Dr. Chengfeng Yang

Associate Professor
Michigan State University, USA

Highest Degree
Ph.D. in Carcinogenesis from National University of Singapore, Singapore

My URL
https://livedna.org/1.9061

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Area of Interest:

Molecular Sciences
Chemical Carcinogenesis
Cancer Biology
Reproductive Toxicology
Cancer Chemoprevention

Selected Publications

  1. Yang, C., Y. Jiang, A.P. Singh and F. Takeshita, 2015. MicroRNAs: Emerging novel targets of cancer therapies. BioMed Res. Int., Vol. 2015. 10.1155/2015/506323.
    CrossRef  |  Direct Link  |  

  2. Humphries, B. and C. Yang, 2015. The microRNA-200 family: Small molecules with novel roles in cancer development, progression and therapy. Oncotarget, 6: 6472-6498.
    PubMed  |  Direct Link  |  

  3. Hu, G., T. Yang, J. Zheng, J. Dai and A. Nan et al., 2015. Functional role and mechanism of lncRNA LOC728228 in malignant 16HBE cells transformed by anti-benzopyrene-trans-7,8-dihydrodiol-9,10-epoxide. Mol. Carcinog. 10.1002/mc.22314.
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  4. Han, Z., Y. Zhang, Q. Yang, B. Liu and J. Wu et al., 2015. MiR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1). Oncotarget, (In Press). .
    PubMed  |  

  5. Yang, Q., Z. Jie, S. Ye, Z. Li and Z. Han et al., 2014. Genetic variations in miR-27a gene decrease mature miR-27a level and reduce gastric cancer susceptibility. Oncogene, 33: 193-202.
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  6. Wang, Z., B. Humphries, H. Xiao, Y. Jiang and C. Yang, 2014. MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b-protein kinase Cα positive feedback loop and inhibiting Rac1 activation. J. Biol. Chem., 289: 18373-18386.
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  7. Wang, Z. and C. Yang, 2014. Circulating microRNAs as diagnostic and prognostic biomarkers for gastric cancer-opportunities and challenges. Am. J. Digest. Dis., 1: 44-49.
    Direct Link  |  

  8. Oom, A.L., B.A. Humphries and C. Yang, 2014. MicroRNAs: Novel players in cancer diagnosis and therapies. BioMed Res. Int., Vol. 2014. 10.1155/2014/959461.
    CrossRef  |  Direct Link  |  

  9. Humphries, B., Z. Wang, A.L. Oom, T. Fisher and D. Tan et al., 2014. MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasis. Carcinogenesis, 35: 2254-2263.

  10. Chen, F., A. Li, S. Gao, D. Hollern and M. Williams et al., 2014. Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression. Cell Death Dis., Vol. 5. 10.1038/cddis.2014.224.
    CrossRef  |  Direct Link  |  

  11. Wu, J., T. Yang, X. Li, Q. Yang and R. Liu et al., 2013. Alteration of serum miR-206 and miR-133b is associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Toxicol. Applied Pharmacol., 267: 238-246.
    CrossRef  |  Direct Link  |  

  12. Wang, Z., B. Humphries, H. Xiao, Y. Jiang and C. Yang, 2013. Epithelial to mesenchymal transition in arsenic-transformed cells promotes angiogenesis through activating β-catenin-vascular endothelial growth factor pathway. Toxicol. Applied Pharmacol., 271: 20-29.
    CrossRef  |  Direct Link  |  

  13. Wang, Z. and C. Yang, 2013. Body Fluid MicroRNAs as Toxicological Biomarkers. In: MicroRNAs in Toxicology and Medicine, Sahu, S.C. (Ed.). John Wiley and Sons Ltd., New York, ISBN: 978-1-118-40161-3, pp: 343-362.

  14. Li, A., C. Zhang, S. Gao, F. Chen, C. Yang, R. Luo and H. Xiao, 2013. TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice. Oncogene, 32: 2273-2281.
    CrossRef  |  Direct Link  |  

  15. Humphries, B. and C. Yang, 2013. MicroRNAs in Cancer Invasion and Metastasis. In: MicroRNAs in Toxicology and Medicine, Sahu, S.C. (Ed.). John Wiley and Sons Ltd., New York, ISBN: 978-1-118-40161-3, pp: 133-152.

  16. Zhao, Y., Y.S. Tan, M.J. Strynar, G. Perez, S.Z. Haslam and C. Yang, 2012. Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice. Reprod. Toxicol., 33: 563-576.
    CrossRef  |  Direct Link  |  

  17. Wang, Z., J. Yang, T. Fisher, H. Xiao, Y. Jiang and C. Yang, 2012. Akt activation is responsible for enhanced migratory and invasive behavior of arsenic-transformed human bronchial epithelial cells. Environ. Health Perspect., 120: 92-97.
    Direct Link  |  

  18. Han, Z., Q. Yang, B. Liu, J. Wu, Y. Li, C. Yang and Y. Jiang, 2012. MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol. Carcinogenesis, 33: 131-139.

  19. Zhao, Y., Z. Wang, Y. Jiang and C. Yang, 2011. Inactivation of Rac1 reduces trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells. Cancer Lett., 313: 54-63.
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  20. Zhao, Y., H. Liu, Y. Li, J. Wu, A.R. Greenlee, C. Yang and Y. Jiang, 2011. The role of miR-506 in transformed 16HBE cells induced by anti-benzo [a] pyrene-trans-7, 8-dihydrodiol-9, 10-epoxide. Toxicol. Lett., 205: 320-326.
    CrossRef  |  Direct Link  |  

  21. Yang, Q., Z. Jie, H. Cao, A.R. Greenlee, C. Yang, F. Zou and Y. Jiang, 2011. Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C. Carcinogenesis, 32: 713-722.

  22. White, S.S., F. Fenton, C. Yang and S.Z. Haslam, 2011. Mammary Gland as a Sensitive Tissue to Developmental Exposures of Perfluorooctanoic Acid (PFOA) in the Mouse. In: Environment and Breast Cancer, Russo, J. (Ed.). Springer, New York, ISBN: 978-1-4419-9895-8, pp: 147-166.

  23. Wang, Z., Y. Zhao, E. Smith, G.J. Goodall, P.A. Drew, T. Babletz and C. Yang, 2011. Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b. Toxicol. Sci., 121: 110-122.

  24. Zhao, Y., Y.S. Tan, S.Z. Haslam and C. Yang, 2010. Perfluorooctanoic acid effects on steroid hormone and growth factor levels mediate stimulation of peripubertal mammary gland development in C57Bl/6 mice. Toxicol. Sci., 115: 214-224.

  25. Sosa, M.S., C. Lopez-Haber, C. Yang, H. Wang and M.A. Lemmon et al., 2010. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol. Cell, 40: 877-892.
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  26. Mauro, L.V., V.C. Grossoni, A.J. Urtreger, C. Yang and L.L. Colombo et al., 2010. PKC delta (PKCδ) promotes tumoral progression of human ductal pancreatic cancer. Pancreas, 39: e31-e41.
    CrossRef  |  Direct Link  |  

  27. Yang, C., Y.S. Tan, J.R. Harkema and S.Z. Haslam, 2009. Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains. Reprod. Toxicol., 27: 299-306.
    CrossRef  |  Direct Link  |  

  28. Yang, C., E. Klein, R. Assoian and M. Kazanietz, 2008. Heregulin β1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1. Biochem. J., 410: 167-175.
    CrossRef  |  Direct Link  |  

  29. Yang, C. and M. Kazanietz, 2007. Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac. Biochem. J., 403: 1-12.
    CrossRef  |  Direct Link  |  

  30. Klein, E.A., C. Yang, M.G. Kazanietz and R.K. Assoian, 2007. NFκB-independent signaling to the cyclin D1 gene by Rac. Cell Cycle, 6: 1115-1121.
    CrossRef  |  Direct Link  |  

  31. Yu, R.A., C. Yang and X.M. Chen, 2006. DNA damage, apoptosis and C-myc, C-fos and C- jun overexpression induced by selenium in rat hepatocytes. Biomed. Environ. Sci., 19: 197-204.
    PubMed  |  

  32. Yang, C., Y. Liu, M.A. Lemmon and M.G. Kazanietz, 2006. Essential role for Rac in heregulin β1 mitogenic signaling: A mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Mol. Cell. Biol., 26: 831-842.
    Direct Link  |  

  33. Wang, H., C. Yang, F.C. Leskow, J. Sun, B. Canagarajah, J.H. Hurley and M.G. Kazanietz, 2006. Phospholipase Cγ/diacylglycerol‐dependent activation of β2‐chimaerin restricts EGF‐induced Rac signaling. EMBO J., 25: 2062-2074.
    CrossRef  |  Direct Link  |  

  34. Yang, C., Y. Liu, F.C. Leskow, V.M. Weaver and M.G. Kazanietz, 2005. Rac-GAP-dependent inhibition of breast cancer cell proliferation by β2-chimerin. J. Biol. Chem., 280: 24363-24370.
    Direct Link  |  

  35. Yang, C., J. Wu, R. Zhang, P. Zhang and J. Eckard et al., 2005. Caffeic Acid Phenethyl Ester (CAPE) prevents transformation of human cells by Arsenite (As) and suppresses growth of As-transformed cells. Toxicology, 213: 81-96.
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  36. Zhang, S., Z.N. Lin, C.F. Yang, X. Shi, C.N. Ong and H.M. Shen, 2004. Suppressed NF-κB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-α-induced apoptosis in human cancer cells. Carcinogenesis, 25: 2191-2199.

  37. Dai, J., C. Huang, J. Wu, C. Yang, K. Frenkel and X. Huang, 2004. Iron-induced interleukin-6 gene expression: Possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. Toxicology, 203: 199-209.
    CrossRef  |  Direct Link  |  

  38. Yang, C. and M.G. Kazanietz, 2003. Divergence and complexities in DAG signaling: Looking beyond PKC. Trends Pharmacol. Sci., 24: 602-608.
    CrossRef  |  Direct Link  |  

  39. Yang, C. and K. Frenkel, 2002. Arsenic-mediated cellular signal transduction, transcription factor activation and aberrant gene expression: Implications in carcinogenesis. J. Environ. Pathol. Toxicol. Oncol., 21: 331-342.
    CrossRef  |  Direct Link  |  

  40. Shen, H.M., C.F. Yang, W.X. Ding, J. Liu and C.N. Ong, 2001. Superoxide radical-initiated apoptotic signalling pathway in selenite-treated HepG2 cells: Mitochondria serve as the main target. Free Radic. Biol. Med., 30: 9-21.
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  41. Liu, J., C.F. Yang, S. Wasser, H.M. Shen, C.E.L. Tan and C.N. Ong, 2001. Protection of Salvia miltiorrhiza against aflatoxin-B1-induced hepatocarcinogenesis in Fischer 344 rats: Dual mechanisms involved. Life Sci., 69: 309-326.
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Member since May, 2015