Dr. Philippe Boucher

Professor
University of Strasbourg, France

Highest Degree
Ph.D. in Pharmacy from University of Lyon, France

My URL
https://livedna.org/33.6329

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Biography

Dr. Philippe Boucher is currently working as Professor at University of Strasbourg France. He obtained his Ph.D. in Pharmacy from University of Lyon, France in 1999. He supervised 20 Masters, 9 PhD, and 5 Postdoctoral Fellows. He also received number of grants for his research work. Dr. Philippe Boucher received honors includes French Society for Endocrinology Award, American Society for Pharmacology and Experimental Therapeutics (ASPET)Young Scientist Travel Award, French National Academy of Medicine Eloi Collery Award, and Young Scientist Jean Valade Award. He is Editor-in-Chief Webmed Central plus and member of editor board in The Journal of Angiology, The Journal of Cardiology and Therapy, and Pharmacologia. He is also serving as reviewer in journals such as Journal of Clinical Investigation, Science Signaling, Faseb journal, Nucleic Acids Research, PloS One, Endocrinology, Atherosclerosis, J.Histochem Cytochem, FEBS Letter, Obesity, Biochem. Pharmacol, Atherosclerosis Thrombosis and Vascular Biology, Circulation Research. He is member of American Society for Pharmacology and Experimental Therapeutics (ASPET), Laureate of the National Academy of Medicine, Paris, France, Societe Française de Physiologie, Nouvelles Societe Francaise d’Atherosclerose (NSFA), Societe Francaise de Pharmacologie et de Therapeutique. The goals of his research program are to determine the Molecular Mechanisms by which Extracellular Signals Regulate Vascular Remodelling, Heart Failure and Chondrogenesis. He has published 28 articles in journals as author/co-author. He also delivered number of invited lectures in Conferences/ Symposium.

Area of Interest:

Pharmacology and Toxicology
Chromatography
Vascular Remodeling
Cell Signaling
Heart Failure

Selected Publications

  1. Mlih, M., L. Host, S. Martin, N. Niederhoffer and L. Monassier et al., 2015. The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/z-disk network during heart development. J. Biol. Chem., 290: 2419-2430.
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  2. Woldt, E., J. Terrand, M. Mlih, R.L. Matz and V. Bruban et al., 2012. The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells. Nat. Commun., Vol. 3. 10.1038/ncomms2087.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Woldt, E., R.L. Matz, J. Terrand, M. Mlih and C. Gracia et al., 2011. Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor. J. Biol. Chem., 286: 16775-16782.
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  4. Boucher, P. and J. Herz, 2011. Signaling through LRP1: Protection from atherosclerosis and beyond. Biochem. Pharmacol., 81: 1-5.
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  5. Zhou, L., Y. Takayama, P. Boucher, M. Tallquist and J. Herz, 2009. LRP1 regulates architecture of the vascular wall by controlling PDGFRβ-dependent phosphatidylinositol 3-kinase activation. PLoS ONE, Vol. 4. 10.1371/journal.pone.0006922.
    CrossRef  |  Direct Link  |  

  6. Terrand, J., V. Bruban, L. Zhou, W. Gong and Z. El Asmar et al., 2009. LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J. Biol. Chem., 284: 381-388.
    CrossRef  |  

  7. May, P., E. Woldt, R.L. Matz and P. Boucher, 2007. The LDL Receptor-Related Protein (LRP) family: An old family of proteins with new physiological functions. Ann. Med., 39: 219-228.
    CrossRef  |  PubMed  |  Direct Link  |  

  8. Boucher, P., W. Li, R.L. Matz, Y. Takayama, J. Auwerx, R.G.W. Anderson and J. Herz, 2007. LRP1 functions as an atheroprotective integrator of TGFβ and PDGF signals in the vascular wall: Implications for marfan syndrome. PLoS ONE, Vol. 2. 10.1371/journal.pone.0000448.
    CrossRef  |  Direct Link  |  

  9. Boucher, P. and M. Gotthardt, 2004. LRP and PDGF signaling: A pathway to atherosclerosis. Trends Cardiovasc. Med., 14: 55-60.
    CrossRef  |  Direct Link  |  

  10. Cachefo, A., P. Boucher, P. Bouletreau, C. Vidon, F. Diraison, M. Beylot and C. Chambrier, 2003. Stimulation of cholesterol synthesis and hepatic lipogenesis in patients with severe malabsorption. J. Lipid Res., 44: 1349-1354.
    CrossRef  |  Direct Link  |  

  11. Boucher, P., M. Gotthardt, W.P. Li, R.G.W. Anderson and J. Herz, 2003. LRP: Role in vascular wall integrity and protection from atherosclerosis. Science, 300: 329-332.
    CrossRef  |  Direct Link  |  

  12. Picaud, J.C., P. Boucher, A. Lapillonne, M. Berthouze and E. Delvin et al., 2002. Influence of dietary cholesterol on vitamin D metabolism in formula-fed preterm neonates. J. Pediatric Gastroenterol. Nutr., 35: 180-184.
    PubMed  |  

  13. Boucher, P., P.H. Ducluzeau, P. Davelu, F. Andreelli and P. Vallier et al., 2002. Expression and regulation by insulin of low-density lipoprotein receptor-related protein mRNA in human skeletal muscle. Biochimica Biophysica Acta (BBA)-Mol. Basis Dis., 1588: 226-231.
    CrossRef  |  Direct Link  |  

  14. Boucher, P., P. Liu, M. Gotthardt, T. Hiesberger, R.G.W. Anderson and J. Herz, 2002. Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low density lipoprotein receptor-related protein in caveolae. J. Biol. Chem., 277: 15507-15513.
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  15. Vidon, C., P. Boucher, A. Cachefo, O. Peroni, F. Diraison and M. Beylot, 2001. Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism. Am. J. Clin. Nutr., 73: 878-884.
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  16. Miachon, S., S. Augier, M. Jouvenet, P. Boucher and J.J. Vallon, 2001. Nutritional parameters modify muricidal behavior of male Wistar rats: Preventive effects of amino acids and 4' Cl diazepam. Life Sci., 69: 2745-2757.
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  17. Cachefo, A., P. Boucher, C. Vidon, E. Dusserre, F. Diraison and M. Beylot, 2001. Hepatic lipogenesis and cholesterol synthesis in hyperthyroid patients. J. Clin. Endocrinol. Metab., 86: 5353-5357.
    CrossRef  |  Direct Link  |  

  18. Sebbag, L., P. Boucher, P. Davelu, P. Boissonnat and G. Champsaur et al., 2000. Thiopurine S-methyltransferase gene polymorphism is predictive of azathioprine-induced myelosuppression in heart transplant recipients. Transplantation, 69: 1524-1527.
    PubMed  |  

  19. Boucher, P., E. Seree, C. Vidon, A.C. de Souza and P.H. Villard et al., 2000. Dietary lipids affect human ethanol-inducible CYP2E1 gene expression in vivo in mononuclear cells. Life Sci., 67: 1307-1316.
    CrossRef  |  Direct Link  |  

  20. De Lorgeril, M., P. Salen, J.L. Martin, I. Monjaud, P. Boucher and N. Mamelle, 1998. Mediterranean dietary pattern in a randomized trial: Prolonged survival and possible reduced cancer rate. Arch. Internal Med., 158: 1181-1187.
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  21. Boucher, P., M. de Lorgeril, P. Salen, P. Crozier and J. Delaye et al., 1998. Effect of dietary cholesterol on low density lipoprotein-receptor, 3-hydroxy-3-methylglutaryl-CoA reductase and low density lipoprotein receptor-related protein mRNA expression in healthy humans. Lipids, 33: 1177-1186.
    CrossRef  |  Direct Link  |  

  22. Boucher, P., M. Accominotti and J.J. Vallon, 1996. Arsenic speciation by ion-pair reversed-phase liquid chromatography with coupled amperometric and ultraviolet detection. J. Chromatogr. Sci., 34: 226-229.
    CrossRef  |  Direct Link  |  

  23. Boucher, P., H. Lejeune, M.C. Pinatel and Y. Gille, 1995. Spermoculture: Improvement of the bacteriological quality of samples by direct verbal counseling before semen collection. Fertil. Steril., 64: 657-660.
    PubMed  |  

  24. Pinatel, M.C., P. Boucher, Y. Gille and F. Pinatel, 1994. Proposition d'un protocole de prelevement pour les spermocultures [A protocol of semen collection for bacteriological screening]. Andrologie, 2: 228-233.
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Member since August, 2015