Dr. Nissar A. Darmani

Associate Dean
Western University of Health Sciences, USA

Highest Degree
Ph.D. in Neuropharmacology from University of Wales, UK

My URL
https://livedna.org/44.6339

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Area of Interest:

Pharmacology and Toxicology
Pharmaceuticals
Biochemistry
Behavioural Neuroscience
Neuropharmacology

Selected Publications

  1. Zhong, W., A.J. Picca, A.S. Lee and N.A. Darmani, 2017. Ca2+ signaling and emesis: Recent progress and new perspectives. Autonomic Neurosci.: Basic Clin., 202: 18-27.
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  2. Zhong, W. and N.A. Darmani, 2017. Intracellular vomit signals and cascades downstream of emetic receptors: Evidence from the least shrew (Cryptotis parva) model of vomiting. Remed Open Access, Vol. 2. .
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  3. Darmani, N.A., S. Chebolu, W. Zhong, W.D. Kim, M. Narlesky, J. Adams and F. Dong, 2017. The anti-asthmatic drug pranlukast suppresses the delayed-phase vomiting and reverses intracellular indices of emesis evoked by cisplatin in the least shrew (Cryptotis parva). Eur. J. Pharmacol., 809: 20-31.
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  4. Darmani, N.A., S. Chebolu and W. Zhong, 2017. Clinical potential of a new class of antiemetic for the prevention of chemotherapy-evoked acute- and delayed vomiting: Supportive evidence from the least shrew (Cryptotis parva) model of emesis. Austin Pharmacol. Pharmaceut., Vol. 2, No. 1. .
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  5. Arodaki, F., W. Khamas, N. Darmani and M. Al-Tikriti, 2017. Histological characteristics of the tracheobronchial tree of the least shrew (Cryptotis parva). Anat. Histol. Embryol., 46: 405-409.
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  6. Zhong, W., S. Chebolu and N.A. Darmani, 2016. Thapsigargin-induced activation of Ca2+-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew. Neuropharmacology, 103: 195-210.
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  7. Hutchinson, T.E., W. Zhong, S. Chebolu, S.M. Wilson and N.A. Darmani, 2015. L-type calcium channels contribute to 5-HT3-receptor-evoked CaMKIIα and ERK activation and induction of emesis in the least shrew (Cryptotis parva). Eur. J. Pharmacol., 755: 110-118.
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  8. Darmani, N.A., W. Zhong, S. Chebolu and F. Mercadante, 2015. Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation. Pharmacol. Biochem. Behav., 131: 104-111.
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  9. Darmani, N.A. and W. Zhong, 2015. Role of calcium in vomiting: Revelations from the least shrew model of emesis. Gastro Open J., 1: 119-128.
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  10. Zhong, W., T.E. Hutchinson, S. Chebolu and N.A. Darmani, 2014. Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva). PLoS ONE, Vol. 9. 10.1371/journal.pone.0104718.
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  11. Zhong, W., S. Chebolu and N.A. Darmani, 2014. Broad-spectrum antiemetic efficacy of the L-type calcium channel blocker amlodipine in the least shrew (Cryptotis parva). Pharmacol. Biochem. Behav., 120: 124-132.
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  12. Sharkey, K.A., N.A. Darmani and L.A. Parker, 2014. Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. Eur. J. Pharmacol., 722: 134-146.
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  13. Darmani, N.A., W. Zhong, S. Chebolu, M. Vaezi and T. Alkam, 2014. Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT3 receptor antagonist palonosetron in the least shrew (Cryptotis parva). Eur. J. Pharmacol., 722: 2-12.
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  14. Darmani, N.A., S. Chebolu, W. Zhong, C. Trinh, B. McClanahan and R.S. Brar, 2014. Additive antiemetic efficacy of low-doses of the cannabinoid CB1/2 receptor agonist Δ9-THC with ultralow-doses of the vanilloid TRPV1 receptor agonist resiniferatoxin in the least shrew (Cryptotis parva). Eur. J. Pharmacol., 722: 147-155.
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  15. Alkam, T., S. Chebolu and N.A. Darmani, 2014. Cyclophosphamide causes activation of Protein Kinase A (PKA) in the brainstem of vomiting least shrews (Cryptotis parva). Eur. J. Pharmacol., 722: 156-164.
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  16. Darmani, N.A., D. Dey, S. Chebolu, B. Amos, R. Kandpal and T. Alkam, 2013. Cisplatin causes over-expression of tachykinin NK1 receptors and increases ERK1/2- and PKA‐ phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem. Eur. J. Pharmacol., 698: 161-169.
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  17. Darmani, N.A., 2013. New vistas in the pathophysiology of vomiting. Family Med. Med. Sci. Res., Vol. 2. 10.4172/2327-4972.1000e105.
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  18. Darmani, N.A. and S. Chebolu, 2013. The Role of Endocannabinoids and Arachidonic Acid Metabolites in Emesis. In: Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features, Murillo-Rodriguez, E., E.S. Onaive, N.A. Darmani and E. Wagner (Eds.). Chapter 2, Bentham Science Publishers, UAE., ISBN: 978-1-60805-125-0, pp: 25-59.

  19. Al-Tikriti, M.S., W. Khamas, S. Chebolu and N.A. Darmani, 2013. Histomorphology and immunohistochemistry of the lower esophageal sphincter of the least shrew (Cryptotis parva). Cells Tissues Org., 198: 390-397.
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  20. Al-Tikriti, M.S., W. Khamas, S. Chebolu and N.A. Darmani, 2012. Distribition of Serotonin-immunoreactive chromaffin cells in the gastrointestinal tract of the least shrew (Cryptotis parva). Int. J. Morphol., 30: 916-923.
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  21. Darmani, N.A., S. Chebolu, B. Amos and T. Alkam, 2011. Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK 1-receptor antagonists in the least shrew (Cryptotis parva). Pharmacol. Biochem. Behav., 99: 573-579.
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  22. Tiwari, V., N.A. Darmani, B.Y. Yue and D. Shukla, 2010. In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phytother. Res., 24: 1132-1140.
    CrossRef  |  PubMed  |  

  23. King, K.S., N.A. Darmani, M.S. Hughes, K.T. Adams and K. Pacak, 2010. Exercise-induced nausea and vomiting: Another sign and symptom of pheochromocytoma and paraganglioma. Endocrine, 37: 403-407.
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  24. Hubbard, S., N.A. Darmani, G.R. Thrush, D. Dey and L. Burnham et al., 2010. Zebrafish-encoded 3-O-sulfotransferase-3 isoform mediates herpes simplex virus type 1 entry and spread. Zebrafish, 7: 181-187.
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  25. Dey, D., J. Abad, A.P. Ray and N.A. Darmani, 2010. Differential temporal changes in brain and gut substance P mRNA expression throughout the Time-course of Cisplatin-induced vomiting in the least shrew (Cryptotis parva). Brain Res., 1310: 103-112.
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  26. Darmani, N.A., 2010. Mechanisms of Broad-spectrum antiemetic efficacy of cannabinoids against Chemotherapy-induced acute and delayed vomiting. Pharmaceuticals, 3: 2930-2955.
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  27. Darmani, N.A., 2010. Cannabinoid-induced hyperemesis: A conundrum-from clinical recognition to basic science mechanisms. Pharmaceuticals, 3: 2163-2177.
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  28. Chebolu, S., Y. Wang, A.P. Ray and N.A. Darmani, 2010. Pranlukast prevents cysteinyl Leukotriene-induced emesis in the least shrew (Cryptotis parva). Eur. J. Pharmacol., 628: 195-201.
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  29. Wang, Y., A.P. Ray, B.A. McClanahan and N.A. Darmani, 2009. The antiemetic interaction of Δ9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew. Pharmacol. Biochem. Behav., 91: 367-373.
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  30. Tiwari, V., N.A. Darmani, G.R. Thrush and D. Shukla, 2009. An unusual dependence of human herpesvirus-8 Glycoproteins-induced Cell-to-cell fusion on heparan sulfate. Biochem. Biophys. Res. Commun., 390: 382-387.
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  31. Ray, A.P., S. Chebolu, J. Ramirez and N.A. Darmani, 2009. Ablation of least shrew central neurokinin NK₁ receptors reduces GR73632-induced vomiting. Behav. Neurosci., 123: 701-706.
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  32. Ray, A.P., S. Chebolu and N.A. Darmani, 2009. Selective agonists induce emesis and Fos expression in the brainstem and and enteric nervous system of the least shrew (Cryptotis parva). Pharmacol. Biochem. Behav., 94: 211-218.
    CrossRef  |  

  33. Ray, A.P., L. Griggs and N.A. Darmani, 2009. Δ9-Tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of Cisplatin-induced emesis in the least shrew. Behav. Brain Res., 196: 30-36.
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  34. Darmani, N.A., J.L. Crim, J.J. Janoyan, J. Abad and J. Ramirez, 2009. A Re-evaluation of the neurotransmitter basis of Chemotherapy-induced immediate and delayed vomiting: Evidence from the least shrew. Brain Res., 1248: 40-58.
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  35. Darmani, N.A. and A.P. Ray, 2009. Evidence for a Re-evaluation of the neurochemical and anatomical bases of Chemotherapy-induced vomiting. Chem. Rev., 109: 3158-3199.
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  36. Darmani, N.A., Y. Wang, J. Abad, A.P. Ray, G.R. Thrush and J. Ramirez, 2008. Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists. Brain Res., 1214: 58-72.
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  37. Ray, A.P. and N.A. Darmani, 2007. A histologically derived stereotaxic atlas and substance P immunohistochemistry in the brain of the least shrew (Cryptotis parva) support its role as a model organism for behavioral and pharmacological research. Brain Res., 1156: 99-111.
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  38. Degenhardt, B.F., N.A. Darmani, J.C. Johnson, L.C. Towns and D.C. Rhodes et al., 2007. Role of osteopathic manipulative treatment in altering pain biomarkers: A pilot study. J. Am. Osteopathic Associat., 107: 387-400.
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  39. Darmani, N.A., J.J. Janoyan, J. Crim and J. Ramirez, 2007. Receptor mechanism and antiemetic activity of Structurally‐diverse cannabinoids against Radiation‐induced emesis in the least shrew. Eur. J. Pharmacol., 563: 187-196.
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  40. Darmani, N.A., 2006. Methods Evaluating Endocannabinoids and Cannabinoid Effects on Gastrointestinal Functions. In: Marijuana and Cannabinoid Research: Methods and Protocols, Onaivi, E.S. (Ed.). Chapter 10, The Humana Press Inc., Totowa, New Jersey, USA., pp: 169-189.

  41. Mock, O.B., S.W. Casteel, N.A. Darmani, J.H. Shaddy, C. Besch-Williford and L.C. Towns, 2005. 1,3-dinitrobenzene toxicity in the least shrew, Cryptotis parva. Environ. Toxicol. Chem., 24: 2519-2525.
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  42. Darmani, N.A., B.A. McClanahan, C. Trinh, S. Petrosino, M. Valenti and V. Di Marzo, 2005. Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew. Neuropharmacology, 49: 502-513.
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  43. Darmani, N.A., A.A. Izzo, B. Degenhardt, M. Valenti and G. Scaglione et al., 2005. Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available Pre-clinical data, and first human studies. Neuropharmacology, 48: 1154-1163.
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  44. Darmani, N.A., 2005. Endocannabinoids and Gastrointestinal Function. In: Endocannabinoids: The Brain and Body's Marijuana and Beyond, Onaivi, E.S., T. Sugiura and V. DiMarzo (Eds.). CRC Press, New York, pp: 393-418.

  45. Darmani, N.A. and J.L. Crim, 2005. Delta-9-tetrahydrocannabinol differentially suppresses emesis versus enhanced locomotor activity produced by chemically diverse dopamine D 2/D< sub>3 receptor agonists in the least shrew (Cryptotis parva). Pharmacol. Biochem. Behav., 80: 35-44.
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  46. Darmani, N.A. and J.C. Johnson, 2004. Central and peripheral mechanisms contribute to the antiemetic actions of Δ9-THC against 5-hydroxytryptophan-induced emesis. Eur. J. Pharmacol., 488: 201-212.

  47. Darmani, N.A., L.J. Sim-Selley, B.R. Martin, J.J. Janoyan, J.L. Crim, B. Parekh and C.S. Breivogel, 2003. Antiemetic and motor-depressive actions of CP55, 940: Cannabinoid CB1 receptor characterization, distribution and G-protein activation. Eur. J. Pharmacol., 459: 83-95.
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  48. Darmani, N.A., J.J. Janoyan, N. Kumar and J.L. Crim, 2003. Behaviorally active doses of the CB1 receptor antagonist SR141716A increase brain serotonin and dopamine levels and turnover. Pharmacol. Biochem. Behav., 75: 777-787.

  49. Janoyan, J., J. Crim and N.A. Darmani, 2002. Antagonism of SR 141716A-induced Head-twitch and Ear-scratch responses in mice by Δ9-THC and other cannabinoids. Pharmacol. Biochem. Behav., 71: 155-162.

  50. Darmani, N.A., 2002. The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by Δ9-Tetrahydrocannabinol and other cannnabinoids. J. Pharmacol. Exp. Ther., 300: 34-42.
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  51. Darmani, N.A., 2002. Antiemetic Action of Δ9-Tetrahydrocannabinold and Synthetic Cannabinoids. In: Biology of Marijuana: From Gene to Behavior, Onaivi, E.S. (Ed.). Chapter 13, Taylor and Francis Books Ltd., London, UK., pp: 356-389.

  52. Tizabi, Y., L.T. Russell, M. Johnson and N.A. Darmani, 2001. Nicotine attenuates DOI-induced Head-twitch response in mice: Implications for tourette syndrome. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 25: 1445-1457.
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  53. Mock, O.B., S.W. Casteel, N.A. Darmani, J.H. Shaddy, C. Besch-Williford and L.C. Towns, 2001. Anatomic and physiologic reference values in least shrews (Cryptotis parva). Compar. Med., 51: 534-537.
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  54. Darmani, N.A., 2001. The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2. Eur. J. Pharmacol., 430: 49-58.
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  55. Darmani, N.A., 2001. Delta-9-tetrahydrocannabinol differentially suppresses Cisplatin-induced emesis and indices of motor function via cannabinoid CB 1 receptors in the least shrew. Pharmacol. Biochem. Behav., 69: 239-249.
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  56. Darmani, N.A., 2001. Cannabinoids of diverse structure inhibit two DOI-induced 5-HT 2A Receptor-mediated behaviors in mice. Pharmacol. Biochem. Behav., 68: 311-317.
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  57. Darmani, N.A., 2001. Δ9-Tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB1 receptor antagonist/inverse agonist SR 141716A. Neuropsychopharmacology, 24: 198-203.
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  58. Dukat, M., R. Young, N.N. Darmani, B. Ahmed and R.A. Glennon, 2000. The 5-HT3 agent N-(3-chlorophenyl) guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay. Psychopharmacology, 150: 200-207.
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  59. Darmani, N.A. and D.K. Pandya, 2000. Involvement of other neurotransmitters in behaviors induced by the cannabinoid CB1 receptor antagonist SR 141716A in naive mice. J. Neural Trans., 107: 931-945.
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  60. Darmani, N.A. and B. Ahmad, 2000. Early postnatal cocaine exposure causes sequential, Dose-dependent, enduring but reversible supersensitivity in 5-HT 2A Receptor-mediated function during development in male mice. Neurotoxicol. Teratol., 22: 61-69.
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