Prof. Dr. Luigi A Agrofoglio

Professor
University of Orleans, France

Highest Degree
Ph.D. in Chemical Sciences from University of Orleans, France

My URL
https://livedna.org/33.20128

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Area of Interest:

Molecular Sciences
Organic Chemistry
Drug Delivery
Chemotherapy
Biomarkers

Selected Publications

  1. Krstulja, A., S. Lettieri, A.J. Hall, V. Roy, P. Favetta and L.A. Agrofoglio, 2017. Tailor‐made molecularly imprinted polymer for selective recognition of the urinary tumor marker pseudouridine. Macromol. Biosci., Vol. 17. 10.1002/mabi.201700250.
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  2. Chevrier, F., Z. Chamas, T. Lequeux, E. Pfund and G. Andrei et al., 2017. Synthesis of 5,5-difluoro-5-phosphono-pent-2-en-1-yl nucleosides as potential antiviral agents. RSC Adv., 7: 32282-32287.
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  3. Plebanek, E., F. Chevrier, V. Roy, T. Garenne and F. Lecaille et al., 2016. Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S. Eur. J. Med. Chem., 121: 12-20.
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  4. Dejous, C., H. Hallil, V. Raimbault, J.L. Lachaud and B. Plano et al., 2016. Love acoustic wave-based devices and molecularly-imprinted polymers as versatile sensors for electronic nose or tongue for cancer monitoring. Sensors, Vol. 16. 10.3390/s16060915.
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  5. Bessieres, M., O. Sari, V. Roy, D. Warszycki and A.J. Bojarski et al., 2016. Sonication-assisted synthesis of (E)-2-methyl-but-2-enyl nucleoside phosphonate prodrugs. ChemistrySelect, 1: 3108-3113.
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  6. Sari, O., V. Roy, M. Metifiot, C. Marchand and Y. Pommier et al., 2015. Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase. Eur. J. Med. Chem., 104: 127-138.
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  7. Laporte, R., A. Prunier, E. Pfund, V. Roy, L.A. Agrofoglio and T. Lequeux, 2015. Synthesis of fluorine-containing 3,3-isubstituted oxetanes and alkylidene oxetanes. Eur. J. Org. Chem., 14: 3121-3128.
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  8. Henry, N., P. Favetta, R. Delepee, J.M. Seigneuret and L.A. Agrofoglio, 2015. Synthesis of a molecularly imprinted polymer to isolate glucosamine from plant extracts by an ionic-non-covalent dual approach. Int. J. Cosmetic Sci., 37: 196-206.
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  9. Garenne, T., A. Saidi, B.F. Gilmore, E. Niemiec and V. Roy et al., 2015. Active site labeling of cysteine cathepsins by a straightforward diazomethylketone probe derived from the N-terminus of human cystatin C. Biochem. Biophys. Res. Commun., 460: 250-254.
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  10. Bessieres, M., F. Chevrier, V. Roy and L.A. Agrofoglio, 2015. Recent progress for the synthesis of selected carbocyclic nucleosides. Future Med. Chem., 7: 1809-1828.
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  11. Niemiec, E., M. Bessieres, V. Roy and L.A. Agrofoglio, 2014. Development of Nucleoside Analogs under Microwave Irradiation. In: Microwaves in Drug Discovery and Development: Recent Advances, Spencer, J. (Ed.). Future Science Ltd., London, ISBN: 9781910419298, pp: 168-179.

  12. Krstulja, A., S. Lettieri, A.J. Hall, R. Delepee, P. Favetta and L.A. Agrofoglio, 2014. Evaluation of molecularly imprinted polymers using 2′,3′,5′-tri-O-acyluridines as templates for pyrimidine nucleoside recognition. Anal. Bioanal. Chem., 406: 6275-6284.
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  13. Krstulja, A., C. de Schutter, P. Favetta, P. Manesiotis and L.A. Agrofoglio, 2014. Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting. J. Chromatogr. A, 1365: 12-18.
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  14. Bessieres, M., V. Roy and L.A. Agrofoglio, 2014. A convenient, highly selective and eco-friendly N-Boc protection of pyrimidines under microwave irradiation. RSC Adv., 4: 59747-59749.
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  15. Bessieres, M., C. de Schutter, V. Roy and L.A. Agofoglio, 2014. Olefin cross-metathesis for the synthesis of alkenyl acyclonucleoside phosphonates. Curr. Protoc. Nucleic Acid Chem., 59: 14.11.1-14.11.17.
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  16. Agrofoglio, L.A., A. Krstulja, C. de Schutter, P. Favetta and R. Delepee et al., 2014. Detection of urinary modified nucleosides by a bulk acoustic wave MIP sensor-results and future work. IRBM, 35: 66-71.
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  17. Sari, O., V. Roy and L.A. Agrofoglio, 2013. Nucleosides Modified at the Base Moiety. In: Chemical Synthesis of Nucleoside Analogues Merino, P. (Ed.). Wiley-VCH GmbH & Co., New York, ISBN: 978-1-1180-0751-8, pp: 49-10.

  18. Sari, O., M. Hamada, V. Roy, S.P. Nolan and L.A. Agrofoglio, 2013. The preparation of trisubstituted alkenyl nucleoside phosphonates under ultrasound-assisted olefin cross-metathesis. Org. Lett., 15: 4390-4393.
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  19. Puzio, K., R. Delepee, R. Vidal and L.A. Agrofoglio, 2013. Combination of computational methods, adsorption isotherms and selectivity tests for the conception of a mixed non-covalent-semi-covalent molecularly imprinted polymer of vanillin. Anal. Chim. Acta, 790: 47-55.
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  20. Lebal, N., H. Hallil, C. Dejous, B. Plano and A. Krstulja et al., 2013. Nucleosides analogues recognition by molecularly imprinted polymer-coated Love wave sensor. Micro Nano Lett., 8: 563-566.
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  21. Hamada, M., V. Roy, T.R. McBrayer, T. Whitaker and C. Urbina-Blanco et al., 2013. Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides. Eur. J. Med. Chem., 67: 398-408.
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  22. Aouled, N.O., N. Lebal, H. Hallil, R. Delepee, L. Agrofoglio, D. Rebiere and C. Dejous, 2013. Study of gaseous compounds adsorption with a love wave sensor based on molecularly imprinted polymeric thin film. Sens. Transducers, 149: 37-42.
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  23. Sari, O., V. Roy, J. Balzarini, R. Snoeck, G. Andrei and L.A. Agrofoglio, 2012. Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2′-deoxyuridines. Eur. J. Med. Chem., 53: 220-228.
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  24. Pradere, U., V. Roy, A. Montagu, O. Sari and M. Hamada et al., 2012. Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides. Eur. J. Med. Chem., 57: 126-133.
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  25. Henry, N., R. Delepee, J.M. Seigneuret and L.A. Agrofoglio, 2012. Synthesis of water-compatible imprinted polymers of in situ produced fructosazine and 2,5-deoxyfructosazine. Talanta, 99: 816-823.
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  26. Fresneau, N., M.A. Hiebel, L.A. Agrofoglio and S. Berteina-Raboin, 2012. One-pot Sonogashira-cyclization protocol to obtain substituted furopyrimidine nucleosides in aqueous conditions. Tetrahedron Lett., 53: 1760-1763.
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  27. Fresneau, N., M.A. Hiebel, L.A. Agrofoglio and S. Berteina-Raboin, 2012. Efficient synthesis of unprotected C-5-aryl/heteroaryl-2'-deoxyuridine via a Suzuki-Miyaura reaction in aqueous media. Molecules, 17: 14409-14417.
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  28. Salwinski, A., V. Roy, L.A. Agrofoglio and R. Delepee, 2011. In situ one-step method for synthesis of “Click”-functionalized monolithic stationary phase for capillary electrochromatography. Macromol. Chem. Phys., 212: 2700-2707.
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  29. Roy, V., U. Pradere, A. Montagu, S.P. Nolan and L.A. Agrofoglio, 2011. Phosphonate synthons bearing biolabile group for olefin cross metathesis synthesis of acyclonucleoside phosphonate analogs. Collection Symp. Ser., 12: 213-217.
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  30. Roy, V., A. Obikhod, H.W. Zhang, S.J. Coats and B.D. Herman et al., 2011. Synthesis and anti-HIV evaluation of 3′-triazolo nucleosides. Nucleosides Nucleotides Nucleic Acids, 30: 264-270.
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  31. Pradere, U., H. Clavier, V. Roy, S.P. Nolan and L.A. Agrofoglio, 2011. The shortest strategy for generating phosphonate prodrugs by olefin cross-metathesis-application to acyclonucleoside phosphonates. Eur. J. Org. Chem., 36: 7324-7330.
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  32. Montagu, A., V. Roy, J. Balzarini, R. Snoeck, G. Andrei and L.A. Agrofoglio, 2011. Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2′-deoxyuridines and their antiviral evaluation. Eur. J. Med. Chem., 46: 778-786.
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  33. Montagu, A., U. Pradere, V. Roy, S.P. Nolan and L.A. Agrofoglio, 2011. Expeditious convergent procedure for the preparation of bis (POC) prodrugs of new (E)-4-phosphono-but-2-en-1-yl nucleosides. Tetrahedron, 67: 5319-5328.
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  34. Topalis, D., U. Pradere, V. Roy, C. Caillat and A. Azzouzi et al., 2010. Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates. J. Med. Chem., 54: 222-232.
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  35. Roy, V., U. Pradere and L.A. Agrofoglio, 2010. Microwave-assisted syntheses of nucleosides and their precursors. Future Med. Chem., 2: 177-192.
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  36. Pradere, U., H. Kumamoto, V. Roy and L.A. Agrofoglio, 2010. Preparation of carbocyclic C-nucleosides from α-chlorooxime precursor. Eur. J. Org. Chem., 4: 749-754.
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  37. Mieczkowski, A. and L.A. Agrofoglio, 2010. Potential and perspectives of cyclonucleosides. Curr. Med. Chem., 17: 1527-1549.
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  38. Lin, J., V. Roy, L. Wang, L. You and L.A. Agrofoglio et al., 2010. 3′-(1,2,3-Triazol-1-yl)-3′-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations. Bioorg. Med. Chem., 18: 3261-3269.
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  39. Deville-Bonne, D., C. El Amri, P. Meyer, Y. Chen, L.A. Agrofoglio and J. Janin, 2010. Human and viral nucleoside/nucleotide kinases involved in antiviral drug activation: Structural and catalytic properties. Antiviral Res., 86: 101-120.
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  40. Mieczkowski, A., V. Roy and L.A. Agrofoglio, 2009. Preparation of cyclonucleosides. Chem. Rev., 110: 1828-1856.
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  41. Mieczkowski, A., P. Peltier, T. Zevaco and L.A. Agrofoglio, 2009. Preparation of C5-substituted O6,5′-cyclouridine. Tetrahedron, 65: 4053-4059.
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  42. Mieczkowski, A., J. Blu, V. Roy and L.A. Agrofoglio, 2009. Preparation of C-5-substituted 6,5′-O-anhydrouridine by Sn-Pd transmetallation-coupling process and their use. Tetrahedron, 65: 9791-9796.
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  43. Broggi, J., N. Joubert, S. Diez-Gonzalez, S. Berteina-Raboin, T. Zevaco, S.P. Nolan and L.A. Agrofoglio, 2009. Synthesis of (±)-1,2,3-triazolo-3′-deoxy-4′-hydroxymethyl carbanucleosides via 'click' cycloaddition. Tetrahedron, 65: 1162-1170.
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  44. Broggi, J., H. Kumamoto, S. Berteina-Raboin, S.P. Nolan and L.A. Agrofoglio, 2009. Click azide-alkyne cycloaddition for the synthesis of D-(-)-1,4-disubstituted triazolo-carbanucleosides. Eur. J. Org. Chem., 12: 1880-1888.
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  45. Breton, F., R. Delepee and L.A. Agrofoglio, 2009. Molecular imprinting of AMP by an ionic-noncovalent dual approach. J. Sep. Sci., 32: 3285-3291.
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  46. Auvynet, C., D. Topalis, C. Caillat, H. Munier-Lehmann and E. Seclaman et al., 2009. Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase. Biochem. Biophys. Res. Commun., 388: 6-11.
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  47. Roy, V., A. Mieczkowski, D. Topalis, S. Berteina-Raboin, D. Deville-Bonne, S.P. Nolan and L.A. Agrofoglio, 2008. Microwave-assisted silylation-amination of uracil acyclonucleosides to 4-alkylamino-2(1H)-pyrimidinone analogues. Synthesis, 13: 2127-2133.
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  48. Pruvost, A., F. Theodoro, L. Agrofoglio, E. Negredo and H. Benech, 2008. Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: Application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells. J. Mass Spectrom., 43: 224-233.
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  49. Pradere, U., V. Roy, T.R. McBrayer, R.F. Schinazi and L.A. Agrofoglio, 2008. Preparation of ribavirin analogues by copper- and ruthenium-catalyzed azide-alkyne 1,3-dipolar cycloaddition. Tetrahedron, 64: 9044-9051.
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  50. Kumamoto, H., D. Topalis, J. Broggi, U. Pradere and V. Roy et al., 2008. Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis. Tetrahedron, 64: 3517-3526.
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  51. Joubert, N., F. Amblard, K.L. Rapp, R.F. Schinazi and L.A. Agrofoglio, 2008. Synthesis and anti-HIV activity of 5-haloethynyl and 5-(1,2-dihalo)vinyl analogues of AZT and FLT. Tetrahedron, 64: 4444-4452.
    CrossRef  |  Direct Link  |  

  52. Jegourel, D., R. Delepee, F. Breton, A. Rolland, R. Vidal and L.A. Agrofoglio, 2008. Molecularly imprinted polymer of 5-methyluridine for solid-phase extraction of pyrimidine nucleoside cancer markers in urine. Bioorg. Med. Chem., 16: 8932-8939.
    CrossRef  |  Direct Link  |  

  53. Caillat, C., D. Topalis, L.A. Agrofoglio, S. Pochet, J. Balzarini, D. Deville-Bonne and P. Meyer, 2008. Crystal structure of poxvirus thymidylate kinase: An unexpected dimerization has implications for antiviral therapy. Proc. Natl. Acad. Sci. USA., 105: 16900-16905.
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  54. Broggi, J., S. Diez-Gonzalez, J.L. Petersen, S. Berteina-Raboin, S.P. Nolan and L.A. Agrofoglio, 2008. Study of copper(I) catalysts for the synthesis of carbanucleosides via azide-alkyne 1,3-dipolar cycloaddition. Synthesis, 1: 141-148.
    CrossRef  |  Direct Link  |  

  55. Breton, F., R. Delepee, D. Jegourel, D. Deville-Bonne and L.A. Agrofoglio, 2008. Selective adenosine-5′-monophosphate uptake by water-compatible molecularly imprinted polymer. Anal. Chim. Acta, 616: 222-229.
    CrossRef  |  Direct Link  |  

  56. Agrofoglio, L.A. and A. Mieczkowski, 2008. Synthesis and Biological Activity of Selected Carbocyclic Nucleosides. In: Modifed Nucleosides in Biochemistry, Biotechnology and Medecine, Herdewijn, P. (Ed.). Wiley-VCH GmbH & Co., Weinheim, ISBN: 978-3-527-31820-9, pp: 525-566.

  57. Topalis, D., H. Kumamoto, M.F.A. Velasco, L. Dugue and A. Haouz et al., 2007. Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives-a screening based on affinity for the UMP-CMP binding site. FEBS J., 274: 3704-3714.
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  58. Topalis, D., H. Kumamoto, J.A. Alexandre, L. Dugue and S. Pochet et al., 2007. Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase. Nucleosides Nucleotides Nucleic Acids, 26: 1369-1373.
    CrossRef  |  Direct Link  |  

  59. Roy, V., H. Kumamoto, S. Berteina-Raboin, S.P. Nolan and D. Topalis et al., 2007. Cross-metathesis mediated synthesis of new acyclic nucleoside phosphonates. Nucleosides Nucleotides Nucleic Acids, 26: 1399-1402.
    CrossRef  |  Direct Link  |  

  60. El Kazzouli, S., S. Berteina-Raboin and L.A. Agrofoglio, 2007. Supported synthesis and functionnalization of 2″-deoxyuridine by Suzuki-Miyaura cross-coupling. Nucleosides Nucleotides Nucleic Acids, 26: 1395-1398.
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  61. Broggi, J., N. Joubert, V. Aucagne, T. Zevaco, S. Berteina-Raboin, S.P. Nolan and L.A. Agrofoglio, 2007. Study of different copper (I) catalysts for the “Click Chemistry” approach to carbanucleosides. Nucleosides Nucleotides Nucleic Acids, 26: 779-783.
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  62. Broggi, J., N. Joubert, V. Aucagne, S. Berteina-Raboin and S. Diez-Gonzalez et al., 2007. Alkyne-azide click chemistry mediated carbanucleosides synthesis. Nucleosides Nucleotides Nucleic Acids, 26: 1391-1394.
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  63. Agrofoglio, L.A., V. Bezy, P. Chaimbault, R. Delepee, B. Rhourri and P. Morin, 2007. Mass spectrometry based methods for analysis of nucleosides as antiviral drugs and potential tumor biomarkers. Nucleosides Nucleotides Nucleic Acids, 26: 1523-1527.
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  64. Bezy, V., P. Chaimbault, P. Morin, S.E. Unger, M.C. Bernard and L.A. Agrofoglio, 2006. Analysis and validation of the phosphorylated metabolites of two anti-human immunodeficiency virus nucleotides (stavudine and didanosine) by pressure-assisted CE-ESI-MS/MS in cell extracts: Sensitivity enhancement by the use of perfluorinated acids and alcohols as coaxial sheath-liquid make-up constituents. Electrophoresis, 27: 2464-2476.
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  65. Agrofoglio, L.A., H. Kumamoto and V. Roy, 2006. Cross-metathesis in the synthesis of bioactive phosphonates. Chimica Today, 24: 16-18.
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  66. Agrofoglio, L.A., 2006. An overview of diazine nucleoside analogues. Curr. Org. Chem., 10: 333-362.
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  67. Joubert, N., R.F. Schinazi and L.A. Agrofoglio, 2005. Efficient Pd(0)-catalyzed synthesis of 1,2,3-triazolo-3′-deoxycarbanucleosides and their analogues. Tetrahedron, 61: 11744-11750.
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  68. Escuret, V., V. Aucagne, N. Joubert, D. Durantel and K.L. Rapp et al., 2005. Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity. Bioorg. Med. Chem., 13: 6015-6024.
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  69. Bezy, V., P. Morin, P. Couerbe, G. Leleu and L. Agrofoglio, 2005. Simultaneous analysis of several antiretroviral nucleosides in rat-plasma by high-performance liquid chromatography with UV using acetic acid/hydroxylamine buffer: Test of this new volatile medium-pH for HPLC-ESI-MS/MS. J. Chromatogr. B, 821: 132-143.
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  70. Amblard, F., V. Aucagne, P. Guenot, R.F. Schinazi and L.A. Agrofoglio, 2005. Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series. Bioorg. Med. Chem., 13: 1239-1248.
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  71. Amblard, F., S.P. Nolan, R.F. Schinazi and L.A. Agrofoglio, 2005. Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies. Tetrahedron, 61: 537-544.
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  72. Amblard, F., S.P. Nolan and L.A. Agrofoglio, 2005. Metathesis strategy in nucleoside chemistry. Tetrahedron, 61: 7067-7080.
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  73. Agrofoglio, L.A. and S.P. Nolan, 2005. Olefin metathesis route to antiviral nucleosides. Curr. Topics Med. Chem., 5: 1541-1558.
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  74. Aucagne, V., S. Berteina-Raboin, P. Guenot and L.A. Agrofoglio, 2004. Palladium-catalyzed synthesis of uridines on polystyrene-based solid supports. J. Comb. Chem., 6: 717-723.
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  75. Aucagne, V., F. Amblard and L.A. Agrofoglio, 2004. Highly efficient AgNO3-catalyzed preparation of substituted furanopyrimidine nucleosides. Synlett, 13: 2406-2408.
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  76. Agrofoglio, L.A., F. Amblard, S.P. Nolan, S. Charamon, I. Gillaizeau, T.A. Zevaco and P. Guenot, 2004. Synthesis of L-cyclopentenyl nucleosides using ring-closing metathesis and palladium-mediated allylic alkylation methodologies. Tetrahedron, 60: 8397-8404.
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  77. Saito, Y., V. Escuret, D. Durantel, F. Zoulim, R.F. Schinazi and L.A. Agrofoglio, 2003. Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon. Bioorg. Med. Chem., 11: 3633-3639.
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  78. Mesplet, N., Y. Saito, P. Morin and L.A. Agrofoglio, 2003. Liquid chromatographic separation of phosphoramidate diastereomers on a polysaccharide-type chiral stationary phase. J. Chromatogr. A, 983: 115-124.
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  79. Mesplet, N., Y. Saito, P. Morin and L.A. Agrofoglio, 2003. HPLC and mass spectrometry analysis of the enzymatic hydrolysis of anti-HIV pronucleotide diastereomers. Bioorg. Chem., 31: 237-247.
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  80. Gillaizeau, I., I.M. Lagoja, S.P. Nolan, V. Aucagne, J. Rozenski, P. Herdewijn and L.A. Agrofoglio, 2003. Straightforward synthesis of labeled and unlabeled pyrimidine d4Ns via 2′,3′-Diyne seco analogues through olefin metathesis reaction. Eur. J. Org. Chem., 4: 666-671.
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  81. Amblard, F., S.P. Nolan, I. Gillaizeau and L.A. Agrofoglio, 2003. A new route to acyclic nucleosides via palladium-mediated allylic alkylation and cross-metathesis. Tetrahedron Lett., 44: 9177-9180.
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  82. Agrofoglio, L.A., I. Gillaizeau and Y. Saito, 2003. Palladium-assisted routes to nucleosides. Chem. Rev., 103: 1875-1916.
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  83. Tumkevicius, S., L.A. Agrofoglio, A. Kaminskas, G. Urbelis, T.A. Zevaco and O. Walter, 2002. Synthesis of a novel heterocyclic ring system: 2-thia-3,5,6,7,9-pentaazabenz[cd]azulenes. Tetrahedron Lett., 43: 695-697.
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  84. Saito, Y., T.A. Zevaco and L.A. Agrofoglio, 2002. Chemical synthesis of 13C labeled anti-HIV nucleosides as mass-internal standards. Tetrahedron, 58: 9593-9603.
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  85. Mesplet, N., P. Morin and L.A. Agrofoglio, 2002. Concurrent analysis of nucleoside reverse transcriptase inhibitors in a pool of endogenous nucleosides by short-end injection-capillary electrochromatography on a β-cyclodextrin-bonded stationary phase. Electrophoresis, 23: 1263-1271.
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  86. Cahours, X., P. Morin, H. Dessans and L.A. Agrofoglio, 2002. Determination of some anti-human immunodeficiency virus nucleosides by capillary zone electrophoresis-tandem mass spectrometry. Electrophoresis, 23: 88-92.
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  87. Saito, Y., A. Nyilas and L.A. Agrofoglio, 2001. Synthesis of isotopically labeled D-[1′-13C]ribonucleoside phosphoramidites. Carbohydr. Res., 331: 83-90.
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  88. Saito, Y., A. Nyilas and L.A. Agrofoglio, 2001. Efficient synthesis of D-[1′-13C]-ribonucleosides for incorporation into oligo-RNA. Nucleosides Nucleotides Nucleic Acids, 20: 937-940.
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  89. Mesplet, N., P. Morin, C. Francois and L.A. Agrofoglio, 2001. Simultaneous quantitation of nucleoside HIV-1 reverse transcriptase inhibitors by short-end injection capillary electrochromatography on a β-cyclodextrin-bonded silica stationary phase. J. Chromatogr. A, 927: 161-168.
    CrossRef  |  Direct Link  |  

  90. Legeret, B., Z. Sarakauskaite, F. Pradaux, Y. Saito, S. Tumkevicius and L.A. Agrofoglio, 2001. Synthesis of carbocyclic phosphononucleosides. Nucleosides Nucleotides Nucleic Acids, 20: 661-664.
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  91. Gillaizeau, I., S. Charamon and L.A. Agrofoglio, 2001. Enantioselective synthesis of carba-L-furanose precursors of carbanucleosides, using ring-closing metathesis. Tetrahedron Lett., 42: 8817-8819.
    CrossRef  |  Direct Link  |  

  92. Cahours, X., T.T. Tran, N. Mesplet, C. Kieda, P. Morin and L.A. Agrofoglio, 2001. Analysis of intracellular didanosine triphosphate at sub-ppb level using LC-MS/MS. J. Pharmaceut. Biomed. Anal., 26: 819-827.
    CrossRef  |  Direct Link  |  

  93. Agrofoglio, L.A., X. Cahours, T.T. Tran, H. Dessans, C. Kieda and P. Morin, 2001. Analysis of anti-HIV nucleoside inhibitors by capillary electrophoresis-electrospray ionization mass spectrometry. Nucleosides Nucleotides Nucleic Acids, 20: 375-381.
    Direct Link  |  

  94. Cahours, X., P. Morin, L. Agrofoglio and M. Dreux, 2000. Fast separation of nucleosides by capillary electrochromatography on non-endcapped phenyl-bonded silica phase using short-end injection method. J. Sep. Sci., 23: 138-142.
    CrossRef  |  Direct Link  |  

  95. Cahours, X., H. Dessans, P. Morin, M. Dreux and L. Agrofoglio, 2000. Determination at ppb level of an anti-human immunodeficiency virus nucleoside drug by capillary electrophoresis-electrospray ionization tandem mass spectrometry. J. Chromatogr. A, 895: 101-109.
    CrossRef  |  Direct Link  |  

  96. Wang, P., L.A. Agrofoglio, M.G. Newton and C.K. Chu, 1999. Chiral synthesis of carbocyclic analogues of L-ribofuranosides. J. Org. Chem., 64: 4173-4178.
    CrossRef  |  Direct Link  |  

  97. Agrofoglio, L.A., F. Girard, F. Fleury and S. Leonce, 1999. Synthesis of 5′-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides. Nucleosides Nucleotides Nucleic Acids, 18: 599-600.
    CrossRef  |  Direct Link  |  

  98. Agrofoglio, L.A., F. Girard, C. Demaison, M.G. Lee, P. Roingeard and A. Fridland, 1999. Stereoselective synthesis of carbocyclic α-L-homonucleosides. Nucleosides Nucleotides Nucleic Acids, 18: 601-602.
    CrossRef  |  Direct Link  |  

  99. Agrofoglio, L.A., C. Demaison and L. Toupet, 1999. Enantiomeric synthesis of - (or 1S,2R,3S,5S)-bicarbocyclic[3.1.0] nucleosides. Tetrahedron, 55: 8075-8082.
    CrossRef  |  Direct Link  |  

  100. Girard, F., M.G. Lee, L.A. Agrofoglio and A. Fridland, 1998. A short and stereoselective synthesis of carbocyclic α-L-dideoxyhomonucleosides. J. Heterocycl. Chem., 35: 911-913.
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  101. Girard, F., C. Demaison, M.G. Lee and L.A. Agrofoglio, 1998. Synthesis of enantiomerically pure carbocyclic α-L-isomeric homonucleosides. Tetrahedron, 54: 8745-8752.
    CrossRef  |  Direct Link  |  

  102. Demaison, C., C. Hourioux, P. Roingeard and L.A. Agrofoglio, 1998. Stereoselective synthesis of α-L-bicarbocyclic nucleosides as potential antiviral drugs. Tetrahedron Lett., 39: 9175-9178.
    CrossRef  |  Direct Link  |  

  103. Zhou, X.J., K. Squires, X.R. Pan-Zhou, S. Bernhard and L. Agrofoglio et al., 1997. Phase I dose-escalation pharmacokinetics of AZT-P-ddI (IVX-E-59) in patients with human immunodeficiency virus. J. Clin. Pharmacol., 37: 201-213.
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  104. Wang, P., L.A. Agrofoglio, M.G. Newton and C.K. Chu, 1997. Asymmetric synthesis of L-cyclopentyl carbocyclic nucleosides. Tetrahedron Lett., 38: 4207-4210.
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  105. Girard, F., S. Leonce and L.A. Agrofoglio, 1997. Synthesis of some 5′-thiopentofuranosylpyrimidines as potential anti-tumor agents. Tetrahedron Lett., 38: 7535-7538.
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  106. Agrofoglio, L.A., J.C. Jacquinet and G. Lancelot, 1997. A multigram, stereoselective synthesis of D-[13C5]ribose from D-[13C6]glucose and its conversion into [13C5]nucleosides. Tetrahedron Lett., 38: 1411-1412.
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  107. Faraj, A., L.A. Agrofoglio, J.K. Wakefield, S. McPherson and C.D. Morrow et al., 1994. Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs. Antimicrob. Agents Chemother., 38: 2300-2305.
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  108. Agrofoglio, L., R. Condom, R. Guedj, S.R. Challand and J. Selway, 1994. Synthesis of three new carbocyclic analogues of 3′-deoxy purine ribonucleosides. Nucleosides Nucleotides Nucleic Acids, 13: 1147-1160.
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  109. Agrofoglio, L., E. Suhas, A. Farese, R. Condom, S.R. Challand, R.A. Earl and R. Guedj, 1994. Synthesis of carbocyclic nucleosides. Tetrahedron, 50: 10611-10670.
    CrossRef  |  Direct Link  |  

  110. Agrofoglio, L., R. Condom, R. Guedj, R. Challand and J. Selway, 1993. Synthesis of a new exocyclic amino carbocyclic nucleoside with potential antiviral activity. Tetrahedron Lett., 34: 6271-6272.
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  111. Agrofoglio, L., R. Condom and R. Guedj, 1992. Steric control of the epoxidation of 1-hydroxymethyl-3-cyclopentene using aryl or silyl hydroxyl protecting groups. Tetrahedron Lett., 33: 5503-5504.
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