Dr. David Izuchukwu Ugwu
LecturerUniversity of Nigeria Nsukka, Nigeria
Highest Degree
Ph.D. in Organic Chemistry from University of Nigeria, Nsukka, Nigeria
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Area of Interest:
Selected Publications
- Ugwuja, D.I., U.C. Okoro, S.S. Soman, R. Soni, S.N. Okafor and D.I. Ugwu, 2019. New peptide derived antimalaria and antimicrobial agents bearing sulphonamide moiety. J. Enzyme Inhibition Med. Chem., 34: 1388-1399.
CrossRef | Direct Link | - Ugwu, D.I., F.U. Eze, B.C. Ogboo, V.N. Okoro and M.C. Ugwu, 2019. Synthesis of multi-target benzene-sulphonamide derivatives for the treatment of trypanosomiasis. Med. Chem., 9: 83-92.
- Ugwu, D.I., E.F. Uchenna, U.C. Okoro and S.N. Okafor, 2019. Biological activity evaluation of some new benzenesulphonamide derivatives. Fron. Chem., Vol. 7. 10.3389/fchem.2019.00634.
CrossRef | Direct Link | - Ogboo, B.C., S.N. Okafor, D.I. Ugwu, S.E. Shaibu, N. Efiong and V.F. Ekpo, 2019. Oxazine and its derivatives: Potential leads for discovery of new and potent antimicrobial and antituberculosis drugs, a review. Global Scient. J., 7: 181 -202.
- Ezeokonkwo, M.A., K.C. Iloka, U.C. Okoro, E.A. Onoabedje, B.E. Ezema, F.N. Ibeanu, D.I. Ugwu, Eze, F.U. and C.P. Uzoewulu, 2019. Synthesis and antimicrobial activity of new derivatives of angular polycyclic phenoxazine ring system. Oriental J. Chem., 35: 1320-1326.
CrossRef | Direct Link | - Eze, F.U., U.C. Okoro, D.I. Ugwu and S.N. Okafor, 2019. New carboxamides bearing benzenesulphonamides: Synthesis, molecular docking and pharmacological properties. Bioorg. Chem., Vol. 92. 10.1016/j.bioorg.2019.103265.
CrossRef | Direct Link | - Ugwuja, D.I., U.C. Okoro and D.I. Ugwu, 2018. Synthesis, antibacterial, antifungal and antioxidant activities of N-pyridin-3-yl-substituted [phenylsulphonamido]acetamide derivatives. Pak. J. Pharm. Sci., 31: 1209-1216.
- Ugwu, D.I., U.C. Okoro, P.O. Ukoha, S. Okafor and A. Gupta, 2018. Novel anti-inflammatory and analgesic agents: Synthesis, molecular docking and in vivo studies. J. Enzyme Inhib. Med. Chem., 33: 405 -415.
CrossRef | Direct Link | - Ugwu, D.I., U.C. Okoro, N.K. Mishra and S.N. Okafor, 2018. Novel phenoxazinones as potent agonist of PPAR-α: Design, synthesis, molecular docking and in vivo studies. Lipids Health Dis.,Vol. 120. 10.1186/s12944-018-0764-y.
CrossRef | Direct Link | - Ugwu, D.I., U.C. Okoro and N.K. Mishra, 2018. Synthesis, characterization and anthelmintic activity evaluation of pyrimidine derivatives bearing carboxamide and sulphonamide moieties. J. Serb. Chem. Soc., 83: 401-409.
Direct Link | - Ugwu, D.I., U.C. Okoro and N.K. Mishra, 2018. Synthesis, characterization and in Vitro antitrypanosomal activities of new carboxamides bearing quinoline moiety. PLOS ONE, Vol. 13. 10.1371/journal.pone.0191234.
CrossRef | Direct Link | - Ugwu, D.I., U.C. Okoro and N.K. Mishra, 2018. Synthesis of proline derived benzenesulfonamides: A potent anti-Trypanosoma brucei gambiense agent. Eur. J. Med. Chem., 154: 110-116.
CrossRef | Direct Link | - Ezema, B.E., S.N. Okafor, S.A. Agada, D.I. Ugwu and C.G. Ezema, 2018. Synthesis, in silico and in vitro studies of potential glucosamine‐6‐phosphate synthase and lanosterol‐14α‐demethylase inhibitors. Chem. Select, 3 : 12001-12006.
CrossRef | Direct Link | - Ezema, B., C. Ezema, K. Akpomie and D. Ugwu, 2018. Synthetic process of vat-dyes of tetraaza derivatives of three-branched phenothiazine heterocycles. Leonardo Electr. J. Pract. Technol., 17: 277-288.
- Ugwu, D.I., U.C. Okoro, P.O. Ukoha, S. Okafor, A. Ibezim and N.M. Kumar, 2017. Synthesis, characterization, molecular docking and in vitro antimalarial properties of new carboxamides bearing sulphonamide. Eur. J. Med. Chem., 135: 349-369.
CrossRef | Direct Link | - Ugwu, D.I., U.C. Okoro and H. Ahmad, 2017. New carboxamide derivatives bearing benzenesulphonamide as a selective COX-II inhibitor: Design, synthesis and structure-activity relationship. PLOS ONE, Vol. 12. 10.1371/journal.pone.0183807.
CrossRef | Direct Link | - Ugwu, D.I., B.E. Ezema, U.C. Okoro, F.U. Eze, O.C. Ekoh, M.C. Egbujor and D.I. Ugwuja, 2015. Syntheses and pharmacological applications of chalcones: A review. Int. J. Chem. Sci., 13: 459-500.
- Ugwu, D.I., B.E. Ezema, F.U. Eze, E.A. Onoabedje, C.G. Ezema, O.C. Ekoh and J.I. Ayogu, 2015. Synthesis and antimalarial activities of chalcone derivatives, Int. J. Chem. Tech. Res., 7: 1966-1984.
- Oni, T.T., U.C. Okoro and D.I. Ugwu, 2015. Synthesis of 1-azabenzo[a]phenoxazin-5-one and 11-amino-1,8,10-triazabenzo[a]phenoxazin-5-one and their functionalized aryl derivatives via mizoroki-heck arylation methodology. Oriental J. Chem., 31: 371-378.
- Odaa, M.E., U.C. Okoro and D.I. Ugwu, 2015. Synthesis of Novel Angular Diazaphenoxazinone Derivatives via palladium catalyzed buchwald-hartwig amidation protocols. Asian J. Chem., 27: 3069-3073.
- Ezema, B.E., C.G. Ezema, J.I. Ayogu, D.I. Ugwu and E.A. Onoabedje, 2015. Synthesis of tetraaza derivatives of benzoxazinophenothiazine. Oriental J. Chem., 31: 133-139.
Direct Link | - Ezema, B.E., C.G. Ezema, J.I. Ayogu, D.I. Ugwu and E.A. Onoabedje, 2015. Synthesis of aza derivatives of isomers of angular and complex phenothiazine rings. Oriental J. Chem., 31: 379-385.
- Egbujor, M.C., U.C. Okoro and D.I. Ugwu, 2015. Synthesis of new derivatives of 1-azaphenothiazine via buchwald-hartwig amination methodology. Asian J. Chem., 27: 1469-1472.
Direct Link | - Edoka, O.L., U.C. Okoro and D.I. Ugwu, 2015. Synthesis of 1,9-diazaphenoxazine carboxamide derivatives via buchwald-hartwig amidation protocol. Asian J. Chem., 27: 3463-3467.
- Ugwu, D.I., U.C. Okoro and T.D. Chukwurah, 2014. Nickel catalyzed synthesis of N-aryl and N-heteroaryl substituted benzene sulphonamides and their biological activity evaluation. Med. Chem., 4: 357-360.
- Ugwu, D.I. and U.C. Okoro, 2014. Synthesis, characterisation and antifungal activities of [4- methylphenyl sulphonamide]-N-(pyridin-2-yl)acetamide derivatives, Med. Chem., 4: 330-333.
- Ugwu D.I. and U.C. Okoro, 2014. Synthesis, characterisation and evaluation for antibacterial activities of n-pyridin-2-yl substituted-p-toluene sulphonamoyl ethanamides. Int. J. Sci. Res., 3: 35-38.
Direct Link | - Francisca, C.O., Chris, O.U. and U.D. Izuchukwu, 2014. Synthesis and antimicrobial activities of N-(Heteroaryl-substituted)-p-toluenesulphonamides. Organic Chem. Int. 2014. 10.1155/2014/748257.
CrossRef | Direct Link | - Ezema, B.E, C.G. Ezema, D.I. Ugwu and J.I. Ayogu, 2014. Synthesis of heterocyclic azo dyes from quinolin-8-ol Chem. Materials Res., 6: 1-6.
Direct Link | - Adekola, E.O., B.E. Ezema, J.I. Ayogu, , D.I. Ugwu C.G. Ezema, P.N. Abuekwu and C.O. Ike, 2014. Synthesis of benzothiazinophenothiazine derivatives and their antimicrobial screening. Orient. J. Chem., 30: 1493-1500.
Direct Link | - Ugwu, D.I., B.E. Ezema, F.U. Eze and D.I. Ugwuja, 2014. Synthesis and structural activity relationship study of antitubercular carboxamides. Int. J. Med. Chem., 2014. 10.1155/2014/614808.
CrossRef | Direct Link | - Onoabedje, E.A., B.E. Ezema, C.G. Ezema and D.I. Ugwu, 2013. Synthesis of some derivatives of benzophenothiazinone of pharmaceutical interests via nickel catalysed grignard couplings. Chem. Process Eng. Res., 8: 6-11.
- Ezema, B.E., C.G. Ezema, E.A. Onoabedje and D.I. Ugwu, 2013. Synthesis of a new and firsttriazadibenzo [A,N] triphenodithiazine. Chem. Process Eng. Res., 8: 35-41.