Dr. Juan Francisco Santibanez Dominguez

Professor
Institute for Medical Research, University of Belgrade, Serbia

Highest Degree
Ph.D. in Biological Sciences from Autonoma University of Madrid, Spain

My URL
https://livedna.org/56.5989

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Biography

Dr. Juan Francisco Santibanez Dominguez is currently working as Professor of Research at Laboratory for Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade. He obtained his PhD Biological Science from Autonoma University of Madrid, Spain in 1999. In past he worked as Assistant Professor and Associate Professor at Universidad de Chile, Santiago, Chile. He also received research grants as Principal Researcher. He has 5 publications in journals, 1 chapter in book, 8 other publications, and more than 65 presentations in Chilean and International Scientific Meetings. He is also serving the editorial committee and reviewer in peer review journals and grants.

Area of Interest:

Molecular Sciences
Tumor Progression
Urokinase
Metalloproteinases
Cell Migration

Selected Publications

  1. Cassetta, L., K. Bruderek, J. Skrzeczynska-Moncznik, O. Osiecka and X. Hu et al., 2020. Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation. J. Immunother. Cancer, Vol. 8. 10.1136/jitc-2020-001223.
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  2. Gatica, S., F. Eltit, J.F. Santibanez, D. Varela, C. Cabello-Verrugio and F. Simon, 2019. Expression suppression and activity inhibition of TRPM7 regulate cytokine production and multiple organ dysfunction syndrome during endotoxemia: A new target for sepsis. Curr. Mol. Med., 19: 547-559.
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  3. Echeverria, C., F. Eltit, J.F. Santibanez, S. Gatica, C. Cabello-Verrugio and F. Simon, 2019. Endothelial dysfunction in pregnancy metabolic disorders. Biochimica et Biophysica Acta (BBA) - Mol. Basis Dis., Vol. 1866. 10.1016/j.bbadis.2019.02.009.
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  4. Diklić, M., O. Mitrović‐Ajtić, T. Subotički, D. Djikić and M. Kovačić et al., 2019. IL6 inhibition of inflammatory S100A8/9 proteins is NF‐κB mediated in essential thrombocythemia. Cell Biochem. Funct., 38: 362-372.
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  5. Bjelica, S., M. Diklić, D. Đikić, M. Kovačić and T. Subotički et al., 2019. Hydroxyurea‐induced senescent peripheral blood mesenchymal stromal cells inhibit bystander cell proliferation of JAK2V617F‐positive human erythroleukemia cells. FEBS J., 286: 3647-3663.
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  6. Bizymi, N., S. Bjelica, A.O. Kittang, S. Mojsilovic and M. Velegraki et al., 2019. Myeloid-derived suppressor cells in hematologic diseases. HemaSphere, Vol. 3. 10.1097/HS9.0000000000000168.
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  7. Umansky, V., G.J. Adema, J. Baran, S. Brandau and J.A. Van Ginderachter et al., 2018. Interactions among myeloid regulatory cells in cancer. Cancer Immunol. Immunother., 68: 645-660.
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  8. Subotički, T., O.M. Ajtić, B.B. Beleslin-Čokić, S. Bjelica and D. Djikić et al., 2018. IL-6 stimulation of DNA replication is JAK1/2 mediated in cross-talk with hyperactivated ERK1/2 signaling. Cell Biol. Int., 43: 192-206.
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  9. Santibanez, J.F., 2018. Urokinase type plasminogen activator and the molecular mechanisms of its regulation in cancer. Protein Peptide Lett.,, Vol. 24. 10.2174/0929866524666170818161132.
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  10. Santibanez, J.F. and S. Bjelica, 2018. Novel patents targeting interleukin-17A; implications in cancer and inflammation. Recent Patents Anti-Cancer Drug Discovery, 13: 133-144.
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  11. Santibanez, J.F. and J. Krstic, 2018. Transforming growth factor-beta and urokinase type plasminogen interplay in cancer. Curr. Protein Peptide Sci., 19: 1155-1163.
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  12. Mojsilovic, S.S., S. Mojsilovic, S. Bjelica and J.F. Santibanez, 2018. Estramustine phosphate inhibits TGF-ß-induced mouse macrophage migration and urokinase-type plasminogen activator production. Anal. Cell. Pathol., Vol. 2018. 10.1155/2018/3134102.
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  13. Millan, C., J.F. Vivanco, I.M. Benjumeda-Wijnhoven, S. Bjelica and J.F. Santibanez, 2018. Mesenchymal stem cells and calcium phosphate bioceramics: implications in periodontal bone regeneration. In: Cell Biol. Transl. Med., Turksen, K., Springer International Publishing, London, pp: 91-112.
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  14. Bruger, A.M., A. Dorhoi, G. Esendagli, K. Barczyk-Kahlert, P. Bruggen, M. Lipoldova, T. Perecko, J. Santibanez, M. Saraiva, J.A.V. Ginderachter and S. Brandau, 2018. How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions. Cancer Immunol. Immun., 68: 631-644.
    CrossRef  |  Direct Link  |  

  15. Trivanović, D., J. Krstić, A. Jauković, D. Bugarski and J.F. Santibanez, 2017. Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition. Dev. Dyn., 247: 359-367.
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  16. Srdic-Rajic, T., J.F. Santibañez, K. Kanjer, N. Tisma-Miletic and M. Cavic et al., 2017. Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells. Sci. Rep., Vol. 7. 10.1038/s41598-017-03898-0.
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  17. Santibanez, J.F., H. Obradović, T. Kukolj and J. Krstić, 2017. Transforming growth factor-β, matrix metalloproteinases, and urokinase-type plasminogen activator interaction in the cancer epithelial to mesenchymal transition. Dev. Dyn., 247: 382-395.
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  18. Kukolj, T., D. Trivanović, I.O. Djordjević, S. Mojsilović, J. Krstić, H. Obradović, S. Janković, J.F. Santibanez, A. Jauković and D. Bugarski, 2017. Lipopolysaccharide can modify differentiation and immunomodulatory potential of periodontal ligament stem cells via ERK1,2 signaling. J. Cell. Physiol., 233: 447-462.
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  19. Krstic, J., D. Trivanovic, H. Obradovic, T. Kukolj, D. Bugarski and J.F. Santibanez, 2017. Regulation of mesenchymal stem cell differentiation by transforming growth factor beta superfamily. Curr. Protein Peptide Sci., 19: 1138-1154.
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  20. Krstic, J., D. Trivanovic, A. Jaukovic, J.F. Santibanez and D. Bugarski, 2017. Metabolic plasticity of stem cells and macrophages in cancer. Front. Immunol., Vol. 8. 10.3389/fimmu.2017.00939.
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  21. Cabello-Verrugio, C., F. Simon, C. Trollet and J.F. Santibañez, 2017. Oxidative stress in disease and aging: mechanisms and therapies 2016a. Oxid. Med. Cell. Longevity, Vol. 2017. 10.1155/2017/4310469.
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  22. Trivanović, D., J. Krstić, I.O. Djordjević, S. Mojsilović, J.F. Santibanez, D. Bugarski and A. Jauković, 2016. The roles of mesenchymal stromal/stem cells in tumor microenvironment associated with inflammation. Mediators Inflammation, Vol. 2016. 10.1155/2016/7314016.
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  23. Trivanović, D., A. Jauković, J. Krstić, S. Nikolić and I.O. Djordjević et al., 2016. Inflammatory cytokines prime adipose tissue mesenchymal stem cells to enhance malignancy of MCF-7 breast cancer cells via transforming growth factor-β1. IUBMB Life, 68: 190-200.
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  24. Obradović, H., J. Krstić, T. Kukolj, D. Trivanović and I.O. Đorđević et al., 2016. Doxycycline inhibits IL-17-Stimulated MMP-9 expression by downregulating ERK1/2 activation: implications in myogenic differentiation. Mediators Inflammation, Vol. 2016. 10.1155/2016/2939658.
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  25. Đorđević, I.O., T. Kukolj, J. Krstić, D. Trivanović and H. Obradović et al., 2015. The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs. Int. J. Biochem. Cell Biol., 71: 92-101.
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  26. Mojsilovic, S. and J.F. Santibanez, 2015. Transforming growth factor-beta differently regulates urokinase type plasminogen activator and matrix metalloproteinase-9 expression in mouse macrophages; analysis of intracellular signal transduction. Cell Biol. Int., (In Press). 10.1002/cbin.10435.
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  27. Krstić, J., D. Trivanović, S. Mojsilović and J.F. Santibanez, 2015. Transforming growth factor-beta and oxidative stress interplay: Implications in tumorigenesis and cancer progression. Oxidative Med. Cellular Longevity, 2015: 1-15.
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  28. Krstic, J., H. Obradovic, T. Kukolj, S. Mojsilovic, I. Okic-Dordevic, D. Bugarski and J. Santibanez, 2015. An overview of interleukin-17A and interleukin-17 receptor a structure, interaction and signaling. Protein Peptide Lett., 22: 570-578.
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  29. Krstic, J., H. Obradovic, A. Jaukovic, I. Okic-Dordevic and D. Trivanovic et al., 2015. Urokinase type plasminogen activator mediates interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration. Biochimica Biophysica Acta (BBA)-Mol. Cell Res., 1853: 431-444.
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  30. Trivanovic, D., S. Nikolic, J. Krstic, A. Jaukovic and S. Mojsilovic et al., 2014. Characteristics of human adipose mesenchymal stem cells isolated from healthy and cancer affected people and their interactions with human breast cancer cell line MCF-7 in vitro. Cell Biol. Int., 38: 254-265.
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  31. Santibanez, J.F. and J. Krstic, 2014. Transforming Growth Factor-beta Regulation of Urokinase Type Plasminogen System: Mutual Interactions and Potential Combinatory Implications in Oncotherapies. In: Plasminogen Activator: Genetic Factors, Functions and Clinical Applications, Rutherford, J.M. (Ed.). Nova Science Publishers, USA., ISBN: 978-1-63117-354-7, pp: 139-208.

  32. Miletic, M., S. Mojsilovic, I. Okic-Dordevic, T. Kukolj and A. Jaukovic et al., 2014. Mesenchymal stem cells isolated from human periodontal ligament. Arch. Biol. Sci., 66: 261-271.
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  33. Krstic, J., I. Maslovaric and J.F. Santibanez, 2014. Novel patents and cancer therapies for transforming growth factor-beta and urokinase type plasminogen activator: Potential use of their interplay in tumorigenesis. Recent Patents Anti-Cancer Drug Discovery, 9: 354-371.
    Direct Link  |  

  34. Villar, V., J. Kocic and J.F. Santibanez, 2013. SKIP regulates TGF-β 1-induced extracellular matrix degrading proteases expression in human PC-3 prostate cancer cells. Prostate Can. 10.1155/2013/398253.
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  35. Trivanovic, D., S. Mojsilovic, V. Ilic, J. Krstic and A. Jaukovic et al., 2013. Immunomodulatory capacity of human mesenchymal stem cells isolated from adipose tissue, dental pulp, peripheral blood and umbilical cord Wharton's jelly. Cent. Eur. J. Immunol., 38: 421-429.
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  36. Trivanovic, D., J. Kocic, S. Mojsilovic, A. Krstic and V. Ilic et al., 2013. Mesenchymal stem cells isolated from peripheral blood and umbilical cord Wharton's jelly. Srpski arhiv za celokupno lekarstvo, 141: 178-186.
    PubMed  |  Direct Link  |  

  37. Santibanez, J.F., 2013. Transforming growth factor-beta and urokinase-type plasminogen activator: Dangerous partners in tumorigenesis-implications in skin cancer. ISRN Dermatol. 10.1155/2013/597927.
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  38. Okic-Djordjevic, I., D. Trivanovic, J. Krstic, A. Jaukovic and S. Mojsilovic et al., 2013. GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. JBUON, 18: 504-510.
    PubMed  |  Direct Link  |  

  39. Krstic, J., A. Jaukovic, S. Mojsilovic, I.O. Dordevic and D. Trivanovic et al., 2013. In vitro effects of IL-17 on angiogenic properties of endothelial cells in relation to oxygen levels. Cell Biol. Int., 37: 1162-1170.
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  40. Krstic, J. and J.F. Santibanez, 2013. Transforming growth factor-beta and matrix metalloproteinases: Functional interactions in tumor stroma-infiltrating myeloid cells. Scientific World J 10.1155/2014/521754.
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  41. Krstic, J. and J.F. Santibanez, 2013. Transforming growth factor-beta and matrix metalloproteinases functional interplay in cancer; implications in epithelial to mesenchymal transition. Cell Biol.: Res. Therapy .
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  42. Kocic, J., J.F. Santibanez, A. Krstic, S. Mojsilovic, V. Ilic and D. Bugarski, 2013. Interleukin-17 modulates myoblast cell migration by inhibiting urokinase type plasminogen activator expression through p38 mitogen-activated protein kinase. The Int. J. Biochem. Cell Biol., 45: 464-475.
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  43. Cokic, V. and J.F. Santibanez, 2013. Janus Kinase 2 and Transforming Growth Factor Beta Signal Transduction Targeted Therapies in Myeloproliferative Neoplasms. In: Frontiers in Anti-Cancer Drug Discovery. Atta-Ur-Rahman, F.R.S. and M.I. Choudhary (Eds.). Bentham Science Publishers, Sharjah, UAE., ISBN-13: 9781608051618, Pages: 779.

  44. Santibanez, J.F. and J. Kocic, 2012. Transforming growth factor-β superfamily, implications in development and differentiation of stem cells. Biomol. Concepts, 3: 429-445.
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  45. Quintanilla, M., G. del Castillo, J. Kocic and J.F. Santibanez, 2012. TGF-B and MMPs: A Complex Regulatory Loop Involved in Tumor Progression. In: Matrix Metalloproteinases: Biology, Functions and Clinical Implications. Oshiro, N. and E. Miyagi (Eds.). Nova Science Publishers, New York, USA., pp: 1-37.

  46. Krstic, A., J. Kocic, V. Ilic, S. Mojsilovic and I. Okic-Dordevic et al., 2012. Effects of IL-17 on erythroid progenitors growth: involvement of MAPKs and GATA transcription factors. J. Biol. Regul. Homeost. Agents, 26: 641-652.
    PubMed  |  

  47. Kocic, J., V. Villar, A. Krstic and J.F. Santibanez, 2012. SKIP downregulation increases TGF-β1-induced Matrix Metalloproteinase-9 production in transformed keratinocytes. Scientifica. 10.6064/2012/861647.
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  48. Kocic, J., J.F. Santibanez, A. Krstic, S. Mojsilovic and I.O. Dordevic et al., 2012. Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1,2. Biochim. Biophys. Acta, Mol. Cell. Res., 1823: 838-849.
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  49. Kocic, J., D. Bugarski and J.F. Santibanez, 2012. SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes. Eur. J. Cancer, 48: 1550-1557.
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  50. Santibanez, J.F., M. Quintanilla and C. Bernabeu, 2011. TGF-β/TGF-β receptor system and its role in physiological and pathological conditions. Clin. Sci., 121: 233-251.
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  51. Nikolic, N., A. Krsti, D. Trivanovic, S. Mojsilovic and J. Kocic et al., 2011. Mesenchymal stem cell properties of dental pulp cells from deciduous teeth. Arch. Biol. Sci., 63: 933-942.
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  52. Mojsilovic, S., A. Krstic, V. Ilic, I. Okic-Dordevic and J. Kocic et al., 2011. IL-17 and FGF signaling involved in mouse mesenchymal stem cell proliferation. Cell Tissue Res., 346: 305-316.
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  53. Krstic, M., S.P. Sovilj, S. Grguric-Sipka, I.R. Evans and S. Borozan et al., 2011. Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines. Eur. J. Med. Chem., 46: 4168-4177.
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  54. Villar, V., J. Kocic, D. Bugarski, G. Jovcic and J.F. Santibanez, 2010. SKIP is required for TGF-β1-induced epithelial mesenchymal transition and migration in transformed keratinocytes. FEBS Lett., 584: 4586-4592.
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  55. Villar, V., J. Kocic and J.F. Santibanez, 2010. Spred2 inhibits TGF-β1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition. Int. J. Cancer, 127: 77-85.
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  56. Tobar, N., V. Villar and J.F. Santibanez, 2010. ROS-NFκΒ mediates TGF-β1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion. Mol. Cell. Biochem., 340: 195-202.
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  57. Santibanez, J.F., J. Kocic, A. Fabra, A. Cano and M. Quintanilla, 2010. Rac1 modulates TGF-β1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes. FEBS Lett., 584: 2305-2310.
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  58. Santibanez, J.F., E. Perez-Gomez, A. Fernandez-L, E.M. Garrido-Martin and A. Carnero et al., 2010. The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras. Carcinogenesis, 31: 2145-2154.
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  59. Perez-Gomez, E., G. del Castillo, J.F. Santibanez, J.M. Lepez-Novoa, C. Bernabeu and M. Quintanilla, 2010. The role of the TGF-β coreceptor endoglin in cancer. Sci. World J., 10: 2367-2384.
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  60. Krstic, M., S.P. Sovilj, S. Grguric-Sipka, I.R. Evans and S. Borozan et al., 2010. New ruthenium(II) complexes with N-alkylphenothiazines: Synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxicity. Eur. J. Med. Chem., 45: 3669-3676.
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  61. Krstic, A., J.F. Santibanez, I. Okic, S. Mojsilovic and J. Kocic et al., 2010. Combined effect of IL-17 and blockade of nitric oxide biosynthesis on haematopoiesis in mice. Acta Physiol., 199: 31-41.
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  62. Echeverria, C., J.F. Santibanez, O. Donoso-Tauda, C.A. Escobar and R. Ramirez-Tagle, 2009. Structural antitumoral activity relationships of synthetic chalcones. Int. J. Mol. Sci., 10: 221-231.
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  63. Tobar, N., M. Caceres, J.F. Santibanez, P.C. Smith and J. Martinez, 2008. RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFκB-dependent mechanism. Cancer Lett., 267: 125-132.
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  64. Santibanez, J.F., F.J. Blanco, E.M. Garrido-Martin, F. Sanz-Rodriguez, M.A. del Pozo and C. Bernabeu, 2008. Caveolin-1 interacts and cooperates with the transforming growth factor-β type I receptor ALK1 in endothelial caveolae. Cardiovasc. Res., 77: 791-799.
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  65. Santibanez, J.F., A. Letamendia, F. Perez-Barriocanal, C. Silvestri and M. Saura et al., 2007. Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-β signaling. J. Cell Physiol., 210: 456-468.
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  66. Santibanez, J.F., 2006. JNK mediates TGF-β1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes. FEBS Lett., 580: 5385-5391.
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  67. Jerkic, M., J.V. Rivas-Elena, J.F. Santibanez, M. Prieto and A. Rodriguez-Barbero et al., 2006. Endoglin regulates cyclooxygenase-2 expression and activity. Circulat. Res., 99: 248-256.
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  68. Eisner, V., A. Criollo, C. Quiroga, C. Olea-Azar and J.F. Santibanez et al., 2006. Hyperosmotic stress-dependent NFκB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes. FEBS Lett., 580: 4495-4500.
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  69. Santibanez, J.F. and C. Hurtado, 2005. Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis. FEBS Lett., 579: 6459-6464.
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  70. Blanco, F.J., J.F. Santibanez, M. Guerrero-Esteo, C. Langa, C.P. Vary and C. Bernabeu, 2005. Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-β receptor complex. J. Cell Physiol., 204: 574-584.
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  71. Smith, P.C., J.F. Santibanez, J.P. Morales and J. Martinez, 2004. Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin. J. Periodontal Res., 39: 380-387.
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  72. Rodriguez, J.P., S. Rios, M. Fernandez and J.F. Santibanez, 2004. Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women. J. Cell Biochem., 92: 745-754.
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  73. Guerrero, J., J.F. Santibanez, A. Gonzalez and J. Martinez, 2004. EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases. Exp. Cell Res., 292: 201-208.
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  74. Santibanez, J.F., D. Olivares, J. Guerrero and J. Martinez, 2003. Cyclic AMP inhibits TGFβ1-induced cell-scattering and invasiveness in murine-transformed keratinocytes. Int. J. Can., 107: 715-720.
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  75. Santibanez, J.F., M. Quintanilla and J. Martinez, 2002. TGF-β1 and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells. FEBS Lett., 520: 171-176.
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  76. Santibanez, J.F., J. Guerrero, M. Quintanilla, A. Fabra and J. Martinez, 2002. Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes. Biochem. Biophys. Res. Commun., 296: 267-273.
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  77. Juretic, N., J.F. Santibanez, C. Hurtado and J. Martinez, 2001. ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line. J. Cell Biochem., 83: 92-98.
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  78. Santibanez, J.F., M. Quintanilla and J. Martinez, 2000. Genistein and curcumin block TGF-β1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes. Nutr. Cancer, 37: 49-54.
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  79. Santibanez, J.F., M. Iglesias, P. Frontelo, J. Martinez and M. Quintanilla, 2000. Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-β1 in transformed keratinocytes. Biochem. Biophys. Res. Commun., 273: 521-527.
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  80. Santibanez, J.F., P. Frontelo, M. Iglesias, J. Martinez and M. Quintanilla, 1999. Urokinase expression and binding activity associated with the transforming growth factor β1-induced migratory and invasive phenotype of mouse epidermal keratinocytes. J. Cell Biochem., 74: 61-73.
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  81. Quintanilla, M., P. Frontelo, J.F. Santibanez, F. Scholl, M. Garcia Gallo and M. Iglesias, 1999. El modelo experimental de la carcinogenesis de piel de raton. Una vision integrada del Cancer. Rev. Cancer, 13: 41-47.

  82. Martinez, J., M. Fuentes, V. Cambiazo and J.F. Santibanez, 1999. Bone extracellular matrix stimulates invasiveness of estrogen-responsive human mammary MCF-7 cells. Int. J. Cancer, 83: 278-282.
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  83. Ronco, A.M., M. Tijmes, J.F. Santibanez and P. Moraga, 1998. Effect of desialylated human chorionic gonadotropin (hCG) on the bioactivity of rat Leydig cells. Cell. Biochem. Funct., 16: 21-28.
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  84. Rodriguez, J.P., J.F. Santibanez and J. Martinez, 1998. Soluble factors secreted by PC-3 cells induce structural changes in proteoglycans produced by fetal rat osteoblasts. Tumour. Biol., 19: 19-29.
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  85. Quintanilla, M., P. Frontelo, J.F. Santibanez, D. Illescas, O. Berlanga and F. Scholl, 1998. Carcinogenesis experimental. El modelo de la carcinogenesis de piel de raton. Oncologia, 21: 35-40.

  86. Depix, M.S., J. Martinez, F. Santibanez, J. Rovirosa, A. San Martin and R.B. Maccioni, 1998. The compound 14-keto-stypodiol diacetate from the algae Stypopodium flabelliforme inhibits microtubules and cell proliferation in DU-145 human prostatic cells. Mol. Cell. Biochem., 187: 191-199.
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  87. Santibanez, J.F., A. Navarro and J. Martinez, 1997. Genistein inhibits proliferation and In vitro invasive potential of human prostatic cancer cell lines. Anticancer Res., 17: 1199-1204.
    PubMed  |  

  88. Santibanez, J.F., S. Silva and J. Martinez, 1996. Soluble factors produced by PC-3 prostate cells decrease collagen content and mineralisation rate in fetal rat osteoblasts in culture. Br. J. Cancer, 74: 418-422.
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  89. Martinez, J., S. Silva and J.F. Santibanez, 1996. Prostate-derived soluble factors block osteoblast differentiation in culture. J. Cell. Biochem., 61: 18-25.
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  90. Santibanez, J.F., R.B. Maccioni and J. Martinez, 1995. The secretion of urokinase-like plasminogen activator is inhibited by microtubule-interacting drugs. Cell. Biochem. Funct., 13: 217-225.
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  91. Martinez, J. and J.F. Santibanez, 1994. Surface-associated plasminogen activation in leukemic cells: Interaction with extracellular matrix. Eur. J. Cell. Biol., 64: 257-263.
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  92. Santibanez, J.F. and J. Martinez, 1993. Membrane-associated procollagenase of leukemic cells is activated by urokinase-type plasminogen activator. Leuk. Res., 17: 1057-1062.
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  93. Martinez, J. and J.F. Santibanez, 1993. Extracellular calcium modulates proliferation of factor dependent hemopoietic cells. Cell. Biochem. Funct., 11: 101-105.
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  94. Martinez, J., J.F. Santibanez, C. Vial and R.B. Maccioni, 1992. The antineoplastic agent estramustine and the derivative estramustine-phosphate inhibit secretion of interleukin-3 in leukemic cells. Possible roles of MAPs. Mol. Cell. Biochem., 117: 165-173.
    PubMed  |  

  95. Lavandero, S., J.F. Santibanez, M.P. Ocaranza, A. Ferreira and M. Sapag-Hagar, 1991. Binding and production of insulin-like growth factor-I in rat mammary gland. Comp. Biochem. Physiol. Part A. Physiol., 99: 507-511.
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  96. Lavandero, S., J.F. Santibanez, M.P. Ocaranza and M. Sapag-Hagar, 1990. Insulin-like growth factor I receptor levels during the lactogenic cycle in rat mammary gland. Biochem. Soc. Trans., 18: 576-577.
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