation. Proc. Natl. Acad. Sci. USA, 100: 9208-92013.
Direct Link | - Irie, Y., M. Saeki, Y. Kamisaki, E. Martin and F. Murad, 2003. Histone H1.2 is a substrate for denitrase, an activity that reduces nitrotyrosine immunoreactivity in proteins. Proc. Natl. Acad. Sci. USA, 100: 5634-5639.
Direct Link | - Martin, E., Y.C. Lee and F. Murad, 2001. YC-1 activation of human soluble guanylyl Cyclase has both heme-dependent and heme-independent components. Proc. Natl. Acad. Sci. USA, 98: 12938-12942.
Direct Link | - Davis, K.L., E. Martin, I.V. Turko and F. Murad, 2001. Novel effects of nitric oxide. Ann. Rev. Pharmacol. Toxicol., 41: 203-236.
CrossRef | PubMed | Direct Link | - Sharina, I.G., J.S. Krumenacker, E. Martin and F. Murad, 2000. Genomic organization of α1 and β1 subunits of the mammalian soluble guanylyl cyclase genes. Proc. Natl. Acad. Sci. USA, 97: 10878-10883.
Direct Link | - Martin, E., K. Davis, K. Bian, Y.C. Lee and F. Murad, 2000. Cellular signaling with Nitric Oxide and cyclic guanosine monophosphate. Semin. Perinatol., 24: 2-6.
Direct Link | - Lee, Y.C., E. Martin and F. Murad, 2000. Human recombinant soluble guanylyl cyclase: Expression, purification and regulation. Proc. Natl. Acad. Sci. USA, 97: 10763-10768.
Direct Link | - Balabanli, B., Y. Kamisaki, E. Martin and F. Murad, 1999. Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine. Proc. Natl. Acad. Sci. USA, 96: 13136-13141.
Direct Link | - Kamisaki, Y., K. Wada, K. Bian, B. Balabanli and K. Davis et al., 1998. An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc. Natl. Acad. Sci. USA, 95: 11584-11589.
Direct Link | - Zaychikov, E., E. Martin, L. Denissova, M. Kozlov and V. Markovtsov et al., 1996. Mapping of catalytic residues in the RNA polymerase active center. Science, 273: 107-109.
Direct Link | - Cho, H.J., E. Martin, Q.W. Xie, S. Sassa and C. Nathan, 1995. Inducible nitric oxide synthase: Identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin. Proc. Natl. Acad. Sci. USA, 92: 11514-11518.
Direct Link | - Martin, E., C. Nathan and Q.W. Xie, 1994. Role of interferon regulatory factor 1 in Induction of nitric oxide synthase. J. Exp. Med., 180: 977-984.
Direct Link | - Kashlev, M., E. Martin, A. Polyakov, K. Severinov, V. Nikiforov and A. Goldfarb, 1993. Histidine-tagged RNA polymerase: Dissection of the transcription cycle using immobilized enzyme. Gene, 130: 9-14.
CrossRef | - Martin, E., V. Sagitov, E. Burova, V. Nikiforov and A. Goldfarb, 1992. Genetic dissection of the transcription cycle. A mutant RNA polymerase that cannot hold onto a promoter. J. Biol. Chem., 267: 20175-20180.
Direct Link | - Gragerov, A.I., E. Martin, M.A. Krupenko, M.V. Kashlev and V.G. Nikiforov, 1991. Protein aggregation and inclusion body formation in Escherichia coli rpoH mutant defective in heat shock protein induction. FEBS Lett., 291: 222-224.
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