Dr. Hendrik Gerhardus Kruger

Professor
University of KwaZulu-Natal, South Africa

Highest Degree
Ph.D. in Chemistry from University of KwaZulu-Natal, Pietermaritzburg, South Africa

My URL
https://livedna.org/27.10909

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Biography

Dr. Hendrik Gerhardus Kruger is currently working as Research Professor at University of KwaZulu-Natal, South Africa. He has completed his Ph.D. in Chemistry from same University. His main area of interest focuses on Pharmacology and Toxicology, and Molecular Sciences. His area of expertise includes Drug Synthesis, Computational Chemistry, HIV Drugs and TB Drugs. He is author and co-author of 53 journal papers.

Area of Interest:

Pharmacology and Toxicology
Drug Synthesis
Computational Chemistry
HIV Drugs
TB Drugs

Selected Publications

  1. Kruger, G., 2012. Dr. Hubrecht van Dalsen word 80: van oraloor. Die Kerkblad, 115: 30-30.
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  2. Karpoormath, R., O.K. Onajole, T. Naicker, T. Govender, G.E. Maguire and H.G. Kruger, 2012. Synthesis and NMR elucidation of novel pentacycloundecane-derived peptides. South Afr. J. Chem., 65: 108-114.
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  3. van Rensburg, C.K.J., R.S. Robinson and H.G. Kruger, 2011. Part II: ab initio and NMR investigations into the barrier to internal rotation of various oxo-and thio-analogues of 2-oxo-2H-chromen-7-yl dimethylcarbamates. South Afr. J. Chem., 64: 210-217.
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  4. Shaikh, M.M., G.E. Maguire, H.G. Kruger and K.D. Toit, 2011. 3-Benzyl-5, 7-dimethoxychroman-4-ol. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 67. 10.1107/S1600536811002066.
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  5. Pietersen, L.K., P. Govender, H.G. Kruger, G.E. Maguire and T. Govender, 2011. Enzymatic activation of a peptide functionalised gold nanoparticle system for prodrug delivery. J. Nanosci. Nanotechnol., 11: 3075-3083.
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  6. Pawar, S., P. Bhatt, T. Govender, H.G. Kruger and G.E. Maguire, 2011. S)-4-Phenyl-2-(1, 2, 3, 4-tetrahydroisoquinolin-3-yl)-1, 3-thiazole. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 68. 10.1107/S1600536811052585.
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  7. Onajole, O.K., T. Govender, H.G. Kruger and G.E. Maguire, 2011. N-(Adamantan-1-yl)-2-chloroacetamide. Acta Crystallogr., Sect. E: Struct. Rep. Online, 67: 1444-1444.
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  8. Naicker, T., T. Govender, H.G. Kruger and G.E. Maguire, 2011. 6, 7-Dimethoxy-3-methoxycarbonyl-1-(2-methoxyphenyl)-3, 4-dihydroisoquinoline 2-oxide. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 67. 10.1107/S1600536811016539.
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  9. Naicker, T., T. Govender, H.G. Kruger and G.E. Maguire, 2011. (1S, 3S)-Methyl 6, 7-dimethoxy-1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylate. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 67. 10.1107/S1600536811018782.
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  10. Naicker, T., T. Govender, H.G. Kruger and G.E. Maguire, 2011. (1R, 3S)-N-Benzhydryl-2-benzyl-6, 7-dimethoxy-1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline-3-carbothioamide. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 67. 10.1107/S1600536811049324.
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  11. Karpoormath, R., T. Naicker, T. Govender, H.G. Kruger and G.E. Maguire, 2011. Benzyl 5-hydroxy-4-oxapentacyclo [5.4. 1.02, 6.03, 10.08, 11] dodecane-3-carboxylate. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 67. 10.1107/S1600536811009020.
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  12. Karpoormath, R., P. Govender, T. Govender, H.G. Kruger and G.E. Maguire, 2011. Endo-11-(dibenzylamino) tetracyclo [5.4. 0.03, 10.05, 9] undecane-8-one. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 67. 10.1107/S160053681100479X.
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  13. Chakka, S.K., M.G. McKay, T. Govender, H.G. Kruger and Maguire, 2011. [(1R, 3S)-6, 7-Dimethoxy-1-phenyl-1, 2, 3, 4-tetrahydroisoquinolin-3-yl] methanol 2.33-hydrate. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 67. 10.1107/S1600536811006052.
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  14. Shiri, M., M.A. Zolfigol, H.G. Kruger and Z. Tanbakouchian, 2010. Advances in the application of N 2 O 4/NO 2 in organic reactions. Tetrahedron, 66: 9077-9106.
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  15. Onajole, O.K., M.M. Makatini, P. Govender, T. Govender, G.E. Maguire and H.G. Kruger, 2010. Synthesis and NMR assignment of pentacycloundecane precursors of potential pharmaceutical agents. Magn. Reson. Chem., 48: 249-255.
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  16. Mohamed, M.E., D. Chopra, K.N. Venugopala, T. Govender, H.G. Kruger and G.E. Maguire, 2010. Tetrakis-μ-l-alanine-κ8O: O'-bis [tetraaquaterbium (III)] hexaperchlorate. Corrigendum. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 66. 10.1107/S1600536810027340.
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  17. Chakka, S.K., O.K. Onajole, T. Govender, G.E. Maguire, H. Su and H.G. Kruger, 2010. 1, 7-Dimethylpentacyclo [5.4. 0.02, 6.03, 10.05, 9] undecane-8, 11-dione. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 66. 10.1107/S1600536810025055.
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  18. Nayak, S.K., K.N. Venugopala, D. Chopra, T. Govender, H.G. Kruger, G.E. Maguire and T.N.G. Row, 2009. 2-(4-Chloro-3-nitrophenyl)-4-(4-chlorophenyl)-1, 3-thiazole. Acta Crystallogr., Sect. E: Struct. Rep. Online, 65: 2611-2612.
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  19. Boyle, G.A., T. Govender, H.G. Kruger, T. Naicker and G.E. Maguire, 2009. The evaluation of novel camphor-derived pyridyl ligands as catalysts in the asymmetric Diels-Alder reaction of cyclopentadiene with 3-acryloyl-2-oxazolidinone. South Afr. J. Chem., 62: 129-133.
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  20. Boyle, G.A., T. Govender, H.G. Kruger and O.K. Onajole, 2008. 2-(Tricyclo [3.3. 1.13, 7] dec-2-ylamino) ethanol hemihydrate. Acta Crystallogr., Sect. E: Struct. Rep. Online, Vol. 64. 10.1107/S1600536808016851.
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  21. Boyle, G.A., H.G. Kruger, G.E.M. Maguire and J. Paraskevopoulos, 2008. (4-Hydroxy-3-nitrobenzyl) methylammonium chloride. Acta Crystallogr. Sect., 64: 625-625.
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  22. Boyle, G.A., T. Govender, H.G. Kruger, G.E.M. Maguire and T.K. Negus, 2007. (S)-(+)-2-Formylamino-3-methylbutanoic acid Acta Crystallogr., Sect., 63: 3912-3912.
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  23. Boyle, G.A., T. Govender, H.G. Kruger, G.E.M. Maguire and T. Naicker, 2007. (S)-(+)-2-Formamido-4-methylpentanoic acid. Acta Crystallogr., Sect., 63: 3445-3445.
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  24. Kruger, H.G., P. Mdluli, T.D. Power, T. Raasch and A. Singh, 2006. Experimental and computational studies of the regioselective protection of hydantoins using anhydride. J. Mol. Struct. : THEOCHEM, 771: 165-170.
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  25. Kruger, H.G., M. Rademeyer, T. Govender and V. Gokul, 2006. 11 B Dihydroxypentacycloundecane B 8,11 Blactam. Acta Crystallogr. Sect. Sect. E: Struct. Rep., .

  26. Kruger, H.G., M. Rademeyer and R. Ramdhani, 2006. Pentacyclo 5.4.0.0(2,6).0(3,10).0(5,9) undecaneB8,11Bdione ethylene acetal. Acta Crystallogr. Sect. Sect. E: Struct. Rep., .

  27. Kruger, H.G., M. Rademeyer and R. Ramdhani, 2006. A pentacycloundecane dimer. Acta Crystallogr. Sect. Sect. E: Struct. Rep., .

  28. Kruger, H.G and R. Ramdhani, 2006. NMR assignments of a di‐pentacyclo‐undecane cyclic ether. Magn. Reson. Chem., 44: 1058-1062.
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  29. Kruger, H.G and R. Ramdhani, 2006. NMR analysis of some pentacycloundecanedione derivatives. South Afr. J. Chem., 59: 71-74.
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  30. Kruger, H.G and P.S. Mdluli, 2006. Regioselective protection of hydantoins-essential for hydantoin based anti-epileptic drugs. Struct. Chem., 17: 121-125.
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  31. Kruger, H., M. Rademeyer and R. Ramdhani, 2006. Pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecaneB8,11Bdione ethylene acetal. Acta Crystallogr. Sect. Sect. E: Struct. Rep., .

  32. Boyle, G.A., H.G. Kruger, G.E.M. Maguire and M. Rademeyer, 2006. 4R,5R-B bis-hydroxydimethylmethyl)B2,2BdimethylB1,3Bdioxolane. Acta Crystallogr. Sect. Sect. E: Struct., .

  33. Kruger, H.G., M. Rademeyer, and R. Ramdhani, 2005. 3,5Bbis 2Bhydroxyethyl B4Boxahexacyclo. Acta Crystallogr. Sect. Sect. E: Struct. Rep. .

  34. Kruger, G., 2005. Jesus-films... in die lig van calvyn se uitleg van die tweede gebod. Die Kerkblad, 108: 34-36.
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  35. Govender, T., H.K. Hariprakasha, H.G. Kruger and T. Raasch, 2005. Synthesis of trishomocubane amino acid derivatives. South Afr. J. Chem., 58: 37-40.
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  36. Govender, T., H.G. Kruger and T. Raasch, 2005. Complete NMR elucidation of two N-protected trishomocubane hydantoins and the ethyl ester of the corresponding amino acid. Struct. Chem., 16: 129-134.
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  37. Martins, F.J.C., A.M. Viljoen, H.G. Kruger and P.L. Wessels, 2004. Structure elucidation of 11‐amino‐8‐hydroxypentacyclo [5.4. 0.02, 6.03, 10.05, 9] undecane‐8, 11‐lactam through selective acetylation and complete 1H and 13C NMR spectral assignment of the mono‐, di‐and triacetates. Magn. Reson. Chem., 42: 402-408.
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  38. Kruger, H.G., F.J. Martins and A.M. Viljoen, 2004. Interconvertions between δ-lactam and δ-lactone derivatives initiated by unique transannular interactions of the rigid cyclohexane boat structure in pentacycloundecane. J. Org. Chem., 69: 4863-4866.
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  39. Govender, T., 2004. A study of chiral pentacyclo-undecane derived macrocycles and ligands. Sch. Chem. Faculty Sci. Univ. KwaZulu-Natal, Durban, .

  40. Gokul, V., H.G. Kruger, T. Govender, L. Fourie and T.D. Power, 2004. An ab initio mechanistic understanding of the regioselective acetylation of 8, 11-dihydroxy-pentacyclo [5.4. 0.0 2, 6. 0 3, 10. 0 5, 9] undecane-8, 11-lactam. J. Mol. Struct.: Theochem, 672: 119-125.
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  41. Fourie, L., T. Govender, H.K. Hariprakasha, H.G. Kruger and T. Raasch, 2004. Complete NMR elucidation of a novel trishomocubane hydantoin and its mono‐and bis‐t‐Boc protected derivatives. Magn. Reson. Chem., 42: 617-623.
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  42. Du Toit, J.D. and G. Kruger, 2004. Jesus sing: skrifstudie. Die Kerkblad, 107: 9-11.
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  43. Boyle, G.A., T. Govender, H.G. Kruger and G.E. Maguire, 2004. Synthesis of chiral pentacyclo-undecane macrocycles and their use in enantioselective Michael addition reactions. Tetrahedron: Asymmetry, 15: 3775-3781.
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  44. Boyle, G.A., T. Govender, H.G. Kruger and G.E. Maguire, 2004. Synthesis of chiral pentacyclo-undecane ligands and their use in the enantioselective alkylation of benzaldehyde with diethylzinc. Tetrahedron: Asymmetry, 15: 2661-2666.
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  45. Bisetty, K., J. Gomez‐Catalan, C. Aleman, E. Giralt, H.G. Kruger and J.J. Perez, 2004. Computational study of the conformational preferences of the (R)‐8‐amino‐pentacyclo [5.4. 0.02, 6.03, 10.05, 9] undecane‐8‐carboxylic acid monopeptide. J. Peptide Sci., 10: 274-284.
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  46. Raasch, T., 2003. A synthetic and computational investigation of trishomocubane-amino acid derivatives. Univ. Natal, Durban, .

  47. Govender, T., H.K. Hariprakasha, H.G. Kruger and A.P. Marchand, 2003. Synthesis and transport studies of a new class of cage-annulated chiral macrocycles. Tetrahedron: Asymmetry, 14: 1553-1557.
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  48. Kruger, H.G., 2002. Ab initio mechanistic study of the protection of alcohols and amines with anhydrides. J. Mol. Struct., 577: 281-285.
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  49. Kruger, G., 2002. Briewe van ons lesers. Die Kerkblad, 105: 35-35.

  50. Mlinaric-Majerski, K. , M. Kaselj, J. Veljkovic, A.P. Marchand, H.G. Kruger, 2001. Experimental and theoretical studies of reactions of 1-halomethyl-2-haloadamantanes with Na and RLi compounds. Abstr. Pap. Am. Chem. Soc., 221: 177-177.

  51. Martins, F.J., A.M. Viljoen, H.G. Kruger, L. Fourie, J. Roscher, A.J. Joubert and P.L. Wessels, 2001. Enantioselective synthesis of amino acids from pentacyclo [5.4. 0.0 2, 6. 0 3, 10. 0 5, 9] undecane-8, 11-dione. Tetrahedron, 57: 1601-1607.
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  52. Marchand, A.P., T.D. Power and H.G. Kruger, 2001. Ab initio theoretical investigation of a formal alkene-enedione intramolecular [2+ 2] photocyclization. Croat. Chem. Acta, 74: 265-270.
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  53. Levitskaia, T.G., B.A. Moyer, P.V. Bonnesen, A.P. Marchand, K. Krishnudu, Z. Chen and A.S. McKim, 2001. Novel approach to sodium hydroxide separation: Synergistic pseudo-hydroxide extraction by a fluorinated alcohol and cage-functionalized crown ethers. J. Amer. Chem. Soc., 123: 12099-12100.
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