Prof. Dr. Francesco Misiti

Professor
University of Cassino and Southern Lazio, Italy

Highest Degree
Ph.D. in Biochemistry from University of Sassari, Italy

My URL
https://livedna.org/39.18570

Share this Profile

Area of Interest:

Public Health
Clinical Investigation
Clinical Hemorheology
Cell Biochemistry
Sport and Health

Selected Publications

  1. Misiti, F., 2017. Exercise vs. high altitude therapy. J. Sport Health Sci., (In Press). 10.1016/j.jshs.2017.07.002.
    CrossRef  |  Direct Link  |  

  2. Carelli-Alinovi, C. And F. Misiti, 2017. Methionine 35 sulphoxide reduces toxicity of Aβ in red blood cell. Eur. J. Clin. Invest., 47: 314-321.
    CrossRef  |  Direct Link  |  

  3. Carelli-Alinovi, C., S. Ficarra, A.M. Russo, E. Giunta and D. Barreca et al., 2016. Involvement of acetylcholinesterase and protein kinase C in the protective effect of caffeine against β-amyloid-induced alterations in red blood cells. Biochimie, 121: 52-59.
    CrossRef  |  Direct Link  |  

  4. Carelli-Alinovi, C., S. Dinarelli, M. Girasole and F. Misiti, 2016. Vascular dysfunction-associated with Alzheimer's disease. Clin. Hemorheol. Microcirc., 64: 679-687.
    CrossRef  |  Direct Link  |  

  5. Carelli-Alinovi, C., D. Pirolli, B. Giardina and F. Misiti, 2015. Protein kinase C mediates caspase 3 activation: A role for erythrocyte morphology changes. Clin. Hemorheol. Microcirc., 59: 345-354.
    CrossRef  |  Direct Link  |  

  6. Carelli-Alinovi, C., B. Giardina and F. Misiti, 2015. Amyloid beta peptide (1-42)-mediated antioxidant imbalance is associated with activation of protein kinase C in red blood cells. Cell Biochem. Funct., 33: 196-201.
    CrossRef  |  Direct Link  |  

  7. Carelli-Alinovi, C., E. Tellone, A.M. Russo, S. Ficarra and D. Pirolli et al., 2014. NO metabolites levels in human red blood cells are affected by palytoxin, an inhibitor of Na+/K+-ATPase pump. Open Biochem. J., 8: 68-73.
    CrossRef  |  Direct Link  |  

  8. Ficarra, S., F. Misiti, A. Russo, C. Carelli-Alinovi and E. Bellocco et al., 2013. Antiepileptic carbamazepine drug treatment induces alteration of membrane in red blood cells: Possible positive effects on metabolism and oxidative stress. Biochimie, 95: 833-841.
    CrossRef  |  Direct Link  |  

  9. Misiti, F., C. Carelli-Alinovi, B. Sampaolese and B. Giardina, 2012. β-amyloid decreases detectable endothelial nitric oxide synthase in human erythrocytes: A role for membrane acetylcholinesterase. Cell Biochem. Funct., 30: 474-479.
    CrossRef  |  Direct Link  |  

  10. Misiti, F., M.E. Clementi and B. Giardina, 2010. Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide (1-42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function. Neurochem. Int., 56: 597-602.
    CrossRef  |  Direct Link  |  

  11. Clementi, E.M. and F. Misiti, 2010. Potential Health Benefits of Rhubarb. In: Bioactive Foods in Promoting Health: Fruits and Vegetables, Watson, R.R. and V.R. Preedy (Eds.). Chapter 27, Academic Press, New York, USA., ISBN-13: 9780080877877, pp: 407-423.

  12. Tavian, D., R. Colombo, F. Misiti, P. Ena and L. Ena et al., 2009. Fibroblast apoptosis in a patient affected by lamellar ichthyosis. J. Cutaneous Pathol., 36: 417-424.
    CrossRef  |  Direct Link  |  

  13. Ficarra, S., E. Tellone, B. Giardina, R. Scatena and A. Russo et al., 2009. Derangement of erythrocytic AE1 in beta-thalassemia by caspase 3: Pathogenic mechanisms and implications in red blood cell senescence. J. Membr. Biol., 228: 43-49.
    CrossRef  |  Direct Link  |  

  14. Tellone, E., S. Ficarra, B. Giardina, R. Scatena and A. Russo et al., 2008. Oxidative effects of gemfibrozil on anion influx and metabolism in normal and beta-thalassemic erythrocytes: Physiological implications. J. Membr. Biol., 224: 1-8.
    CrossRef  |  Direct Link  |  

  15. Piacentini, R., C. Ripoli, L. Leone, F. Misiti and M.E. Clementi et al., 2008. Role of methionine 35 in the intracellular Ca2+ homeostasis dysregulation and Ca2+-dependent apoptosis induced by amyloid β-peptide in human neuroblastoma IMR32 cells. J. Neurochem., 107: 1070-1082.
    CrossRef  |  Direct Link  |  

  16. Misiti, F., F. Orsini, M.E. Clementi, W. Lattanzi, B. Giardina and F. Michetti, 2008. Mitochondrial oxygen consumption inhibition importance for TMT-dependent cell death in undifferentiated PC12 cells. Neurochem. Int., 52: 1092-1099.
    CrossRef  |  Direct Link  |  

  17. Misiti, F., F. Orsini, M.E. Clementi, D. Masala, E. Tellone, A. Galtieri and B. Giardina, 2008. Amyloid peptide inhibits ATP release from human erythrocytes. Biochem. Cell Biol., 86: 501-508.
    CrossRef  |  Direct Link  |  

  18. Clementi, M.E., F. Misiti, F. Orsini, M. Pezzotti and B. Giardina, 2007. Oxygen transport in Amphibia: The functional properties of hemoglobins from Bufo bufoand Bufo viridis J. Boil. Sci., 7: 786-790.
    CrossRef  |  Direct Link  |  

  19. Clementi, M.E., B. Giardina, D. Colucci, A. Galtieri and F. Misiti, 2007. Amyloid-beta peptide affects the oxygen dependence of erythrocyte metabolism: A role for caspase 3. Int. J. Biochem. Cell Biol., 39: 727-735.
    CrossRef  |  Direct Link  |  

  20. Misiti, F., M.E. Clementi, G. Tringali, M. Vairano and F. Orsini et al., 2006. Fragment 31-35 of β-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation: A crucial role for the redox state of methionine-35 residue. Neurochem. Int., 49: 525-532.
    CrossRef  |  Direct Link  |  

  21. Misiti, F., B. Sampaolese, D. Mezzogori, F. Orsini, M. Pezzotti and B. Giardina and M.E. Clementi, 2006. Protective effect of rhubarb derivatives on amyloid beta (1-42) peptide-induced apoptosis in IMR-32 cells: A case of nutrigenomic. Brain Res. Bull., 71: 29-36.
    CrossRef  |  Direct Link  |  

  22. Clementi, M.E., M. Pezzotti, F. Orsini, B. Sampaolese and D. Mezzogori et al., 2006. Alzheimer's amyloid β-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: An intriguing role for methionine 35. Biochem. Biophys. Res. Commun., 342: 206-213.
    CrossRef  |  Direct Link  |  

  23. Alinovi, C.C., M. Pezzotti, D. Mezzogori, M. Elisabetta Clementi, F. Misiti, B. Giardina and F. Orsini, 2006. Aß(25-35) peptide induces cell death in PC12 Cells via mitochondrial damage and cytochrome c release. J. Biological Sci., 6: 140-145.
    CrossRef  |  Direct Link  |  

  24. Misiti, F., B. Sampaolese, M. Pezzotti, S. Marini and M. Coletta et al., 2005. Aβ(31-35) peptide induce apoptosis in PC 12 cells: Contrast with Aβ(25-35) peptide and examination of underlying mechanisms. Neurochem. Int., 46: 575-583.
    CrossRef  |  Direct Link  |  

  25. Clementi, M.E., S. Marini, M. Coletta, F. Orsini, B. Giardina and F. Misiti, 2005. Aβ(31-35) and Aβ(25-35) fragments of amyloid beta‐protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35. FEBS Lett., 579: 2913-2918.
    CrossRef  |  Direct Link  |  

  26. Clementi, M.E. and F. Misiti, 2005. Substitution of methionine 35 inhibits apoptotic effects of Aβ(31-35) and Aβ(25-35) fragments of amyloid-β protein in PC12 cells. Med. Sci. Monit., 11: BR381-BR385.
    Direct Link  |  

  27. Misiti, F., G.E. Martorana, G. Nocca, E. Di Stasio, B. Giardina and M.E. Clementi, 2004. Methionine 35 oxidation reduces toxic and pro-apoptotic effects of the amyloid β-protein fragment (31-35) on isolated brain mitochondria. Neuroscience, 126: 297-303.
    CrossRef  |  Direct Link  |  

  28. Di Stasio, E., P. Bizzarri, F. Misiti, E. Pavoni and A. Brancaccio, 2004. A fast and accurate procedure to collect and analyze unfolding fluorescence signal: The case of dystroglycan domains. Biophys. Chem., 107: 197-211.
    CrossRef  |  Direct Link  |  

  29. Clementi, M.E., G.E. Martorana, M. Pezzotti, B. Giardina and F. Misiti, 2004. Methionine 35 oxidation reduces toxic effects of the amyloid β-protein fragment (31-35) on human red blood cell. Int. J. Biochem. Cell Biol., 36: 2066-2076.
    CrossRef  |  Direct Link  |  

  30. Petruzzelli, R., M.E. Clementi, S. Marini, M. Coletta, E. Di Stasio, B. Giardina and F. Misiti, 2003. Respiratory inhibition of isolated mammalian mitochondria by salivary antifungal peptide histatin-5. Biochem. Biophys. Res. Commun., 311: 1034-1040.
    CrossRef  |  Direct Link  |  

  31. Misiti, F., B. Giardina, A. Mordente and M.E. Clementi, 2003. The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes. Braz. J. Med. Biol. Res., 36: 1643-1651.
    CrossRef  |  Direct Link  |  

  32. Clementi, M.E., B. Giardina, E. Di Stasio, A. Mordente and F. Misiti, 2003. Doxorubicin-derived metabolites induce release of cytochrome C and inhibition of respiration on cardiac isolated mitochondria. Anticancer Res., 23: 2445-2450.
    PubMed  |  

  33. Clementi, M., R. Petruzzelli, M. Filippucci, C. Capo, F. Misiti and B. Giardina, 2003. Molecular adaptation to hibernation: The hemoglobin of Dryomys nitedula. Pflugers Archiv-Eur. J. Physiol., 446: 46-51.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Misiti, F., E. Meucci, C. Zuppi, F. Vincenzoni, B. Giardina, M. Castagnola and I. Messana, 2002. O2-dependent stimulation of the pentose phosphate pathway by S-nitrosocysteine in human erythrocytes. Biochem. Biophys. Res. Commun., 294: 829-834.
    CrossRef  |  Direct Link  |  

  35. Galtieri, A., E. Tellone, L. Romano, F. Misiti and E. Bellocco et al., 2002. Band-3 protein function in human erythrocytes: Effect of oxygenation-deoxygenation. Biochim. Biophys. Acta (BBA)-Biomembr., 1564: 214-218.
    CrossRef  |  Direct Link  |  

  36. Misiti, F., M. Castagnola, C. Zuppi, B. Giardina and I. Messana, 2001. Role of ergothioneine on S-nitrosoglutathione catabolism. Biochem. J., 356: 799-804.
    CrossRef  |  Direct Link  |  

  37. Messana, I., F.A. Bassi, D.V. Rossetti, F. Misiti and F. Vincenzoni et al., 2001. Capillary electrophoresis detection of a complex sensitive to electric field. J. Sep. Sci., 24: 717-722.
    CrossRef  |  Direct Link  |  

  38. Castagnola, M., D. Congiu, G. Denotti, A. Di Nunzio and M.B. Fadda et al., 2001. Determination of the human salivary peptides histatins 1, 3, 5 and statherin by high-performance liquid chromatography and by diode-array detection. J. Chromatogr. B: Biomed. Sci. Applic., 751: 153-160.
    CrossRef  |  Direct Link  |  

  39. Messana, I., L. Ferroni, F. Misiti, G. Girelli and S. Pupella et al., 2000. Blood bank conditions and RBCs: The progressive loss of metabolic modulation. Transfusion, 40: 353-360.
    CrossRef  |  Direct Link  |  

  40. Messana, I., D.V. Rossetti, F. Misiti, F. Vincenzoni, E. Tellone, B. Giardina and M. Castagnola, 2000. Determination of S-nitrosoglutathione in erythrocytes by capillary zone electrophoresis. Electrophoresis, 21: 1606-1610.
    CrossRef  |  Direct Link  |  

  41. Hearn, M.T.W., H.H. Keah, R.I. Boysen, I. Messana and F. Misiti et al., 2000. Determination of biophysical parameters of polypeptide retro-inverso isomers and their analogues by capillary electrophoresis. Anal. Chem., 72: 1964-1972.
    CrossRef  |  Direct Link  |  

  42. Messana, I., F. Misiti, S. El-Sherbini, B. Giardina and M. Castagnola, 1999. Quantitative determination of the main glucose metabolic fluxes in human erythrocytes by 13C- and 1H-MR spectroscopy. J. Biochem. Biophys. Methods, 39: 63-84.
    CrossRef  |  Direct Link  |  

  43. Castagnola, M., D.V. Rossetti, M. Corda, M. Pellegrini and F. Misiti et al., 1998. Predictive model for capillary electrophoretic peptide mobility in 2,2,2-trifluoroethanol-water solution. Electrophoresis, 19: 1728-1732.
    CrossRef  |  Direct Link  |  

  44. Castagnola, M., D.V. Rossetti, M. Corda, M. Pellegrini and A. Olianas et al., 1998. The pH dependence of predictive models relating electrophoretic mobility to peptide chemico-physical properties in capillary zone electrophoresis. Electrophoresis, 19: 2273-2277.
    CrossRef  |  Direct Link  |  

  45. Messana, I., D.V. Rossetti, L. Cassiano, F. Misiti, B. Giardina and M. Castagnola, 1997. Peptide analysis by capillary (zone) electrophoresis. J. Chromatogr. B: Biomed. Sci. Applic., 699: 149-171.
    CrossRef  |  Direct Link  |  

  46. Castagnola, M., D.V. Rossetti, F. Misiti, L. Cassiano, B. Giardina and I. Messana, 1997. Modification of capillary electrophoresis selectivity in hydro-organic solutions: Dissociation constants and Stokes radius measurements of peptides in water-2,2,2-trifluoroethanol mixtures. J. Chromatogr. A, 792: 57-65.
    CrossRef  |  Direct Link  |  

  47. Castagnola, M., D.V. Rossetti, L. Cassiano, F. Misiti, L. Pennacchietti, B. Giardina and I. Messana, 1996. Determination of peptide dissociation constants and stokes radius at different protonation stages by capillary electrophoresis. Electrophoresis, 17: 1925-1930.
    CrossRef  |  Direct Link  |  
Member since September, 2017