Dr. Takuji Machida

Associate professor
Hokkaido University,Japan

Highest Degree
Ph.D. in Pharmacology from Hokkaido University, Japan

My URL
https://livedna.org/81.23092

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Area of Interest:

Pharmacology and Toxicology
Hypertension
Cellular Pharmacology
Fatty Acid Profile
Protein Expression

Selected Publications

  1. Machida, T., Y. Takano, K. Iizuka, M. Machida and M. Hirafuji, 2017. Methotrexate causes acute hyperplasia of enterochromaffin cells containing substance P in the intestinal mucosa of rats. J. Pharmacol. Sci., 133: 190-193.
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  2. Machida, T., K. Iizuka and M. Hirafuji, 2017. [Analysis of vascular smooth muscle cell response to mechanical stress induced by pulsatile pressure-loading apparatus]. Folia Pharmacologica Japonica, 150: 195-200, (In Japanese).
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  3. Machida, T., A. Onoguchi, K. Iizuka, S. Ishibashi, M. Yutani and M. Hirafuji, 2017. Effect of docosahexaenoic acid on voltage-independent Ca2+ entry pathways in cultured vascular smooth muscle cells stimulated with 5-hydroxytryptamine. Biol. Pharm. Bull., 40: 916-921.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Machida, T., R. Matamura, K. Iizuka and M. Hirafuji, 2016. Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. J. Pharmacol. Sci., 132: 211-217.
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  5. Machida, T., 2016. Analysis of vascular cell response to hypertension induced by pressure loading and its application as a tool for exploring pharmacological modes of action. Yakugaku Zasshi, 136: 1485-1490.
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  6. Machida, M., Y. Miyamura, T. Machida, K. Koyama, K. Iizuka and M. Hirafuji, 2015. Administration of olanzapine as an antiemetic agent changes glucose homeostasis in cisplatin-treated rats. Biol. Pharm. Bull., 38: 587-593.
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  7. Takano, Y., T. Machida, Y. Obara, M. Hirano and S. Kudo et al., 2014. Methotrexate causes a change in intestinal 5-hydroxytryptamine metabolism in rats. Eur. J. Pharmacol., 740: 496-503.
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  8. Machida, T., T. Hatanaka, A. Onoguchi, K. Iizuka and M. Hirafuji, 2014. Comparison of fatty acid-binding protein expression in vascular smooth muscle cells from stroke-prone spontaneously hypertensive and Wistar Kyoto rats. Pharmacologia, 5: 12-18.
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  9. Machida, T., K. Iizuka, K. Shinohara, N. Hatakeyama, K. Nakano, Y. Kubo and M. Hirafuji, 2014. Pressure stress reduces inducible NO synthase expression by interleukin-1β stimulation in cultured rat vascular smooth muscle cells. Eur. J. Pharmacol., 731: 44-49.
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  10. Iizuka, K., T. Machida and M. Hirafuji, 2014. [Hope for novel oral anticoagulants and related problems]. Folia Pharmacologica Japonica, 143: 47-47, (In Japanese).
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  11. Iizuka, K., T. Machida and M. Hirafuji, 2014. Skeletal muscle is an endocrine organ. J. Pharmacol. Sci., 125: 125-131.
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  12. Iizuka, K., T. Machida and M. Hirafuji, 2014. Extracellular MCT4 is a possible indicator for skeletal muscle MHC fiber type change. Ann. Clin. Lab. Sci., 44: 272-276.
    PubMed  |  Direct Link  |  

  13. Fujii, K., T. Machida, K. Iizuka and M. Hirafuji, 2014. Sphingosine 1-phosphate increases an intracellular Ca2+ concentration via S1P3 receptor in cultured vascular smooth muscle cells. J. Pharm. Pharmacol., 66: 802-810.
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  14. Machida, T., K. Iizuka and M. Hirafuji, 2013. 5-Hydroxytryptamine and its receptors in systemic vascular walls. Biol. Pharm. Bull., 36: 1416-1419.
    PubMed  |  Direct Link  |  
Member since January, 2018