Dr. Siti Balkis Budin

Associate Professor
Universiti Kebangsaan Malaysia, Malaysia

Highest Degree
Ph.D. in Biomedical Sciences from Universiti Kebangsaan Malaysia, Malaysia

My URL
https://livedna.org/60.16633

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Area of Interest:

Pharmacology and Toxicology
Reproductive Toxicology
Cardiovascular Diseases
Oxidative Stress
Diabetes Mellitus

Selected Publications

  1. Nafizah, A.H.N., S.B. Budin, A.H. Zaryantey, A.R. Mariati and R.L. Santhana et al., 2017. Aqueous calyxes extract of roselle or Hibiscus sabdariffa Linn supplementation improves liver morphology in streptozotocin induced diabetic rats. Arab J. Gastroenterol., 18: 13-20.
    CrossRef  |  Direct Link  |  

  2. Mamood, S.N.H., O. Hidayatulfathi, S.B. Budin, R.G. Ahmad and M.H.I. Zulfakar, 2017. The formulation of the essential oil of Piper aduncum Linnaeus (Piperales: Piperaceae) increases its efficacy as an insect repellent. Bull. Entomol. Res., 107: 49-57.
    CrossRef  |  Direct Link  |  

  3. Budin, S.B., F.J. Fatin, N.F.M.N.A. Siti, L.M.Y. Nur, S.T. Izatus and M. Jamaludin, 2017. Kelulut honey supplementation prevents sperm and testicular oxidative damage in streptozotocin-induced diabetic rats. J. Teknol., 79: 89-95.
    Direct Link  |  

  4. Zainalabidin, S., N.F.S.N.S. Siti and B.B. Siti, 2016. Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats. Sains Malays., 45: 207-214.
    Direct Link  |  

  5. Yi-Cheng, L., B.B.Siti, O. Faizah, L. Jalifah and Z. Satirah, 2016. Roselle polyphenols exert potent negative inotropic effects via modulation of intracellular calcium regulatory channels in isolated rat heart. Cardiovasc. Toxicol., 17: 251-259.
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  6. Ramalingam, A., S.B. Budin, Y.C. Lim, Y.N.L. Si and S. Zainalabidin, 2016. Dietary UKMR-1 roselle supplementation prevents nicotine-induced cardiac injury by inhibiting myocardial oxidative stress. Sains Malaysiana, 45: 1131-1137.
    Direct Link  |  

  7. Mohamed, J., A.H.N. Nafizah, A.H. Zariyantey and S.B. Budin, 2016. Mechanisms of diabetes-induced liver damage: The role of oxidative stress and inflammation. Sultan Qaboos Univ. Med. J., 16: 132-141.
    CrossRef  |  PubMed  |  Direct Link  |  

  8. Mohamad, R.A.P., I. Norhayati, B.B. Siti, I. Rozmi, M.O. Ahmad and A.K. Nor, 2016. Inter-Relationship of illness perception, personality and quality of life among type 2 diabetes Patients: A cross-sectional survey. J. Soc. Sci., 11: 234-241.
    CrossRef  |  Direct Link  |  

  9. Taib, I.S., B.B. Siti, R.G. Ahmad, A.J. Putri, R.L. Santhana and M. Jamaludin, 2015. Palm oil tocotrienol-rich fraction attenuates testicular toxicity induced by fenitrothion via an oxidative stress mechanism. Toxicol. Res., 4: 132-142.

  10. Hussan, F., S.M. Adila, N.H. Siti, T.T.N.E.K.T. Nurul, B.B. Siti and O. Faizah, 2015. Anti-Inflammatory property of Plantago major leaf extract reduces the inflammatory reaction in experimental acetaminophen-induced liver injury. Evidence-Based Compl. Alter. Med., 10.1155/2015/347861.
    CrossRef  |  Direct Link  |  

  11. Zainalabidin, S., B.B. Siti, R. Anand and Y.C. Lim, 2014. Aortic remodelling in chronic nicotine-administered rat. Korean J. Physiol. Pharmacol., 18: 411-418.
    CrossRef  |  Direct Link  |  

  12. Taib, I.S., B.B. Siti, R.G. Ahmad, A.J. Putri and M. Jamaludin, 2014. Fenitrothion alters sperm characteristics in Rats: Ameliorating effects of palm oil tocotrienol-rich fraction. Exp. Anim., 63: 383-393.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Rahman, P.A., B.B. Siti, K.Y. Matthew and K. Sazlina, 2014. Challenges in exploring sexuality issues among women with physical disabilities in Malaysia. Global J. Adv. Pure Appl. Sci., 4: 259-264.
    Direct Link  |  

  14. Mohamed, J., H.K. Wen, M.H.M. Idris, S. Zainalabidin and S.B. Budin, 2014. Reduced red blood cell membrane damage in streptozotocin-induced diabetic rats supplemented with roselle (UKMR-2) calyx extract. Pak. J. Biol. Sci., 17: 682-688.
    CrossRef  |  Direct Link  |  

  15. Jayusman, P.A., B.B. Siti, R.G. Ahmad, S.T. Izatus and R.L. Santhana, 2014. Effects of palm oil tocotrienol-rich fraction on biochemical and morphological alterations of liver in fenitrothion-treated rats. Pak. J. Pharm. Sci., 27: 1873-1880.
    PubMed  |  Direct Link  |  

  16. Hussan, F., S.M. Adila, B.B. Siti and O. Faizah, 2014. Effect of Plantago major extract on plasma cytokine changes in paracetamol-induced liver injury. Cytokine, 7: 49-49.
    CrossRef  |  Direct Link  |  

  17. Budin, S.B., S.T. Izatus, A.J. Putri, H.C. Hui, R. Anand, R.G. Ahmad and M. Jamaludin, 2014. Emoliarative effects of palm oil tocotrienol rich fraction on brain oxidative stress in fenitrothion -administrative rats. Sains Malays., 43: 1031-1036.
    Direct Link  |  

  18. Abdul Hamid, Z., W.H.L. Lin, B.J. Abdalla, O.B. Yuen and E.S. Latif et al., 2014. The role of Hibiscus sabdariffa L. (Roselle) in maintenance of Ex Vivo murine bone Marrow-derived hematopoietic stem cells. Scient. World J., 10.1155/2014/258192.
    CrossRef  |  

  19. Abd Warif, N.M., A.A. Asyraf, M.W.R. Wan, B.B. Siti, Z. Satirah and M. Jamaludin, 2014. Effects of Hibiscus sabdariffa Linn. aqueus extract towards oxidative stress and lymphocyte T population of spleen in streptozotocin induced diabetic rats. J. Sains Kesihatan Malays., 10: 15-21.

  20. Taib, I.S., S.D.Budin, A.R. Ghazali, P.A. Jayusman, S.R. Louis and J. Mohamed, 2013. Fenitrothion induced oxidative stress and morphological alterations of sperm and testes in male sprague-dawley rats. Clinics, 68: 93-100.
    CrossRef  |  Direct Link  |  

  21. Mohamed, J., S.W. Shing, M.H.M. Idris, S.B. Budin and S. Zainalabidin, 2013. The protective effect of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell membrane oxidative stress in rats with streptozotocin-induced diabetes. Clinics, 68: 1358-1363.
    CrossRef  |  

  22. Budin, S.B., J.H. Kim, S.T. Izatus, A.J. Putri, R.G. Ahmad and M. Jamaludin, 2013. Antioxidant activity of tocotrienol rich fraction prevents fenitrothion-induced renal damage in rats. J. Toxicol. Pathol., 26: 111-118.
    CrossRef  |  Direct Link  |  

  23. Budin, S.B., I. Hawa and L.C. Pek, 2013. Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats. Sains Malays., 42: 707-713.
    Direct Link  |  

  24. Osman, K., F.N. Chew, F.I. Siti, B.B. Siti, F.H.F. Jaffar and N.A.A. Wahab, 2012. Albumin improved spermatozoa quality and DNA integrity for freezing-free preservation. Int. J. Biol. Med. Res., 3: 1670-1679.
    Direct Link  |  

  25. Nang, C.F., K. Osman, S.B. Budin, M.I. Ismail, F.H.F. Jaffar, S.F.S. Mohamad and S.F. Ibrahim, 2012. Bovine serum albumin: Survival and osmolarity effect in bovine spermatozoa stored above freezing point. Andrologia, 44: 447-453.
    CrossRef  |  

  26. Mohamed, J., N.I. Maizatul, Y.C. Tham, R.L. Santhana and B.B. Siti, 2012. A study of sperm quality characteristics changes in different storage temperatures above freezing point. Int. J. Collabor. Res. Internal Med. Public Health, 4: 736-743.
    Direct Link  |  

  27. Mohamed, J., H. Norhisham, F.N. Chew, H.M.I. Muhd, K.J. Daren and B.B. Siti, 2012. Role of α-Lipoic acid (ALA) on oxidative stress in sperm of streptozotocin-induced diabetic rats. Rev. Global Med. Healthcare Res., 3: 89-102.
    Direct Link  |  

  28. Matough, F.A., S.B. Budin, Z.A. Hamid, N. Alwahaibi and J. Mohamed, 2012. The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Univ. Med. J., 12: 5-18.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Matough, F.A., S.B. Budin, Z. Abdul Hamid, R. Louis, N. Alwahaibi and J. Mohamed, 2012. Palm vitamin E reduces oxidative stress and physical and morphological alterations of erythrocyte membranes in streptozotocin-iduced diabetic rats. Oxidants Antioxidants Med. Sci., 1: 56-68.
    Direct Link  |  

  30. Idris, M.H.M., S.B. Budin, M. Osman and J. Mohamed, 2012. Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats. EXCLI J., 11: 659-669.
    Direct Link  |  

  31. Hamid, Z.A., S.B. Budin, N.W. Jie, A. Hamid, K. Husain and J. Mohamed, 2012. Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats. J. Zhejiang Univ. Sci. B, 13: 176-185.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. Budin, S.B., S. Hanis, S.T. Izatus, A.J. Putri and M. Jamaludin, 2012. A histological studies of Rats’ lung subacutely treated with fenitrothion. Int. J. Collabor. Res. Internal Med. Public Health, 4: 744-752.
    Direct Link  |  

  33. Budin, S.B., M.S.N.A. Seri, O. Baharudin, S.T. Izatus and O. Hidayatulfathi, 2012. Acute and subacute oral toxicity of Litsea elliptica Blume essential oil in rats. Zhejiang Univ. Sci. B., 13: 783-790.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Budin, S.B., M.H. Cha, A.J. Putri and S.T. Izatus, 2012. Tocotrienol rich fraction prevents fenitrothion induced pancreatic damage by restoring antioxidant status. Pak. J. Biol. Sci., 15: 517-523.
    PubMed  |  

  35. Othman, H., A. Hamid, S.B. Budin and N.F. Rajab, 2011. The effectiveness of learning intervention program among first year students of biomedical science program. Proc.-Soc. Behav. Sci., 18: 367-371.
    CrossRef  |  Direct Link  |  

  36. Mohamed, J., W.L. Wei, N.N.A. Husin, N.Y. Alwahaibi and S.B. Budin, 2011. Selenium supplementation reduced oxidative stress in diethylnitrosamine-induced hepatocellular carcinoma in rats. Pak. J. Biol. Sci., 14: 1055-1060.
    CrossRef  |  Direct Link  |  

  37. Kamaralzaman, S., B.B. Siti, Y. Matthew, S. Hatta, S. Anuar and M. Jamaludin, 2011. Relationship between sensory neuropathy and body imbalance among diabetic malay women. Sains Malays., 40: 945-951.

  38. Hamid, A., S.B. Budin, R.A.P. Mohamed, N.A. Manaf and N.Y. Yuhana et al., 2011. Role of oxidative stress in the protective effects of Zingiber zerumbet smith ethyl-acetate extract against paracetamol-induced hepatotoxicity in Sprague-dawley rats. Aust. J. Basic Applied Sci., 5: 1519-1525.
    Direct Link  |  

  39. Budin, S.B., K.M. Yusof, M.I.M. Hanis, Z.A. Hamid and J. Mohamed, 2011. Tocotrienol-rich fraction of palm oil reduced pancreatic damage and oxidative stress in streptozotocin-induced diabetic rats. Aust. J. Basic Applied Sci., 5: 2367-2374.
    Direct Link  |  

  40. Alwahaibi, N.Y., B.B. Siti and M. Jamaludin, 2011. Absence of p53 gene expression in selenium molecular prevention of chemically Induced hepatocarcinogenesis in rats. Saudi J. Gastroenterol., 17: 328-334.
    CrossRef  |  PubMed  |  Direct Link  |  

  41. Kamaralzaman, S., S. Hatta, Y. Matthew, B.B. Siti, S. Anuar and M. Jamaludin, 2010. Sexual function of malay women with type 2 diabetes Mellitus: A preliminary study. ASEAN J. Psych., 11: 35-45.

  42. Alwahaibi, N.Y., B.B. Siti, M. Jamaludin and A. Alhamdani, 2010. Nuclear factor-kappa B as a promising target for selenium chemoprevention in rat hepatocarcinogenesis. J. Gastroenterol. Hepatol., 25: 766-791.
    CrossRef  |  PubMed  |  Direct Link  |  

  43. Alwahaibi, N.Y., B.B. Siti and M. Jamaludin, 2010. Biochemical profile of sodium selenite on chemically induced hepatocarcinogenesis in male sprague-dawley rats. Afr. J. Biochem. Res., 4: 273-278.
    Direct Link  |  

  44. Taib, I.S., S.B. Budin, S.M. Siti Nor Ain, J. Mohamed and S.R. Louis et al., 2009. Toxic effects of Litsea elliptica, Blume essential oil on red blood cells of Sprague-dawley rats. J. Zhejiang Univ. Sci. B, 10: 813-819.

  45. Hemabarathy, B., S.B. Budin and V. Feizal, 2009. Paracetamol hepatotoxicity in rats treated with crude extract of Alpinia galanga. J. Biol. Sci., 9: 57-62.
    CrossRef  |  Direct Link  |  

  46. Budin, S.B., O. Faizah, R.L. Santhana, M. Abu Bakar, D. Srijit and M. Jamaludin, 2009. Effect of palm Vitamin E supplementation on biochemical parameters, oxidative stress and vascular wall of streptozotocin-induced diabetic rats. Clin., 64: 235-244.

  47. Budin, S.B., O. Faizah, R.L. Santhana, M. Abu Bakar and R. Megat et al., 2009. Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats. Roman. J. Morphol. Embryol., 50: 23-30.
    PubMed  |  Direct Link  |  

  48. Budin, S.B., O. Khairul, N.W.M. Wan, O. Faizah and R.L. Santhana et al., 2008. Alpha lipoic acid reduces plasma glucose and lipid and the ultra-microscopic vascular changes in streptozotocin-induced diabetic rats. Ann. Microsc., 8: 58-65.

  49. Balkis, B.S., R. Nor Fadilah, A. Ezlan, O. Khairul, A.B. Mokhtar and M. Jamaludin, 2008. Oxidative stress and DNA damage in streptozotocin-induced diabetic rats: Effects of alpha lipoic acid. J. Boil. Sci., 8: 622-627.
    CrossRef  |  Direct Link  |  

  50. Fauzi, F., B.B. Siti, Shahrul Azwan and K.Y. Leong, 2007. The effect of 5 weeks exercise program on oxidative stress and response to acute exercise among sedentary subjects. J. Sains Kesihatan Malays., 5: 39-52.
    Direct Link  |  

  51. Budin, S.B., K.P. Kee, M.Y. Eng, K. Osman, M.A. Bakar and J. Mohamed, 2007. Alpha lipoic acid prevents pancreatic islet cells damage and dyslipidemia in streptozotocin-induced diabetic rats. Malay. J. Med. Sci., 14: 47-53.
    PubMed  |  Direct Link  |  

  52. Budin, S.B., F.R. Nor, O. Faizah, R. Megat, R.L. Santhana, M. Abu Bakar and M. Jamaludin, 2007. The occurance of early atherosclerosis process in the aorta of streptozotocin-induced diabetic rats. J. Microscopy Soc. Thailand, 21: 131-135.

  53. Budin, S.B., F.R. Nor, O. Khairul, M.T. Abdul Gapor, N.W.M. Wan, M. Abu Bakar and M. Jamaludin, 2006. Effects of palm vitamin E againts oxidative damage in streptozocin- induced diabetic rats. Malaysian J. Biochem. Mol. Biol., 13: 11-17.

  54. Shahar, S., X.K. Lee, B.B. Siti, M. Abu Bakar, A.U. Nor and M.H. Junara, 2005. Anaemia and cognitive function among chinese elderly in old folk homes. J. Sains Kesihatan Malaysia, 3: 41-54.

  55. Budin, S.B., M.T. Abdul Gapor, N.W.M. Wan, M. Abu Bakar, O. Khairul and M. Jamaludin, 2005. The effects of palm oil vitamin E on glycemic control and lipid profile in streptozotocin - induced diabetic rats. J. Sains Kesihatan Malaysia, 3: 9-18.

  56. Budin, S.B., F.R. Nor, M.T. Abdul Gapor, N. Wan and M. Wan et al., 2005. Assesment of DNA strand breakage by comet assay in streptozocin- induced diabetic rats. Jurnal Sains Kesihatan Malaysia, 3: 19-28.

  57. Abdullah, N., Z.M.S. Nur, H. Abu Hasan, B.B. Siti and K. Sazlina, 2004. Protective effects of the ethanol extract of Zingiber officinale roscoe with paracetamol induced hepatotoxicity in rats. J. Sains Kesihatan Malaysia, 2: 85-95.

  58. Abdul Wahab, K., A.M. Naji, P. Proom, O. Khairul, M. Jamaludin and B.B. Siti, 2003. Haemoprotective effects of Ganoderma lucidum preparation in cisplatin-treated rats. J. Sains Kesihatan Malaysia, 1: 85-88.
Member since July, 2017