Dr. Gamal Abd-Elmegeed Abd-Elghany Aly

Professor
National Research Centre, Egypt

Highest Degree
Ph.D. in Science from Cairo University, Egypt

My URL
https://livedna.org/20.28357

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Area of Interest:

Biomedical Sciences
Medicinal Chemistry
Antioxidant Agents
Hormones
Anticancer Activity

Selected Publications

  1. Nafie, M.S., M.A. Tantawy and G.A. Elmgeed, 2019. Screening of different drug design tools to predict the mode of action of steroidal derivatives as anti-cancer agents. Steroids, Vol. 152. 10.1016/j.steroids.2019.108485.
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  2. El-Kady, D.S., A.A. Abd Rabou, M.A. Tantawy, A.A.H. Abdel-Rahman, A.A.S. Abdel-Megeed, M.M. AbdElhalim and G.A. Elmegeed, 2019. Synthesis and evaluation of novel cholestanoheterocyclic steroids as anticancer agents. Applied Biochem. Biotechnol., 188: 635-662.
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  3. Yahya, S.M., G.A. Elmegeed, M.S. Mohamed, R.M. Mohareb, M.M. Abd-Elhalim and G.H. Elsayed, 2018. The effect of newly synthesized heterosteroids on mirna34a, 98, and 214 expression levels in mcf-7 breast cancer cells. Indian J. Clin. Biochem., 33: 328-333.
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  4. Elhinnawi, M.A., R.M. Mohareb, H.M. Rady, W.K. Khalil, M.M.A. Elhalim and G.A. Elmegeed, 2018. Novel pregnenolone derivatives modulate apoptosis via Bcl-2 family genes in hepatocellular carcinoma in vitro. J. Steroid Biochem. Mol. Biol., 183: 125-136.
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  5. Tantawy, M.A., M.S. Nafie, G.A. Elmegeed and I.A.I. Ali, 2017. Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs. Bioorg. Chem., 73: 128-146.
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  6. Elhalim, M.M.A., N.S. Ismail, S.M. Yahya, Y.Y. Omar and A.A.A. Rabou et al., 2017. Synthesis, characterization and evaluation of cytotoxic effects of novel hybrid steroidal heterocycles as PEG based nanoparticles. Asian Pac. J. Cancer Prev., 18: 1937-1946.
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  7. Elmegeed, G.A., S.M.M. Yahya, M.M. Abd-Elhalim, M.S. Mohamed, R.M. Mohareb and G.H. Elsayed, 2016. Evaluation of heterocyclic steroids and curcumin derivatives as anti-breast cancer agents: Studying the effect on apoptosis in MCF-7 breast cancer cells. Steroids, 115: 80-89.
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  8. Elmegeed, G.A., H.H. Ahmed, M.A. Hashash, M.M. Abd-Elhalim and D.S. El-Kady, 2015. Synthesis of novel steroidal curcumin derivatives as anti-Alzheimer’s disease candidates: Evidences-based on in vivo study. Steroids, 101: 78-89.
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  9. Elmegeed, G.A. and W.W. Wardakhan, 2015. Synthesis of pregnene and androstane heterocyclic derivatives of potential pharmacological activity. Egypt. J. Chem., 48: 407-424.

  10. Ahmed, H.H., G.A. Elmegeed, M.A. Hashash, M.M. Abd-Elhalim and D.S. El-kady, 2015. Highlights on mechanisms of newly synthesized compounds targeting multiple systems provide a novel perspective on alzheimer's disease treatment. J. Chem. Pharm. Res., 7: 297-318.

  11. Younes, M.A., M.S. Hany and A.E. Gamal, 2014. Synthesis and antimicrobial evaluation of novel aminoheterocyclic steroids. Arch. Pharm. Chem. Life Sci., 346: 178-185.

  12. Mohareb, R.M., F. Al-Omran and R.A. Azzam, 2014. Heterocyclic ring extension of estrone: Synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives. Steroids, 84: 46-56.
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  13. Elmegeed, G.A., L.W. Jialin, N. David and L. Alicia, 2014. Synthesis of substrate analogs for study in sterol biosynthesis. Arch. Biochem. Biophys., 525: 11-19.

  14. Elmegeed, G.A., 2014. Novel approach of steroidal heterocyclic drugs. Acta Pharm., 32: 215-227.

  15. Nes, W.D., L. Jialin, A.E. Gamal, L.H. Alicia, A.N. Chizaram and K.C. Emily, 2013. Oriented synthesis and enzymatic evaluation of new fluro-sterols. Arch. Biochem. Biophys., 523: 78-91.

  16. Mohareb, R.M., W.W. Wagnat and A.E. Gamal, 2013. Synthesis and biological evaluation of tri-heterocycles incorporating pyrazoles bonded to steroids. Mol., 18: 47-56.

  17. Liu, J., A.E. Gamal, K.C. Emily and W.N. David, 2013. An effeicient approach to lactandrate analogues with a tricyclic framework. Arch. Pharm. Chem. Life Sci., 346: 512-527.

  18. Mohareb, R.M., W.W. Wardakhan, G.A. Elmegeed and R.M. Ashour, 2012. Heterocyclizations of pregnenolone: Novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations. Steroids, 77: 1560-1569.
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  19. Mohamed, N.R., M.M. Abdelhalim, Y.A. Khadrawy, G.A. Elmegeed and O.M.E. Abdel-Salam, 2012. One-pot three-component synthesis of novel heterocyclic steroids as a central antioxidant and anti-inflammatory agents. Steroids, 77: 1469-1476.
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  20. Howard, A.L., L. Jialin, A.E. Gamal, K.C. Emily, S.G. Kalgi, A.N. Chizaram and W.N. David , 2012. Sterol C24-methyltransferase: Physio- and Stereo-chemical features of the sterol C3 group required for catalytic competence. Arch. Biochem. Biophys., 521: 43-50.
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  21. Mohareb, R.M., H.H. Ahmed, G.A. Elmegeed, M.M. Abdelhalem and R. Wageh, 2011. Development of new indole-derived neuroprotective agents. Biooraganic Med. Chem., 19: 2966-2974.
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  22. Mohareb, R.M., G.A. Elmegeed, O.M.E. Abdel-Salam, S.H. Doss and M.G. William, 2011. Synthesis of modified steroids as a novel class of non-ulcerogenic, anti-inflammatory and anti-nociceptive agents. Steroids, 76: 1190-1203.
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  23. Mohareb, R.M., G.A. Elmegeed, A.R. Baiuomy, E.F. Eskander and M.G. William, 2011. Evaluation of anti‐inflammatory, anti‐nociceptive, and anti‐ulcerogenic activities of novel synthesized thiazolyl and pyrrolyl steroids. Archiv. Pharm., 344: 595-604.
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  24. Elmegeed, G.A., W.K.B. Khalil, R.M. Mohareb, H.H. Ahmed, M.M. Abd-Elhalim and G.H. Elsayed, 2011. Cytotoxicity and gene expression profiles of novel synthesized steroid derivatives as chemotherapeutic anti-breast cancer agents. Bioorg. Med. Chem., 19: 6860-6872.
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  25. Mohamed, N.R., G.A. Elmegeed, M.M. Abdelhalim and H.M. Rady, 2010. Facile synthesis and in vitro cytotoxic evaluation of novel thiadiazole, pyrazole, and dithiole-androstane derivatives. Phosphorus, Sulfur, Silicon, 185: 848-856.
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  26. Elmegeed, G.A., A.R. Baiuomy, M.M. Abdelhalim and H.Y. Hana, 2010. Synthesis and antidepressant evaluation of five novel heterocyclic tryptophan‐hybrid derivatives. Arch. Pharm. Chem. Life Sci., 343: 261-267.
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  27. Ahmed, H.H., G.A. Elmegeed, S.M. El-Sayed, M.M. Abd-Elhalim, W. Shousha and R.W. Shafic, 2010. Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats. Eur. J. Med. Chem., 45: 5452-5459.
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  28. Mohareb, R.M., S.H. Doss, G.A. Elmegeed and E.F. Eskander, 2009. Synthesis of novel hybrid steroids with potential biological activities: Synthesis of C-17-thiazole, isoxazole, pyrazole, thiophene and phthalazine derivatives of epi-androsterone. Curr. Top. Steroid Res., 6: 49-61.

  29. Mohareb, R.M., A.L. Nadia, A.M. Gamal and Y.H. Hanaa, 2009. Synthesis of unnatural tryptophan derivatives of potential biological activity. J. Chilean Chem. Soc., 54: 175-179.

  30. Elmegeed, G.A., M. El-Far, H. Mahrous and M.A. Tantawy, 2009. Aminothienoandrostane: Novel promising anti-tumor agent. Int. J. Med. Med. Sci., 1: 126-131.
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  31. Elmegeed, G.A., E. Mohamed, M.R. Hanaa and A.T. Mohamed, 2009. Facile synthesis and biological evaluation of novel modified amino-steroids. J. Mansoura Univ., 36: 19-37.

  32. El-Far, M., G.A. Elmegeed, E.F. Eskander, H.M. Rady and M.A. Tantawy, 2009. Novel modified steroid derivatives of androstanolone as chemotherapeutic anti-cancer agents. Eur. J. Med. Chem., 44: 3936-3946.
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  33. Ahmed, H.H., G.A. Elmegeed, E.S.M.E. Mahdy, W.G. Shousha and E.A.F. Mohamed, 2009. Efficacy of newly synthesized melatonin derivatives as antiosteoporotic agents in ovariectomized rats. J. Applied Sci. Res., 5: 263-282.

  34. Wardakhan, W.W., O.M. Abdel-Salam and G.A. Elmegeed, 2008. Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives. Acta pharm., 58: 1-14.
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  35. Hana, H.Y., W.K.B. Khalil, A.I. Elmakawy and G.A. Elmeeged, 2008. Androgenic profile and genotoxicity evaluation of testosterone propionate and novel synthesized heterocyclic steroids. J. Steroid Biochem. Mol. Biol., 110: 284-294.
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  36. Gaara, A.H., M.I. Nassar, M. Younis, G.A. Elmegeed, T.J. Mabry and P.W. Pare, 2008. Biologically active polyphenolic compounds from Acacia ehrenbergiana. Rev. Latinoamer. Quim., 36: 52-59.
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  37. Eskander, E.F., F.A. Aymen, A.E. Gamal and I.N. Mahmoud, 2008. Chemical constituents, biological activity and hormonal profile of Myristicafragrans. Egypt. Med. J. Nat. Res. Center, 7: 15-21.

  38. Elmegeed, G.A., W.K. Khalil, A.A. Raouf and M.M. Abd-Elhalim, 2008. Synthesis and in vivo anti-mutagenic activity of novel melatonin derivatives. Eur. J. Med. Chem., 43: 763-770.
    CrossRef  |  

  39. Ahmed, H.H., M.M. Abd Elhalim, G.A. Elmegeed and E.F. Eskander, 2008. Potential role of novel synthesized estrone derivatives in management of osteoporosis in ovariectomized rats. J. Applied Sci. Res., 4: 459-479.

  40. Elmegeed, G.A., A.R. Baiuomy and O.M. Abdel-Salam, 2007. Evaluation of the anti-inflammatory and anti-nociceptive activities of novel synthesized melatonin analogues. Eur. J. Med. Chem., 42: 1285-1292.

  41. Abdelhamid, A.O., M.M. Abdelhalim and G.A. Elmegeed, 2007. New routes to steroidal heterocyclic derivatives: Synthesis of biologically active pyrazolyl‐ and isoxazolylpregnene derivatives. J. Heterocycl. Chem., 44: 7-11.
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  42. Abdelhalim, M., M. El-Saidi, M.S. Rabie and G. Elmegeed, 2007. Synthesis of novel steroidal heterocyclic derivatives as antibacterial agents. Steroids, 72: 459-465.
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  43. Wardakhan, W.W., G.A. Elmegeed and F.M. Manhi, 2005. Utility of 2-aminothiophene-3-carboxamide in the synthesis of biologically active, fused heterocyclic derivatives. Phosphorus, Sulfur, Silicon, 180: 125-140.
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  44. Mohamed, N.R., G.A. Elmegeed, H.A. Abd-ElMalek and M. Younis, 2005. Synthesis of biologically active steroid derivatives by the utility of Lawesson's reagent. Steroids, 70: 131-136.
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  45. Elmegeed, G.A., W.W. Wardakhan and A.R. Baiuomy, 2005. Synthesis of thiazolyl and thieno cholestane derivatives: A novel class of potent antiinflammatory steroids. Pharm. Int. J. Pharm. Sci., 60: 328-333.
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  46. Elmegeed, G.A., H.H. Ahmed and J.S. Hussein, 2005. Novel synthesized aminosteroidal heterocycles intervention for inhibiting iron-induced oxidative stress. Eur. J. Med. Chem., 40: 1283-1294.

  47. Ahmed, H.H., G.A. Elmegeed and M.M. Abdelhalim, 2005. Synthesis and screening of certain new pyrazolo, pyrimidino and pyrido-androstane derivatives for androgenic and antiandrogenic activity. Bull. Fac. Pharm. Cairo Univ., 43: 147-159.

  48. Ahmed, H.H., F. Mannaa, G.A. Elmegeed and S.H. Doss, 2005. Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity. Bioorg. Med. Chem., 3: 1847-1857.
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  49. Elmegeed, G.A., W.W. Wardakhan, M. Younis and N.A. Louca, 2004. Synthesis and antimicrobial evaluation of some novel cholestane heterocyclic derivatives. Arch. Pharm. Chem. Life Sci., 337: 140-147.
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  50. Elmegeed, G.A., 2004. Synthesis of novel pyrazolo, pyrimidino and pyrido androstane derivatives of pharmacological interest. Egypt. J. Chem., 47: 579-590.

  51. Younis, M., G.A. El-megeed and M.I. Nassar, 2003. Antimicrobial activities of acacia ehrenbergiana extracts and its nitrogen fixation ability. Egypt. J. Microbiol., 38: 195-204.

  52. Mohamed, N.R., G.A. Elmegeed and M. Younis, 2003. Studies on Organophosphorus Compounds VII1,2: Transformation of steroidal ketones with lawesson's reagent into thioxo and heterofused steroids. Phosphorus, Sulfur, Silicon, 178: 203-217.
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  53. Doss, S.H., R.M. Mohareb, G.A. Elmegeed and N.A. Luoca, 2003. Synthesis and study of pigment aggregation response of some melatonin derivatives. Die Pharm. Int. J. Pharm. Sci., 58: 607-613.
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  54. Doss, S.H., N.A. Louca, G.A. Elmegeed and R.M. Mohareb, 1999. Sultamo-steroid analogues, part VII: Synthesis of epi-androsterone derivatives with potential activity. Arch. Pharmacal Res., 22: 496-501.
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