Dr. Vincent Castagne
Research ScientistPORSOLT, France
Highest Degree
Ph.D. in Pharmacology from Institut de Neurosciences Cognitives et Intégratives d Aquitaine, France
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Area of Interest:
Selected Publications
- Goineau, S. and V. Castagne, 2018. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers. J. Pharmacol. Toxicol. Meth., 90: 58-66.
CrossRef | Direct Link | - Goineau, S. and V. Castagne, 2017. Proarrhythmic risk assessment using conventional and new in vitro assays. Regul. Toxicol. Pharmacol., 88: 1-11.
CrossRef | - Goineau, S. and V. Castagne, 2017. Complementarity of in vitro and in vivo models for the evaluation of gastro-protective effects of pharmacological substances. Fundam. Clin. Pharmacol., 321: 155-164.
CrossRef | Direct Link | - Esneault, E., G. Peyon and V. Castagne, 2017. Efficacy of anticonvulsant substances in the 6 Hz seizure test: Comparison of two rodent species. Epilepsy Res., 134: 9-15.
CrossRef | Direct Link | - Hernier, A.M., C. Froger-Colleaux and V. Castagne, 2016. CNS safety pharmacology: A focus on cognitive functions. J. Pharmacol. Toxicol. Meth., 81: 286-294.
CrossRef | Direct Link | - Goineau, S. and V. Castagne, 2016. Comparison of three preclinical models for nausea and vomiting assessment. J. Pharmacol. Toxicol. Meth., 82: 45-53.
CrossRef | Direct Link | - Froger-Colleaux, C. and V. Castagne, 2016. Effects of baclofen and raclopride on reinstatement of cocaine self-administration in the rat. Eur. J. Pharmacol., 777: 147-155.
CrossRef | Direct Link | - Goineau, S., P. Guillaume and V. Castagne, 2015. Comparison of the effects of clonidine, loperamide and metoclopramide in two models of gastric emptying in the rat. Fundam. Clin. Pharmacol., 29: 86-94.
CrossRef | Direct Link | - Esneault, E., G. Peyon, C. Froger-Colleaux and V. Castagne, 2015. Evaluation of pro-convulsant risk in the rat: Spontaneous and provoked convulsions. J. Pharmacol. Toxicol. Meth., 72: 59-66.
CrossRef | Direct Link | - Le Cudennec, C. and V. Castagne, 2014. Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: Analgesic activity of pregabalin, tramadol and duloxetine. Eur. J. Pharmacol., 735: 17-25.
CrossRef | Direct Link | - Goineau, S., P. Guillaume, L. Barrais and V. Castagne, 2014. Automated analysis of delayed emesis in the telemetered ferret: detection of synergistic effects of aprepitant and ondansetron. Fundam. Clin. Pharmacol., 28: 643-651.
CrossRef | Direct Link | - Porsolt, R.D., V. Castagne, E. Hayes and D. Virley, 2013. Nonhuman primates: Translational models for predicting antipsychotic-induced movement disorders. J. Pharmacol. Exp. Ther., 347: 542-546.
CrossRef | Direct Link | - Goineau, S., S. Rompion, P. Guillaume, L. Barrais and V. Castagne, 2013. Using telemetry to automate the detection of emesis in the ferret: New vistas for delayed emesis assessment. J. Pharmacol. Toxicol. Meth., 68: 160-165.
CrossRef | - Goineau, S., J.L. Lacaud, C. Legrand, E. Eveilleaux and V. Castagne, 2013. In vitro safety cardiovascular pharmacology studies: Impact of formulation preparation and analysis. Regul. Toxicol. Pharmacol., 67: 499-505.
CrossRef | Direct Link | - Castagne, V., C. Froger-Colleaux, E. Esneault, A.M. Hernier, M. Lemaire and R.D. Porsolt, 2013. Central Nervous System (CNS) Safety Pharmacology Studies. In: Drug Discovery and Evaluation. Safety and Pharmacokinetic Assays, Vogel, H.G., F.J. Hock, J. Maas and D. Mayer (Eds.)., Springer, Heildelberg, pp: 15-60.
- Goineau, S., V. Castagne, P. Guillaume and G. Froget, 2012. The comparative sensitivity of three in vitro safety pharmacology models for the detection of lidocaine-induced cardiac effects. J. Pharmacol. Toxicol. Meth., 66: 52-58.
CrossRef | - Castagne, V., T. Wolinsky, L. Quinn and D. Virley, 2012. Differential behavioral profiling of stimulant substances in the rat using the LABORASTM system. Pharmacol. Biochem. Behav., 101: 553-563.
CrossRef | - Moser, P., T. Wolinsky, V. Castagne and M. Duxon, 2011. Current approaches and issues in non-clinical evaluation of abuse and dependence. J. Pharmacol. Toxicol. Meth., 63: 160-167.
CrossRef | Direct Link | - Lynch, III, J.J., V. Castagne, P.C. Moser and S.W. Mittelstadt, 2011. Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies. J. Pharmacol. Toxicol. Meth., 64: 74-80.
CrossRef | Direct Link | - Froger-Colleaux, C., S. Rompion, P. Guillaume, R.D. Porsolt, V. Castagne and P. Moser, 2011. Continuous evaluation of drug withdrawal in the rat using telemetry: Effects of morphine and chlordiazepoxide. J. Pharmacol. Toxicol. Meth., 64: 81-88.
CrossRef | Direct Link | - Porsolt, R.D., P.C. Moser and V. Castagne, 2010. Behavioral indices in antipsychotic drug discovery. J. Pharmacol. Exp. Ther., 333: 632-638.
CrossRef | Direct Link | - Lynch, III, J.J., E.W. Shek, V. Castagne and S.W. Mittelstadt, 2010. The proconvulsant effects of leptin on glutamate receptor-mediated seizures in mice. Brain Res. Bull., 82: 99-103.
CrossRef | Direct Link | - Castagne, V., P. Moser, S. Roux and R.D. Porsolt, 2010. Rodent models of depression: Forced swim and tail suspension behavioral despair tests in rats and mice. Curr. Prot. Pharmacol., 49: 5-8.
CrossRef | Direct Link | - Castagne, V., R.D. Porsolt and P. Moser, 2009. Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse. Eur. J. Pharmacol., 616: 128-133.
CrossRef | Direct Link | - Castagne, V., P.C. Moser and R.D. Porsolt, 2009. Preclinical behavioral models for predicting antipsychotic activity. Adv. Pharmacol., 57: 381-418.
CrossRef | Direct Link | - Esneault, E., V. Castagne, P. Moser, C. Bonny and M. Bernaudin, 2008. D-JNKi, a peptide inhibitor of c-Jun N-terminal kinase, promotes functional recovery after transient focal cerebral ischemia in rats. Neuroscience, 152: 308-320.
CrossRef | Direct Link | - Castagne, V., P. Moser and R.D. Porsolt, 2008. Behavioral Assessment of Antidepressant Activity in Rodents. In: Methods of Behavioral Analysis in Neuroscience, Buccafusco, J.J. (Ed.)., Taylor and Francis, Boca Raton, Florida.
- Castagne, V., M. Lemaire, I. Kheyfets, J.L. Dugina, S.A. Sergeeva and O.I. Epstein, 2008. Antibodies to S100 proteins have anxiolytic‐like activity at ultra‐low doses in the adult rat. J. Pharm. Pharmacol., 60: 309-316.
CrossRef | Direct Link | - Castagne, V., R.D. Porsolt and P. Moser, 2006. Early behavioral screening for antidepressants and anxiolytics. Drug Dev. Res., 67: 729-742.
CrossRef | Direct Link | - Castagne, V., M. Rougemont, M. Cuenod and K.Q. Do, 2004. Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: Relevance to schizophrenia. Neurobiol. Dis., 15: 93-105.
CrossRef | Direct Link | - Castagne, V., M. Cuenod and K.Q. Do, 2004. An animal model with relevance to schizophrenia: Sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development. Neuroscience, 123: 821-834.
CrossRef | Direct Link | - Rougemont, M., K.Q. Do and V. Castagne, 2002. New model of glutathione deficit during development: Effect on lipid peroxidation in the rat brain. J. Neurosci. Res., 70: 774-783.
CrossRef | Direct Link | - Lefevre, K., P.G. Clarke, E.E. Danthe and V. Castagne, 2002. Involvement of cyclin‐dependent kinases in axotomy‐induced retinal ganglion cell death. J. Comparat. Neurol., 447: 72-81.
Direct Link | - Borsello, T., V. Mottier, V. Castagne and P.G. Clarke, 2002. Ultrastructure of retinal ganglion cell death after axotomy in chick embryos. J. Comparat. Neurol., 453: 361-371.
CrossRef | Direct Link | - Castagne, V., K. Lefevre and P.G.H. Clarke, 2001. Dual role of the NF-κB transcription factor in the death of immature neurons. Neuroscience, 108: 517-526.
Direct Link | - Castagne, V. and P.G. Clarke, 2000. Neuroprotective effects of a new glutathione peroxidase mimetic on neurons of the chick embryo's retina. J. Neurosci. Res., 59: 497-503.
CrossRef | Direct Link | - Castagne, V., P. Barneoud and P.G. Clarke, 1999. Protection of axotomized ganglion cells by salicylic acid. Brain Res., 840: 162-166.
Direct Link | - Castagne, V., M. Gautschi, K. Lefevre, A. Posada and P.G.H. Clarke, 1999. Relationships between neuronal death and the cellular redox status focus on the developing nervous system. Prog. Neurobiol., 59: 397-423.
Direct Link | - Castagne, V., K. Lefevre, R. Natero, D.A. Becker and P.G.H. Clarke, 1999. An optimal redox status for the survival of axotomized ganglion cells in the developing retina. Neuroscience, 93: 313-320.
CrossRef | Direct Link | - Castagne, V. and P.G. Clarke, 1999. Inhibitors of mitogen-activated protein kinases protect axotomized developing neurons. Brain Res., 842: 215-219.
Direct Link | - Clarke, P.G.H., A. Posada, M.P. Primi and V. Castagne, 1998. Neuronal death in the central nervous system during development. Biomed. Pharmacother., 52: 356-362.
CrossRef | Direct Link | - Castagne, V. and P.G.H. Clarke, 1998. Cooperation between glutathione depletion and protein synthesis inhibition against naturally occurring neuronal death. Neuroscience, 86: 895-902.
CrossRef | Direct Link | - Castagne, V. and P.G. Clarke, 1997. Inhibition of glutathione synthesis can enhance cycloheximide-induced protection of developing neurons against axotomy. Dev. Brain Res., 102: 285-290.
CrossRef | Direct Link | - Castagne, V., J.C.E. Maire and M. Gyger, 1996. Neurotoxicology and amino acid intake during development: The case of threonine. Pharmacol. Biochem. Behav., 55: 653-662.
CrossRef | Direct Link | - Castagne, V. and P.G. Clarke, 1996. Axotomy-induced retinal ganglion cell death in development: Its timecourse and its diminution by antioxidants. Proc. R. Soc. Lond. B, 263: 1193-1917.
Direct Link | - Castagne, V., J.C. Maire, D. Moennoz and M. Gyger, 1995. Effect of threonine on the behavioural development of the rat. Pharmacol. Biochem. Behav., 52: 281-289.
CrossRef | Direct Link | - Castagne, V., P.A. Finot and J.C. Maire, 1994. Effects of diet-induced hyperthreoninemia. II) Tissue and extracellular amino acid levels in the brain. Life Sci., 54: 41-48.
CrossRef | Direct Link | - Castagne, V., D. Moennoz, P.A. Finot and J.C. Maire, 1993. Effects of diet-induced hyperthreoninemia. I) amino acid levels in the central nervous system and peripheral tissues. Life Sci., 53: 1803-1810.
CrossRef | Direct Link | - Corder, R., V. Castagne, J.M. Rivet, P. Mormede and R.C. Gaillard, 1992. Central and peripheral effects of repeated stress and high NaCl diet on neuropeptide Y. Physiol. Behav., 52: 205-210.
CrossRef | Direct Link | - Castagne, V., J.M. Rivet and P. Mormede, 1990. The integrity of the ventral noradrenergic bundle (VNAB) is not necessary for a normal neuroendocrine stress response. Brain Res., 511: 349-352.
CrossRef | Direct Link | - Rivet, J.M., V. Castagne, R. Corder, R. Gaillard and P. Mormede, 1989. Study of the influence of stress and adrenalectomy on central and peripheral neuropeptide Y levels. Neuroendocrinology, 50: 413-420.
Direct Link | - Castagne, V., R. Corder, R. Gaillard and P. Mormede, 1987. Stress-induced changes of circulating neuropeptide Y in the rat: Comparison with catecholamines. Regul. Peptides, 19: 55-63.
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