Dr. Manuel D. Gahete

Post-doctoral Fellow
Campus Universitario de Rabanales, Spain

Highest Degree
Ph.D. in Science from University of Cordoba, Spain

My URL
https://livedna.org/34.6020

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Area of Interest:

Biomedical Sciences
General and Comparative Endocrinology
Molecular and Cellular Endocrinology
Neuroendocrinology
Pharmaceuticals

Selected Publications

  1. Luque, R.M., A. Ibanez-Costa, L.M. Lopez-Sanchez, L. Jimenez-Reina and E. Venegas-Moreno et al., 2013. A cellular and molecular basis for the selective Desmopressin-induced ACTH release in cushing disease patients: Key role of AVPR1b receptor and potential therapeutic implications. J. Clin. Endocrinol. Metab., 98: 4160-4169.
    CrossRef  |  

  2. Lubbers, E.R., E.O. List, A. Jara, L. Sackman-Sala and J. Cordoba-Chacon et al., 2013. Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J. Endocrinol., 216: 363-374.
    CrossRef  |  

  3. Gahete, M.D., J. Cordoba-Chacon, R.M. Luque and R.D. Kineman, 2013. The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice. Endocrinology, 154: 263-269.
    CrossRef  |  

  4. Gahete, M.D., J. Cordoba-Chacon, Q. Lin, J.C. Bruning and C.R. Kahn et al., 2013. Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms. Endocrinology, 154: 2410-2420.
    CrossRef  |  

  5. Cordoba-Chacon, J., M.D. Gahete, A.I. Pozo-Salas, J.P. Castano, R.D. Kineman and R.M. Luque, 2013. Endogenous somatostatin is critical in regulating the acute effects of l-arginine on growth hormone and insulin release in mice. Endocrinology, 154: 2393-2398.
    CrossRef  |  

  6. Chanclon, B., R.M. Luque, J. Cordoba-Chacon, M.D. Gahete and A.I. Pozo-Salas et al., 2013. Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions. Plos One, Vol. 8. 10.1371/journal.pone.0057834.
    CrossRef  |  

  7. Duran-Prado, M., M.D. Gahete, E. Delgado-Niebla, A.J. Martinez-Fuentes and R. Vazquez-Martinez et al., 2012. Truncated variants of pig somatostatin receptor subtype 5 (sst5) act as Dominant-negative modulators for sst2-mediated signaling. Am. J. Physiol.-Endocrinol. Metab., 303: E1325-E1334.
    CrossRef  |  

  8. Cordoba-Chacon, J., M.D. Gahete, M.D. Culler, J.P. Castano, R.D. Kineman and R.M. Luque, 2012. Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP. J. Neuroendocrinol., 24: 453-463.
    CrossRef  |  

  9. Cordoba-Chacon, J., M.D. Gahete, J.P. Castano, R.D. Kineman and R.M. Luque, 2012. Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone and ghrelin in a nonhuman primate (Papio Anubis). Endocrinology, 153: 264-272.
    CrossRef  |  

  10. Cordoba-Chacon, J., M.D. Gahete, A.I. Pozo-Salas, A. Moreno-Herrera, J.P. Castano, R.D. Kineman and R.M. Luque, 2012. Peripubertal-onset but not Adult-onset obesity increases IGF-I and drives development of lean mass, which may lessen the metabolic impairment in adult obesity. Am. J. Physiol. -Endocrinol. Metab., 303: E1151-E1157.
    CrossRef  |  

  11. Annunziata, M., R.M. Luque, M. Duran-Prado, A. Baragli and C. Grande et al., 2012. Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility. Hum. Reprod., 27: 2117-2129.
    PubMed  |  

  12. Martinez-Fuentes, A.J., M. Molina, R. Vazquez-Martinez, M.D. Gahete and L. Jimenez-Reina et al., 2011. Expression of functional KISS1 and KISS1R system is altered in human pituitary adenomas: Evidence for apoptotic action of Kisspeptin-10. Eur. J. Endocrinol., 164: 355-362.
    CrossRef  |  

  13. Marazuela, M., A.E. Paniagua, M.D. Gahete, T. Lucas and R. Manzanares et al., 2011. Somatotroph tumor progression during pegvisomant therapy: a clinical and molecular study. J. Clin. Endocrinol. Metab., 96: E251-E259.
    CrossRef  |  

  14. Luque, R.M., M.D. Gahete, J. Cordoba-Chacon, G.V. Childs and R.D. Kineman, 2011. Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes? Ann. N. Y. Acad. Sci., 1220: 82-92.
    CrossRef  |  

  15. Luque, R.M., J. Cordoba-Chacon, M.D. Gahete, V.M. Navarro, M. Tena-Sempere, R. D. Kineman and J.P. Castano, 2011. Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms. Endocrinology, 152: 957-966.
    CrossRef  |  

  16. Gahete, M.D., J. Cordoba-Chacon, R.D. Kineman, R.M. Luque and J.P. Castano, 2011. Role of ghrelin system in neuroprotection and cognitive functions: Implications in Alzheimer's disease. Peptides, 32: 2225-2228.
    CrossRef  |  

  17. Gahete, M.D., J. Cordoba-Chacon, M. Hergueta-Redondo, A.J. Martinez-Fuentes and R.D. Kineman et al., 2011. A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: Potential pathophysiological relevance. Plos One, Vol. 6. 10.1371/journal.pone.0023302.
    CrossRef  |  

  18. Gahete, M.D., J. Cordoba-Chacon, C.V. Anadumaka, Q. Lin and J.C. Bruning et al., 2011. Elevated GH/IGF-I, due to Somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a Diet-dependent manner. Endocrinology, 152: 4825-4837.
    CrossRef  |  

  19. Duran-Prado, M., M.D. Gahete, M. Hergueta-Redondo, A.J. Martinez-Fuentes and J. Cordoba-Chacon et al., 2011. The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells. Oncogene, 31: 2049-2061.
    CrossRef  |  

  20. Cordoba-Chacon, J., M.D. Gahete, M. Duran-Prado, R.M. Luque and J.P. Castano, 2011. Truncated somatostatin receptors as new players in Somatostatin-cortistatin pathophysiology. Ann. N. Y. Acad. Sci., 1220: 6-15.
    CrossRef  |  

  21. Cordoba-Chacon, J., M.D. Gahete, J.P. Castano, R.D. Kineman and R.M. Luque, 2011. Somatostatin and its receptors contribute in a tissue-specific manner to the Sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice. Am. J. Physiol. -Endocrinol. Metab., 300: E46-E54.
    CrossRef  |  

  22. Cordoba-Chacon, J., M.D. Gahete, A.I. Pozo-Salas, A.J. Martinez-Fuentes and L. de Lecea et al., 2011. Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a Gender-dependent fashion: Potential role of ghrelin. Endocrinology, 152: 4800-4812.
    CrossRef  |  

  23. Gahete, M.D., J. Cordoba-Chacon, R. Salvatori, J.P. Castano, R.D. Kineman and R.M. Luque, 2010. Metabolic regulation of Ghrelin O-Acyl Transferase (GOAT) expression in the mouse hypothalamus, pituitary and stomach. Mol. Cell. Endocrinol., 317: 154-160.
    CrossRef  |  

  24. Gahete, M.D., A. Rubio, J. Cordoba-Chacon, F. Gracia-Navarro and R.D. Kineman et al., 2010. Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients. J. Alzheimer's Dis., 22: 819-828.
    CrossRef  |  

  25. Gahete, M. D., A. Rubio, M. Duran-Prado, J. Avila, R.M. Luque and J.P. Castano, 2010. Expression of Somatostatin, cortistatin and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients. J. Alzheimer's Dis., 20: 465-475.
    CrossRef  |  

  26. Gahete M.D., J. Cordoba-Chacon, M. Duran-Prado, M.M. Malagon and A.J. Martinez-Fuentes et al., 2010. Somatostatin and its receptors from fish to mammals. Ann. N.Y. Acad. Sci., 1200: 43-52.
    CrossRef  |  PubMed  |  

  27. Duran-Prado, M., A. Saveanu, R.M. Luque, M.D. Gahete and F. Gracia-Navarro et al., 2010. A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs. J. Clin. Endocrinol. Metab., 95: 2497-2502.
    CrossRef  |  

  28. Cordoba-Chacon, J., M.D. Gahete, M. Duran-Prado, A.I. Pozo-Salas and M.M. Malagon et al., 2010. Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents. Cell. Mol. Life Sci., 67: 1147-1163.
    CrossRef  |  

  29. Rodriguez-Pacheco, F., R. Vazquez-Martinez, A.J. Martinez-Fuentes, M.R. Pulido and M.D. Gahete et al., 2009. Resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways. Endocrinology, 150: 4643-4652.
    CrossRef  |  

  30. Gonzalez-Rubio, S., A.B. Hidalgo, G. Ferrin, R.I. Bello and R. Gonzalez et al., 2009. Mitochondrial-driven ubiquinone enhances extracellular Calcium-dependent nitric oxide production and reduces glycochenodeoxycholic Acid-induced cell death in hepatocytes. Chem. Res. Toxicol., 22: 1984-1991.
    CrossRef  |  

  31. Gahete, M.D., M. Duran-Prado, R.M. Luque, A.J. Martinez-Fuentes and A. Quintero et al., 2009. Understanding the multifactorial control of growth hormone release by somatotropes. Ann. N. Y. Acad. Sci., 1163: 137-153.
    CrossRef  |  

  32. Duran-Prado, M., M.D. Gahete, A.J. Martinez-Fuentes, R.M. Luque and A. Quintero et al., 2009. Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors. J. Clin. Endocrinol. Metab., 94: 2634-2643.
    CrossRef  |  

  33. Malagon, M.M., M. Molina, M.D. Gahete, M. Duran-Prado and A.J. Martinez-Fuentes et al., 2008. Urotensin II and urotensin II-related peptide activate somatostatin receptor subtypes 2 and 5. Peptides, 29: 711-720.
    CrossRef  |  

  34. Gahete, M.D., M. Duran-Prado, R.M. Luque, A.J. Martinez-Fuentes, R. Vazquez-Martinez, M.M. Malagon and J.P. Castano, 2008. Are somatostatin and cortistatin two siblings in regulating endocrine secretions? In vitro work ahead. Mol. Cellular Endocrinol., 286: 128-134.
    CrossRef  |  

  35. Kineman, R.D., M.D. Gahete and R.M. Luque, 2007. Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress. J. Mol. Endocrinol., 38: 511-521.
    CrossRef  |  

  36. Luque, R.M., M.D. Gahete, U. Hochgeschwender and R.D. Kineman, 2006. Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways. Am. J. Physiol.-Endocrinol. Metab., 291: E395-E403.
    CrossRef  |  

  37. Luque, R.M., M.D. Gahete, R.J. Valentine and R.D. Kineman, 2006. Examination of the direct effects of metabolic factors on somatotrope function in a Non-human primate model, Papio anubis. J. Mol. Endocrinol., 37: 25-38.
    CrossRef  |  Direct Link  |  
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