Dr. Lionetti Vincenzo

Associate Professor
Scuola Superiore Sant`Anna, Italy

Highest Degree
Ph.D. in Innovative Strategies in Biomedical Research from Scuola Superiore Sant`Anna, Italy

My URL
https://livedna.org/39.10387

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Biography

Dr. Lionetti Vincenzo is currently working as Associate Professor of Anesthesiology. He has completed his Ph.D. in Innovative Strategies in Biomedical Research from Scuola Superiore Sant’Anna, Italy. His main area of interest focuses on Biomedical Sciences, Critical Care and Cardiovascular Sciences. His area of expertise includes Animal Models, Anesthesiology, Exosomes, Translational Research, Physiology, Epigenetics, Heart Failure, Regenerative Medicine, Magnetic Resonance Imaging, Critical Care Medicine, Heart, and Cardiofunctional Food. He has published 73 research articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
Animal Models
Physiology
Regenerative Medicine
Epigenetics

Selected Publications

  1. Tocchetti, C.G., M. Molinaro, T. Angelone, V. Lionetti and R. Madonna et al., 2015. Nitroso-redox balance and modulation of basal myocardial function: An update from the Italian Society of Cardiovascular Research (SIRC). Curr. Drug Targets. .
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  2. Matteucci, M., G. Papini, E. Ciofini, L. Barile and V. Lionetti, 2015. Epigenetic regulation of myocardial homeostasis, self-regeneration and senescence. Curr. Drug Targets. .
    PubMed  |  

  3. Flori, A., M. Liserani, F. Frijia, G. Giovannetti and V. Lionetti et al., 2015. Real-time cardiac metabolism assessed with hyperpolarized [1-13C]acetate in a large-animal model. Contrast Media Mol. Imaging, 10: 194-202.
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  4. Agostini, S., E. Chiavacci, M. Matteucci, M. Torelli, L. Pitto and V. Lionetti, 2015. Barley β-glucan promotes MnSOD expression and enhances angiogenesis under oxidative microenvironment. J. Cell. Mol. Med., 19: 227-238.
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  5. Lionetti, V., M. Matteucci, M. Ribezzo, D. Di Silvestre and F. Brambilla et al., 2014. Regional mapping of myocardial hibernation phenotype in idiopathic end-stage dilated cardiomyopathy. J. Cell. Mol. Med., 18: 396-414.
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  6. Lionetti, V., 2014. Functional foods for the prevention of chronic heart failure: What we should know? Exp. Clin. Cardiol., 20: 5500-5508.

  7. Casieri, V., S. Agostini and V. Lionetti, 2014. Epigenetic modulation of myocardial angiogenic balance: An emerging therapeutic perspective for adult failing heart. Curr. Angiogenesis, 3: 3-10.
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  8. Cabiati, M., A. Martino, L. Mattii, C. Caselli and T. Prescimone et al., 2014. Adenosine receptor expression in an experimental animal model of myocardial infarction with preserved left ventricular ejection fraction. Heart Vessels, 29: 513-519.
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  9. Barile, L., V. Lionetti, E. Cervio, M. Matteucci and M. Gherghiceanu et al., 2014. Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction. Cardiovasc. Res., 103: 530-541.
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  10. Romano, S.L. and V. Lionetti, 2013. From cell phenotype to epigenetic mechanisms: New insights into regenerating myocardium. Can. J. Physiol. Pharmacol., 91: 579-585.
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  11. Prescimone, T., V. Lionetti, M. Cabiati, C. Caselli and G.D. Aquaro et al., 2013. Apoptotic transcriptional profile remains activated in late remodeled left ventricle after myocardial infarction in swine infarcted hearts with preserved ejection fraction. Pharmacol. Res., 70: 41-49.
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  12. Pingitore, A., G.D. Aquaro, V. Lorenzoni, M. Gallotta and D. de Marchi et al., 2013. Influence of preload and afterload on stroke volume response to low-dose dobutamine stress in patients with non-ischemic heart failure: A cardiac MR study. Int. J. Cardiol., 166: 475-481.
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  13. Padeletti, L., P. Pieragnoli, G. Ricciardi, L. Perrotta and A.P. Perini et al., 2013. Larger interventricular conduction time enhances mechanical response to resynchronization therapy. Pacing Clin. Electrophysiol., 36: 416-423.
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  14. Lionetti, V., S.L. Romano, G. Bianchi, F. Bernini and A. Dushpanova et al., 2013. Impact of acute changes of left ventricular contractility on the transvalvular impedance: Validation study by pressure-volume loop analysis in healthy pigs. PLoS One, Vol. 19. 10.1371/journal.pone.0080591.
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  15. Lionetti, V. and C. Ventura, 2013. Regenerative medicine approach to repair the failing heart. Vascul. Pharmacol., 58: 159-163.
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  16. Lionetti, V. and C. Ventura, 2013. New chemicals drive mesenchymal stem cells towards cardiac cells. Recent Patents Regenerative Med., 3: 47-55.
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  17. Hecker, P.A., V. Lionetti, R.F. Ribeiro Jr., S. Rastogi and B.H. Brown et al., 2013. Glucose 6-phosphate dehydrogenase deficiency increases redox stress and moderately accelerates the development of heart failure. Circulat.: Heart Failure, 6: 118-126.
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  18. Giovannetti, G., F. Frijia, V. Hartwig, S. Attanasio and L. Menichetti et al., 2013. Design of a quadrature surface coil for hyperpolarized 13°C MRS cardiac metabolism studies in pigs. Concepts Magn. Res. Part B: Magn. Res. Eng., 43: 69-77.
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  19. Giovannetti, G., F. Frijia, V. Hartwig, L. Menichetti and V. Positano et al., 2013. Transmit-only/receive-only radiofrequency system for hyperpolarized 13°C MRS cardiac metabolism studies in pigs. Applied Magn. Res., 44: 1125-1138.
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  20. Del Ry, S., M. Cabiati, A. Martino, C. Cavallini and C. Caselli et al., 2013. High concentration of C-type natriuretic peptide promotes VEGF-dependent vasculogenesis in the remodeled region of infarcted swine heart with preserved left ventricular ejection fraction. Int. J. Cardiol., 168: 2426-2434.
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  21. Caselli, C., V. Lionetti, M. Cabiati, T. Prescimone and G.D. Aquaro et al., 2013. Regional evidence of modulation of cardiac adiponectin level in dilated cardiomyopathy: Pilot study in a porcine animal model. Cardiovasc. Diabetol., Vol. 11. .
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  22. Bianchi, G., A. Pucci, M. Matteucci, E. Varone, S.L. Romano, V. Lionetti and M. Glauber, 2013. Mechanical properties and biological interaction of aortic clamps: Are these all minimally invasive? Innovations, 8: 42-49.
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  23. Aquaro, G.D., G. Todiere, G. Di Bella, L. Guiducci, A. Pingitore and V. Lionetti, 2013. A fast and effective method of quantifying myocardial perfusion by magnetic resonance imaging. Int. J. Cardiovasc. Imaging, 29: 1313-1324.
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  24. Aquaro, G.D., F. Frijia, V. Positano, L. Menichetti and M.F. Santarelli et al., 2013. 3D CMR mapping of metabolism by hyperpolarized 13°C-pyruvate in ischemia-reperfusion. JACC Cardiovasc. Imaging, 6: 743-744.
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  25. Agostini, S., V. Lionetti, M. Matteucci, F. Chiuppesi, M. Giacca, M. Pistello and F.A. Recchia, 2013. A new dual-promoter system for cardiomyocyte-specific conditional induction of apoptosis. BioMed Res. Int. 10.1155/2013/845816.
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  26. Santarelli, M.F., V. Positano, G. Giovannetti, F. Frijia and L. Menichetti et al., 2012. How the signal-to-noise ratio influences hyperpolarized 13C dynamic MRS data fitting and parameter estimation. NMR Biomed., 25: 925-934.
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  27. Padeletti, L., P. Pieragnoli, G. Ricciardi, L. Perrotta and G. Grifoni et al., 2012. Acute hemodynamic effect of left ventricular endocardial pacing in cardiac resynchronization therapy assessment by pressure-volume loops. Circulat.: Arrhyth. Electrophysiol., 5: 460-467.
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  28. Menichetti, L., F. Frijia, A. Flori, F. Wiesinger and V. Lionetti et al., 2012. Assessment of real-time myocardial uptake and enzymatic conversion of hyperpolarized [1-13C]pyruvate in pigs using slice selective magnetic resonance spectroscopy. Contrast Media Mol. Imaging, 7: 85-94.
    CrossRef  |  PubMed  |  

  29. Giovannetti, G., V. Hartwig, F. Frijia, L. Menichetti and V. Positano et al., 2012. Hyperpolarized 13C MRS cardiac metabolism studies in pigs: Comparison between surface and volume radiofrequency coils. Applied Magn. Res., 42: 413-428.
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  30. Flori, A., F. Frijia, V. Lionetti, J.H. Ardenkjaer-Larsen and V. Positano et al., 2012. DNP methods for cardiac metabolic imaging with hyperpolarized [1-13C]pyruvate large dose injection in pigs. Applied Magn. Res., 43: 299-310.
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  31. Del Ry, S., M. Cabiati, V. Lionetti, G.D. Aquaro, A. Martino, L. Mattii and M.A. Morales, 2012. Pacing-induced regional differences in adenosine receptors mrna expression in a swine model of dilated cardiomyopathy. PLoS One, Vol. 7. 10.1371/journal.pone.0047011.
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  32. Czuriga, D., A. Toth, E.T. Pasztor, A. Balogh and A. Bodnar et al., 2012. Cell-to-cell variability in troponin I phosphorylation in a porcine model of pacing-induced heart failure. Basic Res. Cardiol., Vol. 107. 10.1007/s00395-012-0244-x.
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  33. Cantoni, S., C. Cavallini, F. Bianchi, F. Bonavita and V. Vaccari et al., 2012. Rosuvastatin elicits KDR-dependent vasculogenic response of human placental stem cells through PI3K/AKT pathway. Pharmacol. Res., 65: 275-284.
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  34. Cabiati, M., C. Caselli, S. Savelli, T. Prescimone, V. Lionetti, D. Giannessi and S. Del Ry, 2012. Exploring PTX3 expression in Sus scrofa cardiac tissue using RNA sequencing. Regul. Pept., 174: 1-5.
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  35. Barile, L. and V. Lionetti, 2012. Prometheus's heart: What lies beneath. J. Cell. Mol. Med., 16: 228-236.
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  36. Agostini, S., F.A. Recchia and V. Lionetti, 2012. Molecular advances in reporter genes: The need to witness the function of stem cells in failing heart in vivo. Stem Cell Rev., 8: 503-512.
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  37. Zoja, C., S. Cattaneo, F. Fiordaliso, V. Lionetti and V. Zambelli et al., 2011. Distinct cardiac and renal effects of ETA receptor antagonist and ACE inhibitor in experimental type 2 diabetes. Am. J. Physiol. Renal Physiol., 301: F1114-F1123.
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  38. Simioniuc, A., M. Campan, V. Lionetti, M. Marinelli and G.D. Aquaro et al., 2011. Placental stem cells pre-treated with a hyaluronan mixed ester of butyric and retinoic acid to cure infarcted pig hearts: A multimodal study. Cardiovasc. Res., 90: 546-556.
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  39. Sahai, R., M. Cecchini, M. Klingauf, A. Ferrari and C. Martino et al., 2011. Microfluidic chip for spatially and temporally controlled biochemical gradient generation in standard cell-culture Petri dishes. Microfluid. Nanofluid., 11: 763-771.
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  40. Prescimone, T., V. Lionetti, C. Caselli, G.D. Aquaro and M. Cabiati et al., 2011. Severity of regional myocardial dysfunction is not affected by cardiomyocyte apoptosis in non-ischemic heart failure. Pharmacol. Res., 63: 207-215.
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  41. Pingitore, A., E. Garbella, P. Piaggi, D. Menicucci and F. Frassi et al., 2011. Early subclinical increase in pulmonary water content in athletes performing sustained heavy exercise at sea level: Ultrasound lung comet-tail evidence. Am. J. Physiol. Heart Circul Physiol., 301: H2161-H2167.
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  42. Lionetti, V., W.C. Stanley and F.A. Recchia, 2011. Modulating fatty acid oxidation in heart failure. Cardiovasc. Res., 90: 202-209.
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  43. Lionetti, V., M. Cecchini and C. Ventura, 2011. Nanomechanics to drive stem cells in injured tissues: Insights from current research and future perspectives. Stem Cells Dev., 20: 561-568.
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  44. Guiducci, L., V. Lionetti, S. Burchielli, C. Simi and S. Masi et al., 2011. A dose-response elevation in hepatic glucose uptake is paralleled by liver triglyceride synthesis and release. Endocrine Res., 36: 9-18.
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  45. Forini, F., V. Lionetti, H. Ardehali, A. Pucci and F. Cecchetti et al., 2011. Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats. J. Cell. Mol. Med., 15: 514-524.
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  46. Campan, M., V. Lionetti, G.D. Aquaro, F. Forini and M. Matteucci et al., 2011. Ferritin as a reporter gene for in vivo tracking of stem cells by 1.5-T cardiac MRI in a rat model of myocardial infarction. Am. J. Physiol. Heart Circul. Physiol., 300: H2238-H2250.
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  47. Buttari, B., E. Profumo, C. Di Cristofano, D. Pietraforte and V. Lionetti et al., 2011. Haemoglobin triggers chemotaxis of human monocyte-derived dendritic cells: Possible role in atherosclerotic lesion instability. Atherosclerosis, 215: 316-322.
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  48. Zentilin, L., U. Puligadda, V. Lionetti, S. Zacchigna and C. Collesi et al., 2010. Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction. FASEB J., 24: 1467-1478.
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  49. Maioli, M., M. Pintus, A. Montella, P. Bandiera and S. Cantoni et al., 2010. Hyaluronan esters drive smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells. PLoS One, Vol. 5. 10.1371/journal.pone.0015151.
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  50. Lionetti, V., S. Cantoni, C. Cavallini, F. Bianchi and S. Valente et al., 2010. Hyaluronan mixed esters of butyric and retinoic acid affording myocardial survival and repair without stem cell transplantation. J. Biol. Chem., 285: 9949-9961.
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  51. Lionetti, V., G. Bianchi, F.A. Recchia and C. Ventura, 2010. Control of autocrine and paracrine myocardial signals: An emerging therapeutic strategy in heart failure. Heart Failure Rev., 15: 531-542.
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  52. Lionetti, V. and F.A. Recchia, 2010. New therapies for the failing heart: Trans-genes versus trans-cells. Trans. Res., 156: 130-135.
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  53. Gemignani, V., E. Bianchini, F. Faita, V. Lionetti and M. Campan et al., 2010. Transthoracic sensor for noninvasive assessment of left ventricular contractility: Validation in a minipig model of chronic heart failure. Pacing Clin. Electrophysiol., 33: 795-803.
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  54. Del Ry, S., M. Cabiati, V. Lionetti and D. Giannessi, 2010. NPR-B, the C-type natriuretic peptide specific receptor, is the predominant biological receptor in mouse and pig myocardial tissue. Minerva Endocrinol., 35: 37-46.
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  55. Lionetti, V., G.D. Aquaro, A. Simioniuc, C. Di Cristofano and F. Forini et al., 2009. Severe mechanical dyssynchrony causes regional hibernation-like changes in pigs with nonischemic heart failure. J. Cardiac Failure, 15: 920-928.
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  56. Lionetti, V., A. Fittipaldi, S. Agostini, M. Giacca, F.A. Recchia and E. Picano, 2009. Enhanced caveolae-mediated endocytosis by diagnostic ultrasound in vitro. Ultrasound Med. Biol., 35: 136-143.
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  57. Del Ry, S., M. Cabiati, V. Lionetti, A. Simioniuc and C. Caselli et al., 2009. Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure. Peptides, 30: 1710-1713.
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  58. Valdastri, P., S. Rossi, A. Menciassi, V. Lionetti, F. Bernini, F.A. Recchia and P. Dario, 2008. An implantable ZigBee ready telemetric platform for in vivo monitoring of physiological parameters. Sens. Actuators A: Phys., 142: 369-378.
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  59. Del Ry, S., M. Cabiati, V. Lionetti, M. Emdin, F.A. Recchia and D. Giannessi, 2008. Expression of C-type natriuretic peptide and of its receptor NPR-B in normal and failing heart. Peptides, 29: 2208-2215.
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  60. Ventura, C., S. Cantoni, F. Bianchi, V. Lionetti and C. Cavallini et al., 2007. Hyaluronan mixed esters of butyric and retinoic acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance cardiac repair in infarcted rat hearts. J. Biol. Chem., 282: 14243-14252.
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  61. Recchia, F.A. and V. Lionetti, 2007. Animal models of dilated cardiomyopathy for translational research. Vet. Res. Commun., 31: 35-41.
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  62. Lionetti, V., L. Guiducci, A. Simioniuc, G.D. Aquaro and C. Simi et al., 2007. Mismatch between uniform increase in cardiac glucose uptake and regional contractile dysfunction in pacing-induced heart failure. Am. J. Physiol. Heart Circul. Physiol., 293: H2747-2756.
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  63. Labinskyy, V., M. Bellomo, M.P. Chandler, M.E. Young and V. Lionetti et al., 2007. Chronic activation of peroxisome proliferator-activated receptor-α with fenofibrate prevents alterations in cardiac metabolic phenotype without changing the onset of decompensation in pacing-induced heart failure. J. Pharmacol. Exp. Ther., 321: 165-171.
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  64. Gargani, L., V. Lionetti, C. Di Cristofano, G. Bevilacqua, F.A. Recchia and E. Picano, 2007. Early detection of acute lung injury uncoupled to hypoxemia in pigs using ultrasound lung comets. Crit. Care Med., 35: 2769-2774.
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  65. Del Ry, S., M. Cabiati, V. Lionetti, C. Colotti and M. Maltinti et al., 2007. Sequencing and cardiac expression of natriuretic peptide receptor 2 (NPR-B) in Sus Scrofa. Peptides, 28: 1390-1396.
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  66. Lionetti, V., A. Lisi, E. Patrucco, P. de Giuli and M.G. Milazzo et al., 2006. Lack of phosphoinositide 3-kinase-γ attenuates ventilator-induced lung injury. Crit. Care Med., 34: 134-141.
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  67. Gupte, S.A., R.J. Levine, R.S. Gupte, M.E. Young and V. Lionetti et al., 2006. Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart. J. Mol. Cell. Cardiol., 41: 340-349.
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  68. D'Agostino, C., V. Labinskyy, V. Lionetti, M.P. Chandler and B. Lei et al., 2006. Altered cardiac metabolic phenotype after prolonged inhibition of NO synthesis in chronically instrumented dogs. Am. J. Physiol. Heart Circul. Physiol., 290: H1721-H1726.
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  69. Lionetti, V., F.A. Recchia and V.M. Ranieri, 2005. Overview of ventilator-induced lung injury mechanisms. Curr. Opin. Crit. Care, 11: 82-86.

  70. Lionetti, V., A. Linke, M.P. Chandler, M.E. Young and M.S. Penn et al., 2005. Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure. Cardiovasc. Res., 66: 454-461.
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  71. Lei, B., V. Lionetti, M.E. Young, M.P. Chandler and C. d'Agostino et al., 2004. Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure. J. Mol. Cell. Cardiol., 36: 567-576.
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  72. Post, H., C. d'Agostino, V. Lionetti, M. Castellari and E.Y. Kang et al., 2003. Reduced left ventricular compliance and mechanical efficiency after prolonged inhibition of NO synthesis in conscious dogs. J. Physiol., 552: 233-239.
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