Dr. Martina Schmidt

Head of Molecular Pharmacology
University Centre for Pharmacy, Netherlands

Highest Degree
Ph.D. in Pharmacology from Ruhr- Universitat Bochum, Germany

My URL
https://livedna.org/49.13902

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Area of Interest:

Pharmacology and Toxicology
Translational Pharmacology
Inflammatory Disorders
Molecular Biology
Microfluidics

Selected Publications

  1. Jansen, S.R., W.J. Poppinga, W. de Jager, F. Lezoualch and X. Cheng et al., 2016. Epac1 links prostaglandin E2 to B-catenin-dependent transcription during epithelial-to-mesenchymal transition. Oncotargets, 10.18632/oncotarget.10128.
    CrossRef  |  Direct Link  |  

  2. Han, B., W.J. Poppinga, H. Zuo, A.B. Zuidhof and I.S. Bos et al., 2016. The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease. Sci. Rep., 10.1038/srep26928.
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  3. Poppinga, W.J., I.H. Heijink, L.J. Holtzer, P. Skroblin and E. Klussmann et al., 2015. A-kinase anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol., 308: 766-775.
    CrossRef  |  Direct Link  |  

  4. Llancao, P.M., D.R. Henriquez, C. Wilson, F. Bodaleo and E.W. Boddeke et al., 2015. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J. Neurosci., 35: 11315-11329.

  5. Jansen, S.R., R. Holman, I. Hedemann, E. Frankes and C.R. Elzinga et al., 2015. Prostaglandin E2 promoties MYCN non-amplified neuroblastoma cell survival via beta-catenin stabilization. J. Cell. Mol. Med., 19: 210-216.
    CrossRef  |  Direct Link  |  

  6. Tania, N.P., M. Schmidt and R. Gosens, 2014. Activin inflammation in COPD. Eur. Resp. J., 43: 954-955.

  7. Poppinga, W.J., P.M. Llancao, C.G. Bilault and M. Schmidt, 2014. Cyclic AMP compartmentalization in chronic pulmonary and neuronal diseases. Br. J. Pharmacol., 171: 5603-5623.

  8. Oldenburger, A., W.J. Poppinga, F. Kos, H.G. de Bruin and W.F. Rijks et al., 2014. A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke. Am. J. Physiol., 306: 585-597.
    CrossRef  |  Direct Link  |  

  9. Oldenburger, A., W. Timens, S. Bos, M. Smit and A.V. Smrcka et al., 2014. Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke. FASEB J., 28: 4617-4628.
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  10. Kumawat, K., M.H. Menzen, R.M. Slegtenhorst, A.J. Halayko, M. Schmidt and R. Gosens, 2014. TGF-beta-activated kinase 1 (TAK1) signaling regulates TGF-beta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin. PLoS One, 10.1371/journal.pone.0094801.
    CrossRef  |  Direct Link  |  

  11. Schmidt, M., F. Dekker and H. Maarsingh, 2013. Exchange protein directly activated by cAMP (Epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol. Rev., 65: 670-709.
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  12. Schmidt, M. , F. Dekker and H. Maarsingh, 2013. Exchange protein directly activated by cAMP (Epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol. Rev., 65: 670-709.
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  13. Kumawat, K., M.H. Menzen, I.S. Bos, H.A. Baarsma and H.A. Borger et al., 2013. Noncanonical WNT-5A signaling regulates TGF-B-induced extracellular matrix production by airway smooth muscle cells. FASEB J., 27: 1631-1643.
    CrossRef  |  Direct Link  |  

  14. Karimian, G., M.B. Homan, M. Schmidt, U.J.F. Tietge and J.F. de Boer et al., 2013. Sphingosine kinase inhibitor protects primary rat hepatocytes against bile acid-induced apoptosis. Biochem. Biophys. Acta, 1832: 1922-1929.
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  15. Talaei, F., H.R. Bouma, M.N. Hylkema, A.M. Strijkstra, A.S. Boerema, M. Schmidt and R.H. Henning, 2012. The role of endogenous H2S in reversible remodeling of lung tissue during hibernation in the Syrian hamster. J. Experiment. Biol., 215: 2912-2919.
    CrossRef  |  Direct Link  |  

  16. Schmidt, M., B.G.J. Dekkers and K. Racke, 2012. Distinct PKA and Epac compartmentalization in airway plasticity and function. Pharmacol. Ther., 137: 248-265.
    CrossRef  |  Direct Link  |  

  17. Oldenburger, A., S.S. Roscioni, E. Jansen, M.H. Menzen and A.J. Halayko et al., 2012. Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease. PLoS One, 10.1371/journal.pone.0031574.
    CrossRef  |  Direct Link  |  

  18. Oldenburger, A., H. Maarsingh and M. Schmidt, 2012. Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung. Pharm., 5: 1291-1331.
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  19. Li, X., M. Gao, X. Han, S. Tao and D. Zheng et al., 2012. Disruption of the phospholipase D gene attenuates virulence of Aspergillus fumigatus. Infect. Immun., 80: 429-440.
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  20. vom Dorp, F., H. Sanders, C. Boergermann, G. Lummen, H. Rubben, K.H. Jakobs and M. Schmidt, 2011. Inhibition of Rho-kinase abrogrates migration of human transitional cell carcinoma cells: results of an in vitro study. Int. Urol., 86: 220-227.
    CrossRef  |  Direct Link  |  

  21. Talaei, F., M.N. Hylkema, H.R. Bouma, A.S. Boerema, R.H. Henning and M. Schmidt, 2011. Reversible remodeling of lung tissue during hibernation in the syrian hamster. J. Experiment. Biol., 214: 1276-1282.
    CrossRef  |  Direct Link  |  

  22. Talaei, F., M.N. Hylkema, H.R. Bouma, A.S. Boerema, R.H. Henning and M. Schmidt, 2011. Hibernating hamsters reverse lung changes. J. Experiment. Biol., 10.1242/jeb.057687.
    CrossRef  |  Direct Link  |  

  23. Talaei, F., H.R. Bouma, A.C. van der Graaf, A.M. Strijkstra, M. Schmidt and R. Henning, 2011. Serotonin and dopamine protect from cold-induced cell damage through cystathione-synthase induced H2S production. PLoS One, 10.1371/journal.pone.0022568.
    CrossRef  |  Direct Link  |  

  24. Schmidt, M. and M.C. Michel, 2011. How Can 1 + 1 = 3? B2-Adrenergic and Glucocorticoid Receptor Agonist Synergism in Obstructive Airway Diseases. Mol. Pharmacol., 80: 955-958.
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  25. Roscioni, S.S., H. Maarsingh, C.R.S. Elzinga, J. Schuur and M. Menzen et al., 2011. Epac as a novel effector of airway smooth muscle relaxation. J. Cell. Mol. Med., 15: 1551-1563.
    CrossRef  |  Direct Link  |  

  26. Roscioni, S.S., B.G.J. Dekkers, A.G. Prins, H. Meurs, M. Schmidt and H. Maarsingh, 2011. cAMP inhibits airway smooth muscle phenotype modulation. Br. J. Pharmacol., 162: 193-209.
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  27. Roscioni, S.S., A.G. Prins, B.G.J. Dekkers, C.R.S. Elzinga, A.J. Halayko, H. Meurs and M. Schmidt, 2011. Functional roles of Epac and PKA in human airway smooth muscle phenotype plasticity. Br. J. Pharmacol., 164: 958-969.

  28. Han, X., R. Yu, X. Han, L. Ji and D. Zhen et al., 2011. InlB-induced phospholipase D activation in Listeria monocytogenes internalization. Mol. Microbiol., 81: 860-880.
    CrossRef  |  Direct Link  |  

  29. Han, X., R. Yu, D. Zhen, S. Tao and M. Schmidt, 2011. B-1,3-glucan-induced host phospholipase D activation and Aspergillus fumigatus internalization into type II human pneumocyte A549 cells. PLoS One, 10.1371/journal.pone.0021468.
    CrossRef  |  Direct Link  |  

  30. Baarsma, H., H. Meurs, A.J. Halayko, M. Schmidt, H.A.M. Kerstjens and R. Gosens, 2011. Gycogen synthase kinase-3 regulates cigarette smoke extract and IL-1b-induced cytokine secretion by airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol., 300: 910-919.
    CrossRef  |  Direct Link  |  

  31. Sand, C., C. Borgermann, P.A.O. Weernink, Y. Mahlke, B. Schwindenhammer, A.A. Weber and M. Schmidt, 2010. 8-pCPT-conjugated cyclic AMP analogs exert thromboxane receptor antagonistic properties. Thromb. Haemost., 103: 662-678.
    CrossRef  |  Direct Link  |  

  32. Ostroveanu, A., E. van der Zee, U.L.M. Eisle, M. Schmidt and I. Nijholt, 2010. Exchange protein directly activated by cyclic AMP2 (Epac2) plays a specific and time-limited role in memory retrieval. Hippocampus, 20: 1018-1026.
    CrossRef  |  Direct Link  |  

  33. Grandoch, M., S.S. Roscioni and M. Schmidt, 2010. Epac: novel cAMP mediators in inflammatory pulmonary and neuronal dysfunction. Br. J. Pharmacol., 159: 265-284.

  34. van Wijk, B., G. van den Berg, R.A. Issa, S. van der Velden and M. Schmidt et al., 2009. Epicardial cells separate from the myocardial lineage under influence of FGF-signaling via Mek1/2. Cir. Res., 105: 431-441.
    CrossRef  |  Direct Link  |  

  35. Roscioni, S.S., L.E.M. Kistemaker, M. Menzen, C.R.S. Elzinga and R. Gosens et al., 2009. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle. Resp. Res., 10.1186/1465-9921-10-88.
    CrossRef  |  Direct Link  |  

  36. Grandoch, M., V. Bujok, D. Fleckenstein, M. Schmidt, J.W. Fischer and A.A. Weber, 2009. Epac inhibits apoptosis of human leukocytes. J. Leuk. Biol., 86: 847-849.
    CrossRef  |  Direct Link  |  

  37. Grandoch, M., P.A.O. Weernink, A.A. Weber, K.H. Kajobs and M. Schmidt, 2009. B cell receptor-induced growth arrest and apoptosis in WEHI-231 cells immature B lymphoma cells involve cyclic AMP and Epac proteins. Cell. Signal., 21: 609-621.
    CrossRef  |  Direct Link  |  

  38. Grandoch, M., A. Rose, M. ter Braak, V. Jendrossek and H. Rubben et al., 2009. Epac inhibits migration and proliferation of human prostate carcinoma cells. Br. J. Cancer, 101: 2038-2042.
    CrossRef  |  Direct Link  |  

  39. Gkoumassi, E., B.G.J. Dekkers, M.J. Droge, C.R.S. Elzinga and R.E. Hasenbosch et al., 2009. Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells. Naunyn-Schmiedebergs Arch. Pharmacol., 380: 67-77.

  40. Schaafsma, D., S.S. Roscioni, H. Meurs and M. Schmidt, 2008. Monomeric G proteins as signal transducers in airway pathophysiology. Cell. Signal., 20: 1705-1714.
    CrossRef  |  Direct Link  |  

  41. Roscioni, S.S., C.R.S. Elzinga and M. Schmidt, 2008. Epac: effectors and biological functions. Naunyn-Schmiedebergs Arch. Pharmacol., 377: 345-357.
    CrossRef  |  Direct Link  |  

  42. Nunes, R.O., M. Schmidt, G. Dueck, H. Baarsma and A.J. Halayko et al., 2008. The GSK-catenin signaling axis in airway smooth muscle: Role in mitogenic signaling. Am. J. Physiol. Lung Cell Mol. Physiol., 294: 1110-1118.

  43. Nijholt, I., A.M. Dolga, T. Vieth, A. Ostroveanu and M. de Bruyn et al., 2008. Neuronal AKAP150 coordinates PKA and Epac mediated PKB/Akt phosphorylation. Cell. Signal., 20: 1715-1724.
    CrossRef  |  Direct Link  |  

  44. Gosens, R., S.S. Roscioni, B.G. Dekkers, T. Pera and M. Schmidt et al., 2008. Pharmacology of airway smooth muscle proliferation. Eur. J. Pharmacol., 585: 385-397.
    CrossRef  |  Direct Link  |  

  45. Gosens, R., H. Meurs and M. Schmidt, 2008. The GSK-3/beta-catenin axis in smooth muscle and its relationship with remodelling. Naunyn-Schmiedebergs Arch. Pharmacol., 378: 345-357.
    CrossRef  |  Direct Link  |  

  46. Weernink, P.A.O., M.L. de Jesus and M. Schmidt, 2007. Phospholipase D signaling: orchestration by PIP2 and small GTPases. Naunyn-Schmiedebergs Arch. Pharmacol., 374: 399-411.
    CrossRef  |  Direct Link  |  

  47. Vogt, A., S. Lutz, U. Rumenapp, L. Han, K.H. Jakobs, M. Schmidt and T. Wieland, 2007. Regulators of G protein signalling 3 redirects prototypical Gi-coupled receptors from Rac to Rho activation. Cell. Signal., 19: 1229-1237.
    CrossRef  |  Direct Link  |  

  48. Schmidt, M., C. Sand, K.H. Jakobs, M.C. Michel and P.A.O. Weernink, 2007. Epac and the cardiovascular system. Curr. Opin. Pharmacol., 7: 193-200.
    CrossRef  |  Direct Link  |  

  49. Gkoumassi, E., M.J. Droge, B.G.J. Dekkers, C.R.S. Elzinga and M. Schmidt et al., 2007. Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells. Br. J. Pharmacol., 151: 1041-1048.
    CrossRef  |  Direct Link  |  

  50. Weernink, P.A.O., L. Han, K.H. Jakobs and M. Schmidt, 2006. Dynamic phospholipid signaling by G protein-coupled receptors. Biochim. Biophys. Acta, 1768: 888-900.
    CrossRef  |  Direct Link  |  

  51. Peters, S.L.M., M. Schmidt and M.C. Michel, 2006. Rho kinase: a target for treating urinary incontinence. Trends Pharmacol. Sci., 27: 492-497.
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  52. Hennenberg, M., E. Biecker, J. Trebicka, K. Jochem and Q. Zhou et al., 2006. Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Gastroenterol., 130: 838-854.
    CrossRef  |  Direct Link  |  

  53. De Jesus, M.L., M.B. Stope, P.A.O. Weernink, C. Borgermann and V.N. Ananaba et al., 2006. Cyclic AMP-dependent and Epac-mediated Activation of R-Ras by G Protein-coupled Receptors Leads to Phospholipase D Stimulation. J. Biol. Chem., 281: 21837-21847.
    CrossRef  |  Direct Link  |  

  54. Lutz, S., A.F. Blomquist, Y. Yang, U. Rumenapp, K.H. Jakobs, M. Schmidt and T. Wieland, 2005. The guanine nucleotide exchange factor p63RhoGEF a specific link between Gq/11-coupled receptor signaling and RhoA. J. Biol. Chem., 280: 11134-11139.
    CrossRef  |  Direct Link  |  

  55. Weernink, P.A.O., M. Schmidt and K.H. Jakobs, 2004. Regulation and cellular roles of phosphoinositide 5-kinases. Eur. J. Pharmacol., 500: 87-99.
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  56. Weernink, P.A.O., K. Meletiadis, S. Hommeltenberg, M. Hinz, H. Ishihara, M. Schmidt and K.H. Jakobs, 2004. Activation of type I phosphatidylinositol-4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42. J. Biol. Chem., 279: 7840-7849.
    CrossRef  |  Direct Link  |  

  57. Stope, M.B., F. Dorp, D. Szatkowski, A. Bohm and M. Keiper et al., 2004. Rap2B-dependent stimulation of phospholipase C-Src phosphorylation of RasGRP3. Cell. Mol. Biol., 24: 4664-4676.
    CrossRef  |  Direct Link  |  

  58. Lutz, S., A.F. Blomquist, U. Rumenapp, M. Schmidt, K.H. Jakobs and T. Wieland, 2004. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. Naunyn Schmiedebergs Arch. Pharmacol., 369: 540-546.
    CrossRef  |  Direct Link  |  

  59. Keiper, M., M.B. Stope, D. Szatkowski, A. Bohm and K. Tysack et al., 2004. Epac- and Ca2+-controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors. J. Biol. Chem., 279: 46497-46508.
    CrossRef  |  Direct Link  |  

  60. Dorp, F., A.Y. Sari, H. Sanders, M. Keiper, P.A.O. Weernink, K.H. Jakobs and M. Schmidt, 2004. Inhibition of phospholipase C- i-coupled receptors. Cell. Signal., 16: 921-928.

  61. Stope, M.B., C. Kunkel, C. Kories, M. Schmidt and M.C. Michel, 2003. Differential agonist-induced regulation of human M2 and M3 muscarinic receptors. Biochem. Pharmacol., 66: 2099-2105.
    CrossRef  |  Direct Link  |  

  62. Schmidt, M., P.A.O. Weernink, F. vom Dorp, M.B. Stope and K.H. Jakobs, 2003. Mammalian phospholipase C. Adv. Mol. Cell Biol., 33: 431-450.
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  63. Genth, H., M. Schmidt, R. Gerhard, K. Aktories and I. Just, 2003. Activation of phospholipase D1 by ADP-ribosylated RhoA. Biochem. Biophys. Res. Commun., 302: 127-132.
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  64. Wilde, C., H. Barth, P. Sehr, L. Han, M. Schmidt, I. Just and K. Aktories, 2002. Interaction of the Rho-ADP-ribosylating C3 exoenzyme with RalA. J. Biol. Chem., 277: 14771-14776.
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  65. Vahid, M.F., N. Gosau, C. Michalek, L. Han and K.H. Jakobs et al., 2002. Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin. J. Mol. Cell Cardiol., 34: 441-453.
    CrossRef  |  Direct Link  |  

  66. Heneweer, C., L.H. Kruse, F. Kindhauser, M. Schmidt, K.H. Jakobs, H.W. Denker and M. Thie, 2002. Adhesiveness of human uterine epithelial RL95-2 cells for trophoblast: Rho protein regulation. Mol. Hum. Reprod., 8: 1014-1022.
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  67. Gosau, N., M.F. Vahid, C. Michalek, M. Schmidt and T. Wieland, 2002. Signalling components involved in the coupling of a1-adrenoceptors to phospholipase D in neonatal rat cardiac myocytes. Naunyn-Schmiedebergs Arch. Pharmacol., 365: 468-476.
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  68. Fetscher, C., M. Fleichmann, M. Schmidt, S. Krege and M.C. Michel, 2002. M3 muscarinic receptors mediate contraction of human urinary bladder. Br. J. Pharmacol., 136: 641-644.
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  69. Evellin, S., J. Nolte, K. Tysack, F. Dorp and M. Thiel et al., 2002. Stimulation of phospholipase C-3 muscarinic acetycholine receptor mediated by cyclic AMP and the GTPase Rap2B. J. Biol. Chem., 277: 16805-16813.
    Direct Link  |  

  70. Schmidt, M., S. Evellin, P.A.O. Weernink, F. Dorp, H. Rehmann, J.W. Lomasney and K.H. Jakobs, 2001. A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nat. Cell Biol., 3: 1020-1024.
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  71. Rumenapp, U., M. Asmus, H. Schablowski, M. Woznicki and L. Han et al., 2001. The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq type G proteins. Regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling. J. Biol. Chem., 276: 2474-2479.
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  72. Weernink, P.A.O., Y. Guo, C. Zhang, M. Schmidt, C.E. Streiber and K.H. Jakobs, 2000. Control of cellular phosphatidylinositol 4,5-bisphosphate levels by adhesion signals and Rho GTPases in NIH 3T3 fibroblasts. Eur. J. Biochem., 267: 5237-5246.
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  73. Weernink, P.A.O., P. Schulte, Y. Guo, J. Wetzel and M. Amano et al., 2000. Stimulation of phosphatidyl-inositol- 4-phosphate 5-kinase by Rho-kinase. J. Biol. Chem., 275: 10168-10174.
    CrossRef  |  Direct Link  |  

  74. Schmidt, M., M. Frings, M.L. Mono, Y. Guo and P.A.O. Weernink et al., 2000. G protein-coupled receptor-induced sensitization of phospholipase C stimulation by receptor tyrosine kinases. J. Biol. Chem., 275: 32603-32610.
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