Dr. Ayman Ahmed El-Faham

Professor
King Saud University, Saudi Arabia

Highest Degree
Ph.D. in Chemistry from University of Massachusetts Dartmouth, USA

My URL
https://livedna.org/20.23758

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Area of Interest:

Chemistry
Organic Chemistry
Reaction Kinetics
Active Compounds
Characterization

Selected Publications

  1. Soliman, S.M. and A. El-Faham, 2018. One pot synthesis of two Mn(II) perchlorate complexes with s-triazine NNN-pincer ligand; molecular structure, Hirshfeld analysis and DFT studies. J. Mol. Struct., 1164: 344-353.
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  2. Soliman, S.M. and A. El-Faham, 2018. Low temperature X-ray structure analyses combined with NBO studies of a new heteroleptic octa-coordinated Holmium(III) complex with N,N,N-tridentate hydrazono-phthalazine-type ligand. J. Mol. Struct., 1157: 222-229.
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  3. Sharma, A., A. Kumar, S.A.H. Abdel Monaim, Y.E. Jad, A. El-Faham, B.G. de la Torre and F. lbericio, 2018. N-methylation in amino acids and peptides: Scope and limitations. Biopolymers. 10.1002/bip.23110.
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  4. Khattab, S.N., H.H. Khalil, A.A. Bekhit, M.M. Abd El‐Rahman, B.G. de la Torre, A. El‐Faham and F. Albericio, 2018. 1,3,5‐triazino peptide derivatives: Synthesis, characterization and preliminary antileishmanial activity. ChemMedChem., 13: 725-735.
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  5. Farooq, M., Z.M. Almarhoon, N. Abu Taha, A.A.R. Baabbad, M.A. Al-Wadaan and A. El-Faham, 2018. Synthesis of novel class of N-alkyl-isatin-3-iminobenzoic acid derivatives and their biological activity in zebrafish embryos and human cancer cell lines. Biol. Pharm. Bull., 41: 350-359.
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  6. Al-Rasheed, H.H., E.N. Sholkamy, M. Al Alshaikh, M.R.H. Siddiqui, A.S. Al-Obaidi and A. El-Faham, 2018. Synthesis, characterization and antimicrobial studies of novel series of 2,4-Bis(hydrazino)-6-substituted-1,3,5-triazine and their Schiff base derivatives. J. Chem., Vol. 2018. 10.1155/2018/8507567.
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  7. Abu-Youssef, M A.M., S.M. Soliman, A. El-Faham, J. Albering and M.M. Sharaf et al., 2018. A new triazoloquinoxaline ligand and its polymeric 1D silver(I) complex: Synthesis, structure and antimicrobial activity. New J. Chem., 42: 7197-7205.
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  8. Abdel Monaim, S.A.H., G.A. Acosta, M. Royo, A. El-Faham, G. Beatriz and F. Albericio, 2018. Solid-phase synthesis of homodetic cyclic peptides from Fmoc-MeDbz-resin. Tetrahedron Lett., 59: 1779-1782.
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  9. Soliman, S.M., J.H. Albering, M. Farooq, M.A.M. Wadaan and A. El-Faham, 2017. Synthesis, structural and biological studies of two new Co(III) complexes with tridentate hydrazone ligand derived from the antihypertensive drug hydralazine. Inorg. Chim. Acta, 466: 16-29.
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  10. Soliman, S.M., H.A. Ghabbour, S.N. Khattab, M.R.H. Siddiqui and A. El-Faham, 2017. Synthesis, crystallographic characterization, DFT and TD-DFT studies of Oxyma-sulfonate esters. J. Chem. Sci., 129: 1469-1481.
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  11. Soliman, S.M., A. El-Faham and J.H. Albering, 2017. Synthesis, X-ray crystal structure and DFT studies of two octahedral cobalt(II) complexes with N,N,N-tridentate triazine-type ligands. J. Coord. Chem., 70: 2261-2279.
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  12. Soliman, S.M. and A. El-Faham, 2017. Synthesis, crystal structure and hirshfeld topology analysis of polymeric Silver(I) complex with s-triazine-type ligand. Crystals, Vol. 7. 10.3390/cryst7060160.
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  13. Sharma, A., Y.E. Jad, H.A. Ghabbour, B.G. de la Torre, H.G. Kruger, F. Albericio and A. El-Faham, 2017. Synthesis, crystal structure and DFT Studies of 1,3- Dimethyl-5-propionylpyrimidine-2,4,6(1H,3H,5H)-trione. Crystals, Vol. 7. 10.3390/cryst7010031.
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  14. Sharma, A., Y. Jad, M.R.H. Siddiqui, B.G. de la Torre, F. Albericio and A. El-Faham, 2017. Synthesis, characterization and tautomerism of 1,3-dimethyl pyrimidine-2,4,6-trione s-triazinyl hydrazine/hydrazone derivatives. J. Chem., Vol. 2017. 10.1155/2017/5702962.
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  15. Sharma, A., I. Ramos‐Tomillero, A. El‐Faham, E. Nicolas, H. Rodriguez, B.G. de la Torre and F. Albericio, 2017. Understanding tetrahydropyranyl as a protecting group in peptide chemistry. ChemistryOpen, 6: 168-177.
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  16. Sharma, A., I. Ramos-Tomillero, A. El-Faham, H. Rodriguez, B.G. de la Torre and F. Albericio, 2017. Tetrahydropyranyl: A non-aromatic, mild acid labile protecting group for hydroxyl protection in solid phase peptide synthesis. ChemistryOpen, 6: 206-210.
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  17. Sharma, A., H. Ghabbour, S.T. Khan, B.G. de la Torre, F. Albericio and A. El-Faham, 2017. Novel pyrazolyl-s-triazine derivatives, molecular 1 structure and antimicrobial activity. J. Mol. Struct., 1145: 244-253.
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  18. Osman, S.M., S.N. Khattab, E.S.A. Aly, E.R. Kenawy and A. El-Faham, 2017. 1,3,5-Triazine-based polymer: Synthesis, characterization and application for immobilization of silver nanoparticles. J. Polym. Res., 24: 231-244.
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  19. Monaim, S.A.A., Y.E. Jad, A. El-Faham, G. Beatriz and F. Albericio, 2017. Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study. Bioorg. Med. Chem. 10.1016/j.bmc.2017.09.040.
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  20. Kumar, A., Y.E. Jad, B.G. de la Torre, A. El-Faham and F. Albericio, 2017. Re-evaluating the stability of COMU in different solvents. J. Pept. Sci., 23: 763-768.
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  21. Kumar, A., Y.E. Jad, A. El-Faham, B.G. de la Torre and F. Albericio, 2017. Green solid- phase peptide synthesis 4. δ-Valerolactone and N-formylmorpholine as green solvents for solid phase peptide synthesis. Tetrahedron Lett., 58: 2986-2988.
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  22. Kumar, A., A. Sharma, E. Haimov, A. El-Faham, B.G. de la Torre and F. Albericio, 2017. Fmoc-Amox, a suitable reagent for the introduction of Fmoc. Org. Process Res. Dev., 21: 1533-1541.
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  23. Khattab, S.N., N.S. Haiba, A.M. Asal, A.A. Bekhit, A.A. Guemei, A. Amer and A. El-Faham, 2017. Study of antileishmanial activity of 2-aminobenzoyl amino acid hydrazides and their quinazoline derivatives. Bioorg. Med. Chem. Lett., 27: 918-921.
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  24. Khattab, S.N., M.I. Massoud, A.M. Abd El-Razek and A. El-Faham, 2017. Physico-chemical and sensory characteristics of steviolbioside synthesized from stevioside and its application in fruit drinks and food. J. Food Sci. Technol., 54: 185-195.
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  25. Jad, Y.E., T. Govender, H.G. Kruger, A. El-Faham, B.G. de la Torre and F. Albericio, 2017. Green solid-phase peptide synthesis (GSPPS) 3. Green solvents for Fmoc removal in peptide chemistry. Org. Process Res. Dev., 21: 365-369.
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  26. Jad, Y., A. El-Faham, B.G. de la Torre and F. Albericio, 2017. Solid-Phase Peptide Synthesis, the State of the Art: Challenges and Opportunities. In: Peptide-based Drug Discovery: Challenges and New Therapeutics, Srivastava, V. (Ed.). Chapter 18, Royal Society of Chemistry, USA., ISBN: 978-1-7826-732-6, pp: 515-550.

  27. El-Faham, A., S.N. Khattab and H.A. Ghabbour, 2017. Crystal structure of 1-methyl-3- [((naphthalen-2-ylsulfonyl)oxy)imino]indolin-2-one, C19H14N2O4S. Zeitschrift fur Kristallographie-New Cryst. Struct., 232: 55-57.
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  28. El-Faham, A., A. El-Merghany and H.A. Ghabbour, 2017. Crystal structure of N′-(2- phenylacetyl) thiophene-2-carbohydrazide monohydrate, C13H14N2O3S. Zeitschrift fur Kristallographie-New Cryst. Struct., 232: 69-71.
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  29. El-Faham, A. and H.A. Ghabbour, 2017. Crystal structure of (E)-1-(2-(thiophen-2- ylmethylene)hydrazinyl)phthalazine hydrochloride-ethanol (1/1), C15H17ClN4OS. Zeitschrift fur Kristallographie-New Cryst. Struct., 232: 95-97.
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  30. Albericio, F., G.A. Acosta, A. El-Faham, Y.E. Jad, A. Kumar and B.G. de la Torre, 2017. Green solid-phase peptide synthesis (GSPPS). Chimia, 71: 523-523.

  31. Al-Zaydi, K.M., H.H. Khalil, A. El-Faham and S.N. Khattab, 2017. Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity. Chem. Cent. J., Vol. 11. 10.1186/s13065-017-0267-3.
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  32. Abdel Monaim, S.A.H., S. Noki, E.J. Ramchuran, A. El-Faham, F. Albericio and B.G. de la Torre, 2017. Investigating of N-terminal amino function of Arg10-teixobactin. Molecules, Vol. 22. 10.3390/molecules22101632.
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  33. Abdel Monaim, S.A.H., E.J. Ramchuran, A. El-Faham, F. Albericio and B.G. de la Torre, 2017. Converting teixobactin into a cationic Antimicrobial Peptide (AMP). J. Med. Chem., 60: 7476-7482.
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  34. Monaim, S.A.H.A., Y.E. Jad, G.A. Acosta, T. Naicker and E.J. Ramchuran et al., 2016. Re-evaluation of the N-terminal substitution and the D-residues of teixobactin. RSC Adv., 6: 73827-73829.
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  35. Monaim, S.A.H.A., Y.E. Jad, E.J. Ramchuran, A. El-Faham, T. Govender, H.G. Kruger, B.G. de la Torre and F. Albericio, 2016. Lysine scanning of Arg10-teixobactin: Deciphering the role of hydrophobic and hydrophilic residues. ACS Omega, 1: 1262-1265.
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  36. Mashaly, A.M.A. and A. El-Faham, 2016. Larvicidal activity of N1,N1,N4,N4- tetramethylpiperazine-1,4-dicarboxamide against Aedes caspius and Culex pipiens (Diptera: Culicidae). Pak. J. Zool., 48: 493-499.
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  37. Khattab, S., S.E.A. Naim, M. El-Sayed, A.A. El Bardan, A.O. Elzoghby, A.A. Bekhit and A. El-Faham, 2016. Design and synthesis of new s-triazine polymers and its application as nanoparticulate drug delivery systems. New J. Chem., 40: 9565-9578.
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  38. Jad, Y.E., G.A. Acosta, S.N. Khattab, B.G. de la Torre and T. Govender et al., 2016. 2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis. Amino Acids, 48: 419-426.
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  39. Jad, Y.E., G. Acosta, T. Govender, H. Kruger, A. El-Faham, B. de la Torre and F. Albericio, 2016. Green solid-phase peptide synthesis-2.1,2-methytetrahydrofuran and ethyl acetate for solid-phase peptide synthesis under green conditions. ACS Sustain. Chem. Eng., 4: 6809-6814.
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  40. Jad, Y.E., B.G. de la Torre, T. Govender, H.G. Kruger, A. El-Faham and F. Albericio, 2016. Oxyma-T, expanding the arsenal of coupling reagents. Tetrahedron Lett., 57: 3523-3525.
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  41. Ghabbour, H.A. and A. El-Faham, 2016. Crystal structure of 4-chloro-N,N-diethyl-6-(piperidin-1-yl)-1,3,5-triazin-2-amine, C12H20ClN5. Zeitschrift fur Kristallographie-New Cryst. Struct., 231: 243-245.
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  42. Fouda, M.M.G., A.M. Abdel-Mohsen, H. Ebaid, I. Hassan and J. Al-Tamimi et al., 2016. Wound healing of different molecular weight of hyaluronan: In-vivo study. Int. J. Biol. Macromol., 89: 582-591.
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  43. El-Mahdy, G.A., H.H. Al-Rasheed, M. Al Alshaikh, H.A. Al-Lohedan and A. El-Faham, 2016. 2,4-Dihydrazino-6-Morpholino-1,3,5-Triaizne (DHMT) and 2,4-Dihydrazino-6-Piperidino-1,3,5-Triaizne (DHPT) as promising corrosion inhibitors of steel in acidic media. Int. J. Electrochem. Sci., 11: 5459-5472.
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  44. El-Faham, A., S.M. Soliman, S.M. Osman, H.A. Ghabbour, M.R.H. Siddiqui, H.K. Fun and F. Albericio, 2016. One pot synthesis, molecular structure and spectroscopic studies (X-ray, IR, NMR, UV-Vis) of novel 2-(4,6-dimethoxy-1,3,5-triazin-2-yl) amino acid ester derivatives. Spectrochim. Acta Part A: Mol. Biomol. Spectrosc., 159: 184-198.

  45. El-Faham, A., S.M. Soliman, H.A. Ghabbour, Y.A. Elnakady, T.A. Mohaya, M.R.H. Siddiqui and F. Albericio, 2016. Ultrasonic promoted synthesis of novel s-triazine-Schiff base derivatives; molecular structure, spectroscopic studies and their preliminary anti-proliferative activities. J. Mol. Struct., 1125: 121-135.
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  46. El-Faham, A., S.M. Osman, H.A. Al-Lohedan and G.A. El-Mahdy, 2016. Hydrazino-methoxy-1,3,5-triazine derivatives’ excellent corrosion organic inhibitors of steel in acidic chloride solution. Molecules, Vol. 21. 10.3390/molecules21060714.
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  47. El-Faham, A., K.A. Dahlous, Z.A. Al Othman, H.A. Al-Lohedan and G.A. El-Mahdy, 2016. sym-Trisubstituted 1,3,5-triazine derivatives as promising organic corrosion inhibitors for steel in acidic solution. Molecules, Vol. 21. 10.3390/molecules21040436.
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  48. Al-Rasheed, H.H., M. Al Alshaikh, J.M. Khaled, N.S. Alharbi and A. El-Faham, 2016. Ultrasonic irradiation: Synthesis, characterization and preliminary antimicrobial activity of novel series of 4,6-disubstituted-1,3,5-triazine containing hydrazone derivatives. J. Chem., Vol. 2016. 10.1155/2016/3464758.
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  49. Tulla-Puche, J., A. El-Faham, A.S. Galanis, E. de Oliveira, A.A. Zompra and F. Albericio, 2015. Peptide Drugs: Peptide Chemistry and Drug Design. In: Methods for the Synthesis and Analysis of Peptides, Dunn, B.M. (Ed.). Wiley and Sons, New York, pp: 11-73.

  50. Soliman, S.M., M.A.M. Abu-Youssef, J. Albering and A. El-Faham, 2015. Molecular structure and DFT investigations on new cobalt(II) chloride complex with superbase guanidine type ligand. J. Chem. Sci., 127: 2137-2149.

  51. Masoud, M.S., A. El Faham, H.H. Hamoud, A E. Alic and H. Beidsas, 2015. Spectral studies and solvatochromic behaviour of 1-hydroxy-benzotriazole and 7-Aza-l-hydroxybenzotriazole in presence of different solvents. J. Chem. Pharm. Res., 7: 781-791.

  52. Khattab, S.N., S.A.H. Moneim, A.A. Bekhit, A. El Massry and S.Y. Hassan et al., 2015. Exploring new selective 3-benzylquinoxaline-based MAO-A inhibitors: Design, synthesis, biological evaluation and docking studies. Eur. J. Med. Chem., 93: 308-320.
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  53. Khattab, S.N., N.S. Haiba, A.M. Asal, A.A. Bekhit, A. Amer, H.M. Abdel-Rahman and A. El-Faham, 2015. Synthesis and evaluation of quinazoline amino acid derivatives as Mono Amine Oxidase (MAO) inhibitors. Bioorg. Med. Chem., 23: 3574-3585.
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  54. Khattab, S.N., M.I. Massoud, Y.E.S. Jad, A.A. Bekhit and A. El-Faham, 2015. Production and physicochemical assessment of new stevia amino acid sweeteners from the natural stevioside. Food Chem., 173: 979-985.
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  55. Khattab, S.N., H.H. Khalil, A.A. Bekhit, M.M.A. El-Rahman, A. El-Faham and F. Albericio, 2015. Synthesis and preliminary biological evaluation of 1,3,5-triazine amino acid derivatives to study their MAO inhibitors. Molecules, 20: 15976-15988.
    CrossRef  |  Direct Link  |  

  56. Khattab, N.S., A. El-Faham and F. Albericio, 2015. Peptide coupling reactions. J. Mol. Pharm. Org. Process Res., Vol. 3. 10.4172/2329-9053.1000e119.
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  57. Jad, Y.E., S.N. Khattab, B.G. de la Torre, T. Govender, H.G. Kruger, A. El-Faham and F. Albericio, 2015. EDC• HCl and potassium salts of oxyma and oxyma-B as superior coupling cocktails for peptide synthesis. Eur. J. Org. Chem., 2015: 3116-3120.
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  58. Jad, Y.E., G.A. Acosta, T. Naicker, M. Ramtahal and A. El-Faham et al., 2015. Synthesis and biological evaluation of a teixobactin analogue. Org. Lett., 17: 6182-6185.
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  59. Jad, Y.E., G. Acosta, S. Khattab, B.G. de la Torre and T. Govender et al., 2015. Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives. Org. Biomol. Chem., 13: 2393-2398.
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  60. El-Newehy, M.H., S.M. Osman, M.S. Refat, S.S. Al-Deyab and A. El-Faham, 2015. Microwave synthesis of copolymers based on itaconic acid moiety and their utility for scavenging of copper (II) and lead (II). J. Macromol. Sci. Part A: Pure Applied Chem., 52: 561-576.
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  61. El-Faham, A., Z. Al Marhoon, A. Abdel-Megeed, S.N. Khattab, A. Bekhit and F. Albericio, 2015. α-Ketoamino acid ester derivatives as promising MAO inhibitors. Bioorg. Med. Chem. Lett., 25: 70-74.
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  62. El-Faham, A., W.N. Hozzein, M.A.M. Wadaan, S.. Khattab, H.A. Ghabbour, H.K. Fun and M.R. Siddiqui, 2015. Microwave synthesis, characterization and antimicrobial activity of some novel isatin derivatives. J. Chem., Vol. 2015. 10.1155/2015/716987.
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  63. El-Faham, A., M. Farooq, S.N. Khattab, N. Abutaha, M.A. Wadaan, H.A. Ghabbour and H.K. Fun, 2015. Synthesis, characterization and anti-cancer activity of some new N′-(2-Oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazones derivatives. Molecules, 20: 14638-14655.
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  64. El-Faham, A. and Y.A. Elnakady, 2015. Synthesis, characterization of novel morpholino-1,3,5-triazinyl amino acid ester derivatives and their anti-proliferation activities. Lett. Org. Chem., 12: 753-758.
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  65. Jad, Y.E., S.N. Khattab, G. Beatriz, T. Govender, H.G. Kruger, A. El-Faham and F. Albericio, 2014. Oxyma-B, an excellent racemization suppressor for peptide synthesis. Org. Biomol. Chem., 12: 8379-8385.
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  66. Jad, Y.E., S.N. Khattab, B.G. de la Torre, T. Govender, H.G. Kruger, A. El-Faham and F. Albericio, 2014. TOMBU and COMBU as novel uronium-type peptide coupling reagents derived from oxyma-B. Molecules, 19: 18953-18965.
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  67. Ibrahim, M.F., A.A. Al-Karewi, S.N. Khattab, E.A. Hamed and A. El-Faham, 2014. Aminolysis of isatin and N-acetyl isatin in acetonitrile and mixed acetonitrile-water solvents. Asian J. Chem., 26: 8029-8038.

  68. Farooq, M., A. El-Faham, S.N. Khattab, A.M. Elkayal and M.F. Ibrahim et al., 2014. Biological screening of novel derivatives of valproic acid for anticancer and antiangiogenic properties. Asian Pac. J. Cancer Prev., 15: 7785-7792.
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  69. El‐Faham, A., S.N. Khattab, R. Subiros‐Funosas and F. Albericio, 2014. BOP‐OXy, BOP‐OBt and BOP‐OAt: Novel organophosphinic coupling reagents useful for solution and solid‐phase peptide synthesis. J. Pept. Sci., 20: 1-6.
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  70. El-Faham, A., Y.A. Elnakdy, S.A.M. El Gazzar, M.M.A. El-Rahman and S.N. Khattab, 2014. Synthesis, characterization and anti-proliferation activities of novel cyano oximino sulfonate esters. Chem. Pharm. Bull., 62: 373-378.
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  71. El-Faham, A., S.N. Khattab, H.A. Ghabbour, H.K. Fun and M.R.H. Siddiqui, 2014. Microwave irradiation: Synthesis and characterization of α-ketoamide and bis (α-ketoamide) derivatives via the ring opening of N-acetylisatin. Chem. Cent. J., Vol. 8. 10.1186/1752-153X-8-27.
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  72. El-Faham, A., M. Farooq, S.N. Khattab, A.M. Elkayal and M.F. Ibrahim, 2014. Synthesis and biological activity of Schiff base series of valproyl, N-valproyl glycinyl, and N-valproyl-4-aminobenzoyl hydrazide derivatives. Chem. Pharm. Bull., 62: 591-599.
    PubMed  |  Direct Link  |  

  73. El-Faham, A., A. Elzatahry, Z. AlOthman and E.A. Elsayed, 2014. Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity. Int. J. Nanomed., 4: 1167-1174.
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  74. Al Marhoon, Z., A. Abdel-Megeed, E.N. Sholkamy, M.R.H. Siddiqui and A. El-Faham, 2014. Synthesis of phenylcarbamic acid and 2-(2-Oxo-3-(4-substituted phenylimino)indolin-1-yl) acetohydrazide derivatives as a promising antifungal agents. Asian J. Chem., 26: 7665-7672.

  75. Al Gerni, T.S., A.M. Ismail, M. Al-Zaben and A. El-Faham, 2014. Solvent effects on the kinetic and mechanism of N-Mannich bases of 3-hydrazonoindole-2-one. Asian J. Chem., 26: 48-52.

  76. Subiros-Funosas, R., S.N. Khattab, L. Nieto-Rodriguez, A. El-Faham and F. Albericio, 2013. Advances in acylation methodologies enabled by oxyma-based reagents. Aldrichim. Acta, 46: 21-40.
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  77. Ghazzali, M., S.A. Khattab, Y.A. Elnakady, F.A. Al-Mekhlafi, K. Al-Farhan and A. El-Faham, 2013. Synthesis, structure, theoretical calculations and biological activity of sulfonate active ester new derivatives. J. Mol. Struct., 1046: 147-152.
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  78. El-Faham, A., Z. Al Marhoon, A. Abdel-Megeed and M. Siddiqui, 2013. An efficient and mild method for the synthesis and hydrazinolysis of N-glyoxylamino acid esters. J. Chem., Vol. 2013. 10.1155/2013/901745.
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  79. El-Faham, A., Z. Al Marhoon, A. Abdel-Megeed and F. Albericio, 2013. OxymaPure/DIC: An efficient reagent for the synthesis of a novel series of 4-[2-(2-Acetylaminophenyl)-2-oxo-acetylamino] benzoyl amino acid ester derivatives. Molecules, 18: 14747-14759.
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  80. Cherkupally, P., G.A. Acosta, L. Nieto‐Rodriguez, J. Spengler and H. Rodriguez et al., 2013. K‐Oxyma: A strong acylation‐promoting, 2‐CTC resin‐friendly coupling additive. Eur. J. Org. Chem., 2013: 6372-6378.
    CrossRef  |  Direct Link  |  

  81. Subiros‐Funosas, R., A. El‐Faham and F. Albericio, 2012. Use of Oxyma as pH modulatory agent to be used in the prevention of base‐driven side reactions and its effect on 2‐chlorotrityl chloride resin. Pept. Sci., 98: 89-97.
    CrossRef  |  Direct Link  |  

  82. Osman, S.M., M.H. El-Newehy, S.S. Al-Deyab and A. El-Faham, 2012. Microwave synthesis and thermal properties of polyacrylate derivatives containing itaconic anhydride moieties. Chem. Cent. J, Vol. 6. 10.1186/1752-153X-6-85.
    CrossRef  |  

  83. Khattab, S.N., R. Subiros‐Funosas, A. El‐Faham and F. Albericio, 2012. Screening of N‐Alkyl‐cyanoacetamido oximes as substitutes for N‐hydroxysuccinimide. ChemistryOpen, 1: 147-152.
    CrossRef  |  Direct Link  |  

  84. Khattab, S.N., R. Subiros-Funosas, A. El-Faham and F. Albericio, 2012. Cyanoacetamide-based oxime carbonates: An efficient, simple alternative for the introduction of Fmoc with minimal dipeptide formation. Tetrahedron, 68: 3056-3062.
    CrossRef  |  Direct Link  |  

  85. Khattab, S.N., M.A.H. Kharaba, A. El-Hawary, A. El-Faham and E.A. Hamed, 2012. Aminolysis of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1- hydroxybenzotriazolyl)-5-nitro-pyridine. Open J. Phys. Chem., 2: 156-168.

  86. Jad, Y.E.S., S.N. Khattab, A. El-Faham and F. Albericio, 2012. Oxime-based carbonates as useful reagents for both N-protection and peptide coupling. Molecules, 17: 14361-14376.

  87. Hassan, H.H.A.M., A.F. El-Husseiny, A.G. Abo ElFadl, A. El-Faham and F. Albericio, 2012. Synthesis and thermal properties of novel polyamides containing amino acid moities: Structure-property relationship. J. Macromol. Sci. Part A: Pure Applied Chem., 49: 41-54.

  88. Ghazzali, M., A. El-Faham, A. Abdel-Megeed and K. Al-Farhan, 2012. Microwave-assisted synthesis, structural elucidation and biological assessment of 2-(2-acetamidophenyl)-2-oxo-N phenyl acetamide and N-(2-(2-oxo-2(phenylamino)acetyl) phenyl)propionamide derivatives. J. Mol. Struct., 1013: 163-167.
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  89. Farooq, M., A. Al Faham, M. Ahmad, A.S. Sami and M.A. Wadaan, 2012. Teratogenic profile of valproic acid and newly synthesized derivatives in zebrafish embryos. Int. J. Agric. Biol., 14: 894-900.
    Direct Link  |  

  90. El-Faham, A., H.H.A.M. Hassan and S.N. Khattab, 2012. Synthesis and characterization of new polyamides derived from alanine and valine derivatives. Chem. Cent. J., Vol. 6. 10.1186/1752-153X-6-128.
    CrossRef  |  

  91. Al-Warhi, T.I., H.M.A. Al-Hazimi and A. El-Faham, 2012. Recent development in peptide coupling reagents. J. Saudi Chem. Soc., 16: 97-116.
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  92. Al-Hazimi, H.M., A. El-Faham, M. Gazzali and K. Al-Farhan, 2012. Microwave irradiation: A facile, scalable and convenient method for synthesis of N-phthaloylamino acids. Arab. J. Chem., 5: 285-289.
    CrossRef  |  Direct Link  |  

  93. Subiros-Funosas, R., A. El-Faham and F. Albericio, 2011. Aspartimide formation in peptide chemistry: Occurrence, prevention strategies and the role of N-hydroxylamines. Tetrahedron, 67: 8595-8606.

  94. Khattab, S.N., E.A. Hamed, F. Albericio and A. El-Faham, 2011. Synthesis and aminolysis of N, N, diethyl carbamic ester of HOBt. Bull. Chem. Soc. Japan., 84: 633-639.

  95. El-Faham, A., R. Subiros-Funosas and F. Albericio, 2011. N-Hydroxyamines for Peptide Synthesis. In: The Chemistry of Hydroxylamine, Oxime and Hydroxamic Acid, Volume 2, Rappoport, Z. and J.F. Liebman (Eds.). Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, pp: 623-730.

  96. El-Faham, A. and F. Albericio, 2011. Peptide coupling reagents, more than a letter soup. Chem. Rev., 111: 6557-6602.

  97. Al-Farhan, K., M. Ghazzali, H.M. Al-Hazimi, A. El-Faham and J. Reedijk, 2011. Hydrogen bonding chains and rings structural motifs in new series of N-phthaloyl aminocarboxylic acid derivatives. Solid state microwave synthesis, structural chemistry, computational calculations and antimicrobial activity. J. Mol. Struct., 994: 269-275.
    CrossRef  |  Direct Link  |  

  98. Subiros-Funosas, R., A. El-Faham and F. Albericio, 2010. PyOxP and PyOxB: The Oxyma-based novel family of phosphonium salts. Org. Biomol. Chem., 8: 3665-3673.
    CrossRef  |  Direct Link  |  

  99. Khattab, S.N., S.Y. Hassan, E.A. Hamed, F. Albericio and A. El-Faham, 2010. Synthesis and aminolysis of N,N-diethyl carbamic ester of HOBt derivatives. Bull. Korean Chem. Soc., 31: 75-81.
    CrossRef  |  

  100. Khattab, S.N., R. Subiros‐Funosas, A. El‐Faham and F. Albericio, 2010. Oxime carbonates: novel reagents for the introduction of fmoc and Alloc protecting groups, free of side reactions. Eur. J. Org. Chem., 2010: 3275-3280.
    CrossRef  |  Direct Link  |  

  101. Ghazzali, M., K. Al-Farhan, A. El-Faham and J. Reedijk, 2010. Coordination chemistry of the ligand 7-aza-1-hydroxy-benzotriazole. Crystal structures and antimicrobial activity of the catena-poly-[μ-chlorido(μ-7-aza-1-oxy-κ2N:O-benzotriazolyl-κN)]cobalt(II) methanol coordination polymer and of a new polymorph of the free ligand 3H-[1,2,3]triazolo[4,5-b]pyridin-3-ol. Polyhedron, 29: 2829-2832.
    CrossRef  |  Direct Link  |  

  102. El‐Faham, A., R. Subiros‐Funosas and F. Albericio, 2010. A novel family of onium salts based upon isonitroso meldrum's acid proves useful as peptide coupling reagents. Eur. J. Org. Chem., 2010: 3641-3649.
    CrossRef  |  Direct Link  |  

  103. El‐Faham, A. and F. Albericio, 2010. COMU: A third generation of uronium‐type coupling reagents. J. Pept. Sci., 16: 6-9.
    CrossRef  |  Direct Link  |  

  104. Albatal, M., M.A. Ghani, A. El-Faham, H.M. Al-Hazimi and H.H. Hammud, 2010. Microwave irradiation and diisopropylcarbodiimide (DIC)/7-Aza-1-hydroxybenzotriazole (HOAt): A potent combination for synthesis of variuos hydrazide from N-protected amino acid and hydrazine. J. Korean Chem. Soc., 54: 419-428.
    CrossRef  |  Direct Link  |  

  105. Al-Warhi, T.I., H. Al-Hazimi, A. El-Faham and F. Albericio, 2010. Synthesis of 2-(4,6-dimethoxy-1,3,5-triazin-2-yloxyimino) derivatives: Application in solution peptide synthesis. Molecules, 15: 9403-9417.
    CrossRef  |  Direct Link  |  

  106. Subiros‐Funosas, R., R. Prohens, R. Barbas, A. El‐Faham and F. Albericio, 2009. Oxyma: An efficient additive for peptide synthesis to replace the benzotriazole‐based HOBt and HOAt with a lower risk of explosion. Chem. Eur. J., 15: 9394-9403.
    CrossRef  |  Direct Link  |  

  107. Subiros-Funosas, R., G.A. Acosta, A. El-Faham and F. Albericio, 2009. Microwave irradiation and COMU: A potent combination for solid-phase peptide synthesis. Tetrahedron Lett., 50: 6200-6202.
    CrossRef  |  Direct Link  |  

  108. Hammud, H.H., K.T. Holman, M.S. Masoud, A. El-Faham and H. Beidas, 2009. 1-Hydroxybenzotriazole (HOBt) acidity, formation constant with different metals and thermodynamic parameters: Synthesis and characterization of some HOBt metal complexes-Crystal structures of two polymers: [Cu2(H2O) 5(OBt) 2(μ-OBt) 2]• 2H2O• EtOH (1A) and [Cu (μ-OBt)(HOBt)(OBt)(EtOH)](1B). Inorg. Chim. Acta, 362: 3526-3540.
    CrossRef  |  Direct Link  |  

  109. El‐Faham, A., R.S. Funosas, R. Prohens and F. Albericio, 2009. COMU: A safer and more effective replacement for benzotriazole‐based uronium coupling reagents. Chem. Eur. J., 15: 9404-9416.
    CrossRef  |  Direct Link  |  

  110. El‐Faham, A. and F. Albericio, 2009. Synthesis and application of N‐hydroxylamine derivatives as potential replacements for HOBt. Eur. J. Org. Chem., 2009: 1499-1501.
    CrossRef  |  Direct Link  |  

  111. El-Faham, A. and S.N. Khattab, 2009. Utilization of N,N,N′,N′-Tetramethylfluoroformamidinium Hexafluorophosphate (TFFH) in peptide and organic synthesis. Synlett, 2009: 886-904.
    CrossRef  |  Direct Link  |  

  112. Carpino, L.A., K. Nasr, A.A. Abdel-Maksoud, A. El-Faham and D. Ionescu et al., 2009. Dicyclopropylmethyl peptide backbone protectant. Org. Lett., 11: 3718-3721.
    CrossRef  |  Direct Link  |  

  113. Khattab, S.N., A.A. Bekhit, A. El-Faham, A.M. El Massry and A. Amer, 2008. Synthesis of some pyridazinylacetic acid derivatives as a novel class of monoamine oxidase-A inhibitors. Chem. Pharm. Bull., 56: 1717-1721.
    CrossRef  |  Direct Link  |  

  114. El‐Faham, A., M. Armand‐Ugon, J.A. Este and F. Albericio, 2008. Use of N‐methylpiperazine for the preparation of piperazine‐based unsymmetrical Bis‐ureas as anti‐HIV agents. ChemMedChem, 3: 1034-1037.
    CrossRef  |  Direct Link  |  

  115. El-Faham, A., R. Subiros and F. Albericio, 2008. A non-explosive replacement for benzotriazole based coupling reagents. J. Pept. Sci., 14: 57-57.
    Direct Link  |  

  116. El-Faham, A. and F. Albericio, 2008. Morpholine-based immonium and halogenoamidinium salts as coupling reagents in peptide synthesis. J. Org. Chem., 73: 2731-2737.
    CrossRef  |  Direct Link  |  

  117. Khattab, S.N., S.Y. Hassan, A. El‐Faham, A.M.M. El Massry and A. Amer, 2007. Reaction of phthalaldehydic acid with different substituted aniline as well as hydrazine derivatives. J. Heterocyclic Chem., 44: 617-626.
    CrossRef  |  Direct Link  |  

  118. Hassan, S.Y., S.N. Khattab and A. El-Faham, 2007. Microwave synthesis of some 1,2,4-triazole derivatives. Bull. Fac. Sci. Alex. Univ., 45: 49-60.

  119. El-Faham, A. and F. Albericio, 2007. Novel proton acceptor immonium-type coupling reagents: Application in solution and solid-phase peptide synthesis. Org. Lett., 9: 4475-4477.
    CrossRef  |  Direct Link  |  

  120. El‐Faham, A., S.N. Khattab, M. Abdul‐Ghani and F. Albericio, 2006. Design and synthesis of new immonium‐type coupling reagents. Eur. J. Org. Chem., 2006: 1563-1573.
    CrossRef  |  Direct Link  |  

  121. El‐Faham, A., M. Chebbo, M. Abdul‐Ghani and G. Younes, 2006. Chloroformamidinium salts: Efficient reagents for preparation of 2‐aminobenzoimidazole, 2‐aminobenzoxazole and 2‐aminobenzothiazole derivatives. J. Heterocyclic Chem., 43: 599-606.
    CrossRef  |  Direct Link  |  

  122. El-Faham, A., S.N. Khattab and M. Abdul-Ghani, 2006. Tetramethylfluoroformamidinium hexafluorophosphate (TFFH)/ benzyltriphenylphosphonium dihydrogen trifluride (PTF) a unique reagent for the conversion of carboxylic acids to the corresponding alcohols as well as hydroxamic acids. Arkivoc, 13: 57-63.

  123. Khattab, S.N., A.M.M. El Massry, A. El‐Faham, A. Amer and A.A. Bekhit, 2004. Coupling reactions of hydralazine with amino acids and their adducts for antihypertensive activities. J. Heterocyclic Chem., 41: 387-392.
    CrossRef  |  Direct Link  |  

  124. Carpino, L.A., J. Xia, C. Zhang and A. El-Faham, 2004. Organophoshorus and nitro- substituted sulfone esters of 1-hydroxy-7-azabenzotriazole as highly efficient fast-Acting peptide coupling reagents. J. Org. Chem., 69: 69-71.

  125. Carpino, L.A., J. Xia and A. El-Faham, 2004. 3-Hydroxy-4-oxo-3,4-dihydro-5-azabenzo-1,2,3-triazene. J. Org. Chem., 69: 54-61.

  126. Abdul-Ghani, M., S.N. Khattab, A.M. El Massry, A. El-Faham and A. Amer, 2004. A novel and direct method for preparation of 4-amino-1,1,3,3-tetrasubstituted guanidines as well as [1,2,4] triazolo fused heterocyclic derivatives. Org. Prep. Perocd. Int., 36: 121-127.

  127. Subiros‐Funosas, R., A. El‐Faham and F. Albericio, 2003. Low‐epimerization peptide bond formation with oxyma pure: Preparation of Z‐L‐Phg‐Val‐OMe. Org. Syntheses, 90: 306-315.
    CrossRef  |  Direct Link  |  

  128. El-Faham, A. and M. Abdul Ghani, 2003. TFFH: A convenient activator for converting carboxylic acids into acid amides, hydrazides and azides. Org. Prep. Proced. Int., 35: 369-374.

  129. Carpino, L.A., D. Ionescu, A. El-Faham, M. Beyermann and P. Henklein et al., 2003. Complex polyfluoride additives in Fmoc-amino acid fluoride coupling processes. Enhanced reactivity and avoidance of stereomutation. Org. Lett., 5: 975-977.
    CrossRef  |  Direct Link  |  

  130. El-Faham, A., A.M. El Massry, A. Amer and Y.M. Gohar, 2002. A versatile synthetic route to chiral quinoxaline derivatives from amino acids precursors. Lett. Pept. Sci., 9: 49-54.
    CrossRef  |  Direct Link  |  

  131. Carpino, L.A., H. Imazumi, A. El‐Faham, F.J. Ferrer and C. Zhang et al., 2002. The uronium/guanidinium peptide coupling reagents: Finally the true uronium salts. Angewandte Chemie Int. Edn., 41: 441-445.
    CrossRef  |  Direct Link  |  

  132. Carpino, L.A., P. Henklein, B.M. Foxman, I. Abdelmoty and B. Costisella et al., 2001. The solid state and solution structure of HAPyU. J. Org. Chem., 66: 5245-5247.
    CrossRef  |  Direct Link  |  

  133. Khattab, S.N., A. El-Faham, A.M. El-Massry, E.M.E. Mansour and M.A. El-Rahman, 2000. Coupling of iminodiacetic acid with amino acid derivatives in solution and solid phase. Lett. Pept. Sci., 7: 331-345.
    CrossRef  |  Direct Link  |  

  134. El-Faham, A., 2000. Addition of HOXt (X=A or B) improve the effeciency of phenol-based coupling reagents during peptide synthesis. Lett. Pept. Sci., 7: 113-121.

  135. Del Fresno, M., A. El-Faham, L.A. Carpino, M. Royo and F. Albericio, 2000. Substituted guanidines: Introducing diversity in combinatorial chemistry. Org. Lett., 2: 3539-3542.
    CrossRef  |  Direct Link  |  

  136. Carpino, L.A., H. Imazumi, B.M. Foxman, M.J. Vela and P. Henklein et al., 2000. Comparison of the effects of 5- and 6-HOAt on model peptide coupling reactions relative to the cases for the 4- and 7-isomers. Org. Lett., 2: 2253-2256.

  137. Klose, J., A. El-Faham, P. Henklein, L.A. Carpino and M. Bienert, 1999. Addition of HOAt dramatically improves the effectiveness of pentafluorophenyl-based coupling reagents. Tetrahedron Lett., 40: 2045-2048.
    CrossRef  |  Direct Link  |  

  138. Carpino, L.A., M. Ismail, G.A. Truran, E.M.E. Mansour and S. Iguchi t al., 1999. The 1, 1-dioxobenzo[b]thiophene-2-ylmethyloxycarbonyl (Bsmoc) amino-protecting group. J. Org. Chem., 64: 4324-4338.
    CrossRef  |  Direct Link  |  

  139. Carpino, L.A. and A. El-Faham, 1999. The diisopropylcarbodiimide/1-hydroxy-7-azabenzotriazole system: Segment coupling and stepwise peptide assembly. Tetrahedron, 55: 6813-6830.
    CrossRef  |  Direct Link  |  

  140. El-Faham, A., 1998. New syntheses of bis(tetramethylene) fluoroformamidinium hexafluorophosphate (BTFFH) and 1,3-dimethyl-2-fluoro-4,5-dihydro-1H-imidazolium hexafluorophosphate (DFIH). Utility in peptide coupling reactions. Org. Prep. Proced. Int., 30: 477-481.
    CrossRef  |  Direct Link  |  

  141. El-Faham, A., 1998. Bis(tetramethylene)fluoroformamidinium Hexafluoro-phosphate (BTFFH): A convenient coupling reagent in solid phase peptide synthesis. Chem. Lett., 7: 671-672.
    CrossRef  |  Direct Link  |  

  142. Carpino, L.A., D. Ionescu, A. El-Faham, P. Henklein, H. Wenschuh, M. Bienert and M. Beyermann, 1998. Protected amino acid chlorides vs protected amino acid fluorides: Reactivity comparisons. Tetrahedron Lett., 39: 241-244.
    CrossRef  |  Direct Link  |  

  143. Albericio, F., J.M. Bofill, A. El-Faham and S.A. Kates, 1998. Use of onium salt-based coupling reagents in peptide synthesis. J. Org. Chem., 63: 9678-9683.
    CrossRef  |  Direct Link  |  

  144. Carpino, L.A., M. Philbin, M. Ismail, G.A. Truran and E.M.E. Mansour et al., 1997. New family of base-and nucleophile-sensitive amino-protecting groups. A Michael-acceptor-based deblocking process. Practical utilization of the 1,1-dioxobenzo[b]thiophene-2-ylmethyloxycarbonyl (Bsmoc) group. J. Am. Chem. Soc., 119: 9915-9916.
    CrossRef  |  Direct Link  |  

  145. Saad, E.F., E.A. Hamed and A. El-Faham, 1996. Spectral characterization of some phenylazodihydroxy naphthalene derivatives. Spectrosc. Lett., 29: 1047-1065.
    CrossRef  |  Direct Link  |  

  146. Hamed, E.A., A. El-Faham, E.F. Saad and A.A. El-Bardan, 1996. Synthesis and spectral studies of some aryl sulfides and sulfones. Phosphorus Sulfur Silicon Related Elements, 119: 11-26.
    CrossRef  |  Direct Link  |  

  147. El-Faham, A., 1996. Azabenzotriazolyluronium salt as a new coupling reagent in peptide synthesis. Bull. Fac. Sci. Alex. Univ., 36: 73-80.

  148. Carpino, L.A., D. Ionescu and A. El-Faham, 1996. Peptide coupling in the presence of highly hindered tertiary amines. J. Org. Chem., 61: 2460-2465.
    CrossRef  |  Direct Link  |  

  149. Wenschuh, H., M. Beyermann, H. Haber, J.K. Seydel and E. Krause et al., 1995. Stepwise automated solid phase synthesis of naturally occurring peptaibols using Fmoc amino acid fluorides. J. Org. Chem., 60: 405-410.
    CrossRef  |  Direct Link  |  

  150. Wenschuh, H., M. Beyermann, A. El-Faham, S. Ghassemi, L.A. Carpino and M. Bienert, 1995. Peptide assembly in the absence of base via Fmoc amino acid fluorides. J. Chem. Soc. Chem. Commun., 1995: 669-670.
    CrossRef  |  Direct Link  |  

  151. Kassem, A.A., A. El-Faham and H.A. El-Wakil, 1995. Aroylhydrazide and hydrazone derivatives of fluorene-9-yl-derivatives. Int. J. Chem., 6: 5-10.

  152. Carpino, L.A., H.G. Chao, S. Ghassemi, E.M.E. Mansour and C. Riemer et al., 1995. Novel carboxylic acid and carboxamide protective groups based on the exceptional stabilization of the cyclopropylmethyl cation. J. Org. Chem., 60: 7718-7719.
    CrossRef  |  Direct Link  |  

  153. Carpino, L.A., A. El-Faham and F. Albericio, 1995. Efficiency in peptide coupling: 1-Hydroxy-7-azabenzotriazole vs 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine. J. Org. Chem., 60: 3561-3564.
    CrossRef  |  Direct Link  |  

  154. Carpino, L.A. and A. El-Faham, 1995. Tetramethylfluoroformamidinium hexafluoro phosphate: A rapid-acting peptide coupling reagent for solution and solid phase peptide synthesis. J. Am. Chem. Soc., 117: 5401-5402.

  155. Carpino, L.A., A. El-Faham, C.A. Minor and F. Albericio, 1994. Advantageous applications of azabenzotriazole (triazolopyridine)-based coupling reagents to solid-phase peptide synthesis. J. Chem. Soc. Chem. Commun., 1994: 201-203.
    CrossRef  |  Direct Link  |  

  156. Carpino, L.A., A. El-Faham and F. Albericio, 1994. Racemization studies during solid-phase peptide synthesis using azabenzotriazole-based coupling reagents. Tetrahedron Lett., 35: 2279-2282.
    CrossRef  |  Direct Link  |  

  157. Carpino, L.A. and A. El-Faham, 1994. Effect of tertiary bases on O-benzotriazolyluronium salt-induced peptide segment coupling. J. Org. Chem., 59: 695-698.
    CrossRef  |  Direct Link  |  

  158. Carpino, L.A., E.M.E. Mansour and A. El-Faham, 1993. Bis(Boc) amino acid fluorides as reactive peptide coupling reagents. J. Org. Chem., 58: 4162-4164.
    CrossRef  |  Direct Link  |  
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