Dr. Brian Rayner

Head
University of Cape Town, South Africa

Highest Degree
Ph.D. in Hypertension from University of Cape Town, South Africa

My URL
https://livedna.org/27.10918

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Biography

Dr. Brian Rayner is currently working as Head of Nephrology and Hypertension at University of Cape Town. He has received his Ph.D. in Hypertension from same University. His main area of interest focuses on Hypertension, and Genetics. His area of expertise includes Hypertension, Genetics, Guidelines, and Treatment and Adherence. He is author and co-author of 94 journal paper.

Area of Interest:

Pharmacology and Toxicology
Hypertension
Genetics
Adherence
Treatment

Selected Publications

  1. Rayner, B. and R. Ramesar, 2015. The importance of g protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment. Rev. J. Mol. Sci., 16: 5741-5749.
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  2. Jones, E. and B.L. Rayner, 2015. Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users. South Afr. Med. J., 105: 199-201.
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  3. Folt, D.A., K.L. Evans, S. Brahmandam, W. He and P.S. Brewster et al., 2015. Regional and physician specialty-associated variations in the medical management of atherosclerotic renal-artery stenosis. J. Am. Soc. Hypertens., 9: 443-452.
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  4. Seedat, Y.K., B.L. Rayner and Y. Veriava, 2014. South African hypertension practice guideline 2014. Cardiovasc. J. Afr., 28: 288-294.
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  5. Okpechi, I.G., T.A. Dlamini, M. Duffield, B.L. Rayner, G. Moturi and C.R. Swanepoel, 2014. Outcome of patients with primary immune-complex type mesangiocapillary glomerulonephritis (MCGN) in Cape Town South Africa. PloS One, Vol. 9. 10.1371/journal.pone.0113302.
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  6. Jones, E.S.W. and B.L. Rayner, 2014. The importance of guidelines. Cardiovasc. J. Afr., 28: 296-297.

  7. Freercks, R.J., C.R. Swanepoel, K.L. Turest-Swartz, H.R. Carrara, S. Moosa, A.S. Lachman and B.L. Rayner, 2014. Vascular calcification is not associated with increased ambulatory central aortic systolic pressure in prevalent dialysis patients. Cardiovasc. J. Afr., 25: 4-8.
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  8. Borkum, M., N. Wearne, A. Alfred, J.A. Dave, N.S. Levitt and B. Rayner, 2014. Ambulatory blood pressure profiles in a subset of HIV-positive patients pre and post antiretroviral therapy. Cardiovasc. J. Afr., 25: 153-157.
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  9. Bobrow, K., T. Brennan, D. Springer, N.S. Levitt and B. Rayner et al., 2014. Efficacy of a text messaging (SMS) based intervention for adults with hypertension: Protocol for the StAR (SMS Text-message Adherence suppoRt trial) randomised controlled trial. BMC Public Health, Vol. 14. 10.1186/1471-2458-14-28.
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  10. Seedat, Y.K. and B.L. Rayner, 2013. The abridged South African hypertension guideline 2011. South Afr. Family Pract., 55: 113-116.
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  11. Rosansky, S.J., G. Cancarini, W.F. Clark, P. Eggers and M. Germaine et al., 2013. Dialysis initiation: What's the rush? Seminars Dial., 26: 650-657.
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  12. Okpechi, I.G., O.E. Ayodele, B.L. Rayner and C.R. Swanepoel, 2013. Kidney disease in elderly South Africans. Clin. Nephrol., 79: 269-276.
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  13. Ogah, O.S. and B.L. Rayner, 2013. Recent advances in hypertension in sub-Saharan Africa. Heart, 99: 1390-1397.
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  14. Moholisa, R.R., B.R. Rayner, E.P. Owen, S.L. Schwager and J.S. Stark et al., 2013. Association of B2 receptor polymorphisms and ACE activity with ACE inhibitor-induced angioedema in black and mixed-race south Africans. J. Clin. Hypertens., 15: 413-419.
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  15. Wearne, N., C.R. Swanepoel, A. Boulle, M.S. Duffield and B.L. Rayner, 2012. The spectrum of renal histologies seen in HIV with outcomes, prognostic indicators and clinical correlations. Nephrol. Dial. Transplant., 27: 4109-4118.
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  16. Rayner, B.L., 2012. The young hypertensive patient. South Afr. Family Pract., 54: S29-S30.

  17. Okpechi, I.G., C.R. Swanepoel, N. Tiffin, M. Duffield and B.L. Rayner, 2012. Clinicopathological insights into lupus nephritis in South Africans: A study of 251 patients. Lupus, 21: 1017-1024.
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  18. Okpechi, I.G., B.L. Rayner and C.R. Swanepoel, 2012. Peritoneal dialysis in Cape Town, South Africa. Perit. Dial. Int., 32: 254-260.
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  19. Jones, E.S.W., E.P. Owen and B.L. Rayner, 2012. The association of the R563Q genotype of the ENaC with phenotypic variation in Southern Africa. Am. J. Hypertens., 25: 1286-1291.
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  20. Freercks, R., C. Swanepoel, H. Carrara, S. Moosa, A. Lachman and B. Rayner, 2012. Vascular calcification in South African dialysis patients: Ethnic variation, prevalence, detection and haemodynamic correlates. Nephrology, 17: 607-615.
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  21. Rayner, B., R. Ramesar, K. Steyn, N. Levitt, C. Lombard and K. Charlton, 2011. G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in black patients with mild-to-moderate hypertension. J. Hum. Hypertens., 26: 334-339.
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  22. Rayner, B., A. Musekiwa, C. Lombard and R.S. Ramesar, 2011. The A142V polymorphism of the G protein coupled receptor kinase 4 gene predicts natriuretic response to saline challenge in young normotensive lean black and white South African men. Nephrol. Rev., 3: 49-53.
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  23. Okpechi, I.G., H.S. Schoeman, B. Longo-Mbenza, D.A. Oke, S. Kingue, J.L. Nkoua and B.L. Rayner, 2011. Achieving blood preSsure goals sTudy in uncontrolled hypeRtensive pAtients treated with a fixed-dose combination of ramipriL/hydrochlorothiazide: The ASTRAL study. Cardiovasc. J. Afr., 22: 79-84.
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  24. Okpechi, I.G. and B.L. Rayner, 2011. Impact of recent landmark clinical trials on hypertension treatment. Clin. Invest., 1: 1141-1154.
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  25. Nel, D. and B.L. Rayner, 2011. HIV vasculopathy of the renal artery manifesting as severe hypertension in a young female: Case report and review. Vascular Dis. Manage., 8: E40-E44.

  26. James, M.F., R.A. Dyer and B.L. Rayner, 2011. A modern look at hypertension and anaesthesia. South Afr. J. Anaesth. Analg., 17: 168-173.

  27. Tiffin, T., A. Meintjes, R. Ramesar, V.B. Bajic and B. Rayner, 2010. Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans. PLoS One, Vol. 5. 10.1371/journal.pone.0012989.
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  28. Rayner, B., 2010. Hypertension: Detection and management in South Africa. Nephron, 414: c269-c273.
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  29. Okpechi, I.G., B.L. Rayner, L. van der Merwe, B.M. Mayosi, A. Adeyemo, N. Tiffin and R. Ramesar, 2010. Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa. PLoS One, Vol. 5. 10.1371/journal.pone.0009086.
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  30. Okpechi, I.G., B.L. Rayner and C.R. Swanepoel, 2010. Nephrotic syndrome in adult black South Africans: HIV-associated nephropathy as the main culprit. J. Natl. Med. Assoc., 102: 1193-1197.
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  31. Okpechi, I.G., A. Motala, E. Panieri and B.L. Rayner, 2010. Adrenal-oncocytic tumor: An unusual cause of secondary hypertension in a young South African male. Nephrol. Rev., 2: 53-55.

  32. Okpechi, I.G. and B.L. Rayner, 2010. Update on the role of candesartan in the optimal management of hypertension and cardiovascular risk reduction. Integr. Blood Pressure, 3: 45-55.
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  33. Okpechi, I., C. Swanepoel, M. Duffield, B. Mahala and N. Wearne et al., 2010. Patterns of renal disease in Cape Town South Africa: A 10-year review of a single-centre renal biopsy database. Nephrol. Dial. Trans. 10.1093/ndt/gfq655.
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  34. Jones, E., E. Owen, J. Davidson, L. van der Merwe and B. Rayner, 2010. The R563Q mutation of the epithelial sodium channel beta-subunit is associated with hypertension. Cardiovasc. J. Afr., 21: 1-4.

  35. Rayner, B., 2009. Do inhibitors of the renin-angiotensin system prevent chronic kidney disease? Editorial. Cardiovasc. J. Afr., 20: 372-375.
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  36. Rayner, B. and H.S. Schoeman, 2009. A cross-sectional study of blood pressure control in hypertensive patients in general practice (the I-TARGET study). Cardiovasc. J. Afr., 20: 224-227.
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  37. Okpechi, I.G., S. Kadiri, B.L. Salako and B.L. Rayner, 2009. Renal acid excretion in hypertensive black Africans. Nephrol. Rev., 1: 5-7.

  38. Rayner, B.L., 2008. Best practice: Primary aldosteronism and aldosterone related hypertension. J. Clin. Path., 61: 825-831.

  39. Okpechi, I.G., B.L. Salako, C.R. Swanepoel and B.L. Rayner, 2008. The metabolic syndrome and kidney disease. Trop. J. Nephrol., 3: 71-79.

  40. Rayner, B.L., Y.K. Seedat, J. Milne, V. Pinkney-Atkinson and Y. Veriava, 2007. The South African Hypertension Guideline 2006 is evidence-based and not cost-effective-a rebuttal. South Afr. Med. J., 97: 152-154.
    PubMed  |  

  41. Rayner, B., M. Blockman, D. Baines and Y. Trinder, 2007. A survey of hypertensive practices at two community health centres in Cape Town. South Afr. Med. J., 97: 280-284.
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  42. Rayner, B., 2007. Clinical lessons from an elderly man with amiodarone-induced interstitial lung disease. South Afr. Med. J., 97: 360-362.
    PubMed  |  

  43. Payne, J.R., S.S. Dhamrait, P. Gohlke, J. Cooper and R.A. Scott et al., 2007. The impact of ACE genotype on serum ACE activity in a black south African male population. Ann. Hum. Genet., 71: 1-7.
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  44. Okpechi, I.G., M.D. Pascoe, C.R. Swanepoel and B.L. Rayner, 2007. Microalbuminuria and the metabolic syndrome in non-diabetic black Africans. Diabetes Vascular Dis. Res., 4: 365-367.
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  45. Lindhorst, J., N. Alexander, J. Blignaut and B. Rayner, 2007. Differences in hypertension between blacks and whites: An overview. Cardiovasc. J. South Afr., 18: 241-247.

  46. Cupido, C. and B. Rayner, 2007. Life-threatening angio-oedema and death associated with the ACE inhibitor enalapril. South Afr. Med. J., 97: 244-245.
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  47. Seedat, Y.K., M.A. Croasdale, F.J. Milne, L.H. Opie, V.J. Pinkney-Atkinson, B.L. Rayner and Y. Veriava, 2006. South African hypertension guidelines. South Afr. Med. J., 96: 336-362.

  48. Rayner, B.L., Y.A. Trinder, D. Baines, S. Isaacs and L.H. Opie, 2006. Effect of losartan versus candesartan on uric acid, renal function and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics. Am. J. Hypertens., 19: 208-213.
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  49. Rayner, B.L., 2006. The South African hypertension guideline 2006: A major step forward for improved management of hypertension. Cardiovasc. J. South Afr., 17: 109-110.
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  50. Rayner, B.L., 2006. Importance of modulating the renin-angiotensin system in preventing renal complications of hypertension. Saudi J. Kidney Dis. Transplant., 17: 469-480.
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  51. Rayner, B. and P. Becker, 2006. The prevalence of microalbuminuria and ECG left ventricular hypertrophy in hypertensive patients in private practices in South Africa. Cardiovasc. J. South Afr., 17: 245-249.
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  52. Moodley, I., B. Rayner and D. Singh, 2006. Losartan appears cost-effective for reducing stroke in people with hypertension and left ventricular hypertrophy. Evidence-Based Cardiov. Med., 10: 94-95.

  53. Dhanjal, M., E.P. Owen, J.E. Davidson, J.A. Anthony, D. Baines and B.L. Rayner, 2006. Association of pre-eclampsia with the R563Q mutation of the β-subunit of the epithelial sodium channel. BJOG, 113: 595-598.

  54. Rayner, B.L., 2005. ASCOT-BPLA signals changes to hypertension guidelines. Cardiovasc. J. South Afr., 16: 244-245.

  55. Noakes, T.D., N. Goodwin, B.L. Rayner, T. Branken and R.K. Taylor, 2005. Water intoxication: A possible complication during endurance exercise. Wilderness Environ. Med., 16: 221-227.
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  56. Rayner, B.L., H. Goodman and L.H. Opie, 2004. The chest radiograph: A useful investigation in the evaluation of hypertensive patients. Am. J. Hypertens., 17: 507-510.
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  57. Rayner, B.L., 2004. Selective imidazoline agonist moxonidine plus the ACE inhibitor ramipril in hypertensive patients with impaired insulin sensitivity: Partners in a successful marriage? Curr. Res. Opin., 20: 359-367.
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  58. Rayner, B.L., 2004. Advances in the treatment of diabetic renal disease: Focus on losartan. Curr. Res. Opin., 20: 333-340.
    PubMed  |  

  59. Rayner, B., B. Jaeger, C.N. Verboom and M. Pascoe, 2004. Potential renoprotective effects of the angiotensin receptor blocker eprosartan: A review of preliminary renal studies. Cardiovasc. J. South Afr., 15: 32-36.
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  60. Rayner, B., 2004. Prescribed minimum benefits or minimum prescribed benefits? South Afr. J. Med., 94: 623-624.
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  61. Rayner, B.L., E.P. Owen, J.A. King, S. Soule and H. Vreede et al., 2003. A new mutation, r563q, of the beta subunit of the epithelial sodium channel associated with low-renin, low-aldosterone hypertension. J. Hypertens., 21: 921-926.
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  62. Rayner, B., 2003. Renal transplantation in South Africa. South Afr. Med. J., 93: 673-674.

  63. Seedat, Y.K. and B.L. Rayner, 2002. South African hypertension guideline 2011: Guideline. South Afr. Med. J., 102: 59-83.
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  64. Rayner, B.L., C. Willet and M. Hollander, 2002. Adequacy of dialysis and nutrition in CAPD patients. South Afr. Med. J., 92: 887-889.

  65. Rayner, B.L., B. Buchanan-Lee, J. Brink and L.H. Opie, 2002. Generic substitution-is it safe in patients at high cardiovascular risk? South Afr. Med. J., 92: 603-604.
    PubMed  |  

  66. Rayner, B.L., 2002. Screening and diagnosis of primary aldosteronism. Cardiovasc. J. South Afr., 13: 97-101.

  67. Rayner, B.L., 2002. Choice of diuretics for hypertension. South Afr. Med. J., 92: 524-525.

  68. Rayner, B.L., S.G. Soule and J.S. Davidson, 2001. Primary aldosteronism: A new perspective in South Africa. Cardiovasc. J. South Afr., 12: 69-72.
    PubMed  |  

  69. Rayner, B.L., M. Voigt, S. Robson and R. Kirsch, 2001. Renal function and sodium handling in patients with portal vein thrombosis compared to normal controls. South Afr. Med. J., 91: 61-65.

  70. Rayner, B.L., J.E. Myers, L.H. Opie, Y.A. Trinder and J.S. Davidson, 2001. Screening for primary aldosteronism-normal ranges for aldosterone and renin in three South African population groups. South Afr. Med. J., 91: 594-599.
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