Dr. Abdul Rahman Asif

Associate Professor
University Medical Center, Goettingen, Germany

Highest Degree
Habilitation in Molecular Medicine from University Medical Center, Goettingen, Germany

My URL
https://livedna.org/49.5611

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Biography

Dr. Abdul Rahman Asif is currently working as Associate Professor of Molecular Medicine at University Medical Center, Goettingen, Germany. He has completed his Habilitation in Molecular Medicine from same University. His main area of interest focuses on Biomedical Sciences, Molecular Sciences, and Proteomics and Mass Spectrometry. His area of expertise includes Proteomics, Clinical Proteomics, Molecular Medicine, Clinical Diagnostics, Mass Spectrometry, Therapeutic Drug Monitoring, Molecular Biology, Molecular Diagnostics, Bioinformatics, Post Translational Modifications, Drug Discovery, Biomarkers and Fungal Antigens. He has 45 publications in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
Proteomics
Mass Spectrometry
Bioinformatics
Biomaterials

Selected Publications

  1. Dieks, J.K., J. Gawinecka, A.R. Asif, D. Varges and K. Gmitterova et al., 2013. Low-abundant CSF proteome alterations in dementia with Lewy bodies. J. Alzheimer's Disease, 34: 387-397.
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  2. Biswas, S., S. Sharmas, A. Saroha, D.S. Bhakuni and R. Malhotra et al., 2013. Identification of novel autoantigen in the synovial fluid of rheumatoid arthritis patients using an immunoproteomics approach. PLoS One, 10.1371/journal.pone.0056246.
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  3. Zahid, S., M. Oellerich, A.R. Asif and N. Ahmed, 2012. Phosphoproteome profiling of substantia nigra and cortex regions of Alzheimer's disease patients. J. Neurochem., 121: 954-963.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Nasim, F.F.H., S. Ejaz, M. Ashraf, A.R. Asif and M. Oellerich et al., 2012. Potential biomarkers in the Sera of Breast Cancer patients from Bahawalpur, Pakistan. Biomarkers Cancer, 4: 19-34.
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  5. Misdaq, M., R. Andag, M. Oellerich, A.R. Asif and N. von Ahsen, 2012. Establishment of Thiopurine S-Methyltransferase gene knockdown in Jurkat T-lymphocytes: An in vitro model of TPMT polymorphism. Ther. Drug Monit., 34: 584-592.
    CrossRef  |  PubMed  |  Direct Link  |  

  6. Gawinecka, J., F. Cardone, A.R. Asif, A.D. Pascalis and W.M. Wemheuer et al., 2012. Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: Impact on Rab3a recycling. Proteomics, 12: 3610-3620.
    CrossRef  |  PubMed  |  Direct Link  |  

  7. Zafar, S., N.V. Ahsen, M. Oellerich, I. Zerr, W.J. Schulz-Schaeffer, V.W. Armstrong and A.R. Asif, 2011. Proteomics approach to identify the interacting partners of cellular prion protein and characterization of Rab7a interaction in neuronal cells. J. Proteome Res., 10: 3123-3135.
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  8. Wakeel, A., A.R. Asif, B. Pitann and S. Schubert, 2011. Proteome analysis of sugar beet (Beta vulgaris L.) elucidates constitutive adaptation during the first phase of salt stress. J. Plant Physiol., 168: 519-526.
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  9. Vasko, R., G.A. Mueller, A.K. von Jaschke, A.R. Asif and H. Dihazi, 2011. Impact of cisplatin administration on protein expression levels in renal cell carcinoma: A proteomic analysis. Eur. J. Pharmacol., 670: 50-57.
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  10. Rahman, H., M. Qasim, F.C. Schultze, M. Oellerich and A.R. Asif, 2011. Fetal calf serum heat inactivation and lipopolysaccharide contamination influence the human T lymphoblast proteome and phosphoproteome. Proteome Sci., Vol. 9. 10.1186/1477-5956-9-71.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Qasim, M., H. Rahman, M. Oellerich and A.R. Asif, 2011. Differential proteome analysis of human embryonic kidney cell line (HEK-293) following mycophenolic acid treatment. Proteome Sci., Vol. 9, 10.1186/1477-5956-9-57.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Petrova, D.T., F. Brehmer, F.C. Schultze, A.R. Asif, O. Gross, M. Oellerich and G. Brandhorst, 2011. Differential kidney proteome profiling in a murine model of renal fibrosis under treatment with Mycophenolate mofetil. Pathobiology, 78: 162-170.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Hruzik, A., A.R. Asif and U. Grob, 2011. Identification of Toxoplasma gondii antigen SUB1 as a marker for the acute infection using an innovative evaluation method. J. Clin. Microbiol., 49: 2419-2425.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Dihazi, H., G.H. Dihazi, O. Jahn, S. Meyer and J. Nolte et al., 2011. Multipotent adult germline stem cells and embryonic stem cells functional proteomics revealed an important role of eukaryotic initiation factor 5A (Eif5a) in stem cell differentiation. J. Proteome. Res., 10: 1962-1973.
    CrossRef  |  PubMed  |  Direct Link  |  

  15. Dihazi, H., G.H. Dihazi, C. Mueller, L. Lahrichi and A.R. Asif et al., 2011. Proteomics characterization of cell model with renal fibrosis phenotype: Osmotic stress as fibrosis triggering factor. J. Proteomics, 74: 304-318.
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  16. Weiss, E., S. Ramljak, A.R. Asif, B. Ciesielczyk and M. Schmitz et al., 2010. Cellular prion protein overexpression disturbs cellular homeostasis in SH-SY5Y neuroblastoma cells but does not alter p53 expression: A proteomic study. Neuroscience, 169: 1640-1650.
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  17. Singh, B., M. Oellerich, R. Kumar, M. Kumar and D.P. Bhadoria et al., 2010. Immuno-reactive molecules identified from the secreted proteome of Aspergillus fumigatus. J. Proteome. Res., 9: 5517-5529.
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  18. Singh, B., G.L. Sharma, M. Oellerich, R. Kumar and S. Singh et al., 2010. Novel cytosolic allergens of Aspergillus fumigatus identified from germinating conidia. J. Proteome. Res., 9: 5530-5541.
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  19. Schultze, F.C., D.T. Petrova, M. Oellerich, V.W. Armstrong and A.R. Asif, 2010. Differential proteome and phosphoproteome signatures in human T-lymphoblast cells induced by sirolimus. Cell Prolif, 43: 396-404.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Schott, P., C. Jacobshagen, J. Kohler, T. Seidler and A.R. Asif et al., 2010. Proteome changes in CaMKIIδC-overexpressing cardiac myocytes. Cardiovasc Pathol., 19: e241-250.
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  21. Knoferle, J., S. Ramljak, J.C. Koch, L. Tonges and A.R. Asif et al., 2010. TGF-β 1 enhances neurite outgrowth via regulation of proteasome function and EFABP. Neurobiol. Dis., 38: 395-404.
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  22. Gawinecka, J., J. Dieks, A.R. Asif, J. Carimalo and U. Heinemann et al., 2010. Codon 129 polymorphism specific cerebrospinal fluid proteome pattern in sporadic Creutzfeldt-Jakob disease and the implication of glycolytic enzymes in prion-induced pathology. J. Proteome Res., 9: 5646-5657.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Asif, A.R., M. Oellerich, V.W. Amstrong, U. Gross and U. Reichard, 2010. Analysis of the cellular Aspergillus fumigatus proteome that reacts with sera from rabbits developing an acquired immunity after experimental aspergillosis. Electrophoresis, 31: 1947-1958.
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  24. Agarwal, N.K., G.A. Mueller, C. Mueller, J.H. Streich, A.R. Asif and H. Dihazi, 2010. Expression proteomics of acute promyelocytic leukaemia cells treated with methotrexate. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1804: 918-928.
    CrossRef  |  PubMed  |  Direct Link  |  

  25. Pal, A., R. Kraetzner, T. Gruene, M. Grapp and K. Schreiber et al., 2009. Structure of tripeptidyl-peptidase I provides insight into the molecular basis of late infantile neuronal ceroid lipofuscinosis. J. Biol. Chem., 284: 3976-3984.
    CrossRef  |  PubMed  |  Direct Link  |  

  26. Linker, R.A., P. Brechlin, S. Jesse, P. Steinacker and D.H. Lee et al., 2009. Proteome profiling in murine models of multiple sclerosis: Identification of stage specific markers and culprits for tissue damage. PLoS One, 10.1371/journal.pone.0007624.
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  27. Heller, T., A.R. Asif, D. Petrova, Y. Doncheva and E. Wieland et al., 2009. Differential proteomic analysis of lymphocytes treated with mycophenolic acid reveals caspase 3-induced cleavage of Rho GDP dissociation inhibitor 2. Ther. Drug Monit., 31: 211-217.
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  28. Asif, A.R., M. Oellerich, V.W. Armstrong, M. Hecker and M. Cattaruzza, 2009. The T-786C polymorphism of the nos-3 gene and the endothelial cell response to fluid shear stress-A proteome analysis. J. Proteome. Res., 8: 3161-3168.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Asif, A.R., M. Hecker and M. Cattaruzza, 2009. Disinhibition of SOD-2 expression to compensate for a genetically determined no deficit in endothelial cells-brief report. Arteriosclerosis Thrombosis Vasc. Biol., 29: 1890-1893.
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  30. Schott, P., A.R. Asif, C. Graf, K. Toischer, G. Hasenfuss and H. Kogler, 2008. Myocardial adaptation of energy metabolism to elevated preload depends on calcineurin activity. Basic Res. Cardiol., 103: 232-243.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. Ramljak, S., A.R. Asif, V.W. Armstrong, A. Wrede and M.H. Groschup et al., 2008. Physiological role of the cellular prion protein (PrPc): Protein profiling study in two cell culture systems. J. Proteome. Res., 7: 2681-2695.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. Petrova, D.T., A.R. Asif, V.W. Armstrong, I. Dimova and S. Toshev et al., 2008. Expression of chloride intracellular channel protein 1 (CLIC1) and tumor protein D52 (TPD52) as potential biomarkers for colorectal cancer. Clin. Biochem., 41: 1224-1236.
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  33. Sabolic, I., A.R. Asif, W.E. Budach, C. Wanke, A. Bahn and G. Burckhardt, 2007. Gender differences in kidney function. Pflug Arch.-Eur. J. Phy., 455: 397-429.
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  34. Dihazi, H., G.A. Muller, S. Lindner, M. Meyer, A.R. Asif, M. Oellerich and F. Strutz, 2007. Characterization of diabetic nephropathy by urinary proteomic analysis: Identification of a processed ubiquitin form as a differentially excreted protein in diabetic nephropathy patients. Clin. Chem., 53: 1636-1645.
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  35. Dihazi, H., C. Muller, A.R. Asif, T. Flad, A. Elmaouhoub and G.A. Muller, 2007. Whole cell profiling and identification of galectin-1 as a potential marker of renal cell carcinoma. Proteomics. Clin. Appl., 1: 200-214.
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  36. Asif, A.R., V.W. Armstrong, A. Voland, E. Wieland, M. Oellerich and M. Shipkova, 2007. Proteins identified as targets of the acyl glucuronide metabolite of mycophenolic acid in kidney tissue from mycophenolate mofetil treated rats. Biochumie, 89: 393-402.
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  37. Reichard, U., B. Lechenne, A.R. Asif, F. Streit, E. Grouzmann, O. Jousson and M. Monod, 2006. Sedolisins, a new class of secreted proteases from Aspergillus fumigatus with endoprotease or tripeptidyl-peptidase activity at acidic pHs. Applied Environ. Microbiol., 72: 1739-1748.
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  38. Koehler, S.C., N.V. Ahsen, C. Schlumbohm, A.R. Asif and U. Goedtel-Armbrust et al., 2006. Marmoset CYP3A21, a model for human CYP3A4: Protein expression and functional characterization of the promoter. Xenobiotica, 36: 1210-1226.
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  39. Asif, A.R., M. Oellerich, V.W. Amstrong, B. Riemenschneider, M. Monod and U. Reichard, 2006. Proteome of conidial surface associated proteins of Aspergillus fumigatus reflecting potential vaccine candidates and allergens. J. Proteome Res., 5: 954-962.
    CrossRef  |  PubMed  |  Direct Link  |  

  40. Asif, A.R., M. Ljubojevic, I. Sabolic, V. Shnitsar and M. Metten et al., 2006. Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEA-S treatment in adrenocortical cells. Am. J. Physiol-Endoc. M, 291: E1351-E1359.
    PubMed  |  

  41. Dihazi, H., A.R. Asif, N.K. Agarwal, Y. Doncheva and G.A. Muller, 2005. Proteomic analysis of cellular response to osmotic stress in thick ascending limb of Henle's loop (TALH) cells. Mol. Cell Proteomics, 4: 1445-1458.
    CrossRef  |  PubMed  |  Direct Link  |  

  42. Asif, A.R., J. Steffgen, M. Metten, R.W. Grunewald and G.A. Muller et al., 2005. Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells. Pflug Arch. Eur. J. Phy., 450: 88-95.
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  43. Hagos, Y., A. Bahn, A.R. Asif, W. Krick, M. Sendler and G. Burckhardt, 2002. Cloning of the pig renal organic anion transporter 1 (pOAT1). Biochimie, 84: 1219-1222.
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  44. Akhtar, M.S., A.R. Asif and M.A. Sheikh, 2000. Antihepatotoxic effects of Butea monosperma flowers against liver damage induced by paracetamol and carbon tetrachloride in rats. Proc. Pak. Acad. Sci., 37: 171-177.

  45. Raza, A., A.R. Asif and G. Yasin, 1999. Uses of Nigela sativa (Ranunculaceae): A tradictional medicine. Int. J. Agric. Biol., 1: 184-187.
Member since January, 2016