Dr. Ashraf B. Abdel-Naim

Professor
King Abdulaziz University, Saudi Arabia

Highest Degree
Ph.D. in Pharmacology from Al-Azhar University, Egypt

My URL
https://livedna.org/20.23863

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Area of Interest:

Pharmacology and Toxicology
Pharmaceutical Sciences
Drug Analysis
Prostatic Disease Research
Drug Toxicity

Selected Publications

  1. Shoieb, S.M., A. Esmat, A.E. Khalifa and A.B. Abdel-Naim, 2018. Chrysin attenuates testosterone-induced benign prostate hyperplasia in rats. Food Chem. Toxicol., 111: 650-659.
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  2. Sallam, A.M., A. Esmat and A.B. Abdel‐Naim, 2018. Cucurbitacin‐B attenuates CCI4‐induced hepatic fibrosis in mice through inhibition of STAT‐3. Chem. Biol. Drug Des., 91: 933-941.
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  3. Ezzat, S.M., M.I. Ezzat, M.M. Okba, E.T. Menze and A.B. Abdel-Naim, 2018. The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity. J. Ethnopharmacol., 214: 113-123.
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  4. Abdel-Aziz, A.K., A.B. Abdel-Naim, S. Shouman, S. Minucci and M. Elgendy, 2018. From resistance to sensitivity: Insights and implications of biphasic modulation of autophagy by sunitinib. Front. Pharmacol., Vol. 8. 10.3389/fphar.2017.00718.
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  5. Sobah, T.R.A., S.N. Ayyad, A. Abdel-Lateff, M.M. Algandaby, H.S. Alorfi and A.B. Abdel-Naim, 2017. Cytotoxic metabolites from Callyspongia siphonella display antiproliferative activity by inducing apoptosis in HCT-116 cells. Pharmacogn. Magaz., 13: S37-S40.

  6. Algandaby, M.M., R.M. Breikaa, B.G. Eid, T.A. Neamatallah, A.B. Abdel-Naim and O.M. Ashour, 2017. Icariin protects against thioacetamide-induced liver fibrosis in rats: Implication of anti-angiogenic and anti-autophagic properties. Pharmacol. Rep., 69: 616-624.
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  7. Al-Abd, A.M., A.J. Alamoudi, A.B. Abdel-Naim, T.A. Neamatallah and O.M. Ashour, 2017. Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies-A review. J. Adv. Res., 8: 591-605.
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  8. Abdel-Naim, A.B., A.A. Alghamdi, M.M. Algandaby, F.A. Al-Abbasi and A.M. Al-Abd et al., 2017. Phenolics isolated from Aframomum meleguta enhance proliferation and ossification markers in bone cells. Molecules, Vol. 22. 10.3390/molecules22091467.
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  9. Abdel-Lateff, A., W.M. Alarif, S.S. Al-Lihaibi and A.B. Abdel-Naim, 2017. Antiproliferative effects of selected marine organisms collected from Red Sea. Pak. J. Pharm. Sci., 30: 381-386.

  10. Youssef, M.M., M.F. Tolba, N.N. Badawy, A.W. Liu and E. El-Ahwany et al., 2016. Novel combination of sorafenib and biochanin-A synergistically enhances the anti-proliferative and pro-apoptotic effects on hepatocellular carcinoma cells. Sci. Rep., Vol. 6. 10.1038/srep30717.
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  11. Tolba, M.F., H.A. Omar, S.S. Azab, A.E. Khalifa, A.B. Abdel-Naim and S.Z. Abdel-Rahman, 2016. Caffeic acid phenethyl ester: A review of its antioxidant activity, protective effects against ischemia-reperfusion injury and drug adverse reactions. Crit. Rev. Food Sci. Nutr., 56: 2183-2190.
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  12. Menze, E.T., A. Esmat, M.G. Tadros, A.E. Khalifa and A.B. Abdel-Naim, 2016. Genistein improves sensorimotor gating: Mechanisms related to its neuroprotective effects on the striatum. Neuropharmacology, 105: 35-46.

  13. Khaleel, S.A., A.M. Al-Abd, A.A. Ali and A.B. Abdel-Naim, 2016. Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity. Sci. Rep., Vol. 6. 10.1038/srep36855.
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  14. Breikaa, R.M., H.A. Mosli and A.B. Abdel-Naim, 2016. Influence of onabotulinumtoxin A on testes of the growing rat. J. Biochem. Mol. Toxicol., 30: 608-613.
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  15. Attia, R.T., M.F. Tolba, R. Trivedi, M.G. Tadros, H.M. Arafa and A.B. Abdel-Naim, 2016. The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells. PeerJ., Vol. 4. 10.7717/peerj.2168.
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  16. Ashmawy, N.S., M.L. Ashour, M. Wink, M. El-Shazly and F.R. Chang et al., 2016. Polyphenols from Erythrina crista-galli: structures, molecular docking and phytoestrogenic activity. Molecules, Vol. 21. 10.3390/molecules21060726.
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  17. Algandaby, M.M., M.M. Al-Sawahli, O.A.A. Ahmed, U.A. Fahmy and H.M. Abdallah et al., 2016. Curcumin-Zein nanospheres improve liver targeting and antifibrotic activity of curcumin in carbon tetrachloride-induced mice liver fibrosis. J. Biomed. Nanotechnol., 12: 1746-1757.
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  18. Algandaby, M.M., A.M. El-Halawany, H.M. Abdallah, A.M. Alahdal, A.A. Nagy, O.M. Ashour and A.B. Abdel-Naim, 2016. Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators. Naunyn-Schmiedeberg's Arch. Pharmacol., 389: 419-428.
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  19. Abdel-Lateff, A., A.M. Al-Abd, A.M. Alahdal, W.M. Alarif and S.E.N. Ayyad et al., 2016. Antiproliferative effects of triterpenoidal derivatives, obtained from the marine sponge Siphonochalina sp., on human hepatic and colorectal cancer cells. Zeitschrift fur Naturforschung C, 71: 29-35.
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  20. Abdel-Latif G.A., A.M. Al-Abd, M.G. Tadros, F.A. Al-Abbasi, A.E. Khalifa, et al ., 2015,. The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Sci. Rep., 10.1038/srep12054.
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  21. Seida, A., H. El-Hefnawy, D. Abou-Hussein, F.A. Mokhtar and A. Abdel-Naim, 2015. Evaluation of Medicago sativa L. sprouts as antihyperlipidemic and antihyperglycemic agent. Pak. J. Pharm. Sci., 28: 2061-2074.
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  22. Mosli, H.H., A. Esmat, R.T. Atawia, S.M. Shoieb, H.A. Mosli and A.B. Abdel-Naim, 2015. Metformin attenuates testosterone-induced prostatic hyperplasia in rats: A pharmacological perspective. Sci. Rep., Vol. 5. 10.1038/srep15639.
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  23. Menze, E.T., A. Esmat, M.G. Tadros, A.B. Abdel-Naim and A.E. Khalifa, 2015. Genistein improves 3-NPA-induced memory impairment in ovariectomized rats: Impact of its antioxidant, anti-inflammatory and acetylcholinesterase modulatory properties. PLoS One, Vol. 10. 10.1371/journal.pone.0117223.
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  24. Mahran, Y.F., E. El-Demerdash, A.S. Nada, R.N. El-Naga, A.A. Ali and A.B. Abdel-Naim, 2015. Growth hormone ameliorates the radiotherapy-induced ovarian follicular loss in rats: Impact on oxidative stress, apoptosis and IGF-1/IGF-1R axis. PLoS One, Vol. 10. 10.1371/journal.pone.0140055.
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  25. Habib, C.N., A.M. Al-Abd, M.F. Tolba, A.E. Khalifa, A. Khedr, H.A. Mosli and A.B. Abdel-Naim, 2015. Leptin influences estrogen metabolism and accelerates prostate cell proliferation. Life Sci., 121: 10-15.
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  26. Ammar, A.E., A. Esmat, M.D. Hassona, M.G. Tadros, A.B. Abdel-Naim and E.S.T. Guns, 2015. The effect of pomegranate fruit extract on testosterone‐induced BPH in rats. Prostate, 75: 679-692.
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  27. Abdel-Monem, A.R., Z.A. Kandil, A.B. Abdel-Naim and E. Abdel-Sattar, 2015. A new triterpene and protective effect of Periploca somaliensis Browicz fruits against CCl4-induced injury on human hepatoma cell line (Huh7). Nat. Prod. Res., 29: 423-429.
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  28. Abdallah, H.M., M.A. Farag, A.B. Abdel‐Naim, S.A. Ghareib and E.A. Abdel‐Sattar, 2015. Mechanistic evidence of Viscum schimperi (Viscaceae) antihyperglycemic activity: From a bioactivity‐guided approach to comprehensive metabolite profiling. Phytother. Res., 29: 1737-1743.
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  29. Mahdy, H.M., M.R. Mohamed, M.A. Emam, A.M. Karim, A.B. Abdel-Naim and A.E. Khalifa, 2014. Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: Possible neuromodulation and antioxidant mechanisms. Neurochem. Res., 39: 321-332.
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  30. Mahdy, H.M., M.R. Mohamed, M.A. Emam, A.M. Karim, A. Abdel-Naim and A.E. Khalifa, 2014. The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats. Can. J. Physiol. Pharmacol., 92: 252-258.
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  31. Breikaa, R.M., H.A. Mosli, A.A. Nagy and A.B. Abdel-Naim, 2014. Adverse testicular effects of Botox® in mature rats. Toxicol. Applied Pharmacol., 275: 182-188.
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  32. Atawia, R.T., H.H. Mosli, M.G. Tadros, A.E. Khalifa, H.A. Mosli and A.B. Abdel-Naim, 2014. Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: Emphasis on PTEN, HIF-1α and NF-κB. Naunyn-Schmiedeberg's Arch. Pharmacol., 387: 1131-1140.
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  33. Al-Lihaibi, S.S., W.M. Alarif, A. Abdel-Lateff, S.E.N. Ayyad, A.B. Abdel-Naim, F.F. El-Senduny and F.A. Badria, 2014. Three new cembranoid-type diterpenes from Red Sea soft coral Sarcophyton glaucum: Isolation and antiproliferative activity against HepG2 cells. Eur. J. Med. Chem., 81: 314-322.
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  34. Al-Abd, A.M., F.A. Al-Abbasi, S.M. Nofal, A.E. Khalifa and R.O. Williams et al., 2014. Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis. PLoS ONE, Vol. 9. 10.1371/journal.pone.0111843.
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  35. Ahmed, O.A., M.I. Afouna, K.M. El-Say, A.B. Abdel-Naim, A. Khedr and Z.M. Banjar, 2014. Optimization of self-nanoemulsifying systems for the enhancement of in vivo hypoglycemic efficacy of glimepiride transdermal patches. Expert Opin. Drug Deliv., 11: 1005-1013.
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  36. Abdel-Aziz, A.K., S. Shouman, E. El-Demerdash, M. Elgendy and A.B. Abdel-Naim, 2014. Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries. Chem.-Biol. Interact., 217: 28-40.
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  37. Abdallah, H.M., A.M. Al-Abd, G.F. Asaad, A.B. Abdel-Naim and A.M. El-Halawany, 2014. Isolation of antiosteoporotic compounds from seeds of Sophora japonica. PLoS ONE, Vol. 9. 10.1371/journal.pone.0098559.
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  38. Abdallah, H.M., A.B. Abdel-Naim, O.M. Ashour, I.A. Shehata and E.A. Abdel-Sattar, 2014. Anti-inflammatory activity of selected plants from Saudi Arabia. Zeitschrift fur Naturforschung C, 69: 1-9.
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  39. Tolba, M.F., S.S. Azab, A.E. Khalifa, S.Z. Abdel‐Rahman and A.B. Abdel‐Naim, 2013. Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: A review on its anti‐inflammatory, neuroprotective, hepatoprotective and cardioprotective effects. IUBMB Life, 65: 699-709.
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  40. Tolba, M.F., A. Esmat, A.M. Al‐Abd, S.S. Azab and A.E. Khalifa t al., 2013. Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells. IUBMB Life, 65: 716-729.
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  41. Nawwar, M., N. Swilam, A. Hashim, A. Al-Abd, A. Abdel-Naim and U. Lindequist, 2013. Cytotoxic isoferulic acidamide from Myricaria germanica (Tamaricaceae). Plant Signal. Behav., Vol. 8. 10.4161/psb.22642.
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  42. Mosli, H.A., M.F. Tolba, A.M. Al-Abd and A.B. Abdel-Naim, 2013. Catechol estrogens induce proliferation and malignant transformation in prostate epithelial cells. Toxicol. Lett., 220: 247-258.
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  43. Michel, H.E., M.G. Tadros, A.B. Abdel-Naim and A.E. Khalifa, 2013. Prepulse inhibition (PPI) disrupting effects of Glycyrrhiza glabra extract in mice: A possible role of monoamines. Neurosci. Lett., 544: 110-114.
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  44. Mahran, Y.F., E. El-Demerdash, A.S. Nada, A.A. Ali and A.B. Abdel-Naim, 2013. Insights into the protective mechanisms of tamoxifen in radiotherapy-induced ovarian follicular loss: Impact on insulin-like growth factor 1. Endocrinology, 154: 3888-3899.
    CrossRef  |  Direct Link  |  

  45. Breikaa, R.M., M.M. Algandaby, E. El-Demerdash and A.B. Abdel-Naim, 2013. Multimechanistic antifibrotic effect of biochanin a in rats: Implications of proinflammatory and profibrogenic mediators. PLoS One, Vol. 8. 10.1371/journal.pone.0069276.
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  46. Breikaa, R.M., M.M. Algandaby, E. El-Demerdash and A.B. Abdel-Naim, 2013. Biochanin A protects against acute carbon tetrachloride-induced hepatotoxicity in rats. Biosci. Biotechnol. Biochem., 77: 909-916.
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  47. Atawia, R.T., M.G. Tadros, A.E. Khalifa, H.A. Mosli and A.B. Abdel-Naim, 2013. Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats. Toxicol. Lett., 219: 160-169.
    CrossRef  |  Direct Link  |  

  48. Al-Abd, A.M., F.A. Al-Abbasi, G.F. Asaad and A.B. Abdel-Naim, 2013. Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity. Eur. J. Pharmacol., 718: 361-369.
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  49. Abdou, A.M., H.M. Abdallah, M.A. Mohamed, G.A. Fawzy and A.B. Abdel-Naim, 2013. A new anti-inflammatory triterpene saponin isolated from Anabasis setifera. Arch. Pharm. Res., 36: 715-722.
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  50. Abdel-Sattar, E.A., H.M. Abdallah, A. Khedr, A.B. Abdel-Naim and I.A. Shehata, 2013. Antihyperglycemic activity of Caralluma tuberculata in streptozotocin-induced diabetic rats. Food Chem. Toxicol., 59: 111-117.
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  51. Saeed, N.M., E. El-Demerdash, H.M. Abdel-Rahman, M.M. Algandaby, F.A. Al-Abbasi and A.B. Abdel-Naim, 2012. Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models. Toxicol. Appl. Pharmacol., 264: 84-93.
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  52. Mosli, H.A., A.M. Al-Abd, M.A. El-Shaer, A. Khedr, F.S. Gazzaz and A.B. Abdel-Naim, 2012. Local inflammation influences oestrogen metabolism in prostatic tissue. BJU Int., 110: 274-282.
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  53. Hamdy, N.M., F.A. Al-Abbasi, H.A. Alghamdi, M.F. Tolba, A. Esmat and A.B. Abdel-Naim, 2012. Role of neutrophils in acrylonitrile-induced gastric mucosal damage. Toxicol. Lett., 208: 108-114.
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  54. Esmat, A., F.A. Al-Abbasi, M.M. Algandaby, A.Y. Moussa, R.M. Labib, N.A. Ayoub and A.B. Abdel-Naim, 2012. Anti-inflammatory activity of Pistacia khinjuk in different experimental models: Isolation and characterization of its flavonoids and galloylated sugars. J. Med. Food, 15: 278-287.
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  55. Esmat, A., A.I. Ghoneim, E. El-Demerdash, A.E. Khalifa and A.B. Abdel-Naim, 2012. Dichloroacetonitrile induces oxidative stress and developmental apoptotic imbalance in mouse fetal brain. Environ. Toxicol. Pharmacol., 33: 78-84.
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  56. Ashour, O.M., A.B. Abdel-Naim, H.M. Abdallah, A.A. Nagy, A.M. Mohamadin and E.A. Abdel-Sattar, 2012. Evaluation of the potential cardioprotective activity of some Saudi plants against doxorubicin toxicity. Zeitschrift Naturforschung C, 67: 297-307.
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  57. Ashour, O.M., A.A. Elberry, A.M. Alahdal, A.M. Al Mohamadi and A.A. Nagy et al., 2011. Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats. Med. Sci. Monitor: Int. Med. J. Exp. Clin. Res., 17: BR110-BR115.
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  58. Mohamadin, A.M. and A.B. Abdel-Naim, 2010. In vitro activation of dibromoacetonitrile to cyanide: Role of xanthine oxidase. Toxicokinetics Metab., 77: 86-93.
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  59. Elberry, A.A., A.B. Abdel-Naim, E.A. Abdel-Sattar, A.A. Nagy, H.A. Mosli, A.M. Mohamadin and O.M. Ashour, 2010. Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. Food Chem. Toxicol., 48: 1178-1184.
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  60. El-Beshbishy, H.A., A.M. Mohamadin, A.A. Nagy and A.B. Abdel-Naim, 2010. Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin. Indian J. Exp. Biol., 48: 280-288.
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  61. Aly, H.A.A., A.M. Mansour, O.M.A. Salem, H.F. Abd-Ellah and A.B. Abdel-Naim, 2010. Potential testicular toxicity of sodium nitrate in adult rats. Food Chem. Toxicol., 48: 572-578.
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  62. Algandaby, M.M., H.A. Alghamdi, O.M. Ashour, A.B. Abdel-Naim, S.A. Ghareib, E.A. Abdel-Sattar and A.S. Hajar, 2010. Mechanisms of the antihyperglycemic activity of Retama raetam in streptozotocin-induced diabetic rats. Food Chem. Toxicol., 48: 2448-2453.
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  63. Al-Abd, A.M., J.J. Inglis, S.M. Nofal, A.E. Khalifa, R.O. Williams, W.I. El-Eraky and A.B. Abdel-Naim, 2010. Nimesulide improves the disease modifying anti-rheumatic profile of methotrexate in mice with collagen-induced arthritis. Eur. J. Pharmacol., 644: 245-250.
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  64. Afouna, M.I., A. Khedr, A.B. Abdel-Naim and A. Al-Marzoqi, 2010. Influence of various concentrations of terpene-4-ol enhancer and carbopol-934 mucoadhesive upon the in vitro ocular transport and the in vivo intraocular pressure lowering effects of dorzolamide ophthalmic formulations using albino rabbits. J. Pharm. Sci., 99: 119-127.
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  65. Adel, M., H.A.S. Awad, A.B. Abdel‐Naim and M.M.M. Al‐Azizi, 2010. Effects of pentoxifylline on coagulation profile and disseminated intravascular coagulation incidence in Egyptian septic neonates. J. Clin. Pharm. Ther., 35: 257-265.
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  66. Nasralla, S.N., A.I. Ghoneim, A.E. Khalifa, M.Z. Gad and A.B. Abdel-Naim, 2009. Lactoperoxidase catalyzes in-vitro activation of acrylonitrile to cyanide. Toxicol. Lett., 191: 347-352.
    PubMed  |  

  67. Mohamadin, A.M., O.M. Ashour, N.A. El-Sherbeny, A.M. Alahdal, G.M. Morsy and A.B. Abdel-Naim, 2009. Melatonin protects against hydrogen peroxide-induced gastric injury in rats. Clin. Exp. Pharmacol. Physiol., 36: 367-372.
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  68. El Naga, R.N.A., E. El-Demerdash, S.S. Youssef, A.B. Abdel-Naim and M. El-Merzabani, 2009. Cytotoxic effects of 2-methoxyestradiol in the hepatocellular carcinoma cell line HepG2. Pharmacology, 84: 9-16.
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  69. Badr, A.M., E. El‐Demerdash, A.E. Khalifa, A.I. Ghoneim, N.A.Ayoub and A.B. Abdel‐Naim, 2009. Rubus sanctus protects against carbon tetrachloride‐induced toxicity in rat isolated hepatocytes: Isolation and characterization of its galloylated flavonoids. J. Pharm. Pharmacol., 61: 1511-1520.
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  70. Azab, S.S., S.A. Salama, A.B. Abdel-Naim, A.E. Khalifa, E. El-Demerdash and A. Al-Hendy, 2009. 2-Methoxyestradiol and multidrug resistance: Can 2-methoxyestradiol chemosensitize resistant breast cancer cells? Breast Cancer Res. Treat., 113: 9-19.
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  71. Aly, H.A., O. Domenech and A.B. Abdelnaim, 2009. Aroclor 1254 impairs spermatogenesis and induces oxidative stress in rat testicular mitochondria. Food Chem. Toxicol., 47: 1733-1738.

  72. Albukhari, A.A., H.M. Gashlan, H.A. El-Beshbishy, A.A. Nagy and A.B. Abdel-Naim, 2009. Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats. Food Chem. Toxicol., 47: 1689-1695.
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  73. Abdel-Naim, A.B., A.A. Nagy, A.M. Mohamadin, H.M. El-Mazar and A.E. Ahmed, 2009. Chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal liver. Toxicol. Lett., 190: 123-127.
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  74. Khedr, A., M. Moustafa, A.B. Abdel-Naim, A. Alahdal and H. Mosli, 2008. High-performance liquid chromatographic method for determination of phenytoin in rabbits receiving sildenafil. Anal. Chem. Insights, 3: 61-67.
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  75. Azab, S.S., S.A. Salama, M.H. Hassan, A.E. Khalifa and E. El-Demerdash et al., 2008. 2-Methoxyestradiol reverses doxorubicin resistance in human breast tumor xenograft. Cancer Chemother. Pharmacol., 62: 893-902.
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  76. Ahmed, A.E., S. Jacob, A.A. Nagy and A.B. Abdel-Naim, 2008. Dibromoacetonitrile-induced protein oxidation and inhibition of proteasomal activity in rat glioma cells. Toxicol. Lett., 179: 29-33.
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  77. Ahmed, A.E., H.M. El-Mazar, A.A. Nagy and A.B. Abdel-Naim, 2008. Chloroacetonitrile induces intrauterine growth restriction and musculoskeletal toxicity in fetal mouse. Toxicol. Ind. Health, 24: 511-518.
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  78. Esmat, A., E. El-Demerdash, H. El-Mesallamy and A.B. Abdel-Naim, 2007. Toxicity and oxidative stress of acrylonitrile in rat primary glial cells: Preventive effects of N-acetylcysteine. Toxicol. Lett., 171: 111-118.
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  79. Tadros, M.G., A.E. Khalifa, A.B. Abdel-Naim and H.M. Arafa, 2005. Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype. Pharmacol. Biochem. Behav., 82: 574-582.
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  80. Mohamadin, A.M., E. El-Demerdash, H.A. El-Beshbishy and A.B. Abdel-Naim, 2005. Acrylonitrile-induced toxicity and oxidative stress in isolated rat colonocytes. Environ. Toxicol. Pharmacol., 19: 371-377.
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  81. Habashy, R.R., A.B. Abdel-Naim, A.E. Khalifa and M.M. Al-Azizi, 2005. Anti-inflammatory effects of jojoba liquid wax in experimental models. Pharmacol. Res., 51: 95-105.
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  82. Abdel-Naim, A.B. and A.M. Mohamadin, 2004. Myeloperoxidase-catalyzed oxidation of chloroacetonitrile to cyanide. Toxicol. Lett., 146: 249-257.
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  83. Salama, S.A., W.W. Au, G.C. Hunter, R.G. Sheahan, O.A. Badary, A.B. Abdel‐Naim and F. Hamada, 2002. Polymorphic metabolizing genes and susceptibility to atherosclerosis among cigarette smokers. Environ. Mol. Mutagenesis, 40: 153-160.
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  84. Mohamadin, A.M., S.S. Ali, O.S. El-Tawil and A.B. Abdel-Naim, 2002. Bromobenzene-induced cytotoxicity and oxidative stress in isolated rat hepatocytes. J. Egypt. Soc. Toxicol., 27: 23-29.

  85. Ghoneim, A.I., A.B. Abdel-Naim, A.E. Khalifa and E.S. El-Denshary, 2002. Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Phamacol. Res., 46: 273-279.
    PubMed  |  

  86. Arafa, H.M.M., A.M. Mansour and A.B. Abdel-Naim, 2002. Pharmacokinetic disposition of meloxicam in male rabbit plasma. Egypt. J. Biomed. Sci., 9: 289-299.

  87. Abdel-Wahab, M.H., H.M. Arafa, M.A. El-Mahdy and A.B. Abdel-Naim, 2002. Potential protective effect of melatonin against dibromoacetonitrile-induced Pharmacol. Res., 46: 287-293.
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  88. Badary, O.A., A.B. Abdel-Naim, M.H. Abdel-Wahab and F.M. Hamada, 2000. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology, 143: 219-226.
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  89. Badary, O.A., A.B. Abdel-Naim, A.E. Khalifa and F.M. Hamada, 2000. Differential alteration of cisplatin cytotoxicity and myelotoxicity by the paclitaxel vehicle cremophor EL. Naunyn-Schmiedeberg's Arch. Pharmacol., 361: 339-344.
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  90. Abdel-Naim, A.B. and A.M. Mohamadin, 2000. Role of xanthine oxidase in gastric damadge induced by chloroacetonitrile in rats. J. Egypt. Soc. Toxicol., 22: 19-25.

  91. Mostafa, A.M., A.B. Abdel-Naim, O. Abo-Salem, A.H. Abdel-Aziz and F.M.A. Hamada, 1999. Renal metabolism of acrylonitrile to cyanide: In vitro studies. Pharmacol. Res., 40: 195-200.
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  92. Mohamadin, A.M. and A.B. Abdel-Naim, 1999. Chloroacetonitrile-induced toxicity and oxidative stress in rat gastric epithelial cells. Pharmacol. Res., 40: 377-383.
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  93. Ahmed, S.H. and A.B. Abdel-Naim, 1999. Effects of guar gum and soybean dietary fiber on the control of glucose and lipid metabolism in normal and diabetic rats: A comparative study. Arab J. Biotechnol., 2: 219-226.
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  94. Abdel-Naim, A.B., M.H. Abdel-Wahab and F.F. Attia, 1999. Protective effects of vitamin E and probucol against GM-induced nephrotoxicity in rats. Pharmacol. Res., 40: 183-187.
    PubMed  |  

  95. Abdel-Naim, A.B., A.M. Gamal El-Din and O.A. Badary, 1999. Induction of oxidative stress in mouse stomach by dibromoacetonitrile. J. Egypt. Soc. Toxicol., 21: 85-90.

  96. El-Tawil, O.S. and A.B. Abdel-Naim, 1998. Toxicity of acrylonitrile on isolated rat hepatocytes: Role of hepatic bioactivation. J. Egypt. Soc. Toxicol., 20: 27-32.

  97. Abdel-Aziz, A.H., A.B. Abdel-Naim, F.M. Hamada and A.E. Ahmed, 1997. In-vitro testicular bioactivation of acrylonitrile. Pharmacol. Res., 35: 129-134.
    CrossRef  |  Direct Link  |  

  98. Abd Allah, A.R., A.B. Abdel-Naim, F.M.A. Hamada, S. Jacob and E.A. Ahmed, 1997. Species differences in acrylonitrile disposition: Whole body autoradiographic study in rats and mice. J. Egypt. Soc. Toxicol., 19: 43-48.

  99. Ahmed, A.E., F.M.A. Hamada, A.H. Abdel-Aziz and A.B. Abdel-Naim, 1993. Evaluation of acrylonitrile toxicity in the rat. Egypt. J. Med. Sci., 14: 427-441.

  100. Hamada, F.M.A., A.H. Abdel-Aziz, A.M. Mostafa, M.S. El-Ficky and A.B. Abdel-Naim, 1992. A new therapeutic use of allopurinol: The drug protects the gastric mucosa from the ulcerogenic effect of alcohol. Arab J. Lab. Med., 18: 283-292.

  101. Hamada, F.M.A., A.H. Abdel-Aziz, M.M. El-Hamouly, M.S. El-Ficky and A.B. Abdel-Naim, 1991. The protective effects of Cucurbita foetidissima HBK root extract against ethanol-induced gastric ulceration in rats. Egypt. J. Med. Sci., 12: 573-587.
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