Dr. Luca Antonioli

Research Scientist
University of Pisa, Italy

Highest Degree
Ph.D. in Medical Pathophysiology and Pharmacology from University of Pisa, Italy

My URL
https://livedna.org/39.6083

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Area of Interest:

Biomedical Sciences
Pathophysiology
Inflammation Biology
Adenosine Receptors
Drug Delivery

Selected Publications

  1. Fornai, M., L. Antonioli, R. Colucci, C. Pellegrini and G. Giustarini et al., 2013. NSAID-induced enteropathy: Are the currently available selective COX-2 inhibitors all the same? J. Pharmacol. Exp. Ther., 348: 86-95.
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  2. Colucci, R., M. Fornai, E. Duranti, L. Antonioli and I. Rugani et al., 2013. Rosuvastatin prevents angiotensin II-induced vascular changes by inhibition of NAD(P)H oxidase and COX-1. Br. J. Pharmacol., 169: 554-566.
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  3. Colucci, R., D. Gambaccini, N. Ghisu, G. Rossi and F. Costa et al., 2013. Influence of the serotonin transporter 5HTTLPR polymorphism on symptom severity in irritable bowel syndrome. PLoS One, Vol. 8. 10.1371/journal.pone.0054831.
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  4. Antonioli, L., R. Colucci, C. Pellegrini, G. Giustarini, M. Tuccori, C. Blandizzi and M. Fornai, 2013. The role of purinergic pathways in the pathophysiology of gut diseases: Pharmacological modulation and potential therapeutic applications. Pharmacol. Ther., 139: 157-188.
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  5. Antonioli, L., P. Pacher, S. Vizi and G. Hasko, 2013. CD39 and CD73 in immunity and inflammation. Trends Mol. Med., 19: 355-367.
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  6. Antonioli, L., M. Fornai, O. Awwad, G. Giustarini and C. Pellegrini et al., 2013. Role of the A2B receptor-adenosine deaminase complex in colonic dysmotility associated with bowel inflammation in rat. Br. J. Pharmacol., (In Press) 10.1111/bph.12539.
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  7. Antonioli, L., C. Blandizzi, P. Pacher and G. Hasko, 2013. Immunity, inflammation and cancer: A leading role for adenosine. Nat. Rev. Cancer, 13: 842-857.
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  8. Tuccori, M., C. Pisani, L. Bachini, M. Pardini and S. Mantarro et al., 2012. Telogen effluvium following bivalent human papillomavirus vaccine administration: A report of two cases. Dermatology, 224: 212-214.
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  9. Colucci, R., L. Antonioli, N. Bernardini, C. Ippolito and C. Segnani et al., 2012. NSAID Activated Gene (NAG-1) plays a role in the impairing effects of cyclooxygenase inhibitors on gastric ulcer healing. J. Pharmacol. Exp. Ther., 342: 140-149.

  10. Antonioli, L., R. Colucci, C. La Motta, M. Tuccori and O. Awwad et al., 2012. Adenosine deaminase in the modulation of immune system and its potential as a novel target for treatment of inflammatory disorders. Curr. Drug Targets, 13: 842-862.
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  11. Virdis, A., R. Colucci, M.F. Neves, I. Rugani and F. Aydinoglu et al., 2011. Resistance artery mechanics and composition in angiotensin II-infused mice: Effects of cyclooxygenase-1 inhibition. Eur. Heart J., 33: 2225-2234.
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  12. Tuccori, M., M. Focosi, C. Blandizzi, M. Pelosini and S. Montagnani et al., 2011. Inclusion of rituximab in treatment protocols for non-hodgkin's lymphomas and risk for progressive multifocal leukoencephalopathy. Oncologist, 15: 1214-1219.
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  13. Tuccori, M., F. Lapi, A. Testi, E. Ruggiero and U. Moretti et al., 2011. Drug-induced taste and smell alterations: A case/non-case evaluation of an Italian database of spontaneous adverse drug reaction reporting. Drug Saf., 34: 849-859.
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  14. Fornai, M., R. Colucci, L. Antonioli, O. Awwad and C. Ugolini et al., 2011. Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: characterization of molecular mechanisms. Pharmacol. Res., 53: 59-67.
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  15. Cristiani, C., M. Tuccori, P. Pepe, A. Sarteschi and F. Maddalo et al., 2011. Safety of MF-59 adjuvanted vaccine for pandemic influenza: Results of the vaccination campaign in an Italian health district. Vaccine, 29: 3443-3448.
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  16. Cosimelli, B., S. Taliani, G. Greco, E. Novellino and A. Sala et al., 2011. Derivatives of benzimidazol-2-yl-quinoline and benzimidazol-2-yl-isoquinoline as selective antagonists at A1 adenosine receptors with stimulant actions on human colon motility. Chem. Med. Chem., 6: 1909-1918.

  17. Antonioli, L., M. Fornai, R. Colucci, O. Awwad and N. Ghisu et al., 2011. Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis. Eur. J. Pharmacol., 650: 639-649.
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  18. Antonioli, L., M. Fornai, R. Colucci, M. Tuccori and C. Blandizzi, 2011. Pharmacological modulation of adenosine receptor pathways and inflammatory disorders: the way towards novel therapeutics? Expert Opin. Investig. Drugs, 20: 717-721.
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  19. Antonioli, L., M. Fornai, R. Colucci, M. Tuccori and C. Blandizzi, 2011. A holistic view of adenosine pathways in the control of intestinal neuromuscular functions: The enteric purinome concept. Br. J. Pharmacol., 164: 1577-1579.
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  20. Tuccori, M., S. Montagnani, A. Testi, E. Ruggiero and S. Mantarro et al., 2010. Use of selective serotonin reuptake inhibitors during pregnancy and risk of major and cardiovascular malformations: An update. Postgrad. Med., 122: 49-65.
    CrossRef  |  PubMed  |  

  21. Tuccori, M., B. Guidi, S. Montagnani, M. Fornai, L. Antonioli, C. Blandizzi and M. Di Paolo, 2010. Transient acute liver failure complicating transurethral resection syndrome. Scand. J. Urol. Nephrol., 44: 269-272.
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  22. Fornai, M., L. Antonioli, R. Colucci, N. Bernardini and N. Ghisu et al., 2010. Emerging role for cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions. Pharmacol. Ther., 125: 62-78.
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  23. Antonioli, L., M. Fornai, R. Colucci, O. Awwad and N. Ghisu et al., 2010. The blockade of adenosine deaminase ameliorates chronic experimental colitis through the recruitment of adenosine A2A and A3 receptors. J. Pharmacol. Exp. Ther., 335: 434-442.
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  24. Antonioli, L., M. Fornai, R. Colucci, N. Ghisu and M. Tuccori et al., 2010. Control of enteric neuromuscular functions by purinergic A3 receptors in normal rat distal colon and experimental bowel inflammation. Br. J. Pharmacol., 161: 856-871.
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  25. Virdis, A., R. Colucci, D. Versari, N. Ghisu and M. Fornai et al., 2009. Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: Role of cyclooxygenase 2-derived contracting Hypertension, 53: 1008-1016.
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  26. Tuccori, M., A. Testi, L. Antonioli, M. Fornai and S. Montagnani et al., 2009. Safety concerns associated with the use of serotonin reuptake inhibitors and other serotonergic/noradrenergic antidepressants during pregnancy: A review. Clin. Ther., 31: 1426-1453.
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  27. La Motta, C., S. Sartini, L. Mugnaini, S. Salerno and F. Simorini et al., 2009. Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors. J. Med. Chem., 52: 1681-1692.
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  28. Fornai, M., R. Colucci, L. Antonioli, N. Ghisu, M. Tuccori, C. Blandizzi and M. Del Tacca, 2009. Effects of pantoprazole on ulcer healing delay associated with NSAID treatment. Naunyn Schmiedebergs Arch. Pharmacol., 379: 305-313.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Fornai, M., L. Antonioli, R. Colucci, N. Ghisu and P. Buccianti et al., 2009. A1 and A2a receptors mediate inhibitory effects of adenosine on the motor activity of human colon. Neurogastroenterol. Motility, 21: 451-466.
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  30. Colucci, R., M. Fornai, L. Antonioli, N. Ghisu, M. Tuccori, C. Blandizzi and M. Del 2009. Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. Digestive Liver Dis., 41: 395-405.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. Blandizzi, C., M. Tuccori, R. Colucci, M. Fornai, L. Antonioli, N. Ghisu and M. Del Tacca, 2009. Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy. Pharmacol. Res., 59: 90-100.
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  32. Fornai, M., R. Colucci, L. Antonioli, N. Ghisu and M. Tuccori et al., 2008. Effects of a bicarbonate-alkaline mineral water on digestive motility in experimental models of functional and inflammatory gastrointestinal disorders. Methods Find Exp. Clin. Pharmacol., 30: 261-269.
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  33. Blandizzi, C., M. Tuccori, R. Colucci, G. Gori and M. Fornai et al., 2008. Clinical efficacy of esomeprazole in the prevention and healing of gastrointestinal toxicity associated with NSAIDs in elderly patients. Drug Aging, 25: 197-208.
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  34. Antonioli, L., M. Fornai, R. Colucci, N. Ghisu, M. Tuccori, M. Del Tacca and C. Blandizzi, 2008. Regulation of enteric functions by adenosine: Pathophysiological and pharmacological implications. Pharmacol. Ther., 120: 233-253.
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  35. Antonioli, L., M. Fornai, R. Colucci, N. Ghisu, M. Tuccori, M. Del Tacca and C. Blandizzi, 2008. Pharmacological modulation of adenosine system: Novel options for treatment of inflammatory bowel diseases. Inflamm. Bowel Dis., 14: 566-574.
    CrossRef  |  PubMed  |  Direct Link  |  

  36. Virdis, A., R. Colucci, M. Fornai, E. Duranti and C. Giannarelli et al., 2007. Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin ii-infused mice. Hypertension, 49: 679-686.
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  37. Fornai, M., R. Colucci, L. Antonioli, F. Crema and P. Buccianti et al., 2007. Cholecystokinin CCK2 receptors mediate the peptide's inhibitory actions on the contractile activity of human distal colon via the nitric oxide pathway. Br. J. Pharmacol., 151: 1246-1253.
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  38. Fornai, M., R. Colucci, L. Antonioli, F. Baschiera and N. Ghisu et al., 2007. CCK2 receptors mediate inhibitory effects of cholecystokinin on the motor activity of guinea-pig distal colon. Eur. J. Pharmacol., 557: 212-220.
    PubMed  |  Direct Link  |  

  39. Colucci, R., M. Fornai, M. Tuccori, L. Antonioli, G. Pasqualetti, C. Blandizzi and M. Del Tacca, 2007. Tolerability profiles of leukotriene receptor antagonists and long-acting beta2-adrenoceptor agonists in combination with inhaled corticosteroids for treatment of asthma: A review. J. Asthma, 44: 411-422.
    PubMed  |  

  40. Antonioli, L., M. Fornai, R. Colucci, N. Ghisu and F. Da Settimo et al., 2007. Inhibition of adenosine deaminase attenuates inflammation in experimental colitis. J. Pharmacol. Exp. Ther., 322: 435-442.
    CrossRef  |  PubMed  |  Direct Link  |  

  41. Fornai, M., R. Colucci, F. Graziani, S. Cei and L. Antonioli et al., 2006. Cyclooxygenase-2 induction after oral surgery does not entirely account for analgesia after selective blockade of cyclooxygenase 2 in the preoperative period. Anesthesiology, 104: 152-157.
    PubMed  |  

  42. Fornai, M., C. Blandizzi, L. Antonioli, R. Colucci and N. Bernardini et al., 2006. Differential role of Cyclooxygenase 1 and 2 isoforms in the modulation of colonic neuromuscular function in experimental inflammation. J. Pharmacol. Exp. Ther., 317: 938-945.
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  43. Antonioli, L., M. Fornai, R. Colucci, N. Ghisu, C. Blandizzi and M. Del Tacca, 2006. A2a receptors mediate inhibitory effects of adenosine on colonic motility in the presence of experimental colitis. Inflamm. Bowel Dis., 12: 117-122.
    PubMed  |  Direct Link  |  

  44. Virdis, A., R. Colucci, M. Fornai, C. Blandizzi and E. Duranti et al., 2005. Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: Role of inducible nitric-oxide synthase and oxidative stress. J. Pharmacol. Exp. Ther., 312: 945-953.
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  45. Graziani, F., L. Corsi, M. Fornai, L. Antonioli and M. Tonelli et al., 2005. Clinical evaluation of piroxicam-FDDF and azithromycin in the prevention of complications associated with impacted lower third molar extraction. Pharmacol. Res., 52: 485-490.
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  46. Fornai, M., G. Natale, R. Colucci, M. Tuccori and G. Carazzina et al., 2005. Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage. Naunyn Schmiedebergs Arch. Pharmacol., 372: 79-87.
    CrossRef  |  PubMed  |  Direct Link  |  

  47. Fornai, M., C. Blandizzi, R. Colucci, L. Antonioli and N. Bernardini et al., 2005. Role of cyclooxygenase -1 and -2 in the modulation of neuromuscular functions in the distal colon of humans and mice. Gut, 54: 608-616.

  48. Blandizzi, C., M. Fornai, R. Colucci, G. Natale and V. Lubrano et al., 2005. Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage. World J. Gastroenterol., 11: 4052-4060.
    PubMed  |  
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