Dr. Giuseppe De Palma

Full Professor
University of Brescia, Italy

Highest Degree
Ph.D. in Prevention Sciences from University of Parma, Italy

My URL
https://livedna.org/39.5532

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Biography

Dr. Giuseppe De Palma is currently working as Assistant Professor at University of Brescia, Italy. He has completed his Ph.D. in Prevention Sciences from University of Parma, Italy. His main area of interest related to Pharmacology and Toxicology, Biomedical Sciences, Environmental Sciences, and Occupational Health. His area of expertise includes Occupational Health, Genetic Susceptibility, Industrial Toxicology, Molecular Epidemiology, Biomarkers, Environmental Health, and Pollutants. He has published more than 79 research articles in journals as author/co-author.

Area of Interest:

Pharmacology and Toxicology
Occupational Health
Industrial Toxicology
Biomarkers
Pollutants

Selected Publications

  1. De Palma, G., S. Catalani, A. Franco, M. Brighenti and P. Apostoli, 2012. Lack of correlation between metallic elements analyzed in hair by ICP-MS and autism. J. Autism. Dev. Disord., 42: 342-353.
    CrossRef  |  PubMed  |  Direct Link  |  

  2. De Palma, G., I. Cortesi, R. Ghitti, D. Festa, R. Bergonzi and P. Apostoli, 2012. Biological monitoring as a valid tool to assess occupational exposure to mixtures of 2,4-:2,6-toluene diisocyanate. Med. Lav., 103: 361-371.
    PubMed  |  

  3. De Palma, G., D. Poli, P. Manini, R. Andreoli, P. Mozzoni, P. Apostoli and A. Mutti, 2012. Biomarkers of exposure to aromatic hydrocarbons and methyl tert-butyl ether in petrol station workers. Biomarkers, 17: 343-351.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. De Palma, G., A. Corsini, E. Gilberti, V. Gabusi and G. Tagliani et al., 2012. Biological monitoring of exposure to carcinogenic metallic elements and polycyclic aromatic hydrocarbons in four secondary metallurgical sectors. G. Ital. Med. Lav. Ergon., 34: 44-47.
    PubMed  |  

  5. Catalani, S., G. De Palma, C. Tomasi, R. Alinovi, A. Mutti and P. Apostoli, 2012. Lack of correlation between blood lead and serum prolactin levels among lead exposed workers. Biomarkers, 17: 513-519.
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  6. Andreoli, R., C. Protano, P. Manini, G. De Palma and M. Goldoni et al., 2012. Association between environmental exposure to benzene and oxidative damage to nucleic acids in children. Med. Lav., 103: 324-337.
    PubMed  |  

  7. Bergonzi, R., G. De Palma, C. Specchia, M. Dinolfo, C. Tomasi, T. Frusca and P. Apostoli, 2011. Persistent organochlorine compounds in fetal and maternal tissues: evaluation of their potential influence on several indicators of fetal growth and health. Sci. Total Environ., 409: 2888-2893.
    CrossRef  |  PubMed  |  Direct Link  |  

  8. Bergonzi, R., G. De Palma and P. Apostoli, 2011. Environmental monitoring of volatile organic compounds and metallic elements in two analysis laboratories. G. Ital. Med. Lav. Ergon., 33: 387-393.
    PubMed  |  

  9. Andreoli, R., A. Mutti, M. Goldoni, P. Manini, P. Apostoli and G. De Palma, 2011. Reference ranges of urinary biomarkers of oxidized guanine in (2'-deoxy)ribonucleotides and nucleic acids. Free Radic. Biol. Med., 50: 254-261.
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  10. Alfieri, R.R., M. Galetti, S. Tramonti, R. Andreoli and P. Mozzoni et al. 2011. Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines. Mol. Cancer, Vol. 10, 10.1186/1476-4598-10-143.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Tiseo, M., G. Rossi, M. Capelletti, G. Sartori, E. Spiritelli and A. Marchioni, et al., 2010. Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): Study of a comprehensive panel of molecular markers. Lung Cancer, 67: 355-360.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Manini, P., G. De Palma, R. Andreoli, P. Mozzoni and D. Poli et al., 2010. Occupational exposure to low levels of benzene: biomarkers of exposure and nucleic acid oxidation and their modulation by polymorphic xenobiotic metabolizing enzymes. Toxicol. Lett., 193: 229-235.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Goldoni, M., A. Caglieri, G. De Palma, O. Acampa and P. Gergelova et al., 2010. Chromium in Exhaled Breath Condensate (EBC), erythrocytes, plasma and urine in the biomonitoring of chrome-plating workers exposed to soluble Cr(VI). J. Environ. Monit., 12: 442-447.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Galetti, M., R.R. Alfieri, A. Cavazzoni, S. La Monica and M. Bonelli et al., 2010. Functional characterization of gefitinib uptake in non-small cell lung cancer cell lines. Biochem. Pharmacol., 80: 179-187.
    CrossRef  |  PubMed  |  Direct Link  |  

  15. Fustinoni, S., P. Manini, L. Campo, G. De Palma and R. Andreoli, et al., 2010. Assessing variability and comparing short-term biomarkers of styrene exposure using a repeated measurements approach. Toxicol. Lett., 192: 40-44.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. De Palma, G., P. Mozzoni, O. Acampa, E. Internullo and P. Carbognani et al., 2010. Expression levels of some antioxidant and epidermal growth factor receptor genes in patients with early-stage non-small cell lung cancer. J. Nucleic. Acids, Vol. 2010, 10.4061/2010/147528.
    CrossRef  |  PubMed  |  Direct Link  |  

  17. De Palma, G., P. Manini, M. Sarnico, S. Molinari and P. Apostoli, 2010. Biological monitoring of tungsten (and cobalt) in workers of a hard metal alloy industry. Int. Arch. Occup. Environ. Health, 83: 173-181.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. De Palma, G., F.D. Dick, S. Calzetti, N.W. Scott and G.J. Prescott et al., 2010. A case-control study of Parkinson's disease and tobacco use: Gene-tobacco interactions. Mov. Disord., 25: 912-919.
    CrossRef  |  PubMed  |  Direct Link  |  

  19. Andreoli, R., P. Manini, G.D. Palma, R. Alinovi, M. Goldoni, W.M.A. Niessen and A. Mutti, 2010. Quantitative determination of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile in healthy volunteers. Biomarkers, 15: 221-231.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Manini, P., G. de Palma, R. Andreoli, B. Marczynski and M. Hanova et al., 2009. Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers. Toxicology Letters, 190: 41-47.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Goldoni, M., A. Caglieri, G. de Palma, S. Longo and O. Acampa et al., 2009. Development and set-up of a portable device to monitor airway exhalation and deposition of particulate matter. Biomarkers, 14: 326-339.
    CrossRef  |  PubMed  |  Direct Link  |  

  22. Corradi, M., O. Acampa, M. Goldoni, R. Andreoli and D. Milton et al., 2009. Metallic elements in exhaled breath condensate and serum of patients with exacerbation of chronic obstructive pulmonary disease. Metallomics, 1: 339-345.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Corradi, M., O. Acampa, M. Goldoni, E. Adami and P. Apostoli et al., 2009. Metallic elements in exhaled breath condensate of patients with interstitial lung diseases. J. Breath Res., Vol. 3, 10.1088/1752-7155/3/4/046003.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Bergonzi, R., G. de Palma, C. Tomasi, M.C. Ricossa and P. Apostoli, 2009. Evaluation of different methods to determine total serum lipids for normalization of circulating organochlorine compounds. Int. Arch. Occupat. Environ. Health, 82: 1241-1247.
    CrossRef  |  PubMed  |  Direct Link  |  

  25. Bergonzi, R., C. Specchia, M. Dinolfo, C. Tomasi and G. De Palma et al., 2009. Distribution of persistent organochlorine pollutants in maternal and foetal tissues: Data from an Italian polluted urban area. Chemosphere, 76: 747-754.
    CrossRef  |  PubMed  |  Direct Link  |  

  26. Apostoli, P., G. De Palma, S. Catalani, F. Bortolotti and F. Tagliaro, 2009. Multielemental analysis of tissues from Cangrande della Scala, Prince of Verona, in the 14th century. J. Anal. Toxicol., 33: 322-327.
    CrossRef  |  PubMed  |  Direct Link  |  

  27. TI Tiseo, M., M. Capelletti, G. de Palma, V. Franciosi and A. Cavazzoni et al., 2008. Epidermal growth factor receptor intron-1 polymorphism predicts gefitinib outcome in advanced non-small cell lung cancer. J. Thoracic Oncol., 3: 1104-1111.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Soleoa, L., P. Lovreglioa, S. Iavicolib, A. Antelmia and I. Dragoa et al., 2008. Significance of urinary arsenic speciation in assessment of seafood ingestion as the main source of organic and inorganic arsenic in a population resident near a coastal area. Chemosphere, 73: 291-299.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Manini, P., G. de Palma, R. Andreoli, D. Poli and M. Petyx et al., 2008. Biological monitoring of low benzene exposure in Italian traffic policemen. Toxicology Letters, 181: 25-30.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Fustinoni, S., L. Campo, P. Manini, M. Buratti and S. Waidyanatha et al., 2008. An integrated approach to biomonitoring exposure to styrene and styrene-(7,8)-oxide using a repeated measurements sampling design. Biomarkers, 13: 560-578.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. De Palma, G., O. Mariotti, D. Lonati, M. Goldoni and S. Catalani et al., 2008. Toxicokinetics and toxicodynamics of elemental mercury following self-administration. Clin. Toxicol., 46: 869-876.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. De Palma, G., M. Goldoni, S. Catalani, P. Carbognani and D. Poli et al., 2008. Metallic elements in pulmonary biopsies from lung cancer and control subjects. Acta Biomed., 79: 43-51.
    PubMed  |  Direct Link  |  

  33. Corradi, D., S. Callegari, R. Maestri, S. Benussi and S. Bosio et al., 2008. Heme oxygenase-1 expression in the left atrial myocardium of patients with chronic atrial fibrillation related to mitral valve disease: its regional relationship with structural remodeling. Human Pathol., 39: 1162-1171.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Catalani, S., G. de Palma, A. Mangili and P. Apostoli, 2008. Metallic elements in lung tissues: Results of a meta-analysis. Acta. Bio. Med. De L'ateneo Parmense, 79: 52-63.
    PubMed  |  Direct Link  |  

  35. Caglieri, A., M. Goldoni, G. de Palma, P. Mozzoni and S. Gemma et al., 2008. Exposure to low levels of hexavalent chromium: Target doses and comparative effects on two human pulmonary cell lines. Acta Biomed., 79: 104-115.
    PubMed  |  Direct Link  |  

  36. Vodicka, P., R. Stetina, V. Polakova, E. Tulupova and A. Naccarati et al., 2007. Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects. Carcinogenesis, 28: 657-664.
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  37. Manini, P., G. de Palma and A. Mutti, 2007. Exposure assessment at the workplace: Implications of biological variability. Toxicology Letter., 168: 210-218.
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  38. Dick, F.D., G. de Palma, A. Ahmadi, N.W. Scott and G.J. Prescott et al., 2007. Environmental risk factors for Parkinson's disease and parkinsonism: The geoparkinson study. Occupat. Environ. Med., 64: 666-672.
    CrossRef  |  PubMed  |  Direct Link  |  

  39. Dick, F.D., G. de Palma, A. Ahmadi, A. Osborne and N.W. Scott et al., 2007. Gene-environment interactions in parkinsonism and Parkinson's disease: The Geoparkinson study. Occupat. Environ. Med., 64: 673-680.
    CrossRef  |  PubMed  |  Direct Link  |  

  40. Migliore, L., A. Naccarati, F. Coppede, E. Bergamaschi and G. de Palma et al., 2006. Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene. Pharmacogenetics. Genomics, 16: 87-99.
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  41. Manini, P., G. de Palma, R. Andreoli, D. Poli and P. Mozzoni et al., 2006. Environmental and biological monitoring of benzene exposure in a cohort of Italian taxi drivers. Toxicology Letters, 167: 142-151.
    CrossRef  |  PubMed  |  Direct Link  |  

  42. Franciosi, V., M. Tiseo, M. Cappelletti, G. de Palma and M. Loprevite et al., 2006. EGFR mutations and egfr intron-1 polymorphism predict gefitinib activity in advanced non-small cell lung cancer (NSCLC). Annals. Oncology, 17: 37-37.

  43. Franciosi, V., M. Tiseo, G. de Palma, M. Loprevite and M. Chiaramondia et al., 2006. Egfr mutation and egfr intron-1 polymorphism predict gefitinib activity in advanced non small cell lung cancer (NSCLC). Annals. Oncology, 17: 218-218.

  44. Alfieri, R.R., M.A. Bonelli, A. Cavazzoni, M. Brigotti and C. Fumarola et al., 2006. Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress. J. Physiology, 576: 391-401.
    CrossRef  |  PubMed  |  Direct Link  |  

  45. Mozzoni, P., G. de Palma, E. Scotti, R. Andreoli and G. Folesani et al., 2005. Heme oxygenase 1 expression in foundry workers. G. Ital. Med. Lav. Ergon., 27: 322-325.
    PubMed  |  

  46. De Palma, G., E. Scotti, P. Mozzoni, R. Alinov and P. Apostoli et al., 2005. ALAD polymorphism and indicators of dose and effects of occupational exposure to inorganic lead. G. Ital. Med. Lav. Ergon., 27: 39-42.
    PubMed  |  

  47. Andreoli, R., P. Manini, R. Alinovi, M. Goldoni and G. de Palma et al., 2005. Chronobiological evaluation of effects biomarkers and sampling. G. Ital. Med. Lav. Ergon., 27: 318-321.
    PubMed  |  

  48. Mozzoni, P., G. De Palma, E. Scotti, M. Capelletti and A. Mutti, 2004. Characterization of GSTM3 polymorphism by real-time polymerase chain reaction with LightCycler. Anal. Biochem., 330: 175-177.
    CrossRef  |  PubMed  |  Direct Link  |  

  49. Manini, P., G. de Palma, R. Andreoli, M. Goldon and A. Mutti, 2004. Determination of urinary styrene metabolites in the general Italian population by liquid chromatography-tandem mass spectrometry. Int. Arch. Occupat. Environ. Health, 77: 433-436.
    CrossRef  |  PubMed  |  Direct Link  |  

  50. Goldoni, M., S. Catalani, G. de Palma, P. Manini and O. Acampa et al., 2004. Exhaled breath condensate as a suitable matrix to assess lung dose and effects in workers exposed to cobalt and tungsten. Environm. Health Perspect., 112: 1293-1298.
    PubMed  |  Direct Link  |  

  51. De Palma, G., M. Corradi, A. Mutti, A. Baccarelli, A. Pesatori and P.A. Bertazzi, 2004. New effect biomarkers. G. Ital. Med. Lav. Ergon., 26: 302-310.
    PubMed  |  

  52. Manini, P., G. De Palma, R. Andreoli, M. Goldoni, D. Poli, G. Lasagni and A. Mutti, 2003. Urinary excretion of 4-vinyl phenol after experimental and occupational exposure to styrene. G. Ital. Med. Lav. Ergon., 25: 61-62.
    PubMed  |  

  53. Fiaccadori, E., U. Maggiore, C. Rotelli, R. Giacosa and D. Ardissino et al, 2003. Acute renal and hepatic failure due to accidental percutaneous absorption of 1,2-dichlorpropane contained in a commercial paint fixative. Nephrol. Dialysis Trans., 18: 219-220.
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  54. De Palma, G., P. Mozzoni, E. Scotti, P. Manini and R. Andreoli et al., 2003. Genetic polymorphism of biotransforming enzymes and genotoxic effects of styrenes. G. Ital. Med. Lav. Ergon., 25: 63-64.
    PubMed  |  

  55. Buzio, L., G. De Palma, P. Mozzoni, M. Tondel and C. Buzio et al., 2003. Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals. Occup. Environ. Med., 60: 789-793.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. Buschini, A., G. De Palma, P. Poli, A. Martino and C. Rossi et al., 2003. Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damage. Environ. Mol. Mutagenesis, 41: 243-252.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. Bergamaschi, E., P. Apostoli, S. Catalani, D. Festa and G. Folesani et al., 2003. Indicators of pulmonary epithelial damage among workers at a foundry exposed to airborne pollutants. G. Ital. Med. Lav. Ergon., 25: 104-106.
    PubMed  |  

  58. Manini, P., R. Andreoli, D. Poli, G. De Palma, A. Mutti and W.M. Niessen, 2002. Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and in rat. Rapid Commun. Mass Spectrom., 16: 2239-2248.
    CrossRef  |  PubMed  |  Direct Link  |  

  59. Manini, P., G. De Palma, P. Mozzoni, R. Andreoli and D. Poli et al., 2002. GSTM1 polymorphism and styrene metabolism: Insights from an acute accidental exposure. Toxicol. Lett., 134: 201-208.
    CrossRef  |  PubMed  |  Direct Link  |  

  60. De Palma, G., P. Mozzoni, E. Scotti, L. Buzio, S. Pizzarotti and A. Scaglioni, 2002. Case-only analysis of gene-environment interactions in Parkinson's disease: Preliminary results. Mov. Disorders, 17: S144-S144.

  61. Buzio, L., M. Tondel, G. De Palma, C. Buzio, I. Franchini, A. Mutti and O. Axelson, 2002. Occupational risk factors for renal cell cancer. An Italian case-control study. Med. Lav., 93: 303-309.
    PubMed  |  

  62. Alinovi, R., L. Buzio, P. Mozzoni, G. De Palma and P. Carta et al., 2002. Effetti renali di basse dosi di mercurio. Med. Lav., 93: 191-201.
    Direct Link  |  

  63. De Palma, G., P. Manini, P. Mozzoni, R. Andreoli and E. Bergamaschi et al., 2001. Polymorphism of xenobiotic-metabolizing enzymes and excretion of styrene-specific mercapturic acids. Chem. Res. Toxicol., 14: 1393-1400.
    CrossRef  |  PubMed  |  Direct Link  |  

  64. Bergamaschi, E., G. De Palma, P. Mozzoni, S. Vanni and M.V. Vettori et al., 2001. Polymorphism of quinone-metabolizing enzymes and susceptibility to ozone-induced acute effects. Am. J. Respir. Crit. Care Med., 163: 1426-1431.
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  65. Manini, P., R. Andreoli, E. Bergamaschi, G. De Palma, A. Mutti and W.M. Niessen, 2000. A new method for the analysis of styrene mercapturic acids by liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun. Mass Spectrom., 14: 2055-2060.
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  66. Bergamaschi, E., A. Brustolin, G. De Palma, P. Manini and P. Mozzoni et al., 1999. Biomarkers of dose and susceptibility in cyclists exposed to monoaromatic hydrocarbons. Toxicol. Lett., 108: 241-247.
    CrossRef  |  PubMed  |  Direct Link  |  

  67. Smargiassi, A., A. Mutti, A. de Rosa, G. de Palma, A. Negrotti and S. Calzetti, 1998. A case-control study of occupational and environmental risk factors for Parkinson's disease in the Emilia-Romagna region of Italy. Neurotoxicology, 19: 709-712.
    PubMed  |  

  68. Neri, T.M., P. Zanelli, G. De Palma, M. Savi and S. Rossetti et al., 1998. Missense mutations in the COL4A5 gene in patients with X-linked Alport syndrome. Human Mutat., 1: S106-S109.
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  69. De Palma, G., P. Mozzoni, A. Mutti, S. Calzetti and A. Negrotti, 1998. Case-control study of interactions between genetic and environmental factors in Parkinson's disease. Lancet, 352: 1986-1987.
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