Dr. Miguel Quintanilla

Research Professor
Spanish National Research Council, Spain

Highest Degree
Ph.D. in Chemistry from University of Valladolid, Spain

My URL
https://livedna.org/34.13898

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Area of Interest:

Chemistry
Skin Homeostasis
Cell Migration
Biochemistry
Oncology

Selected Publications

  1. Santibanez, J.F., J. Krstic, M. Quintanilla and C. Bernabeu, 2016. TGF-β signalling and its role in cancer progression and metastasis. eLS. 10.1002/9780470015902.a0025045.
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  2. Quintanilla, M., P. Carrasco-Ramirez, L. Montero-Montero, A. Ramirez-Lopez, I.L. da Silva, J. Renart and E. Martin-Villar, 2016. Podoplanin promotes malignancy through a diversity of strategies. Cancer Cell Microenviron., Vol. 3. 10.14800/ccm.1384.
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  3. Luengo-Gil, G., M.I. Calvo-SAnchez, E. Martin-Villar, S. Aguila and N. Bohdan et al., 2016. Antithrombin controls tumor migration, invasion and angiogenesis by inhibition of enteropeptidase. Sci. Rep., Vol. 6. 10.1038/srep27544.
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  4. Kucia-Tran, J.A., V. Tulkki, S. Smith, C.G. Scarpini and K. Hughes et al., 2016. Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival. Br. J. Cancer, 115: 212-222.
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  5. Encabo-Berzosa, M.M., M. Gimeno, L. Lujan, M. Sancho-Albero and L. Gomez et al., 2016. Selective delivery of photothermal nanoparticles to tumors using mesenchymal stem cells as Trojan horses. RSC Adv., 6: 58723-58732.
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  6. Carrasco-Ramirez, P., D.W. Greening, G. Andres, S.K. Gopal and E. Martin-Villar et al., 2016. Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation. Oncotarget, 7: 16070-16089.
    PubMed  |  

  7. Andradas, C., S. Blasco-Benito, S. Castillo-Lluva, P. Dillenburg-Pilla and R. Diez-Alarcia et al., 2016. Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer. Oncotarget, 7: 47565-47575.
    CrossRef  |  PubMed  |  Direct Link  |  

  8. Salazar, M., M. Lorente, E. Garcia-Taboada, E.P. Gomez and D. Davila et al., 2015. TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling. Mol. Cell. Oncol., Vol. 2. 10.4161/23723556.2014.980134.
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  9. Salazar, M., M. Lorente, E. Garcia-Taboada, E.P. Gomez and D. Davila et al., 2015. Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation. Cell Death Differ., 22: 131-144.
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  10. Renart, J., P. Carrasco-Ramirez, B. Fernandez-Munoz, E. Martin-Villar, L. Montero, M.M. Yurrita and M. Quintanilla, 2015. New insights into the role of podoplanin in the epithelial-mesenchymal transition. Int. Rev. Cell Mol. Biol., 317: 185-239.

  11. Quintanilla, M., G. del Castillo, E. Sanchez-Blanco, E. Martin-Villar and A.C. Valbuena-Diez et al., 2015. A suppressor role for soluble endoglin in cancer. Cancer Cell Microenviron., Vol. 2. 10.14800/ccm.706.
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  12. Perez-Gomez, E., C. Andradas, M.M. Caffarel, S. Blasco-Benito and E. Garcia-Taboada et al., 2015. Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer. J. Natl. Cancer Inst., Vol. 107. 10.1093/jnci/djv077.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Martin-Villar, E., B.B. D'Agua, P. Carrasco-Ramirez, J. Renart, M. Parsons, M. Quintanilla and G.E. Jones, 2015. Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability. Oncogene, 34: 4531-4544.
    CrossRef  |  Direct Link  |  

  14. Larcher, F., J. Espada, B. Diaz-Ley, P. Jaen, A. Juarranz and M. Quintanilla, 2015. New experimental models of skin homeostasis and diseases. Actas Dermo-Sifiliograficas (English Edn.), 106: 17-28.
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  15. Del Castillo, G., E. Sanchez-Blanco, E. Martin-Villar, A.C. Valbuena-Diez and C. Langa et al., 2015. Soluble endoglin antagonizes Met signaling in spindle carcinoma cells. Carcinogenesis, 36: 212-222.
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  16. Cruz-Bermudez, A., C.G. Vallejo, R.J. Vicente-Blanco, M.E. Gallardo, M.A. Fernandez-Moreno, M. Quintanilla and R. Garesse, 2015. Enhanced tumorigenicity by mitochondrial DNA mild mutations. Oncotarget, 6: 13628-13643.
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  17. Yurrita, M.M., B. Fernandez-Munoz, G. del Castillo, E. Martin-Villar, J. Renart and M. Quintanilla, 2014. Podoplanin is a substrate of presenilin-1/γ-secretase. Int. J. Biochem. Cell Biol., 46: 68-75.
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  18. Tobar, N., M.C. Avalos, N. Mendez, P.C. Smith, C. Bernabeu, M. Quintanilla and J. Martinez, 2014. Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells. Carcinogenesis, 35: 1770-1779.
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  19. Perez-Gomez, E., M. Jerkic, M. Prieto, G. del Castillo and E. Martin-Villar et al., 2014. Impaired wound repair in adult endoglin heterozygous mice associated with lower NO bioavailability. J. Invest. Dermatol., 134: 247-255.
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  20. Vallejo, C.G., A. Cruz-Bermudez, P. Clemente, R. Hernandez-Sierra, R. Garesse and M. Quintanilla, 2013. Evaluation of mitochondrial function and metabolic reprogramming during tumor progression in a cell model of skin carcinogenesis. Biochimie, 95: 1171-1176.
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  21. Perez-Gomez, E., C. Andradas, J.M. Flores, M. Quintanilla, J.M. Paramio, M. Guzman and C. Sanchez, 2013. The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas. Oncogene, 32: 2534-2542.
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  22. Mera-Menendez, F., A. Hinojar-Gutierrez, M.G. Rojas, J.G. de Gregorio and E. Mera-Menendez et al., 2013. Polymorphisms in HIF-1α affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx. Clin. Transl. Oncol., 15: 358-363.
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  23. Belmar-Lopez, C., G. Mendoza, D. Oberg, J. Burnet and C. Simon et al., 2013. Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth. BMC Med., Vol. 11. 10.1186/1741-7015-11-139.
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  24. Quintanilla, M., G. del Castillo, J. Kocic and J.F. Santibanez, 2012. TGF-β and MMPs: A Complex Regulatory Loop Involved in Tumor Progression. In: Matrix Metalloproteinases: Biology, Functions and Clinical Implications, Oshiro, N. and E. Miyagi (Eds.). Nova Science Publishers, Hauppauge, NY., ISBN: 9781621007890, pp: 1-37.

  25. Santibanez, J.F., M. Quintanilla and C. Bernabeu, 2011. TGF-β/TGF-β receptor system and its role in physiological and pathological conditions. Clin. Sci., 121: 233-251.
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  26. Latorre-Romero, C., M.R. Marin-Yaseli, C. Belmar-Lopez, R. del Moral, P.C. Marijuan, M. Quintanilla and P. Martin-Duque, 2011. Using living cells to transport therapeutic genes for cancer treatment. Clin. Transl. Oncol., 13: 10-17.
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  27. Fernandez-Munoz, B., M.M. Yurrita, E. Martin-Villar, P. Carrasco-Ramirez, D. Megias, J. Renart and M. Quintanilla, 2011. The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition. Int. J. Biochem. Cell Biol., 43: 886-896.
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  28. Santibanez, J.F., J. Kocic, A. Fabra, A. Cano and M. Quintanilla, 2010. Rac1 modulates TGF-β1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes. FEBS Lett., 584: 2305-2310.
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  29. Santibanez, J.F., E. Perez-Gomez, A. Fernandez-L, E.M. Garrido-Martin and A. Carnero et al., 2010. The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras. Carcinogenesis, 31: 2145-2154.
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  30. Perez-Gomez, E., G. del Castillo, J.F. Santibanez, J.M. Lepez-Novoa, C. Bernabeu and M. Quintanilla, 2010. The role of the TGF-β coreceptor endoglin in cancer. Sci. World J., 10: 2367-2384.
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  31. Martin-Villar, E., B. Fernandez-Munoz, M. Parsons, M.M. Yurrita and D. Megias et al., 2010. Podoplanin associates with CD44 to promote directional cell migration. Mol. Biol. Cell, 21: 4387-4399.
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  32. Hinojar-Gutierrez, A., M.E. Fernandez-Contreras, S. Alvarez-Carrillo, M. Quintanilla and C. Gamallo, 2010. Role of intratumoral lymphatic vessels in the lymph node dissemination of laryngopharyngeal squamous cell carcinoma. Head Neck, 32: 757-762.
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  33. Peerlinck, I., A. Merron, P. Baril, S. Conchon and P. Martin-Duque et al., 2009. Targeted radionuclide therapy using a Wnt-targeted replicating adenovirus encoding the Na/I symporter. Clin. Cancer Res., 15: 6595-6601.
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  34. Martin-Villar, E., M.M. Yurrita, B. Fernandez-Munoz, M. Quintanilla and J. Renart, 2009. Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis. Int. J. Biochem. Cell Biol., 41: 1421-1429.
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  35. Bernabeu, C., J.M. Lopez-Novoa and M. Quintanilla, 2009. The emerging role of TGF-β superfamily coreceptors in cancer. Biochimica Biophysica Acta (BBA)-Mol. Basis Dis., 1792: 954-973.
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  36. Romero, D., M. Iglesias, C.P. Vary and M. Quintanilla, 2008. Functional blockade of Smad4 leads to a decrease in β-catenin levels and signaling activity in human pancreatic carcinoma cells. Carcinogenesis, 29: 1070-1076.
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  37. Pons, M., P. Mancheno-Corvo, P. Martin-Duque and M. Quintanilla, 2008. Molecular biology of malignant melanoma. Adv. Exp. Med. Biol., 624: 252-264.
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  38. Pons, M., P. Mancheno-Corvo, P. Martin-Duque and M. Quintanilla, 2008. Molecular Biology of Malignant Melanoma. In: Sunlight, Vitamin D and Skin Cancer, Reichrath, J. (Ed.). Springer, New York, pp: 252-264.

  39. Peinado, H., G. Moreno-Bueno, D. Hardisson, E. Perez-Gomez and V. Santos et al., 2008. Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas. Cancer Res., 68: 4541-4550.
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  40. Muller, D., G. Trunk, A. Sichelstiel, K.A. Zettlitz, M. Quintanilla and R.E. Kontermann, 2008. Murine endoglin-specific single-chain Fv fragments for the analysis of vascular targeting strategies in mice. J. Immunol. Methods, 339: 90-98.
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  41. Montiel-Equihua, C.A., P. Martin-Duque, A. de la Vieja, M. Quintanilla, J. Burnet, G. Vassaux and N.R. Lemoine, 2008. Targeting sodium/iodide symporter gene expression for estrogen-regulated imaging and therapy in breast cancer. Cancer Gene Therapy, 15: 465-473.
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  42. Lomas, J., P. Martin-Duque, M. Pons and M. Quintanilla, 2008. The genetics of malignant melanoma. Front. Biosci., 13: 5071-5093.
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  43. Blanco, F.J., M.T. Grande, C. Langa, B. Oujo and S. Velasco et al., 2008. S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology. Circ. Res., 103: 1383-1392.
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  44. Belmar-Lopez, C., P. Mancheno-Corvo, M.A. Saornil, P. Baril, G. Vassaux, M. Quintanilla and P. Martin-Duque, 2008. Uveal vs. cutaneous melanoma. Origins and causes of the differences. Clin. Transl. Oncol., 10: 137-142.
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  45. Villa-Morales, M., J. Santos, E. Perez-Gomez, M. Quintanilla and J. Fernandez-Piqueras, 2007. A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas. Cancer Res., 67: 5107-5116.
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  46. Perez-Gomez, E., M. Villa-Morales, J. Santos, J. Fernandez-Piqueras and C. Gamallo et al., 2007. A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis. Cancer Res., 67: 10268-10277.
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  47. Merron, A., I. Peerlinck, P. Martin-Duque, J. Burnet and M. Quintanilla et al., 2007. SPECT/CT imaging of oncolytic adenovirus propagation in tumours in vivo using the Na/I symporter as a reporter gene. Gene Therapy, 14: 1731-1738.
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  48. Hinojar-Gutierrez, A., M.E. Fernandez-Contreras, R. Gonzalez-Gonzalez, M.J. Fernandez-Luque, A. Hinojar-Arzadun, M. Quintanilla and C. Gamallo, 2007. Intratumoral lymphatic vessels and VEGF-C expression are predictive factors of lymph node relapse in T1-T4 N0 laryngopharyngeal squamous cell carcinoma. Ann. Surgical Oncol., 14: 248-257.
    CrossRef  |  Direct Link  |  

  49. Quintanilla, M., E. Perez-Gomez, D. Romero, M. Pons and J. Renart, 2006. TGF-β Pathway and Cancerogenesis of Epithelial Skin Tumours. In: Molecular Mechanisms of Basal Cell and Squamous Cell Carcinomas, Reichrath, J. (Ed.). Springer, New York, ISBN: 9780387350981, pp: 80-93.

  50. Pons, M. and M. Quintanilla, 2006. Molecular biology of malignant melanoma and other cutaneous tumors. Clin. Trans. Oncol., 8: 466-474.
    CrossRef  |  Direct Link  |  

  51. Martin-Villar, E., D. Megias, S. Castel, M.M. Yurrita, S. Vilaro and M. Quintanilla, 2006. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J. Cell Sci., 119: 4541-4553.
    CrossRef  |  Direct Link  |  

  52. Martin-Duque, P., M. Quintanilla, I. McNeish, R. Lopes and J. Romero et al., 2006. Caspase-1 as a radio-and chemo-sensitiser in vitro and in vivo. Int. J. Mol. Med., 17: 841-847.

  53. Pons, M., J.C. Cigudosa, S. Rodriguez-Perales, J.L. Bella, C. Gonzalez, C. Gamallo and M. Quintanilla, 2005. Chromosomal instability and phenotypic plasticity during the squamous-spindle carcinoma transition: Association of a specific T (14; 15) with malignant progression. Oncogene, 24: 7608-7618.
    CrossRef  |  Direct Link  |  

  54. Perez-Gomez, E., N. Eleno, J.M. Lopez-Novoa, J.R. Ramirez and B. Velasco et al., 2005. Characterization of murine S-endoglin isoform and its effects on tumor development. Oncogene, 24: 4450-4461.
    CrossRef  |  Direct Link  |  

  55. Martin-Villar, E., F.G. Scholl, C. Gamallo, M.M. Yurrita, M. Munoz‐Guerra, J. Cruces and M. Quintanilla, 2005. Characterization of human PA2. 26 antigen (T1α-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int. J. Cancer, 113: 899-910.
    Direct Link  |  

  56. Munoz‐Guerra, M.F., E.G. Marazuela, E. Martin‐Villar, M. Quintanilla and C. Gamallo, 2004. Prognostic significance of intratumoral lymphangiogenesis in squamous cell carcinoma of the oral cavity. Cancer, 100: 553-560.
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  57. Villar, E.M., F.G. Scholl, C.G. Amat and M.Q. Avila, 2003. PA2. 26 antigen (T1α/podoplanin): A small mucin-like transmembrane glycoprotein associated with cell migration and cancer. Revista de Oncologia, 5: 491-499.
    CrossRef  |  Direct Link  |  

  58. Quintanilla, M., P. Frontelo, M. Pons, D. Romero, E. Perez-Gomez, C. Gamallo and M. Iglesias, 2003. TGF-β signaling and epidermal carcinogenesis. Recent Res. Dev. Cell. Biochem., 1: 151-160.

  59. Quintanilla, M., J.R. Ramirez, E. Perez-Gomez, D. Romero and B. Velasco et al., 2003. Expression of the TGF-β coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis. Oncogene, 22: 5976-5985.
    CrossRef  |  Direct Link  |  

  60. Quintanilla, M., 2003. Murine models of skin carcinogenesis. Med. Cutan. Iber Lat. Am., 31: 30-32.

  61. Peinado, H., M. Quintanilla and A. Cano, 2003. Transforming growth factor β-1 induces Snail transcription factor in epithelial cell lines mechanisms for epithelial mesenchymal transitions. J. Biol. Chem., 278: 21113-21123.
    CrossRef  |  Direct Link  |  

  62. Santibanez, J.F., M. Quintanilla and J. Martinez, 2002. TGF-β1 and Smad4 overexpression induces a less invasive phenotype in highly invasive spindle carcinoma cells. FEBS Lett., 520: 171-176.

  63. Santibanez, J.F., J. Guerrero, M. Quintanilla, A. Fabra and J. Martinez, 2002. Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes. Biochem. Biophys. Res. Commun., 296: 267-273.
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  64. Palmer, H.G., J.M. Gonzalez-Sancho, J. Espada, M.T. Berciano and I. Puig et al., 2001. Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling. J. Cell Biol., 154: 369-388.
    CrossRef  |  Direct Link  |  

  65. Scholl, F.G., C. Gamallo and M. Quintanilla, 2000. Ectopic expression of PA2. 26 antigen in epidermal keratinocytes leads to destabilization of adherens junctions and malignant progression. Laboratory Invest., 80: 1749-1759.
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  66. Santibanez, J.F., M. Quintanilla and J. Martinez, 2000. Genistein and curcumin block TGF-β1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes. Nutr. Cancer, 37: 49-54.
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  67. Santibanez, J.F., M. Iglesias, P. Frontelo, J. Martinez and M. Quintanilla, 2000. Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-β1 in transformed keratinocytes. Biochem. Biophys. Res. Commun., 273: 521-527.
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  68. Quintanilla, M., P. Frontelo and M. Iglesia, 2000. Signaling during mouse skin tumor progression. Electr. J. Pathol. Histol., 6: 12-12.
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  69. Iglesias, M., P. Frontelo, C. Gamallo and M. Quintanilla, 2000. Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas. Oncogene, 19: 4134-4145.
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  70. Scholl, F.G., C. Gamallo and M. Quintanilla, 1999. Identification of PA2. 26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes. J. Cell Sci., 112: 4601-4613.
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  71. Santibanez, J.F., P. Frontelo, M. Iglesias, J. Martinez and M. Quintanilla, 1999. Urokinase expression and binding activity associated with the transforming growth factor b1-induced migratory and invasive phenotype of mouse epidermal keratinocytes. J. Cell. Biochem., 74: 61-73.
    Direct Link  |  

  72. Martin-Duque, P., R.S. Prieto, J. Romero, A. Martinez and S. Cebrian et al., 1999. In vivo radiosensitizing effect of the adenovirus E1A gene in murine and human malignant tumors. Int. J. Oncol., 15: 1163-1168.

  73. Martin-Duque, P., A. Covadonga, R. Sanchez-Prieto, M. Lleonart and C. Martinez et al., 1999. Adenovirus lacking the 19 K-and 55 K-E1B genes exerts a marked cytotoxic effect in human malignant cells. Cancer Gen. Ther., 6: 554-563.

  74. Sanchez-Prieto, R., M. Quintanilla, A. Cano, M. Lleonart, P. Martin and S.R. Cajal, 1998. In vivo tumor suppressor effect of retrovirus-mediated gene transfer of the adenovirus E1a gene. Adv. Exp. Med. Biol., 451: 79-86.

  75. Llorens, A., I. Rodrigo, L. Lopez-Barcons, M. Gonzalez-Garrigues and E. Lozano et al., 1998. Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression. Laboratory Invest. J. Technical Methods Pathol., 78: 1131-1142.
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  76. Frontelo, P., M. Gonzalez-Garrigues, S. Vilaro, C. Gamallo, A. Fabra and M. Quintanilla, 1998. Transforming growth factor β1 induces squamous carcinoma cell variants with increased metastatic abilities and a disorganized cytoskeleton. Exp. Cell Res., 244: 420-432.
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  77. Duque, P.M., C. Alonso, R. Sanchez-Prieto, M. Quintanilla and S. Ramon, 1998. Antitumoral effect of E1B defective adenoviruses in human malignant cells. Gene Therapy, 5: 286-287.
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  78. Sanchez-Prieto, R., M. Quintanilla, P. Martin, M. Lleonart, A. Cano and G.P. Dotto, 1997. In vivo antitumor effect of retrovirus-mediated gene transfer of the adenovirus E1a gene. Cancer Gene Therapy, 5: 215-224.
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  79. Gandarillas, A., F.G. Scholl, N. Benito, C. Gamallo and M. Quintanilla, 1997. Induction of PA2. 26, a cell‐surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis. Mol. Carcinog., 20: 10-18.
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  80. Sanchez-Prieto, R., M. Quintanilla, A. Cano, M.L. Leonart, P. Martin and A. Anaya, 1996. Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene. Oncogene, 13: 1083-1092.
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  81. Larcher, F., A.I. Robles, H. Duran, R. Murillas and M. Quintanilla et al., 1996. Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res., 56: 5391-5396.
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  82. Caulin, C., L. Lopez‐Barcons, M. Gonzalez‐Garrigues, P. Navarro and E. Lozano et al., 1996. Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E‐cadherin expression and correlated with reduced levels of Ha‐ras oncogene products. Mol. Carcinog., 15: 104-114.

  83. Cano, A., C. Gamallo, C.J. Kemp, N. Benito, J. Palacios, M. Quintanilla and A. Balmain, 1996. The expression pattern of the cell adhesion molecules E-, P-cadherin and α6β4 integrin is altered in premalignant skin tumors of p53 deficient mice. Int. J. Cancer, 65: 254-262.
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  84. Pizarro, A., C. Gamallo, N. Benito, J. Palacios, M. Quintanilla, A. Cano and F. Contreras, 1995. Differential patterns of placental and epithelial cadherin expression in basal cell carcinoma and in the epidermis overlying tumours. Br. J. Cancer, 72: 327-332.
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  85. Caulin, C., F.G. Scholl, P. Frontelo, C. Gamallo and M. Quintanilla, 1995. Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-β1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Different., 6: 1027-1035.
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  86. Pizarro, A., N. Benito, P. Navarro, J. Palacios and A. Cano et al., 1994. E-cadherin expression in basal cell carcinoma. Br. J. Cancer, 69: 157-162.
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  87. Gamallo, C., J. Palacios and A. Suarez, 1993. Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am. J. Pathol., 142: 987-993.
    PubMed  |  

  88. Caulin, C., C. Bauluz, A. Gandarillas, A. Cano and M. Quintanilla, 1993. Changes in keratin expression during malignant progression of transformed mouse epidermal keratinocytes. Exp. Cell Res., 204: 11-21.
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  89. Caulin, C., A. Gandarillas, F.G. Scholl and M. Quintanilla, 1993. Expression of intermediate filament proteins by normal and transformed mouse epidermal keratinocytes in culture. Int. J. Oncol., 2: 373-379.
    PubMed  |  Direct Link  |  

  90. Larcher, F., C. Bauluz, M. Diaz-Guerra, M. Quintanilla, C.J. Conti, C. Ballestin and J.L. Jorcano, 1992. Mouse skin carcinomas but not papillomas aberrantly express the simple epithelial type II keratin 8. Mol. Carcinog., 6: 112-121.

  91. Inki, P., M. Gomez, M. Quintanilla, A. Cano and M. Jalkanen, 1992. Expression of syndecan in transformed mouse keratinocytes. Lab. Invest. J. Tech. Meth. Pathol., 67: 225-233.
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  92. Gomez, M., P. Navarro, M. Quintanilla and A. Cano, 1992. Expression of α6β4 integrin increases during malignant conversion of mouse epidermal keratinocytes: Association of β4 subunit to the cytokeratin fraction. Exp. Cell Res., 201: 250-261.
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  93. Gandarillas, A., J. Renart and M. Quintanilla, 1992. Biochemical characterization of Artemia ras p21. Mol. Cell. Biochem., 112: 29-33.
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  94. Diaz-Guerra, M., S. Haddow, C. Bauluz, J.L. Jorcano, A. Cano, A. Balmain and M. Quintanilla, 1992. Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations. Cancer Res., 52: 680-687.
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  95. Quintanilla, M., S. Haddow, D. Jonas, G.T. Bowden and A. Balmain, 1991. Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo. Carcinogenesis, 12: 1875-1881.
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  96. Navarro, P., M. Gomez, A. Pizarro, C. Gamallo, M. Quintanilla and A. Cano, 1991. A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J. Cell Biol., 115: 517-533.
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  97. Sastre, L., I. Palmero, M.T. Macias, I. Gil and E. Franco et al., 1989. cDNA Cloning of Developmentally Regulated Artemia Genes. In: Cell and Molecular Biology of Artemia Development, Warner, A.H., T.H. MacRae and J.C. Bagshaw (Eds.). Plenum Publ. Co., New York, pp: 319-327.

  98. Diaz-Guerra, M., M. Quintanilla, I. Paimero, L. Sastre and J. Renart, 1989. Differential expression of a gene highly homologous to c-ras during the development of the brine shrimp Artemia. Biochem. Biophys. Res. Commun., 162: 802-808.
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  99. Quintanilla, M., K. Brown, F. Fee, S. Young and A. Balmain, 1988. Oncogene Mutation and Amplification during Initiation and Progression Stages of Mouse Skin Carcinogenesis. In: Growth Factors, Tumor Promoters and Cancer Genes, Colburn, N., H. Moses and E. Stanbridge (Eds.). Alan R Liss Inc., New York, pp: 257-266.

  100. Diaz, V., M. Quintanilla, J. Cruces, J. Renart and J. Sebastian, 1987. Immunological relationships between Artemia RNA polymerases and between RNA polymerases II from different eukaryotic organisms. Mol. Cell. Biochem., 76: 123-131.
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  101. Balmain, A., K. Brown, R. Bremner, M. Quintanilla and M. Archer, 1987. The Action of Chemical Carcinogens and Oncogenic Retroviruses in Mouse Skin Tumor Induction. In: Radiation Research, Fielden, E.M., J.F. Fowler, J.H. Hendry and D. Scott (Eds.). Vol. 2, Taylor and Francis, Edinburgh, pp: 501-506.

  102. Ramsden, M., M. Quintanilla and A. Balmain, 1986. Activation of Ras Oncogenes in Multistage Carcinogenesis of Mouse Skin. In: Coordinated Regulation of Gene Expression, Clayton, R.M. and D.E.S. Truman (Eds.). Plenum Press, New York, pp: 83-104.

  103. Quintanilla, M., K. Brown, M. Ramsden, A. Balmain, M. Quintanilla, K. Brown, M. Ramsden and A. Balmain, 1986. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature, 322: 78-80.

  104. Brown, K., M. Quintanilla, M. Ramsden, I.B. Kerr, S. Young and A. Balmain, 1986. v-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis. Cell, 46: 447-456.
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  105. Brown, K., M. Quintanilla, M. Ramsden and A. Balmain, 1986. The Role of Oncogenes in Multistage Carcinogenesis. In: Radiation Carcinogenesis and DNA Alterations, Burns, F.J., A.C. Upton and G. Silini (Eds.). Plenum Press, New York, pp: 339-351.

  106. Balmain, A., M. Quintanilla, K. Brown, M. Ramsden, F. Fee and S. Young, 1986. The role of ras gene mutations in initiation of chemical carcinogenesis. Leukemia Res., 10: 737-738.

  107. Balmain, A., M. Quintanilla, K. Brown and M. Ramsden, 1986. An approach to the molecular mechanisms of cancer induction. J. Pathol., 149: 3-8.

  108. Kerr, I.B., F.D. Lee, M. Quintanilla and A. Balmain, 1985. Immunocytochemical demonstration of p21 ras family oncogene product in normal mucosa and in premalignant and malignant tumours of the colorectum. Br. J. Cancer, 52: 695-700.
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  109. Cruces, J., V. Diaz, M. Quintanilla, J. Renart and J. Sebastian, 1984. Purification and subunit structure of RNA polymerase II from different stages of Artemia development. Eur. J. Biochem., 141: 279-282.
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  110. Quintanilla, M. and J. Renart, 1983. Post‐transcriptional regulation of endoribonuclease VI expression during Artemia development. FEBS Lett., 155: 93-96.
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  111. Quintanilla, M. and J. Renart, 1982. Purification and characterization of a novel UpN-specific endoribonuclease VI from Artemia larvae. J. Biol. Chem., 257: 12594-12599.
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  112. Sillero, M.A., R. Villalba, A. Moreno, M. Quintanilla, C.D. Lobaton and A. Sillero, 1977. Dinucleoside triphosphatase from rat liver. Eur. J. Biochem., 76: 331-337.

  113. Vallejo, C.G., C.D. Lobaton, M. Quintanilla, A. Sillero and M.A. Sillero, 1976. Dinucleosidasetetraphosphatase in rat liver and Artemia salina. Biochim. Biophys. Acta (BBA)-Enzymol., 438: 304-309.
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