Dr. Osama Mohamed Ashour Mohamed

Professor
King Abdulaziz University, Saudi Arabia

Highest Degree
Ph.D. in Pharmacology from Minia University, Egypt

My URL
https://livedna.org/20.23857

Share this Profile

Area of Interest:

Pharmacology and Toxicology
Medicine
Drug Delivery
Endocrine Pharmacology
Cardiovascular Pharmacology

Selected Publications

  1. Algandaby, M.M., R.M. Breikaa, B.G. Eid, T.A. Neamatallah, A.B. Abdel-Naim and O.M. Ashour, 2017. Icariin protects against thioacetamide-induced liver fibrosis in rats: Implication of anti-angiogenic and anti-autophagic properties. Pharmacol. Rep., 69: 616-624.
    CrossRef  |  Direct Link  |  

  2. Al-Abd, A.M., A.J. Alamoudi, A.B. Abdel-Naim, T.A. Neamatallah and O.M. Ashour, 2017. Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies-A review. J. Adv. Res., 8: 591-605.
    CrossRef  |  Direct Link  |  

  3. Algandaby, M.M., M.M. Al-Sawahli, O.A.A. Ahmed, U.A. Fahmy and H.M. Abdallah et al., 2016. Curcumin-Zein nanospheres improve liver targeting and antifibrotic activity of curcumin in carbon tetrachloride-induced mice liver fibrosis. J. Biomed. Nanotechnol., 12: 1746-1757.
    CrossRef  |  Direct Link  |  

  4. Algandaby, M.M., A.M. El-Halawany, H.M. Abdallah, A.M. Alahdal, A.A. Nagy, O.M. Ashour and A.B. Abdel-Naim, 2016. Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators. Naunyn-Schmiedeberg's Arch. Pharmacol., 389: 419-428.
    CrossRef  |  Direct Link  |  

  5. Aly, H.A., N.A. El-Shitany, H.A. El-Beshbishy and O.M. Ashour, 2015. Ameliorative effect of lycopene against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced rat liver microsomal toxicity: An in vitro study. Toxicol. Indust. Health, 31: 938-950.
    CrossRef  |  Direct Link  |  

  6. Abdallah, H.M., A.B. Abdel-Naim, O.M. Ashour, I.A. Shehata and E.A. Abdel-Sattar, 2014. Anti-inflammatory activity of selected plants from Saudi Arabia. Zeitschrift fur Naturforschung C, 69: 1-9.
    CrossRef  |  

  7. Elberry, A.A., S.M. Refaie, M. Kamel, T. Ali, H. Darwish and O.M. Ashour, 2013. Oxytocin ameliorates cisplatin-induced nephrotoxicity in Wistar rats. Ann. Saudi Med., 33: 57-62.
    Direct Link  |  

  8. Abdallah, H.M., M.A. Mohamed, A.M. Abdou, M.M. Hamed, A.B. Abdel-Naim and O.M. Ashour, 2013. Protective effect of Centaurea pallescens Del. against CCl4-induced injury on a human hepatoma cell line (Huh7). Med. Chem. Res., 22: 5700-5706.
    CrossRef  |  Direct Link  |  

  9. Ibrahim, S.A., O.M. Ashour, W.Y. Abdel Zahir and H.I. El-Bitar, 2012. Potential interactions between glimepiride and candesartan in alloxan-induced diabetic rats. J. Egypt. Soc. Toxicol., 45: 21-30.

  10. Ashour, O.M., A.B. Abdel-Naim, H.M. Abdallah, A.A. Nagy, A.M. Mohamadin and E.A. Abdel-Sattar, 2012. Evaluation of the potential cardioprotective activity of some Saudi plants against doxorubicin toxicity. Zeitschrift Naturforschung C, 67: 297-307.
    CrossRef  |  Direct Link  |  

  11. Abdel-Sattar, E., S.H. El-Gayed, I. Shehata, O.M. Ashour, A.A. Nagy and A.M. Mohamadin, 2012. Antioxidant and cardioprotective activity of Stachys schimperi Vatke against doxorubicin-induced cardiotoxicity. Bull. Faculty Pharm. Cairo Univ., 50: 41-47.
    CrossRef  |  Direct Link  |  

  12. Ibrahim, M.Y. and O.M. Ashour, 2011. Changes in nitric oxide and free radical levels in rat gastrocnemius muscle during contraction and fatigue. Clin. Exp. Pharmacol. Physiol., 38: 791-795.
    CrossRef  |  Direct Link  |  

  13. Elberry, A.A., S.T. Mufti, J.A. Al-Maghrabi, E.A. Abdel-Sattar, O.M. Ashour, S.A. Ghareib and H.A. Mosli, 2011. Anti-inflammatory and antiproliferative activities of date palm pollen (Phoenix dactylifera) on experimentally-induced atypical prostatic hyperplasia in rats. J. Inflammation, Vol. 8. 10.1186/1476-9255-8-40.
    CrossRef  |  

  14. Ashour, O.M., A.A. Elberry, A.M. Alahdal, A.M. Al Mohamadi and A.A. Nagy et al., 2011. Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats. Med. Sci. Monitor: Int. Med. J. Exp. Clin. Res., 17: BR110-BR115.
    CrossRef  |  Direct Link  |  

  15. Morsy, M.A., O.M. Ashour, A.A. Fouad and S.A. Abdel‐Gaber, 2010. Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin‐induced gastric ulcers in Type 2 diabetic rats. Clin. Exp. Pharmacol. Physiol., 37: 173-177.
    CrossRef  |  Direct Link  |  

  16. Elberry, A.A., A.B. Abdel-Naim, E.A. Abdel-Sattar, A.A. Nagy, H.A. Mosli, A.M. Mohamadin and O.M. Ashour, 2010. Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. Food Chem. Toxicol., 48: 1178-1184.
    CrossRef  |  PubMed  |  Direct Link  |  

  17. Algandaby, M.M., H.A. Alghamdi, O.M. Ashour, A.B. Abdel-Naim, S.A. Ghareib, E.A. Abdel-Sattar and A.S. Hajar, 2010. Mechanisms of the antihyperglycemic activity of Retama raetam in streptozotocin-induced diabetic rats. Food Chem. Toxicol., 48: 2448-2453.
    CrossRef  |  Direct Link  |  

  18. Morsy, M., O. Ashour, E. Amin and R. Rofaeil, 2009. Gastroprotective effects of telmisartan on experimentally-induced gastric ulcers in rats. Die Pharmazie Int. J. Pharm. Sci., 64: 590-594.
    CrossRef  |  Direct Link  |  

  19. Mohamadin, A.M., O.M. Ashour, N.A. El-Sherbeny, A.M. Alahdal, G.M. Morsy and A.B. Abdel-Naim, 2009. Melatonin protects against hydrogen peroxide-induced gastric injury in rats. Clin. Exp. Pharmacol. Physiol., 36: 367-372.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Ibrahim, M.A, O.M. Ashour, Y.F. Ibrahim, H.I. El-Bitar, W. Gomaa and S.R. Abdel-Rahim, 2009. Angiotensin-converting enzyme inhibition and angiotensin AT-receptor antagonism equally improve doxorubicin-induced cardiotoxicity and nephrotoxicity. Pharmacol. Res., 60: 373-381.
    CrossRef  |  Direct Link  |  

  21. Ashour, O.M. and A.S. Sawan, 2009. Celecoxib toxicity on rats' thyroid gland. El-Minia Med. Bull., 20: 26-37.

  22. Ashour, O.M., M.M.A. Khalifa, A.M. Abdelrahman and A.I.M. Geddawy, 2008. Modulation of the pathogenesis of diabetic vascular complications by antioxidants in streptozotocin-induced diabetes in rats. El-Minia Med. Bull., 19: 238-254.

  23. Ismail, H.A.F., M.M.A. Khalifa, M.K. Hassan and O.M. Ashour, 2007. Investigation of the mechanisms underlying the gastroprotective effect of nicorandil. Pharmacology, 79: 76-85.
    CrossRef  |  Direct Link  |  

  24. Ismail, H.A.F., M.M.A. Khalifa, M.K. Hassan and O.M. Ashour, 2007. Insights in the mechanisms underlying the anti-ulcer activity of nicorandil. Die Pharmazie Int. J. Pharm. Sci., 62: 60-66.
    CrossRef  |  Direct Link  |  

  25. Ashour, O.M., A.A. Fouad, M.Y. Kamel and H.I. El-Bitar, 2007. Therapeutic potential of vitamin E and Panax ginseng in experimentally-induced Alzheimer's disease model in rabbits. Alex J. Pharm. Sci., 21: 87-92.

  26. Khalifa, M.M.A., O.M. Ashour, A.M. Abdelrahman, A.A. Fouad and E.F. Amin, 2006. Evaluation of systemic effects of ophthalmic instillation of timolol, betaxolol and carteolol for six weeks in rabbits. Alex J. Pharm. Sci., 20: 137-141.

  27. El-Sayed, S.E.D. and O.M. Ashour, 2005. Possible interaction between nitric oxide modulators and calcium channel blockers in indomethacin-induced gastric ulcer in rats. Bull. Egypt. Soc. Physiol. Sci., 25: 359-378.

  28. Khalifa, M.A., M.K.A. Hassan, O.M. Ashour and G.H. Heeba, 2002. Evaluation of the anti-ulcer activity of pibutidine hydrochloride (IT-066); the new histamine H2-receptor antagonist, in cold-restraint stress- and ethanol-induced ulcer models in rats. El-Azhar Med. J., 31: 33-47.

  29. Abdelrahman, A.M., A.A. Fouad and O.M. Ashour, 2002. Effect of intravenous anesthetics on endothelium-dependent vasodilatation in intact rats. Bull. Alex Fac. Med., 38: 107-111.

  30. Abdel-Ali, S.A., O.M. Ashour and A.B.T.A. Abdel-Haleem, 2002. Possible interactions between gentamicin, cefotaxime, ofloxacin and metronidazole with some non-depolarizing neuromuscular blocking drugs on rat phrenic nerve-hemidiaphragm preparation. Al-Azhar Med. J., 31: 394-405.

  31. Rizk, H.A. and O.M. Ashour, 2001. Rapid colorimetric methods for determining drugs resistance of Mycobacterium tuberculosis in liquid medium. Egypt. J. Med. Microbiol., 10: 781-788.

  32. Ashour, O.M., O.N. Al Safarjalani, F.N. Naguib, N.M. Goudgaon, R.F. Schinazi and M.H. El Kouni, 2000. Modulation of plasma uridine concentration by 5-(phenylselenenyl) acyclouridine, an inhibitor of uridine phosphorylase: Relevance to chemotherapy. Cancer Chemotherapy Pharmacol., 45: 351-361.
    CrossRef  |  Direct Link  |  

  33. Ashour, O.M., F.N. Naguib, R.P. Panzica, O.N. Al Safarjalani and M.H. El Kouni, 2000. Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl) barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor and 2′, 3′, 5′-tri-O-acetyluridine, a prodrug of uridine. Biochem. Pharmacol., 60: 427-431.
    CrossRef  |  Direct Link  |  

  34. Ashour, O.M., F.N. Naguib, N.M. Goudgaon, R.F. Schinazi and M.H. El Kouni, 2000. Effect of administration of 5-(phenylselenenyl) acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2′-deoxyuridine against murine colon tumor C26-10. Biochem. Pharmacol., 60: 687-692.
    CrossRef  |  Direct Link  |  

  35. Ashour, O.M., F.N. Naguib, N.M. Goudgaon, R.F. Schinazi and M.H. El Kouni, 2000. Effect of 5-(phenylselenenyl) acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2′, 3′, 5′-tri-O-acetyluridine, a prodrug of uridine: Relevance to uridine rescue in chemotherapy. Cancer Chemotherapy Pharmacol., 46: 235-240.
    CrossRef  |  Direct Link  |  

  36. Khalifa, M.M.A., M.K.A. Hassan, O.M. Ashour and A.B.T.A. Abdel-Haleem, 1999. Lipid peroxidation and atherosclerosis: Effect of calcium channel blockers and angiotensin converting enzyme inhibitors. J. Egypt. Soc. Toxicol., 21: 1-8.

  37. Ibrahim, I.Y., S.M. Abdel-Hakim, M.K.A. Hassan and O.M. Ashour, 1999. Effect of modulation of nitric oxide and prostaglandin synthesis on the development of experimental gastric ulcers in rats. Bull. Egypt. Soc. Physiol. Sci., 19: 151-166.

  38. Abdel-Hakim, S.M. and O.M. Ashour, 1999. Differential protective effect of melatonin against experimentally-induced gastric mucosal injury in rats. Bull. Egypt. Soc. Physiol. Sci., 19: 168-179.

  39. Ashour, O.M., S.M. Abdel-Hakim and H.M. Abdel-Hafiz, 1998. Effect of the alkali metals: Lithium, cesium and rubidium, on serum glucose level and the role of adrenoceptor antagonism in modulating such effects in male albino rats. Al-Azhar Med. J., 27: 571-585.

  40. Ashour, O.M., M.M.A. Khalifa, M.H. Abdel-Raheem and M.H. El Kouni, 1997. Evaluation of 5-(phenylselenenyl)acyclouridine (PSAU), a novel uridine phosphorylase inhibitor. Ass. Med. J., 21: 31-55.

  41. Ashour, O.M., F.N. Naguib and M.H. El Kouni, 1996. 5-(m-Benzyloxybenzyl) barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor and 2′, 3′, 5′-tri-o-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration: Implications for chemotherapy. Biochem. Pharmacol., 51: 1601-1611.
    CrossRef  |  Direct Link  |  

  42. Ashour, O.M., F.N. Naguib, M.M. Khalifa, M.H. Abdel-Raheem, R.P. Panzica and M.H. El Kouni, 1995. Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl) barbituric acid acyclonucleoside. Cancer Res., 55: 1092-1098.
    Direct Link  |  
Member since April, 2018