Dr. Alexander Sirotkin

Professor
Constantine the Philosopher University in Nitra, Slovakia

Highest Degree
PostDoc. in Biology and Biotechnology from Research Institute of Animal Production, Nitra, Slovakia

My URL
https://livedna.org/421.1310

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Area of Interest:

Biomedical Sciences
Ovary
Hormones
Growth Factors
Protein Kinase

Selected Publications

  1. Sirotkin, A.V., A. Bezakova, J. Laurincik and B. Matejovicova, 2011. Involvement of the metabolic hormones leptin, ghrelin, obestatin, IGF-I and of MAP kinase in control of porcine oocyte maturation. Animal, 5: 94-99.
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  2. Sirotkin, A.V., 2011. Regulators of Ovarian Functions. Nova Science Publishers, New York, USA., ISBN-13: 978-1-61668-040-4, Pages: 194.

  3. Sirotkin, A.V. and M. Bauer, 2011. Heat shock proteins in porcine ovary: synthesis, accumulation and regulation by stress and hormones. Cell Stress Chaperones, 16: 379-387.
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  4. Krockova, J.Z., P. Massanyi, A.V. Sirotkin, J. Pivko and A.V. Makarevich et al., 2011. Nickel induced structural and functional alterations in mouse Leydig cells in vitro. J. Trace Elem. Med. Biol., 25: 14-18.
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  5. Kolesarova, A., M. Capcarova, A.V. Sirotkin, M. Medvedova, A. Kafalova, T. Filipejova and J. Kovacik, 2011. In vitro assessment of molybdenum-induced secretory activity, proliferation and apoptosis of porcine ovarian granulosa cells. J. Environ. Sci. Health Part A: Environ. Sci. Eng., 46: 170-175.
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  6. Kolesarova, A., M. Capcarova, A.V. Sirotkin, M. Medvedova and J. Kovacik, 2011. In vitro assessment of silver effect on porcine ovarian granulosa cells. J. Trace Elements Med. Biol., 25: 166-170.
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  7. Sirotkin, A.V., P. Chrenek, S. Chadio, E. Xylouri, H. Fotopouloy and A.V. Makarevich, 2010. Phosphodiesterase inhibitor 3-isobutyl-methyl-xanthine affects rabbit ovaries and oviduct. Eur. J. Pharmacol., 643: 145-151.
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  8. Sirotkin, A.V., P. Chrenek, J. Pivko, A. Balazi and A.V. Makarevich, 2010. Phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine affects ovarian morphology and stimulates reproduction in rabbits. Eur. J. Inflammation, 8: 173-179.
    Direct Link  |  

  9. Sirotkin, A.V., M. Laukova, D. Ovcharenko and M. Mlyncek, 2010. Identification of microRNAs controlling human ovarian cell proliferation and apoptosis. J. Cell. Physiol., 223: 49-56.
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  10. Sirotkin, A.V., D. Ovcharenko and M. Mlyncek, 2010. Identification of protein kinases that control ovarian hormone release by selective siRNAs. J. Mol. Endocrinol., 44: 45-53.
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  11. Sirotkin, A.V., 2010. Protein kinases: Signaling molecules controlling ovarian functions. Int. J. Biochem. Cell Biol., 42: 1927-1930.
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  12. Sirotkin, A.V., 2010. Effect of two types of stress (heat shock/high temperature and malnutrition/serum deprivation) on porcine ovarian cell functions and their response to hormones. J. Exp. Biol., 213: 2125-2130.
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  13. Makarevich, A.V., E. Kunovicova, A.V. Sirotkin and J. Pivko, 2010. Demonstration of the effect of epidermal growth factor on ram sperm parameters using two fluorescence assays. Vet. Med., 12: 581-589.
    Direct Link  |  

  14. Makarevich, A.V., A.V. Sirotkin and J. Rafay, 2010. Comparison of effects of protein kinase A, mitogen-activated protein kinase, and cyclin-dependent kinase blockers on rabbit ovarian granulosa cell functions. Horm. Metab. Res., 42: 936-943.
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  15. Kolesarova, A., S. Roychoudhury, J. Slivkova, A. Sirotkin, M. Capcarova and P. Massanyi, 2010. In vitro study of the effect of lead and mercury on porcine ovarian granulosa cells. J. Environ. Sci. Health Part A., 45: 320-331.
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  16. Benco, A., A.V. Sirotkin, D. Vasicek, S. Pavlova and J. Zemanova et al., 2009. Involvement of the transcription factor STAT1 in the regulation of porcine ovarian granulosa cell functions treated and not treated with ghrelin. Reproduction, 138: 553-560.
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  17. Sirotkin, A.V., M. Mlyncek, A.V. Makarevich, I. Florkovicova and L. Hetenyi, 2008. Leptin affects proliferation-, apoptosis- and protein kinase A-related peptides in human ovarian granulosa cells. Physiol. Res., 57: 437-442.
    PubMed  |  Direct Link  |  

  18. Sirotkin, A.V., M. Chrenkova, S. Nitrayova, P. Patras and K. Darlak et al., 2008. Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats. Peptides, 29: 1362-1368.
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  19. Meszarosova, M., A.V. Sirotkin, R. Grossmann, K. Darlak and F. Valenzuela, 2008. The effect of obestatin on porcine ovarian granulosa cells. Anim. Reprod. Sci., 108: 196-207.
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  20. Sirotkin, A.V., M. Chrenkova, S. Nitrayova and P. Patras, 2007. Restricted food intake promotes accumulation of proliferation- apoptosis- and anti-apoptotic substances in rat testicular cells. Nutr. Res., 27: 705-709.
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  21. Sirotkin, A.V. and R. Grossmann, 2007. The role of ghrelin and some intracellular mechanisms in controlling the secretory activity of chicken ovarian cells. Comp. Physiol. A Mol. Integrat. Physiol., 147: 239-246.
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  22. Sirotkin, A.V., R. Grossmann, M.T. Maria-Peon, J. Roa, M. Tena-Sempere and S. Klein, 2006. Novel expression and functional role of ghrelin in chicken ovary. Mol. Cell Endocrinol., 257: 15-25.
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  23. Sirotkin, A.V., M. Mlyncek, J. Kotwica, A.V. Makarevich, I. Florkovicova and L. Hetenyi, 2005. Leptin directly controls secretory activity of human ovarian granulosa cells: Possible inter-relationship with the IGF/IGFBP system. Hormone Res., 64: 198-202.
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  24. Sirotkin, A.V., 2005. Control of reproductive processes by growth hormone: Extra- and intracellular mechanisms. Vet. J., 170: 307-317.
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  25. Sirotkin, A.V., P. Sanislo, H.J. Schaeffer, I. Florkovicova, J. Kotwica, J. Bulla and L. Hetenyi, 2004. Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: Involvement of protein kinase A. J. Endocrinol., 183: 595-604.
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  26. Sirotkin, A.V., I. Florkovicova, A.V. Makarevich, H.J. Schaeffer, J. Kotwica, P.G. Marnet and P. Sanislo, 2003. Oxytocin mediates some effects of insulin-like growth factor-I on porcine ovarian follicles. J. Reprod. Dev., 49: 141-149.
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  27. Sirotkin, A.V. and A.V. Makarevich, 2002. Growth hormone can regulate functions of porcine ovarian granulosa cells through the cAMP/protein kinase A system. Anim. Reprod. Sci., 70: 111-126.
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  28. Sirotkin, A.V., A.V. Makarevich, M.R. Corkins, J. Kotwica and J. Bulla, 2001. The transfection-induced overexpression of IGF-binding protein-4 affects the secretory activity of porcine ovarian granulosa cells and their response to hormones and IGF-I. J. Mol. Endocrinol., 26: 241-248.
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  29. Sirotkin, A.V., J. Dukesova, A.V. Makarevich, A. Kubek and J. Bulla, 2000. Evidence that growth factors IGF-I, IGF-II and EGF can stimulate nuclear maturation of porcine oocytes via intracellular protein kinase A. Reprod. Nutr. Dev., 40: 559-569.
    PubMed  |  

  30. Sirotkin, A.V., D. Mertin, K. Suvegova, A.V. Makarevich, H.G. Genieser, M.R. Luck and L.V. Osadchuk, 2000. Effect of restricted food intake on production, catabolism and effects of IGF-I and cyclic nucleotides in cultured ovarian tissue of domestic nutria (Myocastor coypus). Gen. Comp. Endocrinol., 117: 207-217.
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  31. Sirotkin, A.V. and A.V. Makarevich, 1999. GH regulates secretory activity and apoptosis in cultured bovine granulosa cells through the activation of the cAMP/protein kinase A system. J. Endocrinol., 163: 317-327.
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  32. Sirotkin, A.V., A.V. Makarevich, J. Kotwica, P.G. Marnet, H.B. Kwon and L. Hetenyi, 1998. Isolated porcine ovarian follicles as a model for the study of hormone and growth factor action on ovarian secretory activity. J. Endocrinol., 159: 313-321.
    PubMed  |  Direct Link  |  

  33. Sirotkin, A.V. and H.J. Schaeffer, 1997. Direct regulation of mammalian reproductive organs by serotonin and melatonin. J. Endocrinol., 154: 1-5.
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  34. Sirotkin, A.V., 1996. Inter-relationships between nonapeptide hormones and cyclic nucleotides within cultured porcine granulosa cells. J. Endocrinol., 150: 343-348.
    PubMed  |  

  35. Sirotkin, A.V., M. Mlyncek, J. Laurincik, J. Bulla and L. Hetenyi, 1995. The ability of steroid hormones to control cAMP and cGMP production by human granulosa cells in culture. Cell. Signall., 7: 61-65.
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  36. Sirotkin, A.V. and M.R. Luck, 1995. Potential leukocyte attractants in the bovine peri-ovulatory ovary. Reprod. Nutr. Dev., 35: 675-683.
    PubMed  |  

  37. Sirotkin, A.V., J. Nitray, J. Kolena and J. Bulla, 1994. Cooperation between LH-RH and LH in the direct action on the ovary: LH-RH stimulation of LH/hCG receptors, basal and LH-induced cAMP and cGMP release by porcine granulosa cells in vitro. Cell. Signall., 6: 135-140.
    PubMed  |  

  38. Sirotkin, A.V. and J. Nitray, 1993. Steroid hormones regulate cAMP and cGMP production by porcine granulosa cells in vitro. J. Steroid Biochem. Mol. Biol., 46: 573-577.
    PubMed  |  
Member since June, 2010