Dr. Theofilos M. Kolettis

Professor
University of Ioannina, Greece

Highest Degree
Doctorate in Cardiology from Athens University, Greece

My URL
https://livedna.org/30.6359

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Area of Interest:

Biomedical Sciences
Cardiology Research
Medical Hypotheses
Heart Blood Circulation
Electrophysiology

Selected Publications

  1. Kolettis, T.M., M. Barton, D. Langleben and Y. Matsumura, 2013. Endothelin in coronary artery disease and myocardial infarction. Cardiol. Rev., 21: 249-256.
    PubMed  |  

  2. Kolettis, T.M., 2013. Coronary artery disease and ventricular tachyarrhythmia: Pathophysiology and treatment. Curr. Opin. Pharmacol., 13: 210-217.
    CrossRef  |  PubMed  |  

  3. Kolentinis, M.K., I.I. Verginadis, Y.V. Simos, N. Tsitou, S.C. Karkabounas, T.M. Kolettis and A.M. Evangelou, 2013. Cardiovascular effects of vanillylmandelic acid in rats. Eur. J. Pharmacol., 703: 46-52.
    CrossRef  |  PubMed  |  

  4. Vlahos, A.P., F.P. Koutsouka, N.D. Papamichael, A. Makis and G.G. Baltogiannis et al., 2012. Determinants of pulmonary hypertension in patients with Beta-thalassemia major and normal ventricular function. Acta Haematol., 128: 124-129.
    CrossRef  |  

  5. Megalou, A.J., C. Glava, A.D. Vilaeti, D.L. Oikonomidis and G.G. Baltogiannis et al., 2012. Transforming growth factor-L inhibition and endothelin receptor blockade in rats with monocrotaline-induced pulmonary hypertension. Pulm Circ., 2: 461-469.
    CrossRef  |  PubMed  |  

  6. Kolettis, T.M. and A. Tsatsoulis, 2012. Subclinical hypothyroidism: An overlooked cause of atrial fibrillation? J. Atr. Fibrillation, 5: 6-8.

  7. Hyphantis, T.N., A.I. Pappas, A.P. Vlahos, A.F. Carvalho, J.L. Levenson and T.M. Kolettis, 2012. Depressive symptoms and neurocardiogenic syncope in children: A 2-year prospective study. Pediatrics, 130: 906-913.
    CrossRef  |  

  8. Bibli, S.I., E.V. Toli, A.D. Vilaeti, V.C. Varnavas and G.G. Baltogiannis et al., 2012. Endothelin-B receptors and left ventricular dysfunction after regional versus global ischaemia-reperfusion in rat hearts. Cardiol. Res. Pract. .
    Direct Link  |  

  9. Bechlioulis, A., K.K. Naka, S.N. Kalantaridou, A. Kaponis and O. Papanikolaou et al., 2012. Increased vascular inflammation in early menopausal women is associated with hot flush severity. J. Clin. Endocrinol. Metab., 97: 760-764.
    PubMed  |  

  10. Varnavas, V.C., K. Kontaras, C. Glava, C.D. Maniotis and M. Koutouzis et al., 2011. Chronic skeletal muscle ischemia preserves coronary flow in the ischemic rat heart. Am. J. Physiol. Heart Circ. Physiol., 301: 1229-1235.
    PubMed  |  

  11. Maniotis, C., D.G. Tsalikakis, A.T. Tzallas, V. Varnavas and K. Kontaras et al., 2011. Chronic skeletal muscle ischemia in rats decreases the inducibility of ventricular tachyarrhythmias after myocardial infarction. In Vivo, 25: 781-786.
    PubMed  |  

  12. Kolettis, T.M., A. Vilaeti, K. Dimos, N. Tsitou and S. Agathopoulos, 2011. Tissue engineering for post-myocardial infarction ventricular remodeling. Mini. Rev. Med. Chem., 11: 263-270.
    PubMed  |  

  13. Kolettis, T.M., 2011. Endothelin-1 during myocardial ischaemia: A double-edged sword? Hypertens Res., 34: 170-172.
    Direct Link  |  

  14. Oikonomidis, D.L., G.G. Baltogiannis and T.M. Kolettis, 2010. Do endothelin receptor antagonists have an antiarrhythmic potential during acute myocardial infarction? Evidence from experimental studies. J. Interv. Card Electrophysiol., 28: 157-165.
    PubMed  |  

  15. Oikonomidis, D.L., D.G. Tsalikakis, G.G. Baltogiannis, A.T. Tzallas and X. Xourgia et al., 2010. Endothelin-B receptors and ventricular arrhythmogenesis in the rat model of acute myocardial infarction. Basic Res. Cardiol., 105: 235-245.
    PubMed  |  

  16. Megalou, A.J., C. Glava, D.L. Oikonomidis, A. Vilaeti and M.G. Agelaki et al., 2010. Transforming growth factor-L inhibition attenuates pulmonary arterial hypertension in rats. Int. J. Clin. Exp. Med., 3: 332-340.
    PubMed  |  

  17. Kolettis, T.M., K. Kontaras, I. Spartinos, C. Maniotis and V. Varnavas et al., 2010. Dose-dependent effects of sildenafil on post-ischaemic left ventricular function in the rat isolated heart. J. Pharm. Pharmacol., 62: 346-351.
    PubMed  |  

  18. Kolettis, T.M., D.N. Lysitsas, D. Apostolidis, G.G. Baltogiannis, E. Sourla and L.K. Michalis, 2010. Improved cut-down technique for transvenous pacemaker lead implantation. Europace, 12: 1282-1285.
    PubMed  |  

  19. Kapatou, E., A. Skyrlas, M.G. Agelaki, C. Pantos, T.M. Kolettis and V. Malamou-Mitsi, 2010. Amiodarone attenuates apoptosis, but induces phospholipidosis in rat alveolar epithelial cells. J. Physiol. Pharmacol., 61: 671-677.
    PubMed  |  

  20. Papathanassiou, K., K.K. Naka, N. Kazakos, C. Kanioglou and D. Makriyiannis et al., 2009. Pioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetes. Atherosclerosis, 205: 221-226.
    PubMed  |  

  21. Elaiopoulos, D.A. and T.M. Kolettis, 2009. Antiarrhythmic actions of growth hormone during acute myocardial infarction. J. Electrocardiol., 42: 298-299.
    PubMed  |  

  22. Siedlecka, U., M. Arora, T. Kolettis, G.K. Soppa and J. Lee et al., 2008. Effects of clenbuterol on contractility and Ca2+ homeostasis of isolated rat ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol., 295: H1917-H1926.
    PubMed  |  

  23. Kolettis, T.M., Z.S. Kyriakides, E. Zygalaki, S. Kyrzopoulos and L. Kaklamanis et al., 2008. Endothelin system and atrial fibrillation postcardiac surgery. J. Interv Card Electrophysiol., 21: 203-208.
    PubMed  |  

  24. Kolettis, T.M., V.D. Krikos, D. Apostolidis, K.K. Naka, C.S. Katsouras, E. Sourla and L.K. Michalis, 2008. Outcome of patients with haemodynamically stable ventricular tachycardia treated with an implantable cardioverter-defibrillator. Hellenic J. Cardiol., 49: 248-259.
    PubMed  |  

  25. Kolettis, T.M., G.G. Baltogiannis, D.G. Tsalikakis, A.T. Tzallas and M.G. Agelaki et al., 2008. Effects of dual endothelin receptor blockade on sympathetic activation and arrhythmogenesis during acute myocardial infarction in rats. Eur. J. Pharmacol., 580: 241-249.
    PubMed  |  

  26. Kolettis, T.M., C.S. Katsouras and L.K. Michalis, 2008. Electrical cardioversion of atrial fibrillation using four defibrillation patches. Europace, 10: 451-452.
    PubMed  |  

  27. Fox, K., I. Ford, P.G. Steg, M. Tendera, R. Ferrari and Beautiful Investigators, 2008. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): A randomised, double-blind, placebocontrolled trial. Lancet, 372: 807-816.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Beautiful Study Group, R. Ferrari, I. Ford, K. Fox, P.G. Steg and M. Tendera, 2008. The BEAUTIFUL study: Randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction-baseline characteristics of the study population. Cardiology, 110: 271-282.
    PubMed  |  

  29. Vlahos, A.P., M. Tzoufi, C.S. Katsouras, T. Barka and I. Sionti et al., 2007. Provocation of neurocardiogenic syncope during head-up tilt testing in children: comparison between isoproterenol and nitroglycerin. Pediatrics, 119: 419-425.
    PubMed  |  

  30. Kyriakides, Z.S., A.G. Manolis and T.M. Kolettis, 2007. The effects of ventricular asynchrony on myocardial perfusion. Int. J. Cardiol., 119: 3-9.
    PubMed  |  

  31. Korantzopoulos, P., T.M. Kolettis, D. Galaris and J.A. Goudevenos, 2007. The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation. Int. J. Cardiol., 115: 135-143.
    PubMed  |  

  32. Kolettis, T.M., M.G. Agelaki, G.G. Baltogiannis, A.P. Vlahos, I. Mourouzis, A. Fotopoulos and C. Pantos, 2007. Comparative effects of acute vs. chronic oral amiodarone treatment during acute myocardial infarction in rats. Europace, 9: 1099-1104.
    PubMed  |  

  33. Kolettis, T.M., A. Papathanasiou, D. Tziallas, H.J. Milionis, C.K. Kastanioti and K. Achenbach, 2007. Afternoon nap, meal ingestion and circadian variation of acute myocardial infarction. Int. J. Cardiol., 123: 338-340.
    PubMed  |  

  34. Kolettis, T., A.P. Vlahos, M. Louka, K.E. Hatzistergos and G.G. Baltogiannis et al., 2007. Characterisation of a rat model of pulmonary arterial hypertension. Hellenic J. Cardiol., 48: 206-210.
    PubMed  |  

  35. Hatzistergos, K.E., A.C. Mitsi, C. Zachariou, A. Skyrlas and E. Kapatou et al., 2007. Randomised comparison of growth hormone versus IGF-1 on early post-myocardial infarction ventricular remodelling in rats. Growth Horm IGF Res., 18: 157-165.
    PubMed  |  

  36. Elaiopoulos, D.A., D.G. Tsalikakis, M.G. Agelaki, G.G. Baltogiannis, A.C. Mitsi, D.I. Fotiadis and T.M. Kolettis, 2007. Growth hormone decreases phase II ventricular tachyarrhythmias during acute myocardial infarction in rats. Clin. Sci., 112: 385-391.
    PubMed  |  

  37. Christou, L., M. Economou, G. Economou, T.M. Kolettis and E.V. Tsianos, 2007. Characteristics of ascitic fluid in cardiac ascites. Scand. J. Gastroenterol., 42: 1102-1105.
    PubMed  |  

  38. Agelaki, M.G., C. Pantos, P. Korantzopoulos, D.G. Tsalikakis, G.G. Baltogiannis, A. Fotopoulos and T.M. Kolettis, 2007. Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats. Eur. J. Pharmacol., 564: 150-157.
    PubMed  |  

  39. Mitsi, A.C., K.E. Hatzistergos, D. Niokou, L. Pappa and G.G. Baltogiannis et al., 2006. Early, intracoronary growth hormone administration attenuates ventricular remodeling in a porcine model of myocardial infarction. Growth Horm IGF Res., 16: 93-100.
    PubMed  |  

  40. Korantzopoulos, P., T.M. Kolettis, A. Papathanasiou, K.K. Naka and P. Kolios et al., 2006. Propafenone added to ibutilide increases conversion rates of persistent atrial fibrillation. Heart, 92: 631-634.
    PubMed  |  

  41. Korantzopoulos, P., T.M. Kolettis and J.A. Goudevenos, 2006. Effects of N-3 fatty acids on postoperative atrial fibrillation following coronary artery bypass surgery. J. Am. Coll. Cardiol., 47: 467-468.
    PubMed  |  

  42. Kolettis, T.M., 2006. Arrhythmogenesis after cell transplantation post-myocardial infarction. Four burning questions-and some answers. Cardiovasc. Res., 69: 299-301.
    PubMed  |  

  43. Katsouras, C.S., C. Leontaridou, K. Achenbach, G. Maglaras and M.P. Vassiliou et al., 2006. Echocardiographic evidence of posteromedial hypokinesis of the left ventricle in relation to mitral regurgitation in cardiac sarcoidosis. Heart Vessels., 21: 382-384.
    PubMed  |  

  44. Mitsi, A.C., K. Hatzistergos, G.G. Baltogiannis and T.M. Kolettis, 2005. Early, selective growth hormone administration may ameliorate left ventricular remodeling after myocardial infarction. Med. Hypotheses, 64: 582-585.
    PubMed  |  

  45. Korantzopoulos, P., T.M. Kolettis, K. Siogas and J.A. Goudevenos, 2005. The emerging role of inflammation in atrial fibrillation and the potential of anti-inflammatory interventions. Eur. Heart J., 26: 2207-2208.
    PubMed  |  

  46. Korantzopoulos, P., T.M. Kolettis, J.A. Goudevenos and K Siogas, 2005. Errors and pitfalls in the non-invasive management of atrial fibrillation. Int. J. Cardiol., 104: 125-130.
    PubMed  |  

  47. Korantzopoulos, P., T.M. Kolettis, E. Kountouris, V. Dimitroula and P. Karanikis et al., 2005. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation. Int. J. Cardiol., 102: 321-326.
    PubMed  |  

  48. Korantzopoulos, P., T.M. Kolettis, E. Kountouris, K. Siogas and J.A. Goudevenos, 2005. Variation of inflammatory indexes after electrical cardioversion of persistent atrial fibrillation. Is there an association with early recurrence rates? Int. J. Clin. Pract., 59: 881-885.
    PubMed  |  

  49. Korantzopoulos, P., T.M. Kolettis and J.A. Goudevenos, 2005. The anti-inflammatory and antioxidant effects of long-chain Q-3 fatty acids or oil-rich fish may favorably affect atrial remodeling in atrial fibrillation. Med. Hypotheses, 64: 1245-1246.
    PubMed  |  

  50. Korantzopoulos, P., T.M. Kolettis and E. Kountouris, 2005. Inflammation and anti-inflammatory interventions in atrial fibrillation. Int. J. Cardiol., 104: 361-362.
    PubMed  |  

  51. Kolettis, T.M., N. Kazakos, C.S. Katsouras, D. Niokou and L. Pappa et al., 2005. 2005. Intrapericardial drug delivery: Pharmacologic properties and long-term safety in swine. Int. J. Cardiol., 99: 415-421.
    PubMed  |  

  52. Kolettis, T.M., K.K. Naka and C.S. Katsouras, 2005. Radiofrequency catheter ablation for electrical storm in a patient with dilated cardiomyopathy. Hellenic J. Cardiol., 46: 366-369.
    PubMed  |  

  53. Kolettis, T.M., G. Oikonomou, I. Novas and D.A. Sideris, 2005. Transient complete atrioventricular block associated with herb intake. Europace, 73: 225-226.
    PubMed  |  

  54. Kolettis, T.M., C.S. Katsouras, K. Pappas and J. Goudevenos, 2005. Myocardial ischemia caused by cold-water submersion. Int. J. Cardiol., 99: 467-469.
    PubMed  |  

  55. Baltogiannis, G.G., D.G. Tsalikakis, A.C. Mitsi, K.E. Hatzistergos and D. Elaiopoulos et al., 2005. Endothelin receptor-A blockade decreases ventricular arrhythmias after myocardial infarction in rats. Cardiovasc Res., 67: 647-654.
    PubMed  |  

  56. Paravolidakis, K.E., E.S. Hamodraka, T.M. Kolettis, S.N. Psychari and T.S. Apostolou, 2004. Management of inadvertent left ventricular permanent pacing. J. Interv. Card Electrophysiol., 10: 237-240.
    PubMed  |  

  57. Korantzopoulos, P., T. Kolettis, E. Kountouris and K. Siogas, 2004. Atrial remodeling in persistent atrial fibrillation: The potential role of aldosterone. Eur. Heart J., Vol. 25. .
    PubMed  |  Direct Link  |  

  58. Katsouras, C.S., L.K. Michalis, I. Leontaridis, T. Kolettis and K.K. Naka et al., 2004. Treatment of acute lower limb ischemia following the use of the Duett sealing device: Report of three cases and review of the literature. Cardiovasc. Intervent Radiol., 27: 268-270.
    PubMed  |  

  59. Katsouras, C.S., G.F. Greakas, J.A. Goudevenos, L.K. Michalis and T. Kolettis et al., 2004. Localization of accessory pathways by the electrocardiogram: which is the degree of accordance of three algorithms in use? Pacing Clin. Electrophysiol., 27: 189-193.
    PubMed  |  

  60. Kyriakides, Z.S., S.N. Psychari, T.M. Kolettis, M. Georgiadis, A. Antoniadis and D.T. Kremastinos, 2003. Usefulness of endothelin(A) receptor antagonists for the prevention of in-stent restenosis in patients with stable angina pectoris or silent myocardial ischemia. Am. J. Cardiol., 91: 476-479.
    PubMed  |  

  61. Korantzopoulos, P., T. Kolettis, K. Siogas and J. Goudevenos, 2003. Atrial fibrillation and electrical remodeling: The potential role of inflammation and oxidative stress. Med. Sci. Monit., 9: RA225-RA229.
    PubMed  |  

  62. Korantzopoulos, P., T. Kolettis and J. Goudevenos, 2003. Atrial fibrillation in hypertension: An established association with several unresolved issues. Cardiology, 100: 105-106.
    PubMed  |  

  63. Kolettis, T.M., Z.S. Kyriakides, D. Leftheriotis, A. Papalambrou, D.T. Kremastinos and D.J. Webb, 2003. Electrophysiologic effects of endothelin receptor-A blockade in patients with coronary artery disease. J. Interv. Card. Electrophysiol., 8: 173-179.
    PubMed  |  

  64. Kolettis, T.M., K.K. Naka, C. Katsouras, L.K. Michalis and K. Bourantas, 2003. Transient intraventricular conduction delay associated with concurrent intake of propafenone and antineoplastic agents. Cardiovasc Drugs Ther., 17: 381-382.
    PubMed  |  

  65. Kolettis, T.M., E. Psarros, Z.S. Kyriakides, C.S. Katsouras, L.K. Michalis and D.A. Sideris, 2003. Haemodynamic and catecholamine response to simulated ventricular tachycardia in man: Effect of baseline left ventricular function. Heart, 89: 306-310.
    PubMed  |  

  66. Kolettis, T.M. and M.T. Kolettis, 2003. Winter swimming: Healthy or hazardous? Evidence and hypotheses. Med. Hypotheses, 61: 654-656.
    PubMed  |  

  67. Michalis, L.K., M.R. Rees, D. Patsouras, C.S. Katsouras and J. Goudevenos et al., 2002. A prospective randomized trial comparing the safety and efficacy of three commercially available closure devices (Angioseal, Vasoseal and Duett). Cardiovasc Intervent Radiol., 25: 423-429.
    PubMed  |  

  68. Michalis, L.K., A.P. Tambaki, C.S. Katsouras, J.A. Goudevenos and T. Kolettis et al., 2002. Platelet hyperaggregability to platelet activating factor (PAF) in non-ST elevation acute coronary syndromes. Curr. Med. Res. Opin., 18: 108-112.
    PubMed  |  

  69. Kyriakides, Z.S., S. Psychari, E.K. Iliodromitis, T.M. Kolettis, E. Sbarouni and D.T. Kremastinos, 2002. Hyperlipidemia prevents the expected reduction of myocardial ischemia on repeated balloon inflations during angioplasty. Chest, 121: 1211-1215.
    PubMed  |  

  70. Kyriakides, Z.S., D.T. Kremastinos, S.N. Psychari, T. Kolettis, E. Sbarouni and D.J. Webb, 2001. Coronary vasoconstriction after coronary angioplasty is attenuated by endothelin a receptor antagonism. Am. J. Cardiol., 87: 1011-1013.
    PubMed  |  

  71. Kyriakides, Z.S., D.T. Kremastinos, T.M. Kolettis, A. Tasouli, A. Antoniadis and D.J. Webb, 2000. Acute endothelin-A receptor antagonism prevents normal reduction of myocardial ischemia on repeated balloon inflations during angioplasty. Circulation, 102: 1937-1943.
    PubMed  |  

  72. Kolettis, T.M., Z.S. Kyriakides, D. Tsiapras, T. Popov, I.A. Paraskevaides and D.T. Kremastinos, 2000. Improved left ventricular relaxation during short-term right ventricular outflow tract compared to apical pacing. Chest, 117: 60-64.
    PubMed  |  
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