Dr. Zamri Bin Chik

Associate Professor
University of Malaya, Malaysia

Highest Degree
Ph.D. in Clinical Pharmacology from University of London, UK

My URL
https://livedna.org/60.27040

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Area of Interest:

Pharmacology and Toxicology
Drug Formulation
Chromatographic Analysis
Pharmaceutical Analysis
Physiology

Selected Publications

  1. Alsalahi, A., M.A. Alshawsh, Z. Chik and Z. Mohamed, 2018. Effect of Catha edulis (Khat) on pancreatic functions in streptozotocin-induced diabetes in male sprague-dawley rats. Exp. Anim., 67: 517-526.
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  2. Abdullah, N.L., R. Gunasekaran, S.W. Mohd-Zin, B.H. Lim and P. Maniam et al., 2018. Cranial neural tube defect after trimethoprim exposure. BMC Res. Notes, Vol. 11. 10.1186/s13104-018-3593-1.
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  3. Kong, W.M., Z. Mohamed, M.A. Alshawsh and Z. Chik, 2017. Evaluation of pharmacokinetics and blood-brain barrier permeability of mitragynine using in vivo microdialysis technique. J. Pharm. Biomed. Anal., 143: 43-47.
    CrossRef  |  Direct Link  |  

  4. Kong, W.M., Z. Chik, Z. Mohamed and M.A. Alshawsh, 2017. Physicochemical characterization of Mitragyna speciosa alkaloid extract and mitragynine using in vitro high throughput assays. Combinatorial Chem. High Throughput Screen., 20: 796-803.
    CrossRef  |  Direct Link  |  

  5. Khodari, S.N.K., M.I. Noordin, L. Chan and Z. Chik, 2017. In vitro and in vivo evaluation of new topical anaesthetic cream formulated with palm oil base. Curr. Drug Deliv., 14: 690-695.
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  6. Chai, H.J., L.V. Kiew, Y. Chin, A. Norazit and N.S. Mohd et al., 2017. Renal targeting potential of a polymeric drug carrier poly-l-glutamic acid (PG) in normal and diabetic rats. Int. J. Nanomed., 2017: 577-591.
    CrossRef  |  

  7. Almoustafa, H.A., M.A. Alshawsh and Z. Chik, 2017. Technical aspects of preparing PEG-PLGA nanoparticles as carrier for ‎chemotherapeutic ‎agents by nanoprecipitation method. Int. J. Pharm., 533: 275-284.
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  8. Guad, R.M., N.L. Zaharan, Z. Chik, Z. Mohamed, B.S. Haerian, K.P. Ng and W.A.H.W.M. Adnan, 2016. Effects of CYP3A5 genetic polymorphism on the pharmacokinetics of tacrolimus in renal transplant recipients. Transplantation Proc., 48: 81-87.
    CrossRef  |  

  9. Abdul Ghani, Z.D.F., J.M. Husin, A.H. Ab Rashid, K. Shaari and Z. Chik, 2016. Biochemical studies of Piper betle L leaf extract on obese treated animal using 1H-NMR-based metabolomic approach of blood serum samples. J. Ethnopharmacol., 194: 690-697.
    CrossRef  |  Direct Link  |  

  10. Nair, S., Z. Chik and M.I. Noordin, 2015. In vitro characteristics of an insulin suppository developed using palm oil base (HAMIN®) and its hypoglycaemic effect on rabbits. Front. Life Sci., 8: 256-263.
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  11. Meganathan, P., R.S. Jabir, H.G. Fuang, N. Bhoo-Pathy and R.B. Choudhury et al., 2015. A new formulation of gamma delta tocotrienol has superior bioavailability compared to existing tocotrienol-rich fraction in healthy human subjects. Scient. Rep., Vol. 5. 10.1038/srep13550.
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  12. Haron, D.E.M., Z. Chik, M.I. Noordin and Z. Mohamed, 2015. In vitro and in vivo evaluation of a novel testosterone transdermal delivery system (TTDS) using palm oil base. Iranian J. Basic Med. Sci., 18: 1167-1175.

  13. Moghaddam, E., B.T. Teoh, S.S. Sam, R. Lani and P. Hassandarvish et al., 2014. Baicalin, a metabolite of baicalein with antiviral activity against dengue virus. Scient. Rep., Vol. 4. 10.1038/srep05452.
    CrossRef  |  Direct Link  |  

  14. Diong, S.H., N.S.M. Yusoff, M.S. Sim, R.E.R. Aziddin and Z. Chik et al., 2014. Quantitation of methadone and metabolite in patients under maintenance treatment. J. Anal. Toxicol., 38: 660-666.
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  15. Chik, Z., N.M. Deril, E.M.H. Didi, R.C. Basu, J. Ratnasingam and Z. Mohamed, 2014. A bioequivalence comparison of two captopril formulations (25 mg tablets): An open-label, randomized, two-treatment, two-way crossover study in healthy volunteers. J. Bioequivalence Bioavailability, Vol. 6. 10.4172/jbb.1000185.
    CrossRef  |  Direct Link  |  

  16. Hemmati, F., L. Dargahi, S. Nasoohi, R. Omidbakhsh and Z. Mohamed et al., 2013. Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with memantine. Behav. Brain Res., 252: 415-421.
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  17. Hairin, T., A.R. Marzilawati, E.M.H. Didi, S. Mahadeva and Y.K. Lee et al., 2013. Quantitative LC-MS/MS analysis of acetaminophen cysteine adducts (APAP- CYS) and its application in acetaminophen overdose patients. Anal. Methods, 5: 1955-1964.

  18. Bulgiba, A., U.Y. Mohammed, Z. Chik, C. Lee and D. Peramalah, 2013. How well does self-reported adherence fare compared to therapeutic drug monitoring in HAART? Prev. Med., 57: S34-S36.
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  19. Yagoub, U., A. Bulgiba, P. Devi, M. Ali, C. Lee and C. Zamri, 2012. Factors affecting adherence level to HAART (Adherence predictors) in Kuala Lumpur, Malaysia. Life Sci. J., 9: 3600-3603.
    Direct Link  |  

  20. Yagoub, U., A. Bulgiba, P. Devi, M. Ali, C. Lee and C. Zamr, 2012. Analysis of nevirapine and lamivudine in human plasma of HIV infected patients by high-performance liquid chromatographic-mass spectrometric (LC-MS-MS). Life Sci. J., 9: 4637-4645.
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  21. Yagoub, U., A.M. Bulgiba, E.M. Didi, A.M. Mustafa, D. Peramalah, C.T. Lee and Z. Chik, 2011. Validation and analysis of Efavirenz in human plasma using high-performance liquid chromatographic-mass spectrometric (LC-MS-MS). Int. J. Nat. Prod. Pharm. Sci., 2: 72-81.

  22. Kong, W.M., Z. Chik, M. Ramachandra, U. Subramaniam, R.E.R. Aziddin and Z. Mohamed, 2011. Evaluation of the effects of Mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay. Molecules, 16: 7344-7356.
    CrossRef  |  Direct Link  |  

  23. Chik, Z., D.M. Haron, E.D. Ahmad, H. Taha and A.M. Mustafa, 2011. Analysis of melamine migration from melamine food contact articles. Food Addit. Contaminants: Part A, 28: 967-973.
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  24. Chik, Z., R.C. Basu, R. Pendek, T.C. Lee and Z. Mohamed, 2010. A bioequivalence comparison of two formulations of Rifampicin (300-vs 150-mg Capsules): An open-label, randomized, two-treatment, two-way crossover study in healthy volunteers. Clin. Ther., 32: 1822-1831.
    CrossRef  |  

  25. Chik, Z., A.T. Tucker, J.I. Shiel, D.J. Collier, D. Perrett, T.D. Lee and A. Johnston, 2010. Comparative pharmacokinetic assessments of topical drugs: Evaluation by dermatopharmacokinetics, microdialysis and systemic measurement. J. Invest. Dermatol., 130: 2828-2830.
    Direct Link  |  

  26. Chik, Z., A.M. Mustafa, Z. Mohamed and T.C. Lee, 2010. Analysis of captopril in human plasma using gas chromatography-mass spectrometry (GCMS) with solid-phase extraction (SPE). Curr. Anal. Chem., 6: 329-333.
    Direct Link  |  

  27. Chik, Z., R.C. Basu, R. Pendek, T.C. Lee and Z. Mohamed, 2009. Comparative bioavailability study of two salbutamol tablets in healthy adult volunteers. Int. J. Pharmacol. Ther., 47: 413-418.
    Direct Link  |  

  28. Chik, Z., A. Johnston, A.T. Tucker, K. Kirby and C.A. Alam, 2009. Correcting endogenous concentrations of testosterone influences bioequivalence and shows the superiority of TDS (R)-testosterone versus Androgel (R). Int. J. Clin. Pharmacol. Ther., 47: 262-268.

  29. Chik, Z., A.T. Tucker, J.I. Shiel, D.J. Collier, D. Perrett, T.D. Lee and A. Johnston, 2007. Comparative pharmacokinetic assessments of topically applied drugs: Evaluation by dermatopharmacokinetic, microdialysis and systemic measurement. Br. J. Clin. Pharmacol., 63: 775 -776.
    Direct Link  |  

  30. Chik, Z., A. Johnston, A.T. Tucker, R.T. Burn and D. Perrett, 2007. Validation and application of capillary electrophoresis for the analysis of lidocaine in a skin tape stripping study. Biomed. Chromatography, 21: 775-779.
    CrossRef  |  Direct Link  |  

  31. Tucker, A.T., Z. Chik, L. Michaels, K. Kirby, M.P. Seed, A. Johnston and C.A.S. Alam, 2006. Study of a combined percutaneous local anaesthetic and the TDS® system for venepuncture. Anaesthesia, 61: 123-126.
    CrossRef  |  Direct Link  |  

  32. Eng, H.S., Z. Mohamed, R. Calne, C.C. Lang, M.A. Mohd, W.T. Seet and S.Y. Tan, 2006. The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients. Kidney Int., 69: 1858-1864.
    CrossRef  |  Direct Link  |  

  33. Chik, Z., T.D. Lee, D.W. Holt, A. Johnston and A.T. Tucker, 2006. Validation of high-performance liquid chromatographic-mass spectrometric (LC-MS-MS) method for the analysis of lidocaine in human plasma. J. Chromatogr. Sci., 44: 262-265.

  34. Chik, Z., A. Johnston, A.T. Tucker, S.L. Chew, L. Michaels and C.A.S. Alam, 2006. Pharmacokinetics of a new testosterone transdermal delivery system, TDS®‐testosterone in healthy males. Br. J. Clin. Pharmacol., 61: 275-279.
    CrossRef  |  Direct Link  |  

  35. Chik, Z., A. Johnston, A.T. Tucker, S.L. Chew and C.A.S. Alam, 2005. Pharmacokinetic study of the transdermal delivery system, TDS©-testosterone in healthy subjects. Br. J. Clin. Pharmacol., 59: 636-636.
    Direct Link  |  
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