Dr. Khalid M. El-Say

Professor
King Abdulaziz University, Saudi Arabia

Highest Degree
Ph.D. in Pharmaceutics from Al-Azhar University, Egypt

My URL
https://livedna.org/20.22933

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Area of Interest:

Pharmacology and Toxicology
Pharmaceutical Analysis
Industrial Pharmacy
Drug Delivery
Pharmacy

Selected Publications

  1. Elimam, H., K.M. El-Say, A.V. Cybulsky and H. Khalil, 2020. Regulation of autophagy progress via lysosomal depletion by fluvastatin nanoparticle treatment in breast cancer cells. ACS Omega, 5: 15476-15486.
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  2. El-Say, K.M., T.A. Ahmed, O.A.A. Ahmed and H. Elimam, 2020. Enhancing the hypolipidemic effect of simvastatin in poloxamer-induced hyperlipidemic rats via liquisolid approach: pharmacokinetic and pharmacodynamic evaluation. AAPS PharmSciTech, 10.1208/s12249-020-01754-5.
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  3. Basahih, T.S., A.A. Alamoudi, K.M. El-Say, N.A. Alhakamy and O.A.A. Ahmed, 2020. Improved transmucosal delivery of glimepiride via unidirectional release buccal film loaded with vitamin e TPGS-based nanocarrier. Dose-Response, 10.1177/1559325820945164.
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  4. Badawi, N., K. El-Say, D. Attia, M. El-Nabarawi, M. Elmazar and M. Teaima, 2020. Development of pomegranate extract-loaded solid lipid nanoparticles: quality by design approach to screen the variables affecting the quality attributes and characterization. ACS Omega, 5: 21712-21721.
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  5. Al-Amodi, Y.A., K.M. Hosny, W.S. Alharbi, M.K. Safo and K.M. El-Say, 2020. Investigating the potential of transmucosal delivery of febuxostat from oral lyophilized tablets loaded with a self-nanoemulsifying delivery system. Pharmaceutics, 10.3390/pharmaceutics12060534.
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  6. Ahmed, T.A., H. Elimam, A.O. Alrifai, H.M. Nadhrah and L.Y. Masoudi et al., 2020. Rosuvastatin lyophilized tablets loaded with flexible chitosomes for improved drug bioavailability, anti-hyperlipidemic and anti-oxidant activity. Int. J. Pharmaceutics, 10.1016/j.ijpharm.2020.119791.
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  7. El-Say, K.M., O.A.A. Ahmed, A.I. Mohamed, M.K. Safo and A.S.M. Omar, 2019. Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation. Int. J. Nanomed., 14: 7461-7473.
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  8. Aljaeid, B.M., K.M. El-Say and K.M. Hosny, 2019. Chitosan-TPP nanoparticles stabilized by poloxamer for controlling the release and enhancing the bioavailability of doxazosin mesylate: In vitro, and in vivo evaluation. Drug Dev. Ind. Pharm., 45: 1130-1139.
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  9. Al-Gethmy, H.A., U.A. Fahmy, N.A. Alhakamy, O. Ahmed and K.M. El-Say, 2019. Optimization of the factors affecting the absorption of vardenafil from oral disintegrating tablets: A clinical pharmacokinetic investigation. Pharmaceutics, Vol. 11, No. 1. 10.3390/pharmaceutics11010011.
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  10. Ahmed, T.A., M.A. Mussari, S.E.S. Abdel-Hady and K.M. El-Say, 2019. An optimized surfactant-based PEG-PLCL in situ Gel  formulation for enhanced activity of rosuvastatin in poloxamer-induced hyperlipidemic rats. Drug Des., Dev. Ther., 13: 4035-4051.
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  11. Ahmed, T.A., K.M. El-Say, O.A.A. Ahmed and B.M. Aljaeid, 2019. Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel. Int. J. Nanomed., Volume 14: 5555-5567.
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  12. Ahmed, O.A.A., K.M. El-Say, B.M. Aljaeid, S.M. Badr-Eldin and T.A. Ahmed, 2019. Optimized vinpocetine-loaded vitamin e D-α-tocopherol polyethylene glycol 1000 succinate-alpha lipoic acid micelles as a potential transdermal drug delivery system: In vitro and ex vivo studies. Int. J. Nanomed., 14: 33-43.
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  13. Kassem, M.A., M.A. Megahed, S.K. Abu Elyazid, F.I. Abd-Allah, T.M. Abdelghany, A.M. Al-Abd and M. Khalid, 2018. Enhancing the therapeutic efficacy of tamoxifen citrate loaded span-based nano-vesicles on human breast adenocarcinoma cells. AAPS PharmSciTech, 19: 1529-1543.
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  14. Hosny, K.M., K.M. El-Say and H.M. Alkhalidi, 2018. Quality by design approach to screen the formulation and process variables influencing the characteristics of carvedilol solid lipid nanoparticles. J. Drug Delivery Sci. Technol., 45: 168-176.
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  15. El-Say, K.M. and K.M. Hosny, 2018. Optimization of carvedilol solid lipid nanoparticles: an approach to control the release and enhance the oral bioavailability on rabbits. PLoS ONE, 10.1371/journal.pone.0203405.
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  16. El-Sawy, H.S., A.M. Al-Abd, T.A. Ahmed, K.M. El-Say and V.P. Torchilin, 2018. Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: Past, present and future perspectives. ACS Nano, 12: 10636-10664.
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  17. Badawi, N., M. Teaima, K. El-Say, D. Attia, M.E. Nabarawi and M. Elmazar, 2018. Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and In vitro cytotoxicity study. Int. J. Nanomed., 13: 1313-1326.
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  18. Aldawsari, H.M., M.A. Elfaky, U.A. Fahmy, B.M. Aljaeid, O.A. Alshareef and K.M. El-Say, 2018. Development of a fluvastatin-loaded self-nanoemulsifying system to maximize therapeutic efficacy in human colorectal carcinoma cells. J. Drug Deliv. Sci. Technol., 46: 7-13.
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  19. Khalid, M., T.A. Ahmed, O.A. Ahmed, K.M. Hosny and F.I. Abd-Allah, 2017. Self-nanoemulsifying lyophilized tablets for flash oral transmucosal delivery of vitamin K: Development and clinical evaluation. J. Pharmaceut. Sci., 106: 2447-2456.
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  20. Khalid, M. and H.S. El-Sawy, 2017. Polymeric nanoparticles: Promising platform for drug delivery. Int. J. Pharmaceut., 528: 675-691.
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  21. Kassem, M.A., H.S. El-Sawy, F.I. Abd-Allah, T.M. Abdelghany and M. Khalid, 2017. Maximizing the therapeutic efficacy of imatinib mesylate-loaded niosomes on human colon adenocarcinoma using Box-Behnken design. J. Pharmaceut. Sci., 106: 111-122.
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  22. El-Say, K.M., T.A. Ahmed, O.A.A. Ahmed, K.M. Hosny and F.I. Abd-Allah, 2017. Self-nanoemulsifying lyophilized tablets for flash oral transmucosal delivery of vitamin K: Development and clinical evaluation. J. Pharmaceut. Sci., 106: 2447-2456.
    CrossRef  |  Direct Link  |  

  23. El-Say, K.M., O.A. Ahmed, B.M. Aljaeid and A.S. Zidan, 2017. Matrix-type transdermal films to enhance simvastatin ex vivo skin permeability. Pharmaceut. Dev. Technol., 22: 492-499.
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  24. Ahmed, T.A., K.M. El-Say, O.A.A. Ahmed and A.S. Zidan, 2017. Sterile Dosage Forms Loaded Nanosystems for Parenteral, Nasal, Pulmonary and Ocular Administration. In: Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology, Grumezescu, A.M. (Ed.). Chapter 9, Elsevier, New York, USA., ISBN-13: 9780128136300, pp: 335-396.

  25. Ahmed, T.A., K.M. El-Say, K.M. Hosny and B.M. Aljaeid, 2017. Development of optimized Self-Nanoemulsifying Lyophilized Tablets (SNELTs) to improve finasteride clinical pharmacokinetic behavior. Drug Dev. Ind. Pharm., (In Press). 10.1080/03639045.2017.1405977.
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  26. Ahmed, O.A., M. Khalid and A.M. Alahdal, 2017. A PLGA-reinforced PEG in situ gel formulation for improved sustainability of hypoglycaemic activity of glimepiride in streptozotocin-induced diabetic rats. Scient. Rep., Vol. 7. 10.1038/s41598-017-16728-0.
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  27. Hosny, K.M., K.M. El-Say and O.A. Ahmed, 2016. Optimized sildenafil citrate fast orodissolvable film: A promising formula for overcoming the barriers hindering erectile dysfunction treatment. Drug Deliv., 23: 355-361.
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  28. Harbi, I., B. Aljaeid, M. Khalid and A.S. Zidan, 2016. Glycosylated sertraline-loaded liposomes for brain targeting: QbD study of formulation variabilities and brain transport. AAPS PharmSciTech, 17: 1404-1420.
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  29. El-Say, K.M., F.I. Abd-Allah, A.E. Lila, A.E.S.A. Hassan and A.E.A. Kassem, 2016. Diacerein niosomal gel for topical delivery: Development, in vitro and in vivo assessment. J. Liposome Res., 26: 57-68.
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  30. El-Say, K.M., 2016. Optimized gastroretentive floating carvedilol tablets: An approach for prolonged gastric residence time and enhanced absorption. J. Applied Pharmaceut. Sci., 6: 12-19.
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  31. El-Say, K.M., 2016. Maximizing the encapsulation efficiency and the bioavailability of controlled-release cetirizine microspheres using Draper-Lin small composite design. Drug Des. Dev. Ther., 10: 825-839.
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  32. Ali, B.E., A.K. Rabba, M.H.Fayed, K.M. El-Say and M.K. Anwer et al., 2016. Development and optimization of fluoxetine orally disintegrating tablets using Box-Behnken design. Trop. J. Pharm. Res., 15: 667-677.
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  33. Ahmed, T.A., Y.A. Alharby, A.R.M. El-Helw, K.M. Hosny and K.M. El-Say, 2016. Depot injectable atorvastatin biodegradable in situ gel: Development, optimization, in vitro and in vivo evaluation. Drug Design Dev. Therapy, 10: 405-415.
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  34. Ahmed, T.A., K.M. El-Say, B.M. Aljaeid, U.A. Fahmy and F.I. Abd-Allah, 2016. Transdermal glimepiride delivery system based on optimized ethosomal nano-vesicles: Preparation, characterization, in vitro, ex vivo and clinical evaluation. Int. J. Pharmaceut., 500: 245-254.
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  35. Ahmed, T.A. and M. Khalid, 2016. Transdermal film-loaded finasteride microplates to enhance drug skin permeation: Two-step optimization study. Eur. J. Pharmaceut. Sci., 88: 246-256.
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  36. El-Say, K.M., T.A. Ahmed, S.M. Badr-Eldin, U. Fahmy, H. Aldawsari and O.A. Ahmed, 2015. Enhanced permeation parameters of optimized nanostructured simvastatin transdermal films: Ex vivo and in vivo evaluation. Pharm. Dev. Technol., 20: 919-926.
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  37. El-Say, K.M., T.A. Ahmed, M.F. Abdelbary, B.E. Ali, B.M. Aljaeid and A.S. Zidan, 2015. Risperidone oral disintegrating mini-tablets: A robust-product for pediatrics. Acta Pharmaceut., 65: 365-382.
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  38. El-Say, K.M., A.R.M. El-Helw, O.A.A. Ahmed, K.M. Hosny and T.A. Ahmed et al., 2015. Statistical optimization of controlled release microspheres containing cetirizine hydrochloride as a model for water soluble drugs. Pharm. Dev. Technol., 20: 738-746.
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  39. Aljimaee, Y.H.M., A.R.M. El-Helw, O.A.A. Ahmed and K.M. El-Say, 2015. Development and optimization of carvedilol orodispersible tablets: Enhancement of pharmacokinetic parameters in rabbits. Drug Des. Dev. Ther., 9: 1379-1392.
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  40. Al-Subaie, M.M., K.M. Hosny, K.M. El-Say, T.A. Ahmed and B.M. Aljaeid, 2015. Utilization of nanotechnology to enhance percutaneous absorption of acyclovir in the treatment of herpes simplex viral infections. Int. J. Nanomed., 10: 3973-3985.
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  41. Ahmed, T.A. and M. Khalid, 2014. Development of alginate-reinforced chitosan nanoparticles utilizing W/O nanoemulsification/internal crosslinking technique for transdermal delivery of rabeprazole. Life Sci., 110: 35-43.
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  42. Ahmed, O.A., S.M. Badr-Eldin, M.K. Tawfik, T.A. Ahmed, K.M. El-Say and J.M. Badr, 2014. Design and optimization of self-nanoemulsifying delivery system to enhance quercetin hepatoprotective activity in paracetamol-induced hepatotoxicity. J. Pharmaceut. Sci., 103: 602-612.
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  43. Ahmed, O.A., M.I. Afouna, K.M. El-Say, A.B. Abdel-Naim, A. Khedr and Z.M. Banjar, 2014. Optimization of self-nanoemulsifying systems for the enhancement of in vivo hypoglycemic efficacy of glimepiride transdermal patches. Expert Opin. Drug Deliv., 11: 1005-1013.
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  44. Khalid, M., A.R.M. El-Helw, O.A. Ahmed, K.M. Hosny and T.A. Ahmed, 2013. Novel controlled release of antihypertensive drug: Preparation, in-vitro and in-vivo evaluation. Afr. J. Pharm. Pharmacol., 7: 1744-1756.
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  45. Hosny, K.M. and K. M. El-Say, 2013. Development and optimization of gastro retentive floating tablets of atorvastatin calcium using simplex lattice design. Latin Am. J. Pharm., 32: 1396-1404.
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  46. Ahmed, T.A., M. Khalid, M.F. Mahmoud, A.M. Samy and A.A. Badawi, 2012. Miconazole nitrate oral disintegrating tablets: In vivo performance and stability study. AAPS PharmSciTech, 13: 760-771.
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  47. El-Say, K.M., T.A. Refaey, A.M. Samy and A.A. Badawi, 2011. Optimization of formulation variables to produce free flowing granules of bezafibrate by high-shear mixer using Box-Behnken design. J. Pharm. Res., 4: 501-506.

  48. El-Say, K.M., T.A. Refaey, A.M. Samy and A.A. Badawi, 2011. Box-Behnken design for optimization of formulation variables to improve the flowability and compressibility of bezafibrate. Az. J. Pharm. Sci., 43: 40-57.

  49. El-Say, K.M., 2011. Nanodiamond as a drug delivery system: Applications and prospective. J. Applied Pharmaceut. Sci., 1: 29-39.
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  50. El-Say, K.M., 2011. Application of the mixture experimental design for development of novel combination of superdisintegrants in formulation of fast dissolving salbutamol sulphate tablets. Az. J. Pharm. Sci., 43: 1-15.

  51. El-Say, K.M., T.A. Refaey, A.M. Samy and A.A. Badawy, 2010. Comparative study among different techniques to improve the physical and technical properties prevailing to compression of poorly flowing and highly cohesive drug. Int. J. Pharmaceut. Sci. Rev. Res., 4: 67-76.
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  52. El-Say, K.M., A.M. Samy and M.I. Fetouh, 2010. Optimization of rofecoxib liquisolid tablets usingbox-behnken design and desirability function. J. Pharm. Res., 3: 2388-2392.
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  53. El-Say, K.M., A.M. Samy and M.I. Fetouh, 2010. Formulation and evaluation of rofecoxib liquisolid tablets. Int. J. Pharmaceut. Sci. Rev. Res., 3: 135-142.
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  54. El-Say, K.M., A.E. Abdelaziz, A.M. Samy and A.A. Kassem, 2009. Development and optimization of diclofenac sodium niosomes using response surface methodology. Az. J. Pharm. Sci., 40: 272-286.

  55. El-Say, K.M., A.E. Abdelaziz, A.M. Samy and A.A. Kassem, 2008. Screening study for formulation variables in preparation of diclofenac sodium niosomes using Plackett-Burman design. Az. J. Pharm. Sci., 38: 36-53.

  56. Attia, D.A., K.M. El-Say and A.A. Ramadan, 2008. Optimization and characterization of bioadhesive gastroretentive amoxicillin tablets using the mixture experimental design. J. Applied Sci. Res., 4: 1328-1339.

  57. Abo-Salem, O.M., M. El-Say Khalid, M.S.A. Ahmed and I.F. Mohamed, 2006. Study on the possible modulation of the antiinflammatory and analgesic effects of liquisolid tablets of rofecoxib in rats. Egyp. J. Biomed. Sci., 21: 142-152.

  58. Ahmed, A.M.S., K.M. El-Say and M.I. Fetouh, 2001. Effect of polymer on the formulation, micromeritic properties, in-vitro evaluation and stability testing on Ibuprofen microcapsules prepared by the emulsion solvent-evaporation technique. Az. J. Pharm. Sci., 28: 267-284.

  59. Ahmed, A.M.S., K.M. El-Say and M.I. Fetouh, 2001. Effect of polymer on the formulation, micromeritic properties, in-vitro evaluation and stability testing of Salbutamol sulfate microcapsules prepared by the emulsion solvent-evaporation technique. Az. J. Pharm. Sci., 28: 300-318.
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