Dr. Vimaleswaran Karani Santhanakrishnan

Assistant Professor
University of Reading, United Kingdom

Highest Degree
Ph.D. in Molecular Genetics and Genetic Epidemiology from University of Madras, Chennai, India

My URL
https://livedna.org/44.10922

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Biography

Dr. Vimaleswaran Karani Santhanakrishnan is currently working as Assistant Professor at University of Reading, UK. He has completed his Ph.D. in Molecular Genetics and Genetic Epidemiology from University of Madras, Chennai, India, and Post-doctoral training completed from the MRC Epidemniology Unit, University of Cambrdige, UK. His main area of interest focuses on Biomedical Sciences. His area of expertise includes Genetic Epidemiology, Type 2 Diabetes, Obesity and Molecular Genetics. He has 46 publications in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
Genetic Epidemiology
Type 2 Diabetes
Obesity
Molecular Genetics

Selected Publications

  1. Vimaleswaran, K.S., C.I. Le Roy and S.P. Claus, 2015. Foodomics for personalized nutrition: How far are we? Curr. Opin. Food Sci., 4: 129-135.
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  2. Vimaleswaran, K.S., A.M. Minihane, Y. Li, R. Gill, J.A. Lovegrove, C.M. Williams and K.G. Jackson, 2015. The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults. Nutr. Metab., Vol. 12. 10.1186/s12986-015-0002-9.
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  3. Vimaleswaran, K.S., C. Power and E. Hypponen, 2014. Interaction between vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D concentrations on metabolic and cardiovascular disease outcomes. Diabetes Metab., 40: 386-389.
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  4. Vimaleswaran, K.S., A. Cavadino, D.J. Berry, R. Jorde and A.K. Dieffenbach et al., 2014. Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study. Lancet Diabetes Endocrinol., 2: 719-729.
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  5. Vimaleswaran, K.S., A. Cavadino, D.J. Berry, M. Mangino and P. Andrews et al., 2014. Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. BMC Genet., Vol. 15. 10.1186/1471-2156-15-37.
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  6. Meidtner, K., E. Fisher, L. Angquist, C. Holst and K.S. Vimaleswaran et al., 2014. Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight. Genes Nutr., Vol. 9. 10.1007/s12263-014-0385-7.
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  7. Vimaleswaran, K.S., D.J. Berry, C. Lu, E. Tikkanen and S. Pilz et al., 2013. Causal relationship between obesity and vitamin D status: Bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med., Vol. 10. 10.1371/journal.pmed.1001383.
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  8. Vimaleswaran, K.S., A. Cavadino, D.J. Berry, J.C. Whittaker, C. Power, M.R. Jarvelin and E. Hypponen, 2013. Genetic association analysis of vitamin D pathway with obesity traits. Int. J. Obesity, 37: 1399-1406.
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  9. Vimaleswaran, K.S., A. Cavadino and E. Hypponen, 2013. APOA5 genotype influences the association between 25-hydroxyvitamin D and high density lipoprotein cholesterol. Atherosclerosis, 228: 188-192.
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  10. Vimaleswaran, K.S., L. Angquist, R.D. Hansen, N. Bouatia-Naji and C. Holst et al., 2012. Association between FTO variant and change in body weight and its interaction with dietary factors: The DiOGenes study. Obesity, 20: 1669-1674.
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  11. Vimaleswaran, K.S., I. Tachmazidou, J.H. Zhao, J.N. Hirschhorn, F. Dudbridge and R.J. Loos, 2012. Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI. Hum. Mol. Genet., 21: 4537-4542.
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  12. Vimaleswaran, K.S., A. Cavadino and E. Hypponen, 2012. Evidence for a genetic interaction in allergy-related responsiveness to vitamin D deficiency. Allergy, 67: 1033-1040.
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  13. Larsen, L.H., L. Angquist, K.S. Vimaleswaran, J. Hager and N. Viguerie et al., 2012. Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: The DIOGENES study. Am. J. Clin. Nutr., 95: 1254-1260.
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  14. Hooton, H., L. Angquist, C. Holst, J. Hager and F. Rousseau et al., 2012. Dietary factors impact on the association between CTSS variants and obesity related traits. PLoS ONE, Vol. 7. 10.1371/journal.pone.0040394.
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  15. Fisher, E., K. Meidtner, L. Angquist, C. Holst and R.D. Hansen et al., 2012. Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain. Am. J. Clin. Nutr., 95: 1468-1476.
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  16. Bradfield, J.P., H.R. Taal, N.J. Timpson, A. Scherag and C. Lecoeur et al., 2012. A genome-wide association meta-analysis identifies new childhood obesity loci. Nat. Genet., 44: 526-531.
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  17. Berry, D.J., K.S. Vimaleswaran, J.C. Whittaker, A.D. Hingorani and E. Hypponen, 2012. Evaluation of genetic markers as instruments for mendelian randomization studies on vitamin D. PLoS ONE, Vol. 7. 10.1371/journal.pone.0037465.
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  18. Vimaleswaran, K.S., V. Radha, S. Ghosh, P.P. Majumder, M.R.S. Rao and V. Mohan, 2011. Uncoupling protein 2 and 3 gene polymorphisms and their association with type 2 diabetes in Asian Indians. Diabetes Technol. Therapeut., 13: 19-25.
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  19. Vimaleswaran, K.S. and R.J. Loos, 2011. Genetics of Obesity and Diabetes. In: Handbook of Behavioural Medicine: Methods and Applications, Steptoe, A. (Ed.). Chapter 33, Springer, New York, USA., ISBN: 978-0-387-09487-8, pp: 499-521.

  20. Du, H., K.S. Vimaleswaran, L. Angquist, R.D. Hansen and van der A et al., 2011. Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change-the DiOGenes study. PLoS ONE, Vol. 6. 10.1371/journal.pone.0017436.
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  21. Vimaleswaran, K.S., V. Radha, S. Ghosh, P.P. Majumder, M.R.S. Rao and V. Mohan, 2010. A haplotype at the UCP1 gene locus contributes to genetic risk for type 2 diabetes in Asian Indians (CURES-72). Metab. Syndrome Relat. Disord., 8: 63-68.
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  22. Vimaleswaran, K.S., V. Radha, M.G. Jayapriya, S. Ghosh, P.P. Majumder, M.R.S. Rao and V. Mohan, 2010. Evidence for an association with type 2 diabetes mellitus at the PPARG locus in a South Indian population. Metabolism, 59: 457-462.
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  23. Vimaleswaran, K.S., P.W. Franks, S. Brage, A. Grontved, N.J. Wareham, U. Ekelund and R.J. Loos, 2010. Lack of association between PCK1 polymorphisms and obesity, physical activity and fitness in European Youth Heart Study (EYHS). Obesity, 18: 1975-1980.
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  24. Vimaleswaran, K.S., J.H. Zhao, N.W. Wainwright, P.G. Surtees, N.J. Wareham and R.J.F. Loos, 2010. Association between serotonin 5-HT-2C receptor gene (HTR2C) polymorphisms and obesity-and mental health-related phenotypes in a large population-based cohort. Int. J. Obesity, 34: 1028-1033.
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  25. Vimaleswaran, K.S. and R.J. Loos, 2010. Progress in the genetics of common obesity and type 2 diabetes. Expert Rev. Mol. Med., Vol. 12. 10.1017/S1462399410001389.
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  26. Gayathri, S.B., V. Radha, K.S. Vimaleswaran and V. Mohan, 2010. Association of the PPARGC1A gene polymorphism with diabetic nephropathy in an Asian Indian population (CURES-41). Metab. Syndrome Relat. Disord., 8: 119-126.
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  27. Willer, C.J., E.K. Speliotes, R.J. Loos, S. Li and C.M. Lindgren et al., 2009. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet., 41: 25-34.
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  28. Vimaleswaran, K.S., S. Li, J.H. Zhao, J.A. Luan and S.A. Bingham et al., 2009. Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am. J. Clin. Nutr., 90: 425-428.
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  29. Vimaleswaran, K.S., P.W. Franks, S. Brage, L.B. Sardinha and L.B. Andersen et al., 2009. Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS). Obesity, 17: 1453-1457.
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  30. Heid, I.M., C. Huth, R.J. Loos, F. Kronenberg and V. Adamkova et al., 2009. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: Does heterogeneity of estimates relate to study design? PLoS Genet., Vol. 5. 10.1371/journal.pgen.1000694.
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  31. Brito, E.C., K.S. Vimaleswaran, S. Brage, L.B. Andersen and L.B. Sardinha et al., 2009. PPARGC1A sequence variation and cardiovascular risk-factor levels: A study of the main genetic effects and gene × environment interactions in children from the European Youth Heart Study. Diabetologia, 52: 609-613.
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  32. Vimaleswaran, K.S., V. Radha, K. Ramya, H.N.S. Babu and N. Savitha et al., 2008. A novel association of a polymorphism in the first intron of adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia in Asian Indians. Hum. Genet., 123: 599-605.
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  33. Vimaleswaran, K.S., P.W. Franks, I. Barroso, S. Brage and U. Ekelund et al., 2008. Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure. Am. J. Hypertens., 21: 297-302.
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  34. Vimaleswaran, K.S., J.A. Luan, G. Andersen, Y.L. Muller and E. Wheeler et al., 2008. The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: A meta-analysis involving 13,949 individuals. J. Applied Physiol., 105: 1352-1358.
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  35. Loos, R.J.F., K.S. Vimaleswaran and N.J. Wareham, 2008. Interaction between Genes and Lifestyle Factors. In: Obesity: Genomics and Postgenomics, Clement, K. and T.I.A. Sorensen (Eds.). Chapter 7.3, CRC Press, Boca Raton, FL., USA., ISBN-13: 978-0849380891, pp: 287-326.

  36. Vimaleswaran, K.S., V. Radha, R. Deepa and V. Mohan, 2007. Absence of association of metabolic syndrome with PPARGC1A, PPARG and UCP1 gene polymorphisms in Asian Indians. Metab. Syndrome Relat. Disord., 5: 153-162.
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  37. Vimaleswaran, K.S., V. Radha, M. Anjana, R. Deepa and S. Ghosh et al., 2007. Thr394Thr polymorphism of PPARGC1A gene is associated with Type 2 diabetes and total body fat in Asian Indians. Int. J. Obesity, 31: 563-563.
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  38. Radha, V., K.S. Vimaleswaran, S. Babu, R. Deepa and M. Anjana et al., 2007. Lack of association between serum adiponectin levels and the Pro12Ala polymorphism in Asian Indians. Diabetic Med., 24: 398-402.
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  39. Radha, V., K.S. Vimaleswaran, K.A. Ayyappa and V. Mohan, 2007. Association of lipoprotein lipase gene polymorphisms with obesity and type 2 diabetes in an Asian Indian population. Int. J. Obesity, 31: 913-918.
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  40. Vimaleswaran, K.S., V. Radha, M. Anjana, R. Deepa and S. Ghosh et al., 2006. Effect of polymorphisms in the PPARGC1A gene on body fat in Asian Indians. Int. J. Obesity, 30: 884-891.
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  41. Vimaleswaran, K.S., V. Radha and V. Mohan, 2006. Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians. Metabolism, 55: 1222-1226.
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  42. Radha, V., K.S. Vimaleswaran, H.N.S. Babu, N. Abate and M. Chandalia et al., 2006. Role of genetic polymorphism peroxisome proliferator-activated receptor-γ2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects evidence for heterogeneity. Diabetes Care, 29: 1046-1051.
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  43. Vimaleswaran, K.S., V. Radha, S. Ghosh, P.P. Majumder and R. Deepa et al., 2005. Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians. Diabetic Med., 22: 1516-1521.
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  44. Mohan, V., R. Deepa, R. Pradeepa, K.S. Vimaleswaran, A. Mohan, K. Velmurugan and V. Radha, 2005. Association of low adiponectin levels with the metabolic syndrome-the Chennai Urban Rural Epidemiology Study (CURES-4). Metabolism, 54: 476-481.
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  45. Anjana, M., S. Sandeep, R. Deepa, K.S. Vimaleswaran, S. Farooq and V. Mohan, 2004. Visceral and central abdominal fat and anthropometry in relation to diabetes in Asian Indians. Diabetes Care, 27: 2948-2953.
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  46. Radha, V., K.S. Vimaleswaran, R. Deepa and V. Mohan, 2003. The genetics of diabetes mellitus. Indian J. Med. Res., 117: 225-238.
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