Dr. Roberto Martinez

Research Scientist
Institute of Chemistry, Mexico

Highest Degree
Ph.D. in Chemistry from CINVESTAV, Mexico

My URL
https://livedna.org/52.31517

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Area of Interest:

Chemistry
Physical Chemistry
Organic Chemistry
Medicinal Chemistry
Pharmaceutical Chemistry

Selected Publications

  1. Martinez, R., G.J.N. Zamudio, G. Pretelin-Castillo, R.O. Torres-Ochoa and J.L. Medina-Franco et al., 2019. Synthesis and antitubercular activity of new N-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-(nitroheteroaryl)carboxamides. Heterocycl. Commun., 25: 52-59.
    CrossRef  |  Direct Link  |  

  2. Martinez, R., C.I. Espitia-Pinzon, M.S. Miranda, R.M. Chavez‐Santos and G. Pretelin-Castillo et al., 2019. Synthesis and antituberculosis activity of new acylthiosemicarbazides designed by structural modification. Drug Dev. Res., (In Press). 10.1002/ddr.21626.
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  3. Gonzalez-Chavez, M.M., V. Arana-Argaez, J.R. Zapata-Morales, A.K. Avila-Venegas, A.J. Alonso-Castro, M. Isiordia-Espinoza and R. Martinez, 2017. Pharmacological evaluation of 2-angeloyl ent-dihydrotucumanoic acid. Pharmaceut. Biol., 55: 873-879.
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  4. Chavez-Santos, R.M., P.E. Reyes-Gutierrez, R.O. Torres-Ochoa, M.T. Ramirez-Apan and R. Martinez, 2017. 5,6-dihydropyrrolo[2,1-a]isoquinolines as alternative of new drugs with cytotoxic activity. Chem. Pharmaceut. Bull., 65: 973-981.
    CrossRef  |  Direct Link  |  

  5. Alonso-Castro, A.J., M.M. Gonzalez-Chavez, J.R. Zapata-Morales, A.K. Verdinez-Portales and A. Sanchez-Recillas et al., 2017. Antinociceptive activity of ent-dihydrotucumanoic acid isolated from Gymnosperma glutinosum Spreng less. Drug Dev. Res., 78: 340-348.
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  6. Torres-Ochoa, R.O., P.E. Reyes-Gutierrez and R. Martinez, 2014. Synthesis of the pentacyclic framework of the alkaloid tronocarpine. Eur. J. Org. Chem., 1: 48-52.
    CrossRef  |  Direct Link  |  

  7. Noriega-Navarro, R., O. Lopez-Charcas, B. Hernandez-Enriquez, P.E. Reyes-Gutierrez and R. Martinez et al., 2014. Novel TASK channels inhibitors derived from dihydropyrrolo[2,1-a]isoquinoline. Neuropharmacology, 79: 28-36.
    CrossRef  |  Direct Link  |  

  8. Gonzalez-Chavez, R., R. Martinez, M.E. Torre-Bouscoulet, M. Gallo and M.M. Gonzalez-Chavez, 2014. De novo design of non-coordinating indolones as potential inhibitors for lanosterol 14-α-demethylase (CYP51). Chem. Pharmaceut. Bull., 62: 16-24.
    CrossRef  |  Direct Link  |  

  9. Chay, C.I.C., R.G. Cansino, C.I.E. Pinzon, R.O. Torres-Ochoa and R. Martinez, 2014. Synthesis and anti-tuberculosis activity of the marine natural product caulerpin and its analogues. Mar. Drugs, 12: 1757-1772.
    CrossRef  |  Direct Link  |  

  10. Ramirez-Martinez, J., R. Gonzalez-Chavez, R. Guerrero-Alba, P. Reyes-Gutierrez and R. Martinez et al., 2013. Dibenzo[1,2,5]thiadiazepines are non-competitive GABAA receptor antagonists. Molecules, 18: 894-913.
    CrossRef  |  Direct Link  |  

  11. O'Reilly, B., A.M. Plutin, H. Perez, O. Calderon and R. Ramos et al., 2012. Synthesis and structural characterization of cobalt(II) and copper(II) complexes with N,N-disubstituted-N′-acylthioureas. Polyhedron, 36: 133-140.
    CrossRef  |  Direct Link  |  

  12. Perez, H., B. O'Reilly, A.M. Plutin, R. Martinez, R. Duran, I.G. Collado and Y.P. Mascarenhas, 2011. Synthesis, characterization and crystal structure of Ni(II) and Cu(II) complexes with N-furoyl-N′,N′-diethylthiourea: Antifungal activity. J. Coord. Chem., 64: 2890-2898.
    CrossRef  |  Direct Link  |  

  13. Gonzalez-Chavez, M.M., F. Mendez, R. Martinez, C. Perez-Gonzalez and F. Martinez-Gutierrez, 2011. Design and synthesis of anti-MRSA benzimidazolylbenzene-sulfonamides. QSAR studies for prediction of antibacterial activity. Molecules, 16: 175-189.
    CrossRef  |  Direct Link  |  

  14. Villarreal, C. and R. Martinez, 2010. Synthesis of novel furo-, thieno- and pyrroloazepines. Synthesis, 19: 3346-3352.
    CrossRef  |  Direct Link  |  

  15. Reyes-Gutierrez, P.E., J.R. Camacho, M.T. Ramirez-Apan, Y.M. Osornio and R. Martinez, 2010. Synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines featuring an intramolecular radical-oxidative cyclization of polysubstituted pyrroles and evaluation of their cytotoxic activity. Org. Biomol. Chem., 8: 4374-4382.
    CrossRef  |  Direct Link  |  

  16. Plutin, A.M., M. Suarez, T. Machado, A. Alvarez and A. Rodriguez et al., 2010. On the selective methylation of benzoyl and furoylthiocarbamates. Arkivoc, 10: 276-290.
    CrossRef  |  Direct Link  |  

  17. Cespedes, C.L., M.E. Rodriguez, J.G. Avila and R. Martinez, 2010. Plant growth inhibitory activity of N,N'-di-(4-R-phenyl)-alkanediamides. Bol. Latinoam. Caribe Plantas Med. Arom., 9: 246-257.
    Direct Link  |  

  18. Reyes-Gutierrez, P.E., R.O. Torres-Ochoa, R. Martinez and L.D. Miranda, 2009. Synthesis of azepino[4,5-b]indolones via an intermolecular radical oxidative substitution of N-Boc tryptamine. Org. Biomol. Chem., 7: 1388-1396.
    CrossRef  |  Direct Link  |  

  19. Martinez, R., S. Hernandez-Ortega, L. Triana and J. Camacho, 2009. 3-Hydroxy-5,5-dimethyl-2-(2-oxopropyl)cyclohex-2-enone. Acta Crystallogr. Sect. E: Struct. Rep. Online, 65: o3186-o3186.
    CrossRef  |  Direct Link  |  

  20. Martinez, R., M.M. Arzate and M.T. Ramirez-Apan, 2009. Synthesis and cytotoxic activity of new azepino[3′,4′:4,5]pyrrolo[2,1-a]isoquinolin-12-ones. Bioorg. Med. Chem., 17: 1849-1856.
    CrossRef  |  Direct Link  |  

  21. Martinez, R., A. Clara-Sosa and M.T.R. Apan, 2007. Synthesis and cytotoxic evaluation of new (4,5,6,7-tetrahydro-indol-1-yl)-3-R-propionic acids and propionic acid ethyl esters generated by molecular mimicry. Bioorg. Med. Chem., 15: 3912-3918.
    CrossRef  |  Direct Link  |  

  22. Martinez, R., J.G. Avila, M.T. Ramirez, A. Perez and A. Martinez, 2006. Tetrahydropyrrolo[3,2-c]azepin-4-ones as a new class of cytotoxic compounds. Bioorg. Med. Chem., 14: 4007-4016.
    CrossRef  |  Direct Link  |  

  23. Martinez, R. and L. Chacon-Garcia, 2005. The search of DNA-intercalators as antitumoral drugs: What it worked and what did not work. Curr. Med. Chem., 12: 127-151.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Negron, G., D. Angeles, L. Lomas, A. Martinez, M. Ramirez and R. Martinez, 2004. An efficient synthesis of 6,6-Dimethyl-2-(4-nitrophenyl)-1-(R-phenyl)-4,5,6,7-tetrahydro-1H-4-indolones using a solid sulfated zirconia as catalyst. Heterocycles, 63: 367-371.
    CrossRef  |  Direct Link  |  

  25. Menes-Arzate, M., R. Martinez, R. Cruz-Almanza, J.M. Muchowski, Y.M. Osornio and L.D. Miranda, 2004. Efficient, “Tin-Free” radical cyclization to aromatic systems. Synthesis of 5,6,8,9,10,11-hexahydroindolo[2,1-a]isoquinolines. J. Org. Chem., 69: 4001-4004.
    CrossRef  |  Direct Link  |  

  26. Martinez, R., G. Avila-Zarraga, M.T. Ramirez and A. Perez, 2003. Cytotoxic evaluation of substituted azetopyrroloazepinones. ARKIVOC: Arch. Org. Chem., 11: 48-55.
    CrossRef  |  Direct Link  |  

  27. Juaristi, E. and R. Martinez, 2003. A few comments on the development of organic chemistry in Mexico. ARKIVOC: Arch. Org. Chem., 11: 1-3.
    CrossRef  |  Direct Link  |  

  28. Chacon-Garcia, L., M.E. Rodriguez and R. Martinez, 2003. Cytotoxic evaluation of a series of bisalkanoic anilides and bisbenzoyl diamines. Rev. Soc. Quim. Mexico, 47: 186-189.
    Direct Link  |  

  29. Reyes-Duarte, D., E. Castillo, R. Martinez and A. Lopez-Munguia, 2002. Lipase-catalysed synthesis of olvanil in organic solvents. Biotechnol. Lett., 24: 2057-2061.
    CrossRef  |  Direct Link  |  

  30. Martinez, L.R., J.G.A. Zarraga, M.E. Duran, M.T.R. Apam and R. Canas, 2002. Synthesis of novel furo, thieno and benzazetoazepines and evaluation of their cytotoxicity. Bioorg. Med. Chem. Lett., 12: 1675-1677.
    CrossRef  |  Direct Link  |  

  31. Insuasty, B., F. Fernandez, J. Quiroga, R. Martinez, R. Gavino and E. Angeles, 2002. Reaction of 1,2-diaminobenzimidazole with 1-aryl-2-bromo-3-phenylpropanone. synthesis of 2-aryl-3-benzyl-9-aminoimidazo[1,2-A] benzimidazoles. Heterocycl. Commun., 8: 151-156.
    CrossRef  |  Direct Link  |  

  32. Chacon-Garcia, L., R. Martinez and M.I. Chavez, 2002. A non-sterically preferred conformation in bis-1,4-(2-methyl-4, 5-dihydro-1H-benzo[g]indolyl)benzene. Rev. Soc. Quim. Mexico, 46: 216-218.
    Direct Link  |  

  33. Chacon-Garcia, L. and R. Martinez, 2002. Synthesis and in vitro cytotoxic activity of pyrrolo[2,3-e]indole derivatives and a dihydro benzoindole analogue. Eur. J. Med. Chem., 37: 261-266.
    CrossRef  |  Direct Link  |  

  34. Insuasty, B., R. Rodriguez, J. Quiroga, R. Abonia, R. Martinez, A. Toscano and E. Angeles, 2001. Synthesis of 1-benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines. Molecules, 6: 710-715.
    CrossRef  |  Direct Link  |  

  35. Chacon-Garcia, L. and R. Martinez, 2001. Cytotoxic activity and QSAR of N,N′-diarylalkanediamides. Eur. J. Med. Chem., 36: 731-736.
    CrossRef  |  Direct Link  |  

  36. Avila-Zarraga, J.G. and R. Martinez, 2001. Efficient methylation of carboxylic acids with potassium hydroxide/methyl sulfoxide and iodomethane. Synth. Commun., 31: 2177-2183.
    CrossRef  |  Direct Link  |  

  37. Angeles, E., H. Santillan, I. Menconi, I. Martinez and A. Ramirez et al., 2001. Rearrangement of o-nitrobenzaldehyde in the Hantzsch reaction. Molecules, 6: 683-693.
    CrossRef  |  Direct Link  |  

  38. Nava-Salgado, V.O., R. Martinez, M.R. Arroyo and G.R. Galicia, 2000. Molecular association for the design of anti-HIV-1 agents. Conformational study of {3′-azido-3′-deoxythymidine}-{4,5,6,7-tetrahydro-5-methylimidazo-[4,5,1-jk][1,4]benzodiazepin-2(1H)-one} derivatives. J. Mol. Struct.: THEOCHEM, 504: 69-75.
    CrossRef  |  Direct Link  |  

  39. Martinez, R., J.G. Avila-Zarraga, G. Lopez-Lopez and V.O. Nava-Salgado, 2000. Synthesis of the new triheterocyclic system C3N-C4N-C6N. 3-Aryl-2,5,5-trimethyl-9a-methylsulfanyl-9-phenoxy-4,5,6,8,9,9a-hexahydro-3H-azeto[1,2-a]pyrrolo[3,2-c]azepin-8-ones. Heterocycles, 53: 557-570.
    CrossRef  |  Direct Link  |  

  40. Martinez, R., J.A. Cogordan, C. Mancera and M.L. Diaz, 2000. Synthesis and cytotoxic evaluation of N1,Nm-bis[(tetrahydrobenzo[a]acridin-12-yl)phenyl]alkanediamides and N1,Nm-bis[(tetrahydrobenzo[c]acridin-7-yl)phenyl]alkanediamides. Il Farmaco, 55: 631-636.
    CrossRef  |  Direct Link  |  

  41. Angeles, E., P. Martinez, J. Keller, R. Martinez and M. Rubio et al., 2000. Ethyl and methylphenylcarbamates as antihelmintic agents: Theoretical study for predicting their biological activity by PM3. J. Mol. Struct.: THEOCHEM, 504: 141-170.
    CrossRef  |  Direct Link  |  

  42. Valle, L., M.M. Gonzalez and R. Martinez, 1999. Reaction of 4(7)-aminobenzimidazole with ethyl 2-alkylmalonates in 1,2,4-trichlorobenzene. Rev. Soc. Quim. Mexico, 43: 110-112.
    Direct Link  |  

  43. Ramirez, G., M.R. Arroyo, R. Martinez and E. Angeles, 1999. Rearrangement of substituted 11-phenyl-1H-dibenzo[b,e] [1,4]diazepin-1-one to dihydrophenazin-1-(2H)-one: A theoretical approach. J. Mol. Struct.: THEOCHEM, 489: 7-17.
    CrossRef  |  Direct Link  |  

  44. Martinez, R., M.E. Duran, C. Cortes and J.G. Avila, 1999. 2-Aryl-7,7-dimethyl-5,6,7,8-tetrahydrothieno[3,2-c]azepin-4-ones from 5,5-dimethyl-1,3-cyclohexanedione. J. Heterocycl. Chem., 36: 687-690.
    CrossRef  |  Direct Link  |  

  45. Lara, F., R. Cruz, M. Martinez, R. Martineza and B. Villaneda et al., 1999. A novel crown ether. 2C60 complex. Supramol. Chem., 10: 185-191.
    CrossRef  |  Direct Link  |  

  46. Cogordan, J.A., M. Mayoral, E. Angeles, R.A. Toscano and R. Martinez, 1999. Neuroleptic and antidepressant tricyclic compounds: Theoretical study for predicting their biological activity by semiempirical, density functional and Hartree-Fock methods. Int. J. Quantum Chem., 71: 415-432.
    CrossRef  |  Direct Link  |  

  47. Martinez, R., J.S. Oloarte and G. Avila, 1998. 1,3-cyclohexanedione as the precursor of C4X-C6-C4Y systems. Synthesis of pyrrolo[2,3-e]indoles and thieno[2,3-e]indoles. J. Heterocycl. Chem., 35: 585-589.
    CrossRef  |  Direct Link  |  

  48. Martinez, R., H.M. Mendoza and E. Angeles, 1998. 5-Aryl-3-methyl-2-cyclohexen-1-ones from 4-aryl-1, 4-dihydropyridines (Hantzsch esters). Synth. Commun., 28: 2813-2820.
    CrossRef  |  Direct Link  |  

  49. Insuasty, B., J. Quiroga, J.C. Argoti, S. Gomez and R. Martinez et al., 1998. Synthesis of 4-aryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]-diazepin-6-ones from 4,5-diamino-1H-pyrimidin-6-ones and 1-aryl-3-(dimethylamino)-1-propanones. J. Heterocycl. Chem., 35: 1397-1399.
    CrossRef  |  Direct Link  |  

  50. Insuasty, B., F. Ferneandez, J. Quiroga, R. Moreno and R. Martinez et al., 1998. Synthesis of 2-(p-R-benzoylmethylene)-3-(p-R-phenyl)-1H-quinoxalines. J. Heterocycl. Chem., 35: 977-981.
    CrossRef  |  Direct Link  |  

  51. Grosu, I., S. Mager, R. Martinez, B.D.C. Camacho, G. Ple and C. Mesaros, 1998. The synthesis, stereochemistry and nmr spectra of some new spiro-1,3-dioxanes. Revue Roumaine Chimie, 43: 725-733.
    Direct Link  |  

  52. Ayala, G.F., E. Campos, R. Martinez, A. Nieto and J. Taboada, 1998. Effect of 1,5-benzodiazepine derivatives on sleep. Proc. Western Pharmacol. Soc., 41: 29-32.
    PubMed  |  

  53. Martinez, R., R. Gavino and G. Avila, 1997. Synthesis, reactivity and spectral properties of some 12-(o- and p-R-phenyl)-9, 9-dimethyl-8,9,10,11-tetrahydrobenz[a]acridin-11-ones and 7-(o- and p-R-phenyl)-10,10-dimethyl-8,9,10,11-tetrahydrobenz[c]acridin-8-ones. Trends Heterocycl. Chem., 5: 75-81.
    Direct Link  |  

  54. Martinez, R., R. Cetina, F. Jimenez, L. Velasco and J. Perez, 1997. A mass spectrometric investigation on some 5-substituted adamantan-2-ones. Spectroscopy, 13: 207-212.
    CrossRef  |  Direct Link  |  

  55. Martinez, R., M. Velasco, I. Martinez, I. Menconi and A. Ramfrez et al., 1997. Clay catalized rearrangement of phenyloxiranes. J. Heterocycl. Chem., 34: 1865-1866.
    CrossRef  |  Direct Link  |  

  56. Martinez, R., L. Valle, M. Gonzalez and C. Romano, 1997. Heterocyclic variants of the 1,5-benzodiazepine system. VIII. Reaction of 4(7)-aminobenzimidazole with ethyl 2-alkylmalonates. J. Heterocycl. Chem., 34: 1043-1045.
    CrossRef  |  Direct Link  |  

  57. Insuasty, B., R. Rodriguez, J. Quiroga, R. Martinez and E. Angeles, 1997. Synthesis of substituted 1-benzyl-2,4,6-triphenyl-2,3-dihydro-pyrazolo [3,4-b] [1,4]diazepines. J. Heterocycl. Chem., 34: 1131-1133.
    CrossRef  |  Direct Link  |  

  58. Grosu, I., S. Mager, G. Ple, N. Ple, A. Toscano, E. Mesaros and R. Martinez, 1997. Synthesis and stereochemistry of some 1,3-dioxane diacetals of o-phthaldialdehyde. Liebigs Annalen, 11: 2371-2377.
    CrossRef  |  Direct Link  |  

  59. Grosu, I., G. Ple, S. Mager, R. Martinez, C. Mesaros and B.D.C. Camacho, 1997. Synthesis and stereochemistry of some new chiral spiro-1,3-dioxanes. Tetrahedron, 53: 6215-6232.
    CrossRef  |  Direct Link  |  

  60. Grosu, I., B.D.C. Camacho, A. Toscano, G. Ple, S. Mager, R. Martinez and R.R. Gavino, 1997. Synthesis and stereochemistry of some new brominated spiro 1,3-dioxanes. J. Chem. Soc. Perkin Trans., 1: 775-782.
    CrossRef  |  Direct Link  |  

  61. Gaytan, P., J. Yan, X. Soberon and R. Martinez, 1997. A new method for oligonucleotide derivatization of the 3′ or 5′- termini with a CPG-support carrying the natural product isoargentatin-D. Tetrahedron Lett., 38: 6123-6126.
    CrossRef  |  Direct Link  |  

  62. Martinez, R., R.C. Espinosa, R.A. Toscano, J.A. Cogordan and M.D.R. Arellano et al., 1996. Computational studies, synthesis and biological investigations of N-[(p-bromo)carboxyphenyl]dibenz[b,f]azepine. J. Heterocycl. Chem., 33: 715-718.
    CrossRef  |  Direct Link  |  

  63. Martinez, R., P.E. Hernandez and E. Angeles, 1996. Heterocyclic variants of 1,5-benzodiazepine system. VII. Synthesis of substituted 2a-phenyl-4-methylsulfonyl-2-methoxy-1,2,2a,3-tetrahydroazeto[1,2-a][1,5]benzodiazepine-1-ones. J. Heterocycl. Chem., 33: 271-274.
    CrossRef  |  Direct Link  |  

  64. Martinez, R., P. Arteaga and C. Mancera, 1996. Azo dyes derived from Aminophenylbenzacridinones. VIII. J. Heterocycl. Chem., 33: 489-491.
    CrossRef  |  Direct Link  |  

  65. Martinez, R., M.F. Rubio, A. Toxqui and R. Cetina, 1996. Physicochemical properties and electronic structure of 12-(ortho- and para-R-phenyl)-9,9-dimethyl-8,9,10,11-tetrahydrobenz[a]acridin-11-ones. Anales de Quimica, 92: 167-170.

  66. Martinez, R., E. Angeles and F. Martinez, 1996. Reaction of substituted 2,3,4,5,10,11-hexahydro-3,3-dimethyl-11-phenyl-1H-dibenz[b,e][1,4]diazepin-1-ones with m-chloroperoxybenzoic acid. Heterocycl. Commun., 2: 47-50.
    CrossRef  |  Direct Link  |  

  67. Grosu, I., S. Mager, G. Ple and R. Martinez, 1996. Considerations about the chirality of the saturated six‐membered rings with two or more heteroatoms. Chirality, 8: 311-315.
    CrossRef  |  Direct Link  |  

  68. Menconi, I., E. Angeles, L. Martinez, M.E. Posada, R.A. Toscano and R. Martinez, 1995. Abnormal ring closure and oxidation in situ of 2-hydroxy-5-nitrobenzaldehyde in the hantzsch synthesis. J. Heterocycl. Chem., 32: 831-833.
    CrossRef  |  Direct Link  |  

  69. Martinez-Vazquez, M., R. Martinez and R.A. Toscano, 1995. Preparation, spectral studies and X-ray crystal structures of (16S, 17R, 20S)-3-oxo-16-hydroxy-25-nor-lanostan-24-oic lactone (II) and (16S, 17R, 20S)-4,16-dihydroxy-25-nor-3,4-seco-lanostan-3,24-dioic acid dilactone (III). J. Chem. Crystallogr., 25: 331-337.
    CrossRef  |  Direct Link  |  

  70. Martinez, R., M.F. Rubio, R.G. Guillermo, T. Camacho, L.E. Irma and C. Mancera, 1995. Reaction of tetrahydrobenz[a]acridinones with hydroxylamine hydrochloride. VII. J. Heterocycl. Chem., 32: 827-830.
    CrossRef  |  Direct Link  |  

  71. Martinez, R., M.F. Rubio, L.J. Alfaro and R. Salcedo, 1995. Conformational analysis of analogs of fentanyl: A theoretical approach. Possible influence of the anomeric effect on its biological activity. J. Mol. Struct.: THEOCHEM, 342: 141-146.
    CrossRef  |  Direct Link  |  

  72. Martinez, R., G. Lopez and A.Z. Gustavo, 1995. Synthesis and spectral properties of 6H-1-(2-, 3‐ and 4-R-Phenyl)-2,7,7-trimethyl-4,5,7,8-tetrahydropyrrolo[3,2-c]azepin-4-ones. J. Heterocycl. Chem., 32: 491-493.
    CrossRef  |  Direct Link  |  

  73. Martinez, R., G. Espinosa-Perez and M. Brito-Arias, 1995. Synthesis of 3,4-dihydro-3,3-dimethyl-1(2H)-acridinone. J. Chem. Crystallogr., 25: 201-203.
    CrossRef  |  Direct Link  |  

  74. Martinez, R., G. Avila and E. Reyes, 1995. Unusual sulfonation of 1-(4-R-phenyl)-2.6,6-trimethyl-4-oxo-4,5,6,7-tetrahydroindoles under Schmidt conditions. Synth. Commun., 25: 1071-1076.
    CrossRef  |  Direct Link  |  

  75. Martinez, R., E. Limon, M.D.R. Arellano, M. Martinez and M. Brito, 1995. Synthesis of pyrazole analogs from argentatin B. Collect. Czech. Chem. Commun., 60: 612-618.
    CrossRef  |  Direct Link  |  

  76. Grosu, I., S. Mager, G. Ple, R. Martinez, M. Horn and R.R. Gavino, 1995. The stereochemistry of some new chiral brominated compounds with a 2,4,8,10-tetraoxaspiro[5.5]undecanic skeleton. Chem. Monthly, 126: 1021-1030.
    CrossRef  |  Direct Link  |  

  77. Grosu, I., S. Mager, G. Ple, R. Martinez, L. Muntean and E. Mesaros, 1995. Synthesis and stereochemistry of chiral 1,3-dioxanic compounds obtained from α-alkylated β-ketoesters. Heterocycles, 10: 2233-2244.
    CrossRef  |  Direct Link  |  

  78. Glass, R.S., W.P. Singh, R.M. Mobashar and A. Petsom, 1995. Synthesis of 1,2-dithiolane 1-oxides from substituted 1,3-dithaianes. A synthesis of the methyl ester of asparagusic acid S-oxides. Sulfur Lett., 18: 259-266.

  79. Calzada, L., E.L. Salazar, J. Tellez, M. Martinez and R. Martinez, 1995. Effect of tetracyclic triterpenes (argentatins A, B and D) on the estradiol receptor of hormone-dependent tumours of human breast. Med. Sci. Res., 23: 815-816.

  80. Martinez-Vazquez, M., R. Martinez, G.E. Perez, M. Diaz and M.H. Sanchez, 1994. Antimicrobial properties of argentatine A, isolated from Parthenium argentatum. Fitoterapia, 65: 371-372.

  81. Martinez, R., M.F. Rubio, R.A. Toscano, X. Villalobos and M.A. Brito, 1994. Praziquantel analogs. Synthesis of substituted 4-(2-,3- and 4-R)-carboxyphenyl-1,4-pyrazin-2-ones. J. Heterocycl. Chem., 31: 1521-1523.
    CrossRef  |  Direct Link  |  

  82. Martinez, R., L. Velasco, T. Reyes, H. Pozas, P. Carballo, A. Javier and M. Melchor, 1994. Electron impact mass spectrometry of N-(2-methylpropyl)-3-(o-, m- and p-R-phenyl)-2-propenamidesl. J. Spectrosc., 12: 9-20.
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  83. Martinez, R., L. Velasco, G. Lopez and G. Avila, 1994. A mass spectrometric investigation on some 1-aryl-4-oxo-4,5,6,7-tetrahydroindole derivatives. Spectrosc.: Int. J., 12: 109-116.

  84. Martinez, R., J.S. Calderon, R.A. Toscano, L. Valle-Aguilera and H.M. Mendoza-Candelaria, 1994. Ent-neoclerodane diterpenes from Gymnosperma glutinosum. Phytochemistry, 35: 1505-1507.
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  85. Martinez, R., C.C. Eduardo, S.E. Olivia and L.E. Irma, 1994. Reactions on the dimethylphenylbenzacridinones. VI. Hydrogenation of ortho-nitrophenyl derivatives. J. Heterocycl. Chem., 31: 1061-1063.
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  86. Angeles, E., A. Santillan, I. Martinez, A. Ramirez, E. Moreno, M. Salmon and R. Martinez, 1994. A simple method for the synthesis of carbamates. Synth. Commun., 24: 2441-2447.
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  87. Martinez, R., M.D.R. Arellano-Garcia, M. Martinez-Vazquez and A.G. Julian, 1993. Synthesis of carbenoxolone analogs from argentatin B. Org. Prep. Proced. Int., 25: 698-703.
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  88. Martinez-Vazquez, M., H.M. Vazquez and R. Martinez, 1992. Aromatic metabolites from Conoclinium gregii (Gray). Phytochemistry (Life Sci. Adv.), 11: 47-49.

  89. Martinez, R., R.A. Toscano, I.E. Linzaga and H. Sanchez, 1992. Synthesis of tetrahydrobenzophenanthridinones. V. J. Heterocycl. Chem., 29: 1385-1388.
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  90. Martinez, R., E. Cortes and L.J.A. Lopez, 1992. Electron impact mass spectrometry of 3-(2-hydroxyphenylcarbonyl)-4-(o- and p-R-phenyl)-1,2,3,4-tetrahydro-2H-benzo [f]quinolin-2-ones. Org. Mass Spectrom., 27: 121-122.
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  91. Gordillo, B., E. Juaristi, R. Martinez, R.A. Toscano, P.S. White and E.L. Eliel, 1992. Conformational analysis of 5-substituted 1,3-dioxanes. 5. Bond eclipsing in tert-butylsulfonyl substituted 1,3-dioxanes and cyclohexanes. X-ray diffraction studies, MMP2 calculations and interpretation. J. Am. Chem. Soc., 114: 2157-2162.
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  92. Cortes, E.C., R. Martinez and J.G. Avila-arraga, 1992. Synthesis and spectral properties of 6H-2,7,7-trimethyl-7,8-dihydrofuro[3,2-c]azepines. J. Heterocycl. Chem., 29: 1617-1619.
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  93. Campos-Sepulveda, A.E., F. Ayala-Guerrero, J. Taboada, L. Sanvicente and R. Martinez, 1992. Anticonvulsant effect of the 7-(p-chlorophenyl)-8-phenoxy-4,5-benzo-3-aza-2-nonem. Proc. Western Pharmacol. Soc., 35: 191-193.
    PubMed  |  

  94. Ayala-Guerrero, F., C. Blanco, U. Guevara, J. Taboada, R. Martinez and A.E. Campos, 1992. Effects of the bromophenyl-dihidro-2H-1,5-benzodiazepine-2-thione on sleep. Proc. Western Pharmacol. Soc., 35: 153-155.
    PubMed  |  

  95. Martinez, R., M.F. Rubio, A.R.C. Rosado and M.B.P. Ibarra, 1991. Electron impact mass spectrometry of praziquantel derivatives. Org. Mass Spectrom., 26: 503-504.
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  96. Martinez, R., E. Cortes, R.A. Toscano, L.J. Alfaro and J.G. Avila, 1991. Isolation of 1,2,3,4-tetrahydrobenzo[f]quinolin-2-ones on the reaction of 2-arylidenenaphthylamines with 4-hydroxycoumarin. IV. J. Heterocycl. Chem., 28: 589-592.
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  97. Cortes, E.C., R. Martinez, M. Ugalde and N. Maldonado, 1991. Electron impact mass spectrometry of substituted s-triazolo[4,3-α] [l,5]benzodiazepine-1-ones. Org. Mass Spectrom., 26: 113-115.
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  98. Cortes, E., R. Martinez, M. Ugalde and N. Maldonado, 1991. Heterocyclic variants of the 1,5-benzodiazepine system. VI. Derivatives of 2-methylthio-4-(p-r-phenyl)-3H-1,5-benzodiazepines. J. Heterocycl. Chem., 28: 365-368.
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  99. Cortes, E., R. Martinez and M.B.G. Gomez, 1991. Synthesis and spectral properties of 4-oxothiazolin-2-yl-[N-R1-2-(para-R2-phenyl)indol-3-yl] hydrazones. J. Heterocycl. Chem., 28: 1413-1415.
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  100. Cortes, E., R. Martinez and J.I. Ramirez, 1991. Mass spectra of some 2-(o-R1-phenyl)-indole-3-carboxaldehyde derivatives. II. Org. Mass Spectrom., 26: 1095-1096.
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  101. Cortes, C.E., R. Martinez and M.B.G. Gomez, 1991. Mass spectra of some 2-(p-R2-phenyl)-indole-3-carboxaldehyde derivatives. Org. Mass Spectrom., 26: 695-696.
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  102. Ayala-Guerrero, F., L. Vargas-Reyna, J. Taboada, R. Martinez and E. Cortes, 1991. Sleep effects of the 7-(p-bromophenyl)-8-phenoxy-4,5,benzo-3-aza-2-nonem. Proc. Western Pharmacol. Soc., 34: 297-302.
    PubMed  |  

  103. Martinez, R., M. Martinez-Vazquez and O. Zamorano-Macias, 1990. Electron impact mass spectrometry of triterpenoids from guayule. Org. Mass Spectrom., 25: 237-238.
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  104. Martinez, R., E. Cortes, R.A. Toscano and L.J. Alfaro, 1990. Reaction of β-arylidennaphthylamines with 4-hydroxycoumarin. A correction in structural assignment of the product. III. J. Heterocycl. Chem., 27: 1273-1276.
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  105. Martinez, R., E. Cortes, R.A. Toscano and I. Linzaga, 1990. Synthesis and spectra of 12-(o- and p-R-phenyl)-9,9-dimethyl-7,8,9,10,11,12-hexahydro and 8,9,10,11-tetrahydrobenz[a]acridin-11-ones. Structure correction of 1,2,3,4,5,6-hexahydro and 1,2,3,4‐tetrahydro-2,2-dimethyl-5-aryl-6-aza-9,10-benzophenanthren-4-ones. II. J. Heterocycl. Chem., 27: 363-366.
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  106. Cortes, E.C., E.C. Romero, R. Martinez and M.E.C. Rodarte, 1990. Electron impact mass spectrometry of substituted 1,2,4-triazine-3,5(2H,4H)-diobes. Org. Mass Spectrom., 25: 386-387.
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  107. Cortes, E.C., E.C. Romero, R. Martinez and J.C.G. Davila, 1990. Electron impact mass spectrometry of N-alkyl and N-aryl-2,5-bis(p-R2-phenyl)pyrroles. Org. Mass Spectrom., 25: 127-128.
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  108. Juaristi, E., B. Gordillo, R. Martinez and R.A. Toscano, 1989. Conformational analysis of 5-substituted 1,3-dioxanes. 4. The use of precise structural information for the understanding of the conformational behavior of cis-5-(tert-butylsulfonyl)- and cis-5-(tert-butylsulfinyl)-2-tert-butyl-1,3-dioxane. J. Org. Chem., 54: 5963-5967.
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  109. Eduardo, C.C., C.R. Eduardo, R. Martinez, G. Avila and A. Sandoval, 1989. Synthesis and spectral properties of 4-(ortho-R-benzylideneamine)-5-[2-(2-pyridyl)ethenyl]-3-methylisoxazole. J. Heterocycl. Chem., 26: 1561-1562.
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  110. Cortes, E.C., R. Martinez and R. Hernandez, 1989. Electron impact mass spectrometry of substituted tetrahydroazeto[1,2-a][1,5]-benzodiazepin-1-ones and 5-(2-methoxy-acetyl)-tetrahydroazeto[1,2-a][1,5]-benzodiazepin-1-ones. Org. Mass Spectrom., 24: 276-278.
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  111. Cortes, E.C., E.C. Romero, R. Martinez and P. Antonio, 1989. Electron impact mass spectrometry of 7α-8-trans-cycloheptane-[1,2-c]-1-methyl-8-(o- and p-Rphenyl)-Δ2-pyrazolines. Org. Mass Spectrom., 24: 427-428.
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  112. Cones, E., R. Martinez and I. Ceballos, 1989. Heterocyclic variants of the 1,5-benzodiazepine system. V. Derivatives of 2-(ortho-R1-anilino)-4-(p-R2-phenyl)-3H-1,5-benzodiazepines. J. Heterocycl. Chem., 26: 119-124.
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  113. Cortes, E., R. Martinez, J.G. Avila and R.A. Toscano, 1988. Synthesis and spectra of 7-(o- and p-R-phenyl)-10,10-dimethyl-8,9,10,11-tetrahydrobenz[c]acridin-8-ones. Structure correction of 1,2,3,4-tetrahydro-2,2-dimethyl-5-aryl-6-aza-7,8-benzophenanthren-4-ones. J. Heterocycl. Chem., 25: 895-899.
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  114. Cortes, E., R. Martinez and J.G. Avila, 1988. Electron impact mass spectrometry of 7-(o- and p-R-phenyl)-10,10-dimethyl-8,9,10,11-tetrahydrobenz[c]acridin-8-ones. Org. Mass Spectrom., 23: 672-673.
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  115. Soriano-Garcia, M., E. Cortes, R.A. Toscano, M.D.R. Arellano and R. Martinez, 1987. Structure and stereochemistry of 11-(o-chlorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one hemiethanol solvate. Acta Crystallogr. Sect. C: Cryst. Struct. Commun., 43: 1161-1163.
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  116. Juaristi, E., R. Martinez, R. Mendez, R.A. Toscano and M. Soriano-Garcia et al., 1987. Conformational analysis of 1,3-dioxanes with sulfide, sulfoxide and sulfone substitution at C(5). Finding an eclipsed conformation in cis-2-tert-butyl-5-(tert-butylsulfonyl)-1,3-dioxane. J. Org. Chem., 52: 3806-3811.
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  117. Glass, R.S., A. Petsom, G.S. Wilson, R. Martinez and E. Juaristi, 1986. Electrosynthesis of 1,2-dithiolane 1-oxides from substituted 1,3-dithianes. J. Org. Chem., 51: 4337-4342.
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  118. Cortes, E., R. Martinez and E. Arzacoya, 1986. The fragmentation of 7-(o- and p-R-benzylidene)-3-(o- and p-R-phenyl)-2-methyl-3,3a,4,5,6,7-hexahydro-2H-indazoles under electron impact. II. J. Heterocycl. Chem., 23: 203-207.
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  119. Cortes, E., R. Martinez and E. Arzacoya, 1985. Electron impact induced fragmentation of some 7-(o- and p-R-benzylidene)-3-(o- and p-R-phenyl)-3,3a,4,5,6,7-hexahydro-2H-indazoles. I. J. Heterocycl. Chem., 22: 541-544.
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  120. Soriano-Garcia, M., R.A. Toscano, E. Cortes and R. Martinez, 1984. Structure and stereochemistry of 2-methylthio-7-(p-bromophenyl)-8-phenoxy-4,5-benzo-3-aza-2-nonem, C24H19BrN2O2S. Acta Crystallogr. Sect. C: Cryst. Struct. Commun., 40: 1460-1462.
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  121. Cortes, E.C. and R. Martinez, 1984. Electron impact mass spectrometry of 1-(p-R-phenyl)-3,3-dimercaptoprop-2-en-1-ones. Org. Mass Spectrom., 19: 206-206.
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  122. Cortes, E., R. Martinez and A.M. Mutio, 1984. Mass spectral fragmentation patterns of 2,5-bis(p-R2-phenyl)-(3,4)-R1-furans. J. Heterocycl. Chem., 21: 855-860.
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  123. Cortes, E., R. Martinez and A. Zarza, 1983. Mass spectral fragmentation patterns of 11-(o- and p-R-anilino)-5H-dibenzo[b,e][1,4]diazepines. IV. J. Heterocycl. Chem., 20: 1615-1620.
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  124. Cortes, E. and R. Martinez, 1983. Synthesis and mass spectral fragmentation of 2-methylthio-7-(p-R-phenyl)-8-phenoxy-4,5-benzo-3-aza-2-nonem. III. J. Heterocycl. Chem., 20: 161-167.
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  125. Zugazagoitia, R., R. Martinez and E. Cortes, 1982. Ortho effects of a nitro group in 2′,3′ and 4′monosubstituted-trans-2,4-dinitrostilbenes on electron impact. IV. J. Heterocycl. Chem., 19: 85-87.
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  126. Maza, M.E., M. Galindez, R. Martinez and E. Cortes, 1982. Mass spectral fragmentation patterns of 1,5-benzodiazepines. I. ortho effects of R2-substituent on 2-(ortho-R2-aniline)-4-(para-R1-phenyl)-3H-1,5-benzodiazepines. J. Heterocycl. Chem., 19: 107-111.
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  127. Arellano, M.D.R., R. Martinez and E. Cortes, 1982. Mass spectral fragmentation patterns of 3,3-dimethyl-2,3,4,5,10,11-hexahydro-11-(o- and p-R-phenyl)-1H-dibenzo-[b,e][1,4]diazepin-1-ones. II. J. Heterocycl. Chem., 19: 321-326.
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  128. Martinez, R. and E. Cortes, 1981. Ortho effects in 3-methyl-5-(o-r-styryl)-4-aminoisoxazoles on electron impact. III. J. Heterocycl. Chem., 18: 185-187.
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  129. Ortega, A., R. Lara, R. Martinez and E. Diaz, 1980. Sphaerocephalin, a germacranolide isolated from Viguiera sphaerocephala. Phytochemistry, 19: 1545-1546.
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  130. Martinez, R. and E. Cortes, 1980. The behaviour of 3-methyl-5-(o-r-styryl)-4-nitroisoxazoles under electron impact. I. J. Heterocycl. Chem., 17: 585-587.
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  131. Martinez, R. and E. Cortes, 1980. Electron impact mass spectrometry of 3-methyl-4-benzylideneamine-5-styrylisoxazoles. II. J. Heterocycl. Chem., 17: 805-807.
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  132. Maldonado, J.E., R. Martinez and M. Martinez, 1980. Glaucolides D and E of Vernonia liatroides DC. Rev. Latinoam. Quim., 11: 58-59.
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