Dr. Iskra Ventseslavova Sainova

Assistant Professor
Institute of Experimental Morphology and Anthropology with Muzeum, Bulgaria

Highest Degree
Ph.D. in Biomedical Sciences from Institute of Experimental Morphology and Anthropology with Museum, Bulgaria

My URL
https://livedna.org/359.30188

Share this Profile

Area of Interest:

Biomedical Sciences
Pathology
Morphology
Mass Spectrometry
Vaccine Development

Selected Publications

  1. Sainova, I., T. Markova, A. Baldzhiev, A. Alishev and M. Nenchev, 2019. Comparison of protein composition from sperm probe with other biological materials by combining of several methods for assay. A pilot study. J. Chem. Biol. Phys. Sci., 9: 251-259.

  2. Ilieva, I., I. Sainova and B. Nikolov, 2019. Free radicals, male reproductivity diseases and male infertility: Review. Can. J. Biomed. Res., 1: 1-28.

  3. Zvetkova, E., I. Ilieva, I. Sainova and B. Nikolov, 2018. Sperm mitochondrial biology during spermatogenesis and fertilization. Acta Morphol. Anthropol., 25: 171-181.

  4. Sainova, I.V., I.P. Valkova, T.Z. Markova and E.B. Nikolova, 2018. Development of methods for safe application of viral vectors for gene-engineering manipulations. J. Bioeng. Biomed. Sci., Vol. 8. 10.4172/2155-9538.1000247.
    CrossRef  |  Direct Link  |  

  5. Sainova, I., I. Valkova, T. Markova, E. Nikolova, A. Baldziev, A. Alishev and M. Nenchev, 2018. Development of methods for identification of protein composition in mammalian sperm fluid and comparison with other biological materials. A pilot study. J. Chem. Biol. Phys. Sci., 8: 373-379.
    CrossRef  |  

  6. Sainova, I., I. Valkova, T. Markova and E. Nikolova, 2018. Development of methods for safe application of viral vectors for production of gene-engineering vaccines. Virol. Immunol. J., Vol. 2. 10.23880/VIJ-16000176.
    CrossRef  |  

  7. Kolyovska, V., I.V. Sainova, S. Dimitrova, I. Ivanova-Pandourska and R. Eneva et al., 2018. Presence and levels of anti-GM3 antibodies and GM3 ganglioside molecules in probes from experimental in vitro-models. Biochem. Mol. Biol. J., Vol. 4. 10.21767/2471-8084.100067.
    CrossRef  |  

  8. Sainova, I.V., I. Valkova, T. Markova, E. Nikolova, A. Baldziev, A. Alishev and M. Nenchev, 2017. Application of low-dose laser irradiation and 3D-observation methods for detection and assay of features for cell differentiation directions: A pilot study. J. Chem. Biol. Phys. Sci., 7: 1351-1360.
    CrossRef  |  

  9. Sainova, I.V., I. Valkova, T. Markova, E. Nikolova, A. Baldzhiev, A. Alishev and M. Nenchev, 2017. Development of techniques for identification of protein composition in mammalian sperm fluid by comparison with other biological probes from mammals, by combining different assay methods. A pilot study. J. Chem. Biol. Phys. Sci., 7: 701-709.
    CrossRef  |  

  10. Sainova, I., I. Valkova, T. Markova and E. Nikolova, 2017. Development of strategies for prevention of neoplastic processes on cellular and organism levels in vitro and in vivo. A pilot study. Eur. J. Pharm. Med. Res., 4: 34-38.

  11. Pencheva, M., K. Kavaldzhieva, V. Lazarov, N. Trifonova and I. Sainova et al., 2017. Role of IL-18 in inflammation. Med. Rev., 53: 10-15.

  12. Ilieva, I., R. Toshkova, E. Zvetkova, I. Sainova and I. Vladov, 2017. Morphological studies on the spermatogenesis and graffi myeloid tumor cell dissemination (Methastases) in the testes of tumor-bearing hamsters. Acta Morphol. Anthropol., 24: 33-40.
    Direct Link  |  

  13. Ilieva, I., I. Sainova and E. Zvetkova, 2017. Sperm mitochondria-associated male infertility: Sperm quality defects and mitochondria (mtDNA) anomalies: Review. Acta Morphol. Anthropol., 24: 114-122.
    Direct Link  |  

  14. Valkova, I., I. Sainova and E. Nikolova, 2016. Development of strategies for appropriate laboratory incubation of adult stem/progenitor cells and explants from different tissues. Int. J. Sci. Res. Methodol., 4: 58-67.

  15. Sainova, I.V., I. Valkova and E. Nikolova, 2016. Cytoskeleton molecules and inter-molecular interactions, underlining the cell differentiation direction in various types of biological systems with mouse, rat and human origin. J. Chem. Biol. Phys. Sci., 6: 377-387.

  16. Sainova, I., I. Valkova, E. Nikolova, B. Alexieva, A. Baldziev, A. Alishev and M. Nenchev, 2016. A pilot study on the relationship of the cytoskeleton components with normal cellular functions and injuries in malignant and neuro-degenerative multi-factor disorders, using biological systems with rat, mouse and human origin. World J. Pharm. Sci., 4: 4-12.
    Direct Link  |  

  17. Sainova, I., I. Valkova, E. Nikolova, A. Baldziev, A. Alishev and M. Nenchev, 2016. Development of novel observation and evaluation methods for understanding the role of cytoskeleton components in the cell life processes. A pilot study. World J. Pharm. Pharm. Sci., 5: 124-135.
    CrossRef  |  Direct Link  |  

  18. Sainova, I., I. Valkova, B. Alexieva, E. Nikolova and A. Baldziev et al., 2016. A pilot study of methods about detection of inter-molecular interactions as individual units of intra-cellular structures, intra- and extra-cellular cascade regulatory pathways. Int. Rev. Mol. Sci., 1: 1-13.

  19. Sainova, I., I. Valkova, B. Alexieva and E. Nikolova, 2016. Investigation on the relationship of cytoskeleton components with normal cell functions and injuries in neuro-degenerative disorders, using in vitro-, in vivo- and ex vivo-biological systems with mouse, rat and human origin. World J. Pharm. Res., 5: 38-53.
    CrossRef  |  

  20. Sainova, I., I. Valkova and E. Nikolova, 2016. Investigation on the role of the cytoskeleton components and interactions with their participation for the cell differentiation direction in several types of biological systems with mouse and human origin. Mitteilungen Klosterneuburg, 66: 176-188.

  21. Ilieva, I., R. Toshkova, I. Sainova, I. Vladov and E. Zvetkova, 2016. Histopathological changes in the testis of hamsters with experimentally induced myeloid tumor of Graffi Acta Morphol. Anthropol., 23: 32-39.
    Direct Link  |  

  22. Ilieva, I., P. Tzvetkova, I. Sainova, P. Taushanova, M. Kacarov and E. Zvetkova, 2016. Immature spermatogenic cells in semen fluids of infertile men. Compt. Rend. del ‘Acad. Bulg. Sci., 69: 85-94.

  23. Valkova, I., I. Sainova, B. Alexieva and E. Nikolova, 2015. Investigation of the molecular and intra-molecular mechanisms, determining the cell differentiation direction in appropriate incubation conditions, on cellular and organism levels. Int. J. Adv. Res., 6: 908-917.

  24. Valkova, I., I. Sainova and E. Nikolova, 2015. Directions of in vitro-differentiation of adult stem/progenitor cells, depending of the respective sources and incubation conditions. Int. J. Adv. Res. Biol. Sci., 2: 75-79.

  25. Sainova, I., V. Pavlova, B. Alexieva, I. Valkova, T. Markova and E. Nikolova, 2015. Experimental models for investigation of antioxidant and immunomodulatory effects in vitro of Aronia melanocarpa extract. Bull. Environ. Pharmacol. Life Sci., 4: 79-82.

  26. Sainova, I., V. Pavlova, B. Alexieva, I. Valkova and E. Nikolova, 2015. Experimental models of cell in vitro-differentiation by different laboratory incubation times in the presence of Aronia melanocarpa fruit extract. Int. J. Adv. Res. Biol. Sci., 2: 206-210.

  27. Sainova, I., I. Valkova, B. Alexieva, I. Ilieva and E. Nikolova, 2015. Development of methods for activation of genes from Cul-Nedd-, STAT- and NK-κB-mediated cascade regulatory pathways. Int. J. Lat. Res. Sci. Technol., 4: 62-69.

  28. Sainova, I., I. Valkova, B. Alexieva, I. Ilieva and E. Nikolova, 2015. Activation of mechanisms, mediated by Dcn1-HACE1-, JAK-STAT- and NF-κB-cascade regulatory pathways in in vitro- and in vivo-experimental models. Int. J. Innov. Biol. Chem. Sci., 6: 48-59.

  29. Sainova, I., I. Valkova, B. Alexieva and E. Nikolova, 2015. Testing the influence of growth factors, extra-cellular matrix components, plant extracts and organic detergents, on the osteoblast and osteoclast in vitro-differentiation direction of human and mouse cell progenitors from different sources. Int. J. Pharm. Res. Innov., 8: 23-28.
    Direct Link  |  

  30. Sainova, I., B. Alexieva, E. Nikolova, A. Baldziev, A. Alishev and M. Nenchev, 2015. Development of methods for detection of intra- and extra-cellular intra-molecular interactions, underlining the direction of cell differentiation. A pilot study. J. Chem. Biol. Phys. Sci., 5: 2801-2808.

  31. Ilieva, I., P. Tzvetkova, M. Kacarov, I. Sainova, P. Taushanova, I. Vladov and E. Zvetkova, 2015. Round immature spermatogenic cells in semen fluids of infertile men with diagnose “migrating testis”. Two casuistic cases in adults. Acta Morphol. Anthropol., 22: 15-23.

  32. Valkova, I., I. Sainova, V. Pavlova, A. Georgieva, B. Alexieva and E. Nikolova, 2014. In vitro-cultivation of human oral mucosa epithelial cells and tissue explants as a modern method for applications in therapy of limbal stem cell deficiency: A pilot study. Acta Morphol. Anthropol., 20: 62-66.

  33. Sainova, I., V. Pavlova, B. Alexieva, I. Valkova, T. Markova and E. Nikolova, 2014. Development of novel engineering and bio-informatics methods for protein identification. J. Chem. Biol. Phys. Sci., 4: 2304-2309.

  34. Sainova, I., V. Pavlova, B. Alexieva, I. Valkova, T. Markova and E. Nikolova, 2014. Antioxidant effects of Aronia melanocarpa extract after doxorubicin treatment in vitro and in vivo. Adv. Biores., 5: 119-123.

  35. Sainova, I., V. Pavlova, B. Alexieva, I. Valkova, T. Markova and E. Nikolova, 2014. Achievement of balanced activity between oncogenes, tumor-suppressor genes and their protein products in experimental models from human, rat and mouse. Int. Sci. J., 1: 87-95.

  36. Sainova, I., V. Pavlova, B. Alexieva, I. Valkova and E. Nikolova, 2014. Experimental models for investigation on the influence of Aronia melanocarpa fruit extract on the cell differentiation and antioxidant capacity in vitro. Asian J. Innovat. Res. Sci. Eng. Technol., 1: 13-19.

  37. Sainova, I., I. Vavrek, V. Pavlova, T. Daneva and I. Iliev et al., 2014. Experimental in vitro-rodent and human normal and malignant cell models. Int. J. Recent Sci. Res., 5: 1018-1021.

  38. Sainova, I., I. Valkova, V. Pavlova and E. Nikolova, 2014. Experimental human and rodent models for balanced activity of oncogenes and tumor-suppressor genes and their protein products. Prime Res. Med., 3: 134-139.

  39. Sainova, I., I. Valkova, B. Alexieva, B. Georgieva and E. Nikolova, 2014. Development of methods for safe in vitro-differentiation of different progenitor types in osteoblasts/osteoblast-like and osteoclast/osteoclast-like cells with human and mouse origin. Integr. J. Br., 1: 1-10.

  40. Sainova, I., B. Alexieva, I. Valkova and E. Nikolova, 2014. Experimental in vitro-models from rodent and human for balanced activity between oncogenes and tumor-suppressor genes. Scholarly J. Scient. Res. Essay, 3: 95-99.

  41. Pavlova, V., I. Sainova, B. Alexieva, I. Valkova, T. Markova and E. Nikolova, 2014. Antioxidant effect of Aronia melanocarpa extract after doxorubicin treatment. Bulg. J. Agric. Sci., 20: 188-192.
    Direct Link  |  

  42. Pavlova, V., B. Alexieva, I. Sainova, T. Markova and E. Nikolova, 2014. Transmission electron microscope study on the beneficial role of Aronia melanocarpa fruit extract on Dox-induced cardiotoxicity in mice. Int. J. Pharm. Chem. Biol. Sci., 4: 460-465.

  43. Alexieva, B., I. Sainova, V. Pavlova, T. Markova, I. Valkova and E. Nikolova, 2014. Insights into mechanisms of doxorubicin toxicity. J. Physiol. Pharmacol. Adv., 4: 342-348.

  44. Valkova, I., I. Sainova, A. Georgieva, A. Neronov, M. Bratanov and E. Nikolova, 2013. Development of novel in vitro-cultivation techniques for derivation of corneal epithelial explants. Bull. Environ. Pharmacol. Life Sci., 2: 43-47.

  45. Sainova, I., I. Valkova, V. Pavlova and E. Nikolova, 2013. Experimental rodent and human models for balanced activity of oncogenes and tumor-suppressor genes and their protein products. Adv. Biores., 4: 7-12.

  46. Sainova, I., I. Valkova, V. Pavlova and E. Nikolova, 2013. Differentiation of stem and progenitor cells from bone marrow in activated dendritic cells and lymphocytes with anti-malignant properties. Afr. J. Pharm. Pharmacol., 7: 1426-1437.
    CrossRef  |  

  47. Sainova, I., I. Valkova, V. Pavlova and E. Nikolova, 2013. Development of improved methods for protein separation and identification. Int. J. Electron. Commun. Comput. Eng., 4: 415-417.

  48. Markova, T., B. Alexieva, I. Sainova, K. Simeonova and E. Nikolova, 2013. Immune mechanisms in bronchial asthma. Med. Rev., 49: 9-12.

  49. Sainova, I.V., I. Vavrek, V. Pavlova, I. Iliev, L. Yossifova, E. Gardeva and E. Nikolova, 2012. Differentiation of stem and progenitor cells in activated immune cells with anti-malignant properties. J. Clin. Immunol. Immunopathol. Res., 4: 8-11.
    CrossRef  |  Direct Link  |  

  50. Sainova, I., I. Vavrek, V. Pavlova, T. Daneva, S. Pashova and E. Nikolova, 2012. Experimental in vitro-human and animal models for balanced activity of oncogenes and tumor-suppressor genes and their protein products. Scholarly J. Biotechnol., 1: 8-14.

  51. Sainova, I., I. Vavrek, V. Pavlova, T. Daneva, S. Pashova and E. Nikolova, 2012. Experimental human and animal models for balanced activity of oncogenes and tumor- suppressor genes and their protein products. J. Med. Res. Pract., 1: 52-58.

  52. Sainova, I., I. Vavrek, V. Pavlova, T. Daneva and I. Iliev et al., 2012. Experimental in vitro-stem cell models for balanced activity of oncogenes and tumor-suppressor genes from mouse and human. Adv. Biores., 3: 69-72.

  53. Sainova, I., I. Vavrek, V. Pavlova, T. Daneva and I. Iliev et al., 2012. Experimental in vitro-mouse and human stem cell models for balanced activity of oncogenes and tumor-suppressor genes. J. Physiol. Pharmacol. Adv., 2: 64-68.

  54. Sainova, I., I. Vavrek, V. Pavlova, T. Daneva and I. Iliev et al., 2012. Experimental human and rodent models for balanced activity of oncogenes and tumor-suppressor genes in vitro and in vivo. J. Sci. Res. Pharm., 1: 38-42.

  55. Sainova, I., I. Vavrek, I. Atanassov, K. Lazov and V. Pavlova et al., 2012. Experimental rodent and human in vitro-models for balanced activity of oncogenes and tumor-suppressor genes. Bull. Environ. Pharmacol. Life Sci., 1: 46-54.
    Direct Link  |  

  56. Sainova, I.V., I. Vavrek, V. Pavlova, T. Daneva and I. Iliev et al., 2011. Achievement of balanced oncogenes and tumor-suppressor genes activity in normal and malignant cells in vitro and in vivo. J. Dev. Biol. Tissue Eng., 3: 119-125.
    CrossRef  |  Direct Link  |  

  57. Sainova, I.V., I. Vavrek, V. Pavlova, I. Iliev and L. Yossifova et al., 2011. In vitro- and in vivo-experimental models for balanced activity of oncogenes and tumor-suppressor genes in normal and malignant cells. Clin. Rev. Opin., 3: 37-44.
    Direct Link  |  

  58. Sainova, I., I. Vavrek, V. Pavlova, T. Daneva and I. Iliev et al., 2011. Experimental model for safe in vitro- and in vivo-influence of internal and external factors of cell differentiation. Afr. J. Pharm. Pharmacol., 5: 786-791.
    CrossRef  |  

  59. Sainova, I., I. Vavrek, V. Pavlova, T. Daneva and I. Iliev et al., 2011. Experimental in vitro rodent and human normal and malignant cell models for balanced activity of oncogenes and tumor-suppressor genes. J. Life Sci., 5: 454-459.

  60. Sainova, I., R. Nitsh, A. Nitsh, I. Vavrek and V. Pavlova et al., 2010. Experimental in vitro-model for safe gene transfer in stem and progenitor cells by recombinant gene constructs. Ser. Biomech., 25: 179-183.

  61. Sainova, I., I. Vavrek, V. Pavlova, T. Daneva, S. Manchev and E. Nikolova, 2010. Experimental model for safe gene transfer by recombinant gene constructs. Biotechnol. Biotechnol., 24: 134-138.
    CrossRef  |  Direct Link  |  

  62. Sainova, I. and Y. Gluhcheva, 2009. Malignant stem cell-targeted treatment in therapeutic strategies against cancer and leukemia. Acta Morphol. Anthropol., 14: 163-166.

  63. Savov, Y., E. Zvetkova, I. Sainova, Y. Gluhcheva and N. Antonova et al., 2008. Leucocyte cytochemistry and hematometric indices in chronic heroin addicts. Acta Morphol. Anthropol., 13: 159-163.

  64. Savov, Y., N. Antonova, E. Zvetkova, Y. Gluhcheva and I. Ivanov et al., 2007. Changes in blood viscosity and erythrocyte indices in chronic heroin abusers. Acta Morphol. Anthropol., 12: 67-71.

  65. Sainova, I., 2007. In vitro-differentiation of embryonic mammalian cells as a material base for gene-engineering manipulations. Int. J. Bioautomation, 8: 201-206.
    Direct Link  |  

  66. Savov, Y., N. Antonova, E. Zvetkova, Y. Gluhcheva, I. Ivanov and I. Sainova, 2006. Whole blood viscosity and erythrocyte hematometric indices in chronic heroin addicts. Clin. Hemorheol. Microcirculation, 35: 129-133.
    Direct Link  |  

  67. Sainova, I., E. Bichkidjieva, Y. Savov, I. Ilieva, Y. Gluhcheva and E. Zvetkova, 2006. Evaluation of berberine as a DNA-specific fluorescent dye and DNA-intercalating antitumor alkaloid. Acta Morphol. Anthropol., 11: 139-142.

  68. Sainova, I., Y. Savov, Y. Gluhcheva, R. Toschkova, E. Bichkidjieva, I. Ilieva and E. Zvetkova, 2005. Evaluation of berberine as a DNA-specific fluorescent dye, antitumor-, antioxidant- and immunomodulatory drug. Exp. Pathol. Parasitol., 8: 52-59.

  69. Sainova, I., A. Kril, K. Simeonov, T. Popova and I. Ivanov, 2005. Investigation of the morphology of cell clones, derived from the mammalian EBTr cell line and their susceptibility to the vaccine avian poxvirus strains FK and Dessau. J. Virol. Methods, 127: 37-40.
    CrossRef  |  PubMed  |  

  70. Alexandrova, R., G. Rashkova, D. Salkova and I. Sainova, 2002. Something more about zinc. Exp. Pathol. Parasitol., 8: 17-24.

  71. Sainova, I., A. Kril and I. Ivanov, 2001. Propagation of avian pox virus vaccine strains in a mammalian EBTr cell line: A pilot study. Exp. Pathol. Parasitol., 4: 40-46.

  72. Sainova, I., 2001. Polygene diseases and disorders. Clinic Pre-Clinic, 2: 11-13.

  73. Ivanov, I.G., A.I. Kril and I.V. Sainova, 2001. Propagation of avian virus strains in the permanent duck embryo cell line DEC 99. Exp. Pathol. Parasitol., 5: 31-34.

  74. Ivanov, I., Z. Halkova, S. Tsolova, K. Simeonov, I. Sainova and M. Tasheva, 2001. Cytotoxicity induced by herbicides glyphosate and alachlor in vitro. Exp. Pathol. Parasitol., 6: 46-49.

  75. Ivanov, I., I. Sainova, E. Shikova and K. Troev, 2001. Cytotoxicity induced by 3-ethyl-2-oxa- 1,4,2 oxazaphosphorinane and α-ethyl-α-N-(hydroxyethylamino) methylphosphonic acid in vitro. Exp. Pathol. Parasitol., 5: 26-30.

  76. Ivanov, I., I. Sainova, A. Kril and K. Simeonov, 2001. Propagation of avian poxvirus vaccine strains in duck embryo cell line DEC 99. Exp. Pathol. Parasitol., 6: 20-26.

  77. Toncheva, D. and I. Sainova, 2000. Interferometric microscope for investigation of biological objects. Opt. Las. Biomed. Cult., 5: 307-312.

  78. Ivanov, I., A. Kril, K. Simeonov, T. Popova, I. Sainova and Y. Tzvetkov, 2000. Propagation of avian pox virus vaccine strains in duck embryo cell cultures. Macedonian Vet. Rev., 29: 33-38.

  79. Alexandrova, R., T. Varadinova, M. Velcheva, P. Genova and I. Sainova, 2000. Cytotoxic effect of isoquinoline alkaloids on tumor cell lines. Exp. Pathol. Parasitol., 4: 8-14.

  80. Toncheva, D., V. Michov, I. Sainova, S. Atanassova and B. Zaharieva, 1999. Low level of sex chromosomal mosaicism in patients with schizophrenia. Balkan J. Med. Genet., 2: 31-34.

  81. Toncheva, D., V. Michov, I. Sainova, S. Atanassova and B. Zaharieva, 1999. Frequency and type of structural chromosomal aberrations in patients with schizophrenia. Balkan J. Med. Genet., 2: 27-30.
Member since August, 2019