Dr. Atanas Georgiev Atanasov

Senior Scientist
University of Vienna, Austria

Highest Degree
Ph.D. in Biochemistry from University of Bern, Switzerland

My URL
https://livedna.org/359.8359

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Biography

Dr. Atanas Georgiev Atanasov is currently working as Senior Researcher at the Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Austria. He obtained his PhD in Biochemistry from University of Bern, Switzerland in 2005. His area of research focuses on Molecular Mechanisms of Pharmacological Action, Cell Signalling and Regulatory Pathways relevant for Inflammation and Cardio Metabolic Disease, Discovery and Characterization of Novel Bioactivities of Natural Products, Use of Small Molecules as Tools for Biological Systems Manipulation and Basic Research (Chemical Biology). Dr. Atanas Georgiev received number of honors includes Focus of Excellence Award 2012, POENIX Pharmacy Science Award, Research Fellowship from Roche Research Foundation, Award for Excellent Performance during Studies, and Awarded 20 times a State Fellowship from the Republic of Bulgaria. He is a recipient of various research grants. He is professional member of American Chemical Society, and American Association for the Advancement of Science. He is also working as editorial board member of Frontiers in Molecular Neuroscience, Leader of MedChemNet, Reviewer for the Evaluation of Research Proposals, Advisory board member of Biocognizance, and Referee for 17 international peer-reviewed journals. He is also invited to deliver lectures in many Universities. He has 55 publications in journals contributed as author/co-author.

Area of Interest:

Molecular Sciences
Molecular Mechanisms
Cell Signaling
Inflammation
Natural Products

Selected Publications

  1. Zimmermann, K., J. Baldinger, B. Mayerhofer, A.G. Atanasov, V.M. Dirsch and E.H. Heiss, 2015. Activated ampk boosts the nrf2/ho-1 signaling axis-a role for the unfolded protein response. Free Radic. Biol. Med., 10.1016/j.freeradbiomed.2015.03.030.
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  2. Tran, T.V., C. Malainer, S. Schwaiger, T. Hung and A.G. Atanasov et al., 2015. Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: Assessing the activity of flavonoids from the stem bark of Oroxylum indicum. J. Ethnopharmacol., 159: 36-42.
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  3. Liu, R., E.H. Heiss, N. Sider, A. Schinkovitz and B. Groblacher et al., 2015. Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation. Mol. Nutr. Food Res., 59: 843-852.
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  4. Liu, R., E.H. Heiss, D. Guo, V.M. Dirsch and A.G. Atanasov, 2015. Capsaicin from chili (Capsicum spp.) inhibits vascular smooth muscle cell proliferation. F1000Research, Vol. 4. 10.12688/f1000research.6007.1.
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  5. Kiss, I., C. Unger, C.N. Huu, A.G. Atanasov and N. Kramer et al., 2015. Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation. Cancer Lett., 356: 994-1006.
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  6. Xie, L.W., A.G. Atanasov, D.A. Guo, C. Malainer and J.X. Zhang et al., 2014. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller. J. Ethnopharmacol., 152: 470-477.
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  7. Wang, L., B. Waltenberger, E.M. Pferschy-Wenzig, M. Blunder and X. Liu et al., 2014. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): A review. Biochem. Pharmacol., 92: 73-89.
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  8. Tran, T.V., C. Malainer, S. Schwaiger, A.G. Atanasov, E.H. Heiss, V.M. Dirsch and H. Stuppner, 2014. NF-κB Inhibitors from Eurycoma longifolia. J. Nat. Prod., 77: 483-488.
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  9. Pitschmann, A., M. Zehl, A.G. Atanasov, V.M. Dirsch, E. Heiss and S. Glasl, 2014. Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro. J. Ethnopharmacol., 152: 599-602.
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  10. Pferschy-Wenzig, E.M., A.G. Atanasov, C. Malainer, S.M. Noha and O. Kunert et al., 2014. Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. J. Nat. Prod., 77: 842-847.
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  11. Liu, X., O. Kunert, M. Blunder, N. Fakhrudin and S.M. Noha et al., 2014. Polyyne Hybrid Compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects. J. Nat. Prod., 77: 2513-2521.
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  12. Heiss, E.H., T.V. Tran, K. Zimmermann, S. Schwaiger and C. Vouk et al., 2014. Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata. J. Nat. Prod., 77: 503-508.
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  13. Heiss, E.H., M.P. Kramer, A.G. Atanasov, H. Beres, D. Schachner and V.M. Dirsch, 2014. Glycolytic switch in response to betulinic acid in non-cancer cells. PLoS One, Vol. 9. 10.1371/journal.pone.0115683.
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  14. Blazevic, T., A.M. Schaible, K. Weinhaupl, D. Schachner and F. Nikels et al., 2014. Indirubin-3'-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration. Cardiovasc Res., 101: 522-532.
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  15. Vogl, S., P. Picker, J. Mihaly-Bison, N. Fakhrudin and A.G. Atanasov et al., 2013. Ethnopharmacological in vitro studies on Austria's folk medicine: An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs. J. Ethnopharmacol., 149: 750-771.
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  16. Vogl, S., A.G. Atanasov, M. Binder, M. Bulusu, M. Zehl, N. Fakhrudin and B. Kopp, 2013. The herbal drug Melampyrum pratense l. (koch): isolation and identification of its bioactive compounds targeting mediators of inflammation. Evid Based Complement. Alternat. Med., 10.1155/2013/395316.
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  17. Viola, K., S. Kopf, L. Rarova, K. Jarukamjorn and N. Kretschy et al., 2013. Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis. Arch. Toxicol., 87: 1301-1312.
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  18. Teichmann, M., N. Kretschy, S. Kopf, K. Jarukamjorn and A.G. Atanasov et al., 2013. Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: Drug testing in a 3D model. Arch. Toxicol., 88: 691-699.
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  19. Oettl, S.K., J. Gerstmeier, S. Khan, K. Wiechmann and J. Bauer et al., 2013. Imbricaric acid and perlatolic acid: Multi-targeting anti-inflammatory depsides from Cetrelia monachorum. PLoS One, Vol. 8. 10.1371/journal.pone.0076929.
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  20. Nashev, L.G., A.G. Atanasov, M.E. Baker and A. Odermatt, 2013. Cysteine-10 on 17β-hydroxysteroid dehydrogenase 1 has stabilizing interactions in the cofactor binding region and renders sensitivity to sulfhydryl modifying chemicals. J. Cell Biol., Vol. 2013. 10.1155/2013/769536.
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  21. Kretschy, N., M. Teichmann, S. Kopf, A.G. Atanasov and P. Saiko et al., 2013. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br. J. Cancer, 108: 570-578.
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  22. Kopf, S., K. Viola, A.G. Atanasov, K. Jarukamjorn and L. Rarova et al., 2013. In vitro characterisation of the anti-intravasative properties of the marine product heteronemin. Arch. Toxicol., 87: 1851-1861.
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  23. Fakhrudin, N., B. Waltenberger, M. Cabaravdic, A.G. Atanasov and C. Malainer et al., 2013. Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. Br. J. Pharmacol., 171: 1676-1686.
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  24. Blazevic, T., A.V. Schwaiberger, C.E. Schreiner, D. Schachner and A.M. Schaible et al., 2013. 12/15-Lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3. J. Biol. Chem., 288: 35592-35603.
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  25. Atanasov, A.G., M. Blunder, N. Fakhrudin, X. Liu and S.M. Noha et al., 2013. Polyacetylenes from Notopterygium incisum- new selective partial agonists of peroxisome proliferator-activated receptor-gamma. PLoS One, Vol. 8. 10.1371/journal.pone.0061755.
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  26. Atanasov, A.G., J.N. Wang, S.P. Gu, J. Bu and M.P. Kramer et al., 2013. Honokiol: A non-adipogenic PPARγ agonist from nature. Biochim. Biophys. Acta, 1830: 4813-4819.
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  27. Steinmann, D., R.R. Baumgartner, E.H. Heiss, S. Bartenstein and A.G. Atanasov et al., 2012. Bioguided Isolation of (9Z)-Octadec-9-enoic acid from Phellodendron amurense Rupr. and identification of fatty acids as PTP1B inhibitors. Planta Med., 78: 219-224.
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  28. Rozema, E., A.G. Atanasov, N. Fakhrudin, J. Singhuber, U. Namduang, E.H. Heiss and B. Kopp, 2012. Selected extracts of chinese herbal medicines: their effect on nf-κb, pparα and pparγ and the respective bioactive compounds. Evidence Based Complementary Altern. Med., 10.1155/2012/983023.
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  29. Ladurner, A., C.A. Schmitt, D. Schachner, A.G. Atanasov, E.R. Werner, V.M. Dirsch and E.H. Heiss, 2012. Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status. Free Radic Biol. Med., 52: 2082-2090.
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  30. Ladurner, A., A.G. Atanasov, E.H. Heiss, L. Baumgartner and S. Schweiger et al., 2012. 2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells. Biochem. Pharmacol., 84: 804-812.
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  31. Kurin, E., A.G. Atanasov, O. Donath, E.H. Heiss, V.M. Dirsch and M. Nagy, 2012. Synergy study of the inhibitory potential of red wine polyphenols on vascular smooth muscle cell proliferation. Planta Med., 78: 772-778.
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  32. Heiss, E.H., L. Baumgartner, S. Schwaiger, R.J. Heredia and A.G. Atanasov et al., 2012. Ratanhiaphenol III from ratanhiae radix is a PTP1B inhibitor. Planta Med., 78: 678-681.
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  33. Giessrigl, B., G. Yazici, M. Teichmann, S. Kopf and S. Ghassemi et al., 2012. Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers. Int. J. Oncol., 40: 2063-2074.
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  34. Schreiner, C.E., M. Kumerz, J. Gesslbauer, D. Schachner and H. Joa et al., 2011. Resveratrol blocks Akt activation in Angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner. Cardiovasc. Res., 90: 140-147.
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  35. Noha, S.M., A.G. Atanasov, D. Schuster, P. Markt and N. Fakhrudin et al., 2011. Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques. Bioorg. Med. Chem. Lett., 21: 577-583.
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  36. Kumerz, M., E.H. Heiss, D. Schachner, A.G. Atanasov and V.M. Dirsch, 2011. Resveratrol inhibits migration and Rac1 activation in EGF- but not PDGF-activated vascular smooth muscle cells. Mol. Nutr. Food Res., 55: 1230-1236.
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  37. Joa, H., S. Vogl, A.G. Atanasov, M. Zehl and T. Nakel et al., 2011. Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation. J. Nat. Prod., 74: 1513-1516.
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  38. Baumgartner, L., S. Sosa, A.G. Atanasov, A. Bodensieck and N. Fakhrudin et al., 2011. Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. J. Natu. Prod., 74: 1779-1786.
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  39. Schwaiberger, A.V., E.H. Heiss, M. Cabaravdic, T. Oberan and J. Zaujec et al., 2010. Indirubin-3'-Monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo. Arterioscler Thromb. Vasc. Biol., 30: 2475-2481.
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  40. Fakhrudin, N., A. Ladurner, A.G. Atanasov, E.H. Heiss and L. Baumgartner et al., 2010. Computer-aided discovery, validation and mechanistic characterization of novel neolignan activators of Peroxisome Proliferator-Activated Receptor γ. Mol. Pharmacol., 77: 559-566.
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  41. Baumgartner, R.R., D. Steinmann, E.H. Heiss, A.G. Atanasov, M. Ganzera, H. Stuppner and V.M. Dirsch, 2010. Bioactivity-guided Isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B Inhibitor. J. Nat. Prod., 73: 1578-1581.
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  42. Odermatt, A. and A.G. Atanasov, 2009. Mineralocorticoid receptors: Emerging complexity and functional diversity. Steroids, 74: 163-171.
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  43. Atanasov, A.G., L.G. Nashev, L. Gelman, B. Legeza, R. Sack, R. Portmann and A. Odermatt, 2008. Direct protein-protein interaction of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen. Biochim. Biophys. Acta, 1783: 1536-1543.
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  44. Atanasov, A.G., D. Leiser, C. Roesselet, M. Noti, N. Corazza, K. Schoonjans and T. Brunner, 2008. Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells. FASEB J., 22: 4117-4125.
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  45. Nashev, L.G., C. Chandsawangbhuwana, Z. Balazs, A.G. Atanasov and B. Dick et al., 2007. Hexose-6-phosphate dehydrogenase modulates 11β-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7β-hydroxy-neurosteroids. PLoS One, Vol. 2. 10.1371/journal.pone.0000561.
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  46. Mueller, M., A. Atanasov, I. Cima, N. Corazza, K. Schoonjans and T. Brunner, 2007. Differential regulation of glucocorticoid synthesis in murine intestinal epithelial versus adrenocortical cell lines. Endocrinology, 148: 1445-1453.
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  47. Atanasov, A.G., I.D. Ignatova, L.G. Nashev, B. Dick, P. Ferrari, F.J. Frey and A. Odermatt, 2007. Impaired protein stability of 11β-hydroxysteroid dehydrogenase type 2: A novel mechanism of apparent mineralocorticoid excess. J. Am. Soc. Nephrol., 18: 1262-1270.
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  48. Atanasov, A.G. and A. Odermatt, 2007. Readjusting the glucocorticoid balance: An opportunity for modulators of 11β -hydroxysteroid dehydrogenase type 1 activity? Endocr. Metab. Immune Disord Drug Targets, 7: 125-140.
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  49. Odermatt, A., C. Gumy, A.G. Atanasov and A.A. Dzyakanchuk, 2006. Disruption of glucocorticoid action by environmental chemicals: Potential mechanisms and relevance. J. Steroid Biochem. Mol. Biol., 102: 222-231.
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  50. Odermatt, A., A.G. Atanasov, Z. Balazs, R.A. Schweizer, L.G. Nashev, D. Schuster and T. Langer, 2006. Why is 11β-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen?: Physiological relevance of the membrane topology of 11β-HSD1. Mol. Cell. Endocrinol., 248: 15-23.
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  51. Atanasov, A.G., A.A. Dzyakanchuk, R.A. Schweizer, L.G. Nashev, E.M. Maurer and A. Odermatt, 2006. Coffee inhibits the reactivation of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1: A glucocorticoid connection in the anti-diabetic action of coffee? FEBS Lett., 580: 4081-4085.
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  52. Atanasov, A.G., L.G. Nashev, S. Tam, M.E. Baker and A. Odermatt, 2005. Organotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids. Environ. Health Perspect., 113: 1600-1606.
    PubMed  |  

  53. Frick, C., A.G. Atanasov, P. Arnold, J. Ozols and A. Odermatt, 2004. Appropriate function of 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase. J. Biol. Chem., 279: 31131-31138.
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  54. Atanasov, A.G., L.G. Nashev, R.A. Schweizer, C. Frick and A. Odermatt, 2004. Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase. FEBS Lett., 571: 129-133.
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  55. Frey, B.M. and A. Odermatt, 2003. A rapid screening assay for inhibitors of 11β-hydroxysteroid dehydrogenases (11β-HSD): Flavanone selectively inhibits 11β-HSD1 reductase activity. Mol. Cell. Endocrinol., 212: 41-49.
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  56. Atanasov, A.G., S. Tam, J.M. Rocken, M.E. Baker and A. Odermatt, 2003. Inhibition of 11β-hydroxysteroid dehydrogenase type 2 by dithiocarbamates. Biochem. Biophys. Res. Commun., 308: 257-262.
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