Dr. Enrico Brugnera

Senior Scientist
University Zurich, Switzerland

Highest Degree
Ph.D. in Molecular Biology from University of Zurich, Switzerland

My URL
https://livedna.org/39.20643

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Area of Interest:

Biomedical Sciences
Molecualar Biology
Biochemistry
Microbiology
Immunology

Selected Publications

  1. Sydler, T., S. Bragger, M. Handke, S. Hartnack, F.I. Lewis, X. Sidler and E. Brugnera, 2016. Latent porcine circovirus type 2-infected domestic pigs: A potential infection model for the effective development of vaccines against latent or chronic virus induced diseases. Vaccine, 34: 1047-1053.
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  2. Klausmann, S., T. Sydler, A. Summerfield, F.I. Lewis, R. Weilenmann, X. Sidler and E. Brugnera, 2015. T-cell reprogramming through targeted CD4-coreceptor and T-cell receptor expression on maturing thymocytes by latent Circoviridae family member porcine circovirus type 2 cell infections in the thymus. Emerg. Microbes Infect., Vol. 4. 10.1038/emi.2015.15.
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  3. Khaiseb, S., T. Sydler, D. Zimmermann, A. Pospischil, X. Sidler and E. Brugnera, 2011. Coreplication of the major genotype group members of porcine circovirus type 2 as a prerequisite to coevolution may explain the variable disease manifestations. J. Virol., 85: 11111-11120.
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  4. Khaiseb, S., T. Sydler, D. Zimmermann, A. Pospischil, X. Sidler and E. Brugnera, 2011. Porcine circovirus 2 major genotype group members' co-replication as a prerequisite to co-evolution that may explain the variable disease manifestations. J. Virol., Vol. 85. 10.1128/JVI.05156-11.
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  5. Wiederkehr, D.D., T. Sydler, E. Buergi, M. Haessig and D. Zimmermann et al., 2009. A new emerging genotype subgroup within PCV-2b dominates the PMWS epizooty in Switzerland. Vet. Microbiol., 136: 27-35.
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  6. Lu, M., J.M. Kinchen, K.L. Rossman, C. Grimsley and C. de Bakker et al., 2004. Provides biochemical evidence that Dock180, although lacking a DH domain, can have Rho GEF activity. Nat. Struct. Mol. Biol., 11: 756-762.

  7. Brugnera, E., L. Haney, C. Grimsley, M. Lu and S.F. Walk et al., 2002. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nature Cell Biol., 4: 574-582.
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  8. Gumienny, T.L., E. Brugnera, A.C. Tosello-Trampont, J.M. Kinchen and L.B. Haney et al., 2001. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell, 107: 27-41.
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  9. Brugnera, E., A. Bhandoola, R. Cibotti, Q. Yu and T.I. Guinter et al., 2000. Coreceptor reversal in the thymus: Signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. Immunity, 13: 59-71.
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Member since October, 2017