Dr. Mario Daniel Galigniana

Professor
Department of Biological Chemistry,The University of Buenos Aires, Exact & Natural Sciences School, Argentinav

Highest Degree
PostDoc Fellow in Pharmacology from University of Michigan, USA

My URL
https://livedna.org/54.8348

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Biography

Dr. Mario Daniel Galigniana is currently working as Professor in Department of Biological Chemistry at FCEN University of Buenos Aires and Principal Investigator of the Argentine Research Council (CONICET), Director of the Laboratory of Nuclear Receptors. He obtained his PhD in Biochemistry from University of Michigan Medical School. He is having 21 years of working experience. He is professional member American Society for Biochemistry & Molecular Biology, American Society for Microbiology, Society for Neuroscience, Evaluation Board of The University of Buenos Aires, Evaluation Board of ANPCYT, Argentina, Evaluation Board of CONICET, Argentine Society for Biochemistry and Molecular Biology, Argentine Society for Clinical Investigation, Endocrine Society, Cell Stress Society International. Dr. Mario Daniel received number of distinctions include, Elsevier Award in Appreciation of Scientific Excellence, Cherni Foundation Accesit Award, University of Buenos Aires, Young Investigator Award and Travel Awards. He is also member of editorial board. He has published 77 articles in journal and 6 chapters in book as writer/co-writer.

Area of Interest:

Molecular Sciences
Molecular Chaperone
Cancer
Apoptosis
Molecular Endocrinology

Selected Publications

  1. Galigniana, M.D., S.M. Ciucci and G.I. Mazaira, 2023. Roles of GR isoforms and Hsp90-binding immunophilins in the modulation of glucocorticoid biological responses. Curr. Rev. Clin. Exp. Pharmacol., 18: 242-254.
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  2. Zgajnar, N.R., C. Daneri-Becerra, A. Cauerhff and M.D. Galigniana, 2022. The scaffold immunophilin FKBP51 is a phosphoprotein that undergoes dynamic mitochondrial-nuclear shuttling. Cells, Vol. 11. 10.3390/cells11233771.
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  3. Mazaira, G.I., G.P. Pilipuk and M.D. Galigniana, 2021. Corticosteroid receptors as a model for the Hsp90•immunophilin-based transport machinery. Trends Endocrinol. Metab., 32: 827-838.
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  4. Daneri-Becerra, C., S.M. Ciucci, G. Mazaira and M.D. Galigniana, 2021. Role of mitochondrial heat-shock proteins and immunophilins in neuro degenerative diseases. Curr. Drug Targets, 22: 1596-1617.
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  5. Mazaira, G.I., P.C. Echeverria and M.D. Galigniana, 2020. Nucleocytoplasmic shuttling of the glucocorticoid receptor is influenced by tetratricopeptide repeat-containing proteins. J. Cell Sci., Vol. 133. 10.1242/jcs.238873.
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  6. Leo, S.A.D., N.R. Zgajnar, G.I. Mazaira, A.G. Erlejman and M.D. Galigniana, 2020. Role of the Hsp90-immunophilin heterocomplex in cancer biology. Curr. Cancer Ther. Rev., 16: 19-28.
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  7. Gupta, S.D., P.S. Swapanthi, D. Bhagya, F. Federicci and G.I. Mazaira et al., 2020. Rational identification of Hsp90 inhibitors as anticancer lead molecules by structure based drug designing approach. Anti-Cancer Agents Medic. Chem., 20: 369-385.
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  8. Galigniana, M.D., 2020. Peptidyl-prolyl isomerase activity of immunophilins could be the mere consequence of protein complex organization. BioEssays, Vol. 42. 10.1002/bies.202000073.
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  9. Zgajnar, N., S.D. Leo, C. Lotufo, A. Erlejman, G. Piwien-Pilipuk and M. Galigniana, 2019. Biological Actions of the Hsp90-binding Immunophilins FKBP51 and FKBP52. Biomolecules, Vol. 9. 10.3390/biom9020052.
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  10. Mazaira, G.I., N.R. Zgajnar, C.M. Lotufo, C. Daneri-Becerra and J.C. Sivils et al., 2019. Nuclear receptors: a historical perspective. Methods Mol. Biol., 1966: 1-5.
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  11. Mazaira, G.I. and M.D. Galigniana, 2019. Reconstitution of the steroid receptor heterocomplex. Methods Mol. Biol., 1966: 125-135.
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  12. Leonardi, D., N. Anselmino, J. Brandani, F. Jaworski and A. Páez et al., 2019. Heme oxygenase 1 impairs glucocorticoid receptor activity in prostate cancer. Int. J. Mol. Sci., Vol. 20. 10.3390/ijms20051006.
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  13. Daneri-Becerra, C., N.R. Zgajnar, C.M. Lotufo, A.B.R. Hryb, G. Piwien-Pilipuk and M.D. Galigniana, 2019.  Regulation of FKBP51 and FKBP52 functions by post-translational modifications. Biochem. Soc. Trans., 47: 1815-1831.
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  14. Mazaira, G.I., N.R. Zgajnar, C.M. Lotufo, C. Daneri-Becerra and J.C. Sivils et al., 2018. The nuclear receptor field: a historical overview and future challenges. Nucl. Recept. Res., Vol. 5. 10.11131/2018/101320.
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  15. Mazaira, G.I., C. Daneri-Becerra, N.R. Zgajnar, C.M. Lotufo and M.D. Galigniana, 2017.  Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90. Biochem. Soc. Trans., 46: 51-65.
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  16. Laiseca, J.E., M.F. Ladelfa, J. Cotignola, L.Y. Peche and F.A. Pascucci et al., 2017. Functional interaction between co-expressed mage-a proteins. PLoS ONE, Vol. 12. 10.1371/journal.pone.0178370.
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  17. Laiseca, J.E., M.F. Ladelfa, J. Cotignola, L.Y. Peche and F.A. Pascucci et al., 2017. Functional interaction between co-expressed MAGE-A proteins. MageA6 expression induces MageA11 protein stability. PLoS One. .

  18. Michelini, F.M., C.A. Bueno, A.M. Molinari, M.D. Galigniana, L.R. Galagovsky, L.E. Alche and J.A. Ramirez, 2016. Synthetic stigmastanes with dual antiherpetic and immunomodulating activities inhibit ERK and Akt signaling pathways without binding to glucocorticoid receptors. Biochim. Biophys. Acta-Gen. Subjects, 1860: 129-139.
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  19. Mazaira, G.I., M.F. Camisay, S. de Leo, A.G. Erlejman and M.D. Galigniana, 2016. Biological relevance of Hsp90‐binding immunophilins in cancer development and treatment. Int. J. Cancer, 138: 797-808.
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  20. Lagadari, M., S.A. de Leo, M.F. Camisay, M.D. Galigniana and A.G. Erlejman, 2016. Regulation of NF-ΚB signalling cascade by immunophilins. Curr. Mol. Pharmacol., 9: 99-108.
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  21. Lagadari, M., N.R. Zgajnar, L.I. Gallo and M.D. Galigniana, 2016. Hsp90-Binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity. Mol. Oncol., 10: 1086-1098.
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  22. Galigniana, M.D., 2016. Editorial: Immunophilins, protein chemistry and cell biology of a promising new class of drug targets-part I. Curr. Mol. Pharmacol., 9: 3-4.
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  23. Daneri-Becerra, C. and M.D. Galigniana, 2016. Regulatory role of heat-shock proteins in autoimmune and inflammatory diseases. Integr. Mol. Med., Vol. 3. 10.15761/IMM.1000 S1001.
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  24. Cauerhff, A.A. and M.D. Galigniana, 2016. Structural Aspects and Functional Relationships for Hsp90-TPR Protein Interactions. In: Frontiers in Structural Biology: Role of Molecular Chaperones on Structural Folding, Biological Functions and Drug Interactions of Client Proteins, Galigniana, M.D. (Ed.)., Bentham Publishers, Bussum, The Netherlands.

  25. Mazaira, G.I., A.G. Erlejman and M.D. Galigniana, 2015. Molecular chaperones shape steroid receptor action and pharmacologic strategies. J. Cell Mol. Biol., Vol. 1. .
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  26. Guy, N., Y.A. Garcia, J.C. Sivils, M.D. Galigniana and M.B. Cox, 2015. Functions of Hsp90-Binding FKBP Immunophilins. In: Networking of Chaperones by Co-chaperones, Blatch, G. and A.L. Edkins (Eds.)., Vol. 78, Chapter 2, Springer, New York, USA., pp: 35-68.

  27. Gupta, S.D., M.K. Bommaka, G.I. Mazaira, M.D. Galigniana and C.V. Satya et al., 2015. Molecular docking study, synthesis and biological evaluation of Mannich bases as Hsp90 inhibitors. Int. J. Biol. Macromol., 80: 253-259.
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  28. Gupta, S.D., B. Revathi, G.I. Mazaira, M.D. Galigniana, C.V.S. Subrahmanyam, N.L. Gowrishankar and N.M. Raghavendra, 2015. 2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: Rational identification of a new anticancer lead. Bioorg. Chem., 59: 97-105.
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  29. Davola, M.E., G.I. Mazaira, M.D. Galigniana, L.E. Alche, J.A. Ramirez and A.A. Barquero, 2015. Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of herpes simplex virus type 1. Antiviral Res., 122: 55-63.
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  30. Napimoga, M.H., M.D. Galigniana, A.C.M. Figueira, S.A. Onate and S. Castro-Obregon, 2014. Nuclear receptor research: Contributions from Latin America. Nucl. Receptor Res., Vol. 1. 10.11131/2014/101149.
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  31. Mazaira, G.I., M. Lagadari, A.G. Erlejman and M.D. Galigniana, 2014. The emerging role of TPR-domain immunophilins in the mechanism of action of steroid receptors. Nucl. Receptor Res., Vol. 1. 10.11131/2014/101094.
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  32. Gupta, S.D., D. Snigdha, G.I. Mazaira, M.D. Galigniana, C.V.S. Subrahmanyam, N.L. Gowrishankar and N.M. Raghavendra, 2014. Molecular docking study, synthesis and biological evaluation of Schiff bases as Hsp90 inhibitors. Biomed. Pharmacother., 68: 369-376.
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  33. Galigniana, M.D., 2014. Editorial: The biology of molecular chaperonesvery complex activities for quite simple proteins. Curr. Protein Peptide Sci., 15: 169-170.

  34. Erlejman, A.G., S.A. De Leo, G.I. Mazaira, A.M. Molinari and M.F. Camisay et al., 2014. NF-κB transcriptional activity is modulated by FK506-binding proteins FKBP51 and FKBP52: A role for peptidyl-prolyl isomerase activity. J. Biol. Chem., 289: 26263-26276.
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  35. Erlejman, A.G., M. Lagadari, M. Cox and M.D. Galigniana, 2014. Molecular chaperone activity of TPR-domain immunophilins. Curr. Protein Peptide Sci., 15: 205-215.

  36. Erlejman, A.G., M. Lagadari, J. Toneatto, G. Piwien-Pilipuk and M.D. Galigniana, 2014. Regulatory role of the 90-kDa-heat-shock protein (Hsp90) and associated factors on gene expression. Biochimica et Biophysica Acta, 1839: 71-87.

  37. Toneatto, J., S. Guber, N.L. Charo, S. Susperreguy, J. Schwartz, M.D. Galigniana and G. Piwien-Pilipuk, 2013. Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by PKA signaling pathway to control gene expression in the process of adipocyte differentiation. J. Cell Sci., 126: 5357-5368.

  38. Molinari, A., M. Machado, G. Mazaira, A. Erlejman and M.D. Galigniana, 2013. Molecular basis of mineralo-corticoid receptor action in the nervous system. CNS Neurol. Disorders-Drug Targets, 12: 1163-1174.

  39. Galigniana, M.D., 2013. When the cell stress society international became South American: Meeting report of the IX international workshop on the molecular biology of stress responses. Cell Stress Chaperones, 18: 3-9.
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  40. Galigniana, M.D., 2013. Editorial: Steroid-dependent management of biological responses in the nervous system. CNS Neurol. Disorders-Drug Targets, 12: 1143-1145.

  41. Erlejman, A.G., M. Lagadari and M.D. Galigniana, 2013. Hsp90-binding immunophilins as a potential new platform for drug treatment. Future Med. Chem., 5: 591-607.
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  42. Quinta, H.R., N.M. Galigniana, C.R. Daneri, M. Lagadari and M.D. Galigniana, 2012. Microtubule Organization. The Housekeeping Role of Heat-Shock Proteins and Immunophilins. In: Tubulin: Structure, Functions and Roles in Disease, Yamauchi, W. and A. Sokic (Eds.). Nova Science Publishers, New York, USA., pp: 41-67.

  43. Quinta, H.R. and M.D. Galigniana, 2012. The neuroregenerative mechanism mediated by the Hspp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation. Br. J. Pharmacol., 166: 637-649.

  44. Galigniana, N.M., L.T. Ballmer, J. Toneatto, A.G. Erlejman, M. Lagadari and M.D. Galigniana, 2012. Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51. J. Neurochem., 122: 4-18.

  45. Galigniana, M.D., 2012. Steroid receptor coupling becomes nuclear. Chem. Biol., 19: 662-663.
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  46. Brookes, J.C., M.D. Galigniana, A.H. Harker, A.M. Stoneham and G.P. Vinson, 2012. System among the corticosteroids: Specificity and molecular dynamics. J. Royal Soc. Interface, 9: 43-53.
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  47. Storer, C.L., C. Dickey, M.D. Galigniana, T. Rein and M. Cox, 2011. Roles for the 51-kDa and 52-kDa FK506-binding proteins in signaling and disease. Trends Endocrinol. Metab., 22: 481-490.

  48. Sivils, J., C.L. Storer, M.D. Galigniana and M.B. Cox, 2011. Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52). Curr. Opin. Pharmacol., 11: 314-319.
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  49. Quinta, H.R., N.M. Galigniana, C.R. Daneri-Becerra, A.G. Erlejman, M. Lagadari and M.D. Galigniana, 2011. Housekeeping role of heat-shock proteins and immunophilins in the organization of cytoskeleton involves early recruitment to nascent filaments. Cell. Signal., 23: 1907-1920.

  50. Gallo, L.I., M. Lagadari, G.P. Pilipuk and M.D. Galigniana, 2011. TPR-domain immunophilin FKBP51 is a novel mitochondrial factor with antiapoptotic function. J. Biol. Chem., 286: 30152-30160.

  51. Quinta, H.R., D. Maschi, C. Gomez-Sanchez, G. Piwien-Pilipuk and M.D. Galigniana, 2010. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. J. Neurochem., 115: 716-734.

  52. Galigniana, M.D., P.C. Echeverria, A.G. Erlejman and G. Piwien-Pilipuk, 2010. Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore. Nucleus, 1: 299-308.

  53. Galigniana, M.D., A.G. Erlejman, M. Monte, C. Gomez-Sanchez and G. Piwien-Pilipuk, 2010. The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events. Mol. Cell. Biol., 30: 1285-1298.
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  54. Erlejman, A.G., M. Lagadari, H.R. Quinta, G. Piwien-Pilipuk and M.D. Galigniana, 2010. A Novel Model for Nuclear Receptor Action. In: Recent Advances in Molecular and Cell Biology, Mohan, R.M. (Ed.). Global Research Network Inc., Londres-Toronto-Kerala, pp: 1-16.

  55. Gomez-Sanchez, C.E., E.P. Gomez-Sanchez and M.D. Galigniana, 2009. Aldosterone Receptors and their Renal Effects: Molecular Biology and Gene Regulation. In: Textbook of Nephro-Endocrinology, Singh, A. and G. Williams (Eds.). Elsevier Inc., San Diego, CA., pp: 329-348.

  56. Echeverria, P.C., G. Mazaira, A. Erlejman, C.G. Sanchez, G.P. Pilipuk and M.D. Galigniana, 2009. Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol. Cell. Biol., 29: 4788-4797.
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  57. Colo, G., M. Rubio, I. Nojek, P.C. Echeverria and C.V. Alvarado et al., 2008. The p160 nuclear receptor co-activator RAC3 exerts an anti-apoptotic role through a cytoplasmatic action. Oncogene, 27: 2430-2444.
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  58. Pilipuk, G.P., G.P. Vinson, C.G. Sanchez and M.D. Galigniana, 2007. Evidence for an NL1-independent nuclear translocation of the mineralocorticoid receptor in permeabilized cells. Biochemistry, 46: 1389-1397.
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  59. Pilipuk, G.P., G.P. Vinson, C.G. Sanchez and M.D. Galigniana, 2007. Evidence for NL1-independent nuclear translocation of the mineralocorticoid receptor. Biochemistry, 46: 1389-1397.
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  60. Gallo, L.I., A. Ghini, G. Piwien and M.D. Galigniana, 2007. Differential recruitment of tetratricopeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity. Biochemsitry, 46: 14044-14057.
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  61. Aviezer-Hagai, K., J. Skovorodnikova, M. Galigniana, O. Farchi-Pisanty and E. Maayan et al., 2007. Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced and bind HSP90. Plant Mol. Biol., 63: 237-255.
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  62. Salatino, M., W. Beguelin, M.G. Peters, R. Carnevale and C.J. Proietti et al., 2006. Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation. Oncogene, 25: 7723-7739.
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  63. Presman, D.M., E. Hoijman, N.R. Ceballos, M.D. Galigniana and A. Pecci, 2006. Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes. Endocrinology, 147: 5452-5459.
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  64. Piwien-Pilipuk, G. and M.D. Galigniana, 2006. Subcellular Movement of Signaling Molecules. How and Why? In: Focus on Cellular Signalling Research, Leeds, D.T. (Ed.). Nova Science Publishers, New York, USA., ISBN: 9781594546198, pp: 72-106.

  65. Pratt, W.B., M.D. Galigniana, J.M. Harrell and D. DeFranco, 2004. Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement. Cell. Signal., 16: 857-872.
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  66. Pratt, W.B., M.D. Galigniana and P. Murphy, 2004. Role of molecular chaperones in steroid receptor action. Essays Biochem., 40: 41-58.
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  67. Murphy, P.J., M.D. Galigniana, J.M. Harrell, M. Lujngman and W.B. Pratt, 2004. Pifithrin-α is a specific inhibitor of p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. J. Biol. Chem., 279: 30195-30201.

  68. Harrell, J.M., P.J. Murphy, Y. Morishima, H. Chen, J.F. Mansfield, M.D. Galigniana and W.B. Pratt, 2004.. Evidence for glucocorticoid receptor transport on microtubules by dynein. J. Biol. Chem., 279: 54647-54654.
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  69. Galigniana, M.D., Y. Morishima, P.A. Gallay and W.B. Pratt, 2004. Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex. J. Biol. Chem., 279: 55754-55759.
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  70. Galigniana, M.D., J.M. Harrell, P.R. Housley, C. Patterson, S.K. Fisher and W. Pratt, 2004. Retrograde transport of the GR in neurites requires dynamic assembly of complexes with hsp90 and is linked to the CHIP component of the proteosome. Mol. Brain Res., 123: 27-36.
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  71. Galigniana, M.D., G.P. Pilipuk, K.C. Kanelakis, G. Burton and C.P. Lantos, 2004. Molecular mechanism of activation and nuclear translocation of the mineralocorticoid receptor upon binding of novel pregnanesteroids. Mol. Cell. Endocrinol., 217: 167-179.
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  72. Galigniana, M.D. and G.P. Pilipuk, 2004. Activation of the ligand-mineralocorticoid receptor functional unit by ancient, classical and novel ligands. Structure-activity-relationship. Vitamins Hormones, 69: 31-68.
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  73. Galigniana M.D., J.M. Harrell, H.M. O'Hagen, M. Ljungman and W.B. Pratt, 2004. Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. J. Biol. Chem., 279: 22483-22489.
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  74. Pilipuk, G.P., M.D. Galigniana and J. Schwartz, 2003. Subnuclear localization of C/EBPβ is regulated by growth hormone and dependent on MAPK. J. Biol. Chem., 278: 35668-35677.

  75. Murphy, P.J., Y. Morishima, S. Simons, J.F. Mansfield, M.D. Galigniana and W.P. Pratt, 2003. Visualization and mechanism of assembly of a glucocorticoid receptor-hsp70 complex primed by subsequent hsp90-dependent opening of the steroid binding cleft. J. Biol. Chem., 278: 34764-34773.
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  76. Vicent, G.P., A. Pecci, A.A. Ghini, G.P. Pilipuk and M.D. Galigniana, 2002. Differences in nuclear retention characteristics of agonist-activated glucocorticoid receptor may determine specific biological responses. Exp. Cell Res., 276: 142-154.
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  77. Rios, M.C., M.B. Mazzetti, M.D. Galigniana, C. Aldonatti, J.M. Tomio and L. San Martin, 2002. The decrease in uroporphyrinogen activity induced by ethanol predisposes the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage. Braz. J. Med. Biol. Res., 11: 1273-1283.
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  78. Piwien-Pilipuk, G., K.C. Kanelakis and M.D. Galigniana, 2002. Correlation between pregnanesteroid conformation, receptor affinity and antinatriuretic effect. Eur. J. Pharmacol., 454: 131-143.

  79. Pilipuk, G.P., K. Kanelakis, A. Ghini, C. Lantos, G. Litwack, G. Burton and M.D. Galigniana, 2002. Modification of an essential amino group in the mineralocorticoid receptor evidences a differential conformational change of the receptor protein upon binding of antagonists, natural agonists and the synthetic agonist 11,19-oxido-progesterone. Biochimica et Biophysica Acta, 1589: 31-48.

  80. Pilipuk, G.P., A. Ayala, A. Machado and M.D. Galigniana, 2002. Impairment of mineralocorticoid receptor-dependent biological response by oxidative stress and ageing. Correlation with post-translational modification of MR and decreased ADP-ribosylatable level of EF-2 in kidney cells. J. Biol. Chem., 277: 11896-11903.

  81. Harrell, J.M., I. Kurek, A. Breiman, C. Radanyi, J.M. Renoir, W.B. Pratt and M.D. Galigniana, 2002. All of the protein interactions that link steroid receptor-hsp90-immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells. Biochemistry, 41: 5581-5587.

  82. Galigniana, M.D., J.M. Harrell, J.P. Murphy, C. Radanyi, J.M. Renoir, M. Zhang and W.B. Pratt, 2002. Binding of hsp-90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain. Biochemistry, 41: 13602-13619.

  83. Murphy, P.J.M., K.C. Kanelakis, M.D. Galigniana, Y. Morishima and W.B. Pratt, 2001. Stoichiometry, abundance and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate. J. Biol. Chem., 276: 30092-30098.
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  84. Houshyar, H., M.D. Galigniana, W.B. Pratt and J.H. Woods, 2001. Chronic morphine treatment alters pituitary-adrenal negative feedback sensitivity and downregulates glucocorticoid receptors in the rat brain. J. Neuroendocrinol., 13: 875-886.

  85. Galigniana, M.D., C. Radanyi, J.M. Renoir, P.R. Housley and W.B. Pratt, 2001. Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus. J. Biol. Chem., 276: 14884-14889.
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  86. Pratt, W.B., A.M. Silverstein and M.D. Galigniana, 2000. A Model for the Cytoplasmic Trafficking of Signaling Proteins Involving the hsp90-Binding Immunophilin FKBP52. In: Immunophilins in the Brain: FKPB Ligands: Novel Strategies for the Treatment of Neurodegenerative Disorders, Gold, B., G. Fischer and T. Herdegen (Eds.). Prous Science, Philadelphia, USA., pp: 37-47.

  87. Piwien-Pilipuk, G. and M.D. Galigniana, 2000. Oxidative stress induced by L-buthionine-(S, R)-sulfoximine, a selective inhibitor of glutathione metabolism, abrogates mouse kidney mineralocorticoid receptor function. Biochimica et Biophysica Acta (BBA)-Mol. Cell Res., 1495: 263-280.
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  88. Kanelakis, K.C., P.J. Murphy, M.D. Galigniana, Y. Morishima and S. Takayama et al., 2000. hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1. Biochemistry, 39: 14314-14321.
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  89. Galigniana, M.D., G.P. Vicent, G. Piwien-Pilipuk, G. Burton and C.P. Lantos, 2000. Mechanism of action of the potent sodium-retaining steroid 11, 19-oxidoprogesterone. Mol. Pharmacol., 58: 58-70.
    CrossRef  |  Direct Link  |  

  90. Galigniana, M.D., 2000. Functional regulation of corticosteroid receptors by phosphorylation and redox potential. Curr. Top. Steroid Res., 3: 1-22.

  91. Vicent, G.P., A. Pecci, A.A. Ghini, G. Piwien-Pilipuk and A.S. Veleiro et al., 1999. The glucocorticoid properties of the synthetic steroid pregna-1,4-diene-11β-ol-3,20-dione (ΔHOP) are not entirely correlated with the steroid binding to the glucocorticoid receptor. Mol. Cell. Endocrinol., 149: 207-219.
    CrossRef  |  Direct Link  |  

  92. Silverstein, A.M., M.D. Galigniana, K.C. Kanelakis, C. Radanyi, J.M. Renoir and W.B. Pratt, 1999. Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90 and cytoplasmic dynein. J. Biol. Chem., 274: 36980-36986.
    CrossRef  |  Direct Link  |  

  93. Pratt, W.B., A.M. Silverstein and M.D. Galigniana, 1999. A model for the cytoplasmic trafficking of signalling proteins involving the hsp90-binding immunophilins and p50cdc37. Cell. Signalling, 11: 839-851.
    CrossRef  |  Direct Link  |  

  94. Kanelakis, K.C., Y. Morishima, K.D. Dittmar, M.D. Galigniana, S. Takayama, J.C. Reed and W.B. Pratt, 1999. Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery. J. Biol. Chem., 274: 34134-34140.
    CrossRef  |  Direct Link  |  

  95. Galigniana, M.D., P.R. Housley, D.B. DeFranco and W.B. Pratt, 1999. Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton. J. Biol. Chem., 274: 16222-16227.
    CrossRef  |  Direct Link  |  

  96. Galigniana, M.D., G. Piwien-Pilipuk and J. Assreuy, 1999. Inhibition of glucocorticoid receptor by nitric oxide. Mol. Pharmacol., 55: 317-323.

  97. Galigniana, M.D. and G. Piwien-Pilipuk, 1999. Comparative inhibition by hard and soft metal ions of steroid-binding capacity of renal mineralocorticoid receptor cross-linked to the 90-kDa heat-shock protein heterocomplex. Bioch. J., 341: 585-592.
    CrossRef  |  

  98. Vicent, G.P., G. Burton, A. Ghini, C.P. Lantos and M.D. Galigniana, 1998. Influence of calf serum on glucocorticoid-responses of certain progesterone derivatives. J. Steroid Biochem. Mol. Biol., 66: 211-216.
    CrossRef  |  Direct Link  |  

  99. Piwien-Pilipuk, G. and M.D. Galigniana, 1998. Tautomycin inhibits phosphatase-dependent transformation of the rat kidney mineralocorticoid receptor. Mol. Cell. Endocrinol., 144: 119-130.
    CrossRef  |  Direct Link  |  

  100. Galigniana, M.D., P.R. Housley and W.B. Pratt, 1998. Hsp90-Dependent Movement of the Glucocorticoid Receptor Towards the Nucleus. In: Molecular Chaperones and the Heat-Shock Response, Gross, C. and A. Horwich (Eds.). CSH Science, New York, USA., pp: 80-87.

  101. Galigniana, M.D., J.L. Scruggs, J. Herrington, M.J. Welsh, C. Carter-Su, P.R. Housley and W. Pratt, 1998. Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton. Mol. Cell. Endocrinol., 12: 1903-1913.
    CrossRef  |  Direct Link  |  

  102. Galigniana, M.D., 1998. Native rat kidney mineralocorticoid receptor is a phosphoprotein whose transformation to a DNA-binding form is induced by phosphatases. Bioch. J., 333: 555-563.
    CrossRef  |  Direct Link  |  

  103. Dittmar, K.D., M. Banach, M.D. Galigniana and W.B. Pratt, 1998. The role of DnaJ-like proteins in the glucocorticoid receptor-hsp90 heterocomplex assembly by the reconstituted hsp90-p60-hsp70 foldosome complex. J. Biol. Chem., 273: 7358-7366.
    CrossRef  |  Direct Link  |  

  104. Vicent, G.P., M.C. Monteserin, A.S. Veleiro, G. Burton, C.P. Lantos and M.D. Galigniana, 1997. 21-OH-6,19-oxido-progesterone: A novel synthetic steroid with specific anti-glucocorticoid properties. Mol. Pharmacol., 52: 749-753.

  105. Silverstein, A.M., M.D. Galigniana, M.S. Chen, J.K. Owens-Grillo, M. Chinkers and W.B. Pratt, 1997. Protein phosphatase 5 is a major component of glucocorticoid receptor-hsp90 complexes with properties of an FK506-binding immunophilins. J. Biol. Chem., 272: 16224-16230.
    CrossRef  |  Direct Link  |  

  106. Czar, M.J., M.D. Galigniana, A.M. Silverstein and W.B. Pratt, 1997. Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus. Biochemistry, 36: 7776-7785.
    CrossRef  |  Direct Link  |  

  107. Galigniana, M.D., G.P. Vicent, G. Burton and C.P. Lantos, 1996. Features of the shuttle pair 11β-hydroxy-progesterone/11-ketoprogesterone. Steroids, 62: 358-364.

  108. Galigniana, M.D., 1996. Stability study on renal type I mineralocorticoid receptor. Life Sci., 59: 511-521.
    CrossRef  |  Direct Link  |  

  109. Burton, G., M.D. Galigniana, S. de Lavallaz, A. Brachet-Cota and E. Sproviero et al., 1995. Sodium-retaining activity of some natural and synthetic 21-deoxysteroids. Mol. Pharmacol., 47: 535-543.

  110. Galigniana, M.D., G.P. Vicent, C.P. Lantos and G. Burton, 1994. 11,19-oxidoprogesterone: A potent sodium retaining steroid binding to an alternative site in rat kidney type I receptor. Eur. J. Endocrinol., 130: 260-260.

  111. Galigniana, M.D., G.P. Vicent, C.P. Lantos and G. Burton, 1993. Ligand properties of 11,19-oxidoprogesterone: A preliminary report. J. Argentine Chem. Soc., 81: 333-340.
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