Dr. Luis Enrique Cuca

Professor
Universidad Nacional de Colombia, Colombia

Highest Degree
Ph.D. in Organic Chemistry Natural Products from Universidad Nacional de Colombia, Colombia

My URL
https://livedna.org/242.20802

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Biography

The Professor Luis Enrique Cuca is Chemist, M Sc. in Chemistry os Botanical Natural Products and Dr. Sc. en Chemistry of Botanical Natural products, Dr. Cuca is a Full proffesor of Chemistry deparment of Universidad nacional de Colombia since 2007 and is proffesor of the same deparment since 1972. Dr. Cuca is the director of research group in Chemical study and Biological activity of Colombian Myristicaceas and Rutaceas species.

Area of Interest:

Chemistry
Chromatography
Organic Chemistry
Natural Products
Crystallography

Selected Publications

  1. Macias-Villamizar, V., L. Cuca-Suarez, F.V. Gonzalez and S. Rodriguez, 2016. Lignoids isolated from Nectandra turbacensis (kunth) nees (lauraceae). Rec. Nat. Prod., 10: 654-658.
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  2. Granados-Falla, D., A. Gomez-Galindo, A. Daza, S. Robledo, C. Coy-Barrera, L. Cuca and G. Delgado, 2016. Seco-limonoid derived from Raputia heptaphylla promotes the control of cutaneous leishmaniasis in hamsters (Mesocricetus auratus). Parasitol., 143: 289-299.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Gil, E., L.E. Cuca and W.A. Delgado, 2016. Chemical composition and antimicrobial activity of the essential oil of the leaves of ocotea caudata (nees) mez (lauraceae) from Colombia. Bol. Latinoam. Caribe Plant. Med. Aromat., 15: 258-263.
    Direct Link  |  

  4. Corredor, J.A.E., L.E.C. Suarez and M.F.G. Pabon, 2016. Assesment of platelet antiaggregant activity of a fraction from an ethanolic extract of the bark of Nectandra amazonum nees. Vitae, 23: 119-123.
    Direct Link  |  

  5. Alvarez, J.M., A. Raya-Baron, P.M. Nieto, L.E. Cuca, A. Carrasco-Pancorbo, A. Fernandez-Gutierrez and I. Fernandez, 2016. Flavonoid glycosides from Persea caerulea. Unraveling their interactions with SDS-micelles through matrix-assisted DOSY, PGSE, mass spectrometry and NOESY. Magn. Reson. Chem., 54: 718-728.
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  6. Macias-Villamizar, V.E., L.E. Cuca-Suarez and E.D. Coy-Barrera, 2015. Genus nectandra: ''Phytochemistry and biological activity''. Bol. Latinoam. Caribe Plant. Med. Aromat., 14: 317-342.
    Direct Link  |  

  7. Guzman, J.D., T. Pesnot, D.A. Barrera, H.M. Davies and E. McMahon et al., 2015. Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase. J. Antimicrob. Chemother., 70: 1691-1703.
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  8. Cuca-Suarez, L.E., F. Della-Monache and E. Coy-Barrera, 2015. Cytotoxic constituents from bark and leaves of amyris pinnata kunth. Rec. Nat. Prod., 9: 441-445.
    Direct Link  |  

  9. Bernal, F.A., L.E. Cuca and L. Fadini, 2015. A facile approach toward 8-O-4'-neolignans: Synthesis of threo-7', 8'-dihydromachilin D through Jacobsen epoxidation. Rev. Facultad Cien. Basicas, 11: 114-129.
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  10. Valdes-Barrera, I.D., L.E. Cuca-Suarez and E.D. Coy-Barrera, 2014. Nectandra amazonum-derived flavonoids as COX-1 inhibitors: In vitro and docking studies. Nat. Prod. Commun., 9: 649-652.
    PubMed  |  Direct Link  |  

  11. Garcia-Beltran, O., C. Areche, B.K. Cassels and L.E.C. Suarez, 2014. Coumarins isolated from Esenbeckia alata (rutaceae). Biochem. Syst. Ecol., 52: 38-40.
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  12. Estrada, M.H., H. Insuasty, L.E. Cuca, M. Marder, A. Fierro and M.F. Guerrero, 2014. Anticonvulsant profile of 2-ethylthio-7-methyl-4-(4-methylphenyl) pyrazolo [1, 5-a][1, 3, 5] triazine. Braz. J. Pharm. Sci., 50: 73-81.
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  13. Enciso, N.C., E.D. Coy-Barrera, O.J. Patino, L.E. Cuca and G. Delgado, 2014. Evaluation of the leishmanicidal activity of rutaceae and lauraceae ethanol extracts on golden Syrian hamster (Mesocricetus auratus) peritoneal macrophages. Indian J. Pharm. Sci., 76: 188-197.
    Direct Link  |  

  14. Avila, M.M., S.L. Cuca and S.J. Ceron, 2014. Chemical composition and insecticidal properties of essential oils of piper septuplinervium and P. subtomentosum (piperaceae). Nat. Prod. Commun., 9: 1527-1530.
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  15. Granados-Falla, D., C. Coy-Barrera, L. Cuca and G. Delgado, 2013. Seco-limonoid 11α, 19β-dihydroxy-7-acetoxy-7-deoxoichangin promotes the resolution of Leishmania panamensis infection. Adv. Biosci. Biotechnol., 4: 304-315.
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  16. Cuca, L.E., C.A. Ramos and E.D. Coy-Barrera, 2013. Novel cadinane-related sesquiterpenes from Nectandra amazonum. Phytochem. Lett., 6: 435-438.
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  17. Bernal, F.A., L.E. Cuca-Suarez, L.F. Yamaguchi and E.D. Coy-Barrera, 2013. LC-DAD-UV and LC-ESI-MS-based analyses, antioxidant capacity, and antimicrobial activity of a polar fraction from Iryanthera ulei leaves. Rec. Nat. Prod., 7: 152-156.
    Direct Link  |  

  18. Barrera, C., C. Andres, C. Suarez, L. Enrique and C.Q. Londono, 2013. Pharmacognosy and pharmacobotany of species of genera Esenbeckia and Raputia (rutaceae). Rev. Cubana Plant. Med., 18: 638-653.
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  19. Cuca-Suarez, L.E. and E. Coy-Barrera, 2012. Essential oil composition of Pleurothyrium cinereum leaves. Faculty Basic Sci. Mag., 8: 310-315.
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  20. Coy-Barrera, E.D., L.E. Cuca-Suarez, M. Sefkow and U. Schilde, 2012. Cinerin C: A macrophyllin-type bicyclo [3.2. 1] octane neolignan from Pleurothyrium cinereum (lauraceae). Acta Crystallogr. Sec. C Cryst. Struct. Commun., Vol. 68. 10.1107/S0108270112030946.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Sanchez-Suarez, J., E. Coy-Barrera, L.E. Cuca and G. Delgado, 2011. Leishmanicidal and cytotoxic activities of extracts and naturally-occurring compounds from two lauraceae species. Nat. Prod. Commun., 6: 231-234.
    PubMed  |  Direct Link  |  

  22. Prieto, J.A., O.J. Patino, W.A. Delgado, J.P. Moreno and L.E. Cuca, 2011. Chemical composition, insecticidal, and antifungal activities of fruit essential oils of three Colombian Zanthoxylum species. Chil. J. Agric. Res., 71: 73-82.
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  23. Patino, O.J. and L.E. Cuca, 2011. Monophyllidin, a new alkaloid L-proline derivative from Zanthoxylum monophyllum. Phytochem. Lett., 4: 22-25.
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  24. Cuca-Suarez, L.E., E.D.C. Barrera and J.M.A. Caballero, 2011. Quinoline alkaloids and friedelane-type triterpenes isolated from leaves and wood of Esenbeckia alata kunt (rutaceae). Quim. Nova, 34: 984-986.
    CrossRef  |  Direct Link  |  

  25. Cuca, L.E., E.D. Coy, M.A. Alarcon, A. Fernandez and F.A. Aristizabal, 2011. Cytotoxic effect of some natural compounds isolated from lauraceae plants and synthetic derivatives. Biomed., 31: 335-343.
    CrossRef  |  PubMed  |  Direct Link  |  

  26. Coy-Barrera, E.D. and L.E. Cuca-Suarez, 2011. In vitro anti-inflammatory effects of naturally-occurring compounds from two lauraceae plants. Anais Academia Bras. Cienc., 83: 1397-1402.
    CrossRef  |  PubMed  |  Direct Link  |  

  27. Barrera, C.A.C., E.D.C. Barrera, D.S.G. Falla, G.D. Murcia and L.E.C. Suarez, 2011. seco-limonoids and quinoline alkaloids from Raputia heptaphylla and their antileishmanial activity. Chem. Pharm. Bull., 59: 855-859.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Barinas, J.A.C. and L.E.C. Suarez, 2011. Chemical constituents of Talauma arcabucoana (magnoliaceae): Their brine shrimp lethality and antimicrobial activity. Nat. Prod. Res., 25: 1497-1504.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Patino, O.J. and L.E. Cuca, 2010. Isoquinoline alkaloids of Zanthoxylum quinduensis (Rutaceae). Biochem. Syst. and Ecol., 38: 853-856.

  30. Pabon, L.C. and L.E. Cuca, 2010. Aporphine alkaloids from Ocotea macrophylla (Lauraceae). Quim. Nova, 33: 875-879.
    CrossRef  |  Direct Link  |  

  31. Macias, V., E. Victor, B. Coy, D. Ericsson and L.E. Cuca, 2010. Novel furocarbazole alkaloids and antibacterial activity of ethanol extract from Zanthoxylum fagara (l.) sargent. Rev. Colomb. Quim., 39: 333-341.
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  32. Ladino, O.J.P., C. Suarez and L. Enrique, 2010. Chemical constituents of the wood from Zanthoxylum quinduense tul. (Rutaceae). Quim. Nova, 33: 1019-1021.
    CrossRef  |  Direct Link  |  

  33. Guzman, J.D., A. Gupta, D. Evangelopoulos, C. Basavannacharya and L.C. Pabon et al., 2010. Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis. J. Antimicrob. Chemother., 65: 2101-2107.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Coy, E.D., L.E. Cuca and M. Sefkow, 2010. Pd-NHC catalyzed biaryl coupling by direct C-H activation: A novel strategy for the synthesis of dibenzocyclooctane lignans. Synth. Commun., 41: 41-51.
    CrossRef  |  Direct Link  |  

  35. Coy, B.E., S.L. Cuca and M. Sefkow, 2010. The first diastereoselective synthesis of cinerins AC, PAF-antagonistic macrophyllin-type bicyclo [3.2.1] octane neolignans, using a novel Pd-catalysed oxyarylation. Organ. Biomol. Chem., 8: 2003-2005.
    CrossRef  |  PubMed  |  Direct Link  |  

  36. Coy, B.E. and S.L. Cuca, 2010. In vitro inhibitory activities of lauraceae aporphine alkaloids. Nat. Prod. Commun., 5: 383-386.
    PubMed  |  Direct Link  |  

  37. Suarez, L.E.C., M.E. Pattarroyo, J.M. Lozano and F.D. Monache, 2009. Biological activity of secondary metabolites from Peltostigma guatemalense. Nat. Prod. Res., 23: 370-374.
    CrossRef  |  PubMed  |  Direct Link  |  

  38. Lopez, R., L.E. Cuca and G. Delgado, 2009. Antileishmanial and immunomodulatory activity of Xylopia discreta. Parasite Immunol., 31: 623-630.
    CrossRef  |  PubMed  |  Direct Link  |  

  39. Cuca, L.E., P. Leon and E.D. Coy, 2009. A bicyclo [3.2.1] octanoid neolignan and toxicity of the ethanol extract from the fruit of Ocotea heterochroma. Chem. Nat. Compd., 45: 179-181.
    CrossRef  |  Direct Link  |  

  40. Cuca, L.E., F.A. Bernal, C.A. Coy and E.D. Coy, 2009. Essential oil composition and antimicrobial activity of fruits of iryanthera ulei W. from Colombia. J. Chil. Chem. Soc., 54: 363-365.
    CrossRef  |  Direct Link  |  

  41. Coy-Barrera, E.D., L.E. Cuca-Suarez and M. Sefkow, 2009. PAF-antagonistic bicyclo [3.2.1] octanoid neolignans from leaves of Ocotea macrophylla kunth. (lauraceae). Phytochem., 70: 1309-1314.
    CrossRef  |  Direct Link  |  

  42. Coy, E.D., L.E. Cuca and M. Sefkow, 2009. PAF-antagonist 7.3', 8.5'-connected bicyclo [3.2.1] octane neolignans obtained from three colombian lauraceae species and their synthesis. Planta Med., Vol. 75. 10.1055/s-0029-1234380.
    CrossRef  |  Direct Link  |  

  43. Coy, E.D., L.E. Cuca and M. Sefkow, 2009. Macrophyllin-type bicyclo [3.2.1] octanoid neolignans from the leaves of Pleurothyrium cinereum. J. Nat. Prod., 72: 1245-1248.
    CrossRef  |  PubMed  |  Direct Link  |  

  44. Coy, E.D., L.E. Cuca and M. Sefkow, 2009. COX, LOX and platelet aggregation inhibitory properties of lauraceae neolignans. Bioorg. Med. Chem. Lett., 19: 6922-6925.
    CrossRef  |  PubMed  |  Direct Link  |  

  45. Bernal, F.A. and L.E.C. Suarez, 2009. Chemical constituents from iryanthera ulei warb. Biochem. Syst. Ecol., 37: 772-775.

  46. Barrera, E.D.C. and L.E.C. Suarez, 2009. Three new 7.3', 8.5'-connected bicyclo [3.2.1] octanoids and other neolignans from leaves of Nectandra amazonum NEES. (lauraceae). Chem. Pharm. Bull., 57: 639-642.
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  47. Barrera, E.D.C. and L.E.C. Suarez, 2009. Aporphine alkaloids from leaves of ocotea macrophylla (kunth)(lauraceae) from Colombia. Biochem. Syst. Ecol., 37: 522-524.

  48. Suarez, L.E.C. and C.A.C. Barrera, 2007. Metabolites isolated from esenbeckia alata (karst and triana)(rutaceae). Biochem. Syst. Ecol., 35: 386-388.

  49. Castro, E., L.E.C. Suarez, P. Siengalewicz, R. Gutmann, G. Czermak and P. Brueggeller, 2004. 3, 6-Dihydroxy-2-(11-phenylundecanoyl) cyclohex-2-en-1-one from Virola venosa bark. Acta Crystallogr. Sec. C Cryst. Struct. Commun., Vol. 60. 10.1107/S0108270104010650.
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  50. Suarez, L.E.C., F. Menichini and F.D. Monache, 2002. Tetranortriterpenoids and dihydrocinnamic acid derivatives from Hortia colombiana. J. Braz. Chem. Soc., 13: 339-344.
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  51. Juan, C., V. Martinez and S.L.E. Cuca, 1987. Flavonoids from virola calophylloidea. J. Nat. Prod., 50: 1045-1047.
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  52. Monache, F.D., L.C. Suarez and G.B. Marini-Bettolo, 1978. Flavonoids from the seeds of six lonchocarpus species. Phytochem., 17: 1812-1813.
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