Dr. Leonardo Fernandes Fraceto
Associate ProfessorState University of Sao Paulo, Brazil
Highest Degree
Ph.D. in Biology from State University of Campinas, Brazil
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Biography
Dr. Leonardo Fernandes Fraceto is currently working as Associate Profesor at State University of Sao Paulo/Unesp/Campus Sorocaba Brazil. He obtained his Ph.D. in Biology from State University of Campinas, Brazil in 2003. His area of interest focused on Micro and Nanotechnology, Controlled Release Systems, Bioactive Compounds, Spectroscopy. He has 100 scietific publications in journals, 120 poster presentations in national meeting, 50 poster presentations in international meetings, and 8 oral presentations in meetings contributed as author/co-author. He also supervised several PhD and Masters students. He is also serving as reviewer in number of journals.
Area of Interest:
Selected Publications
- Vieira, E.G., I.V. Soares, N.L. Dias Filho, N.C. da Silva and E.F. Garcia et al., 2013. 2013. Preconcentration and determination of metal ions from fuel ethanol with a new 2,2'-dipyridylamine bonded silica. J. Colloid Interface Sci., 391: 116-124.
Direct Link | - Soares, I.V., E.G. Vieira, N.L. Dias Filho, N.C. Da Silva and A.D.C. Bastos et al., 2013. Study of adsorption and preconcentration by using a new silica organomodified with [3-(2,2'-dipyridylamine)propyl] groups. J. Separat. Sci., 36: 817-825.
Direct Link | - Campos, R., E. Vangelie, S. de Melo, N. Ferreira and V.A. Guilherme et al., 2013. Preparation and characterization of poly (ε-caprolactone) nanospheres containing the local anesthetic lidocaine. J. Pharmaceut. Sci., 102: 215-226.
Direct Link | - Volobuef, C., C.M. Moraes, S. Nunes, A. Lazaro and S. Cereda et al., 2012. Sufentanil-2‐hydroxypropyl‐β‐cyclodextrin inclusion complex for pain treatment: Physicochemical, cytotoxicity and pharmacological evaluation. J. Pharmaceut. Sci., 101: 3698-3707.
Direct Link | - Vieira, E.G., I.V. Soares, N.L.D. Filho, N.C. da Silva and S.D. Perujo et al., 2012. Study on soluble heavy metals with preconcentration by using a new modified oligosilsesquioxane sorbent. J. Hazard. Mater., 237-238: 215-222.
CrossRef | - Napimoga, M.H., C.A. da Silva, V. Carregaro, T.S. Farnesi-de-Assuncao, P.M. Duarte, N.F. de Melo and L.F. Fraceto, 2012. Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. J. Immunol., 189: 1043-1052.
Direct Link | - De Paula, E., C.M. Cereda, L.F. Fraceto, D.R. de Araujo and M. Franz-Montan et al., 2012. Micro and nanosystems for delivering local anesthetics. Exp. Opin. Drug Delivery, 9: 1505-1524.
Direct Link | - De Melo, S., N. Ferreira, D.R. de Araujo, R. Grillo and C.M. Moraes et al., 2012. Benzocaine-loaded polymeric nanocapsules: Study of the anesthetic activities. J. Pharmaceut. Sci., 101: 1157-1165.
Direct Link | - De Lima, R.A.F., M.B. de Jesus, C.M.S. Cereda, G.R. Tofoli and L.F. Cabeca et al., 2012. Improvement of tetracaine antinociceptive effect by inclusion in cyclodextrins. J. Drug Target., 20: 85-96.
Direct Link | - De Lima, R., L.O. Feitosa, R. Grillo, A.E. Pereira and L.F. Fraceto, 2012. Evaluation of the genotoxicity of polymeric microparticles containing ametryn herbicide. J. Environ. Sci. Eng., 4: 553-565.
- De Lima, R., L.O. Feitosa, C.R. Maruyama, M.A. Barga and P.C. Yamawaki, 2012. Evaluation of the genotoxicity of cellulose nanofibers. Int. J. Nanomed., 7: 3555-3565.
Direct Link | - De Jesus, M.B., L.F. Fraceto, M.F. Martini, M. Pickholz, C.V. Ferreira and E. de Paula, 2012. Non-inclusion complexes between riboflavin and cyclodextrins. J. Pharm. Pharmacol., 64: 832-842.
Direct Link | - Cocenza, D.S., M.A. de Moraes, M.M. Beppu and L.F. Fraceto, 2012. Use of biopolymeric membranes for adsorption of paraquat herbicide from water. Water Air Soil Pollut., 223: 3093-3104.
Direct Link | - Clemente-Napimoga, J.T., J.A. Moreira, R. Grillo, N.F. de Melo, L.F. Fraceto and M.H. Napimoga, 2012. 15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. Life Sci., 90: 944-949.
Direct Link | - Clemente, Z., V.L.S.S. Castro, C.M. Jonsson and L.F. Fraceto, 2012. Ecotoxicology of nano-TiO2 an evaluation of its toxicity to organisms of aquatic ecosystems. Int. J. Environ. Res., 6: 33-50.
- Campos, V., R. Fracacio, L.F. Fraceto and A.H. Rosa, 2012. Fecal sterols in estuarine sediments as markers of sewage contamination in the Cubatao area, Sao Paulo, Brazil. Aquatic Geochem., 12: 234-245.
Direct Link | - Tonello, P.S., D. Goveia, A.H. Rosa, L.F. Fraceto and A.A. Menegario, 2011. Determination of labile inorganic and organic species of Al and Cu in river waters using the diffusive gradients in thin films technique. Anal. Bioanal. Chem., 399: 2563-2570.
Direct Link | - Rodrigues, S.G., I. de Souza Chaves, N.F.S. de Melo, M.B. de Jesus and L.F. Fraceto et al., 2011. Computational analysis and physico-chemical characterization of an inclusion compound between praziquantel and methyl-β-cyclodextrin for use as an alternative in the treatment of schistosomiasis. J. Inclusion Phenomena Macrocyclic Chem., 70: 19-28.
Direct Link | - Moraes, C.M., A.P. de Matos, R. Grillo, N.F. de Melo and E. de Paula et al., 2011. Screening of formulation variables for the preparation of poly(epslon-caprolactone) nanocapsules containing the local anesthetic benzocaine. J. Nanosci. Nanotechnol., 11: 2450-2457.
Direct Link | - Lobo, F.A., D. Goveia, A.P. Oliveira, L.P. Romao, L.F. Fraceto, N.L.D. Filho and A.H. Rosa, 2011. Development of a method to determine Ni and Cd in biodiesel by graphite furnace atomic absorption spectrometry. Fuel, 90: 142-146.
Direct Link | - Lobo, F.A., C.L. de Aguirre, M.S. Silva, R. Grillo and N.F.S. de Melo et al., 2011. Poly(hydroxybutyrate-co-hydroxyvalerate) microspheres loaded with atrazine herbicide: Screening of conditions for preparation, physico-chemical characterization and in vitro release studies. Polymer Bull., 67: 479-495.
Direct Link | - Grillo, R., A.D.E. Santo Pereira, N.F.S. de Melo, R.M. Porto and L.OGrillo, R., A.D.E. Santo Pereira, N.F.S. de Melo, R.M. Porto and L.O. Feitosa et al.,. Feitosa et al., 2011. Controlled release system for ametryn using polymer microspheres: Preparation, characterization and release kinetics in water. J. Hazard. Mater., 186: 1645-1651.
Direct Link | - Goveia, D., F.A. Lobo, I.C. Bellin, L.F. Fraceto, A.A. Menegario, P. Burba and A.H. Rosa, 2011. In situ differentiation of labile/inert metal species in Brazilian tropical rivers by means of a time-controlled batch-procedure based on TEPHA resin. Int. J. Environ. Anal. Chem., 91: 1296-1306.
Direct Link | - Felippotti, T.T., D.R. do Carmo, L.L. Paim, N.R. Stradiotto and U. de Oliveira Bicalho et al., 2011. Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides μ 1 receptor-mediated post-ictal antinociception. Nanomedicine: Nanotechnol. Biol. Med., 7: 871-880.
Direct Link | - Dos Santos Silva, M., D.S. Cocenza, R. Grillo, N.F.S. de Melo and P.S. Tonello et al., 2011. Paraquat-loaded alginate/chitosan nanoparticles: Preparation, characterization and soil sorption studies. J. Hazard. Mater., 190: 366-374.
Direct Link | - De Melo, N.F.S., R. Grillo, V.A. Guilherme, D.R. de Araujo, E. de Paula, A.H. Rosa and L.F. Fraceto, 2011. Poly(Lactide-co-Glycolide) nanocapsules containing benzocaine: Influence of the composition of the oily nucleus on physico-chemical properties and anesthetic activity. Pharmaceut. Res., 28: 1984-1994.
Direct Link | - De Lima, R., A.D.E.S. Pereira, R.M. Porto and L.F. Fraceto, 2011. Evaluation of cyto- and genotoxicity of poly(lactide-co-glycolide) nanoparticles. J. Polym. Environ., 19: 196-202.
Direct Link | - Botero, W.G., L.C.D. Oliveira, B.B. Cunha, L.K.D. Oliveira and D. Goveia et al., 2011. Characterization of the interactions between endocrine disruptors and aquatic humic substances from tropical rivers. J. Braz. Chem. Soc., 22: 1103-1110.
- Alves, C.F., N.F.S. de Melo, L.F. Fraceto, D.R. de Araujo and M.H. Napimoga, 2011. Effects of 15d-PGJ2-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. Br. J. Pharmacol., 162: 623-632.
Direct Link | - De Paula, E., C. Cereda, G.R. Tofoli, M. Franz-Montan, L.F. Fraceto and D.R. de Araujo, 2010. Drug delivery systems for local anesthetics. Recent Patents Drug Delivery Formul., 4: 23-34.
Direct Link | - De Jesus, M.B., L.D.M.A. Pinto, L.F. Fraceto, L.A. Magalhaes, E.M. Zanotti-Magalhaes and E. de Paula, 2010. Improvement of the oral praziquantel anthelmintic effect by cyclodextrin complexation. J. Drug Target., 18: 21-26.
Direct Link | - Soares, L.A., A.F.V.B. Leal, L.F. Fraceto, E.R. Maia and I.S. Resck et al., 2009. Host-guest system of 4-nerolidylcatechol in 2-hydroxypropyl-beta-cyclodextrin: Characterization, phase solubility and molecular modeling. J. Inclusion Phenomena Macrocyclic Chem., 64: 23-35.
Direct Link | - Pickholz, M., L.F. Fraceto and E. de Paula, 2009. Preferential location of prilocaine and etidocaine in phospholipid bilayers: A molecular dynamics study. Synthetic Metals., 159: 2157-2158.
Direct Link | - Moraes, C.M., D.R.D. Araujo, M.G. Issa, H.G. Ferraz and F. Yokaichiya et al., 2009. Inclusion complex of S (-) bupivacaine and 2-hydroxypropyl-β-cyclodextrin: Study of morphology and cytotoxicity. Revista de Ciencias Farmaceuticas Basica e Aplicada, 27: 207-212.
- Moraes, C.M., A.P. Matos, E. de Paula, A.H. Rosa and L.F. Fraceto, 2009. Benzocaine loaded biodegradable poly-(d,l-lactide-co-glycolide) nanocapsules: Factorial design and characterization. Mater. Sci. Eng. B, 165: 243-246.
Direct Link | - Lobo, F.A., D. Goveia, A.P. de Oliveira, E.R. Pereira-Filho and L.F. Fraceto et al., 2009. Comparison of the univariate and multivariate methods in the optimization of experimental conditions for determining Cu, Pb, Ni and Cd in biodiesel by GFAAS. Fuel, 88: 1907-1914.
Direct Link | - Grillo, R., N.F. de Melo, D.R. de Araujo, E. de Paula, N.L.D. Filho, A.H. Rosa and L.F. Fraceto, 2009. Validation of an HPLC method for quantitative determination of benzocaine in PHBV-microparticles and PLA-nanoparticles. Acta Farmaceutica Bonaerense, 28: 393-399.
Direct Link | - Pickholz, M., L.F. Fraceto and E. de Paula, 2008. Distribution of neutral prilocaine in a phospholipid bilayer: Insights from molecular dynamics simulations. Int. J. Quantum Chem., 108: 2386-2391.
Direct Link | - Grillo, R., N.F. de Melo, C.M. Moraes, R. de Lima and C.M. Menezes et al., 2008. Study of the interaction between Hydroxymethylnitrofurazone and 2-Hydroxypropyl-beta-Cyclodextrin. J. Pharmaceut. Biomed. Anal., 47: 295-302.
Direct Link | - Goveia, D., A.H. Rosa, I.C. Bellin, F.A. Lobo and L.F. Fraceto et al., 2008. In situ application of cellulose bag and ion exchanger for differentiation of labile and inert metal species in aquatic systems. Anal. Bioanal. Chem., 390: 1173-1180.
Direct Link | - De Paula, E., S. Schreier, H.C. Jarrell and L.F. Fraceto, 2008. Preferential location of lidocaine and etidocaine in lecithin bilayers as determined by EPR, fluorescence and 2H-NMR. Biophys. Chem., 132: 47-54.
Direct Link | - De Melo, N.F., R. Grillo, A.H. Rosa and L.F. Fraceto, 2008. Interaction between nitroheterocyclic compounds with β-cyclodextrins: Phase solubility and HPLC studies. J. Pharmaceut. Biomed. Anal., 47: 865-869.
Direct Link | - De Araujo, D.R., S.S. Tsuneda, C.M.S. Cereda, F.D.G.F. Carvalho and P.S.C. Prete et al., 2008. Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-β-cyclodextrin inclusion complex. Eur. J. Pharm. Sci., 33: 60-71.
CrossRef | Direct Link | - Cereda, C.M.S., G.R. Tofoli, R.B. de Brito, Jr., M.B. de Jesus and L.F. Fraceto et al., 2008. Stability and local toxicity evaluation of a liposomal prilocaine formulation. J. Liposome Res., 18: 329-339.
Direct Link | - Araujo, D.R., C.M.S. Cereda, G.B. Brunetto, V.U. Vomero and A. Pierucci, 2008. Pharmacological and local toxicity studies of a liposomal formulation for the novel local. J. Pharm. Pharmacol., 60: 1449-1457.
Direct Link | - Varca, G.H., N. Andreo-Filho, L.F. Fraceto, T.M. Kaneko and H.G. Ferraz, 2007. Thermal chacracterization and cytotoxicity of complexes formed by papain. J. Biol. Phys., 33: 463-475.
Direct Link | - Silva, J.A., D.C. Damico, P.A. Baldasso, M.A. Mattioli and L.F. Fraceto et al., 2007. Isolation and biochemical characterization of a galactoside binding lectin from Bauhinia variegata Candida (BvcL) seeds. Protein J., 26: 193-201.
Direct Link | - Moraes, C.M., P. Abrami, E. de Paula, A.A. Braga and L.F. Fraceto, 2007. Study of the interaction between S (-) bupivacaine and 2-hydroxypropyl-beta-Cyclodextrin. Int. J. Pharmaceut., 311: 99-106.
Direct Link | - Moraes, C.M., P. Abrami, D.R. de Araujo, A.F. Braga and M.G. Issa et al., 2007. 2007. Characterization of lidocaine: Hydroxypropyl-beta-cyclodextrin inclusion complex. J. Inclusion Phenomena Macrocyclic Chem., 57: 313-316.
Direct Link | - Moraes, C.M., A.P. de Matos, R. de Lima, A.H. Rosa, E. de Paula and L.F. Fraceto, 2007. Initial development and characterization of PLGA nanospheres containing ropivacaine. J. Biol. Phys., 33: 455-461.
Direct Link | - Grillo, R., N.F.S. de Melo, C.M. Moraes, A.H. Rosa and J.A.F. Roveda et al., 2007. Hydroxymethylnitrofurazone: Dimethyl-β-cyclodextin inclusion complex: a physical-chemistry characterization. J. Biol. Phys., 33: 445-453.
- Fraceto, L.F., S. Oyama, C.R. Nakaie, A. Spisni, E. de Paula and T.A. Pertinhez, 2006. Interaction of local anesthetics with a peptide encompassing the IV/S4-S5 linker of the Na+ channel. Biophys. Chem., 123: 29-39.
Direct Link | - De Jesus, M.B., L. de Matos Alves Pinto, L.F. Fraceto, Y. Takahata and A. Lino et al., 2006. Theoretical and experimental study of a praziquantel and beta-cyclodextrin inclusion complex usingmolecular mechanic calculations and 1h-nuclear magnetic resonance. J. Pharmaceut. Biomed. Anal., 41: 1428-1432.
Direct Link | - Pinto, L.M., L.F. Fraceto, M.H.A. Santana, T.A. Pertinhez, S. Oyama, Jr. and E. de Paula, 2005. Physico-chemical characterization of benzocaine-β-cyclodextrin inclusion complexes. J. Pharmaceut. Biomed. Anal., 39: 956-963.
Direct Link | - Fraceto, L.F., A. Spisni, S. Schreier and E. de Paula, 2005. Differential effects of uncharged aminoamide local anesthetics on phospholipid bilayers, as monitored by H-NMR measurements. Biophys. Chem., 115: 11-18.
Direct Link | - Malheiros, S.V., L.M. Pinto, L. Gottardo, D.K. Yokaichiya, L.F. Fraceto, N.C. Meirelles and E. de Paula, 2004. A new look at the hemolytic effect of local anesthetics, considering their real membrane/water partitioning at pH 7.4. Biophys. Chem., 110: 213-221.
Direct Link | - Fraceto, L.F., L.D.M.A. Pinto, L. Franzoni, A.A.C. Braga, A. Spisni, S. Schreier and E. de Paula, 2002. Spectroscopic evidence for a preferential location of lidocaine inside phospholipid bilayers. Biophys. Chem., 99: 229-243.
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