Dr. Beom-Jin Lee

Professor
Ajou University, South Korea

Highest Degree
Ph.D. in Pharmacy from Oregon State University, USA

My URL
https://livedna.org/82.5526

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Biography

Dr. Beom-Jin Lee holds a position of Dean and Professor at College of Pharmacy, Ajou University, Korea. He obtained his Ph.D. in Pharmacy from Oregon State University, USA. His main area of interest related to Biomedical Sciences, Pharmaceutics, Drug Delivery, and Nanomedicine. His area of expertise includes pharmaceutical formulations, controlled bioavailability, and drug delivery system, nano-conjugation, solubilization of poorly soluble drug, nanomedicine, incrementally modified drug, and pharmaceutical coating technique. He is author and co-author of 115 journal papers.

Area of Interest:

Biomedical Sciences
Pharmaceutics
Drug Delivery
Nanomedicine
Pharmacy

Selected Publications

  1. Tran, P.H.L., T.T.D. Tran and B.J. Lee, 2013. Biodistribution and pharmacokinetics in rats and antitumor effect in various types of tumor-bearing mice of novel self-assembled gelatin-oleic acid nanoparticles containing paclitaxel. J. Biomed. Nanotechnol., 9: 1-12.

  2. P.H.L. Tran, T.T.D. Tran, Z.Z. Piao, T.V. Vo and J.B. Park et al., 2013. Physical properties and in vivo bioavailability in human volunteers of isradipine using controlled release matrix tablet containing self-emulsifying solid dispersion. Int. J. Pharm., 450: 79-86.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Cao, L., J. Pu, Q.R. Cao, B.W. Chen, B.J. Lee and J.H. Cui, 2013. Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration. Fitoterapia, 86: 202-207.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Yun, J.M., S.Y. Park, E.S. Lee, Y.S. Youn and G.Y. Park et al., 2012. Physicochemical characterizations of amphiphilic block copolymers with different MWs and micelles for development of anticancer drug nanocarriers. Macromol. Res., 20: 944-953.
    CrossRef  |  Direct Link  |  

  5. Yan, Y.D., J.H. Sung, K.K. Kim, D.W Kim, J.O. Kim, B.J. Lee, C.S Yong and H.G. Choi, 2012. Novel valsartan-loaded solid dispersion with enhanced bioavailability and no crystalline changes. Int. J. Pharm., 422: 202-210.
    CrossRef  |  PubMed  |  Direct Link  |  

  6. Waldmann, S., M. Almukainzi, N.A. Bou-Chacra, G.L. Amidon and B.J. Lee et al., 2012. Provisional biopharmaceutical classification of some common herbs used in Western medicine. Mol. Pharm., 9: 815-822.
    CrossRef  |  PubMed  |  Direct Link  |  

  7. Tran, T.T.D., P.H.L. Tran, J.B. Park and B.J. Lee, 2012. Effects of solvents and crystallization conditions on the polymorphic behaviors and dissolution rates of valsartan. Arch. Pharm. Res., 35: 1223-1230.
    CrossRef  |  PubMed  |  Direct Link  |  

  8. Tran, P.H.L., T.T.D. Tran, T. Van Vo and B.J. Lee, 2012. Promising iron oxide-based magnetic nanoparticles in biomedical engineering. Arch. Pharm. Res., 35: 2045-2061.
    CrossRef  |  PubMed  |  Direct Link  |  

  9. Sohn, Y., S.Y. Lee, G.H. Lee, Y.J. Na and S.Y. Kim et al., 2012. Development of self-microemulsifying bilayer tablets for pH-independent fast release of candesartan cilexetil. Pharmazie Int. J. Pharm. Sci., 67: 917-924.
    CrossRef  |  PubMed  |  Direct Link  |  

  10. Qiang, F., H.J. Shin, B.J. Lee and H.K. Han, 2012. Enhanced systemic exposure of fexofenadine via the intranasal administration of chitosan-coated liposome. Int. J. Pharm., 430: 161-166.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Park, C.W., H.M. Mansour, T.O. Oh, J.Y. Kim and J.M. Ha et al., 2012. Phase behavior of itraconazole-phenol mixtures and its pharmaceutical applications. Int. J. Pharm., 436: 652-658.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Lee, E.S., C. Lim, H.T. Song, J.M. Yun and K.S. Lee et al., 2012. A nanosized delivery system of superparamagnetic iron oxide for tumor MR imaging. Int. J. Pharm., 439: 342-348.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Cao, Q.R., Y. Liu, W.J. Xu, B.J. Lee, M. Yang and J.H. Cui, 2012. Enhanced oral bioavailability of novel mucoadhesive pellets containing valsartan prepared by a dry powder-coating technique. Int. J. Pharm., 434: 325-333.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Cao, Q.R., J.S. Choi, Y. Liu, W.J. Xu, M. Yang, B.J. Lee and J.H. Cui, 2012. A formulation approach for development of HPMC-based sustained release tablets for tolterodine tartrate with a low release variation. Drug Dev. Ind. Pharm., 10.3109/03639045.2012.730528.
    CrossRef  |  PubMed  |  Direct Link  |  

  15. Youn, Y.S. and B.J. Lee, 2011. Conference report: Pharmaceutical technology, biopharmaceutics and drug delivery. Ther. Delivery, 2: 297-299.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Tran, T.H. and B.J. Lee, 2011. On-off pulsed oral drug-delivery systems: A possible tool for drug delivery in chronotherapy. Ther. Delivery, 2: 1199-1214.
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  17. Tran, P.H.L., T.T.D. Tran, J.B. Park, D.H. Min and H.G. Choi et al., 2011. Investigation of physicochemical factors affecting the stability of a pH-modulated solid dispersion and a tablet during storage. Int. J. Pharm., 414: 48-55.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Tran, P.H.L., T.T.D. Tran, J.B. Park and B.J. Lee, 2011. Controlled release systems containing solid dispersions: Strategies and mechanisms. Pharm. Res., 28: 2353-2378.
    CrossRef  |  PubMed  |  Direct Link  |  

  19. Tran, H.T.T., J.B. Park, K.H. Hong, H.G. Choi and H.K. Han et al., 2011. Preparation and characterization of pH-independent sustained release tablet containing solid dispersion granules of a poorly water-soluble drug. Int. J. Pharm., 415: 83-88.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Phuong, H.L.T., T.T.D. Tran, S.A. Lee, V.H. Nho, S.C. Chi and B.J. Lee, 2011. Roles of MgO release from polyethylene glycol 6000-based solid dispersions on microenvironmental pH, enhanced dissolution and reduced gastrointestinal damage of telmisartan. Arch. Pharm. Res., 34: 747-755.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Oh, D.H., J.H. Kang, D.W. Kim, B.J. Lee and J.O. Kim et al., 2011. Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier. Int. J. Pharm., 420: 412-418.
    CrossRef  |  PubMed  |  Direct Link  |  

  22. Kang, M.J., S.Y. Jung, W.H. Song, J.S. Park and S.U. Choi et al., 2011. Immediate release of ibuprofen from Fujicalin®-based fast-dissolving self-emulsifying tablets. Drug Dev. Ind. Pharm., 37: 1298-1305.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Han, H.K., B.J. Lee and H.K. Lee, 2011. Enhanced dissolution and bioavailability of biochanin A via the preparation of solid dispersion: In vitro and in vivo evaluation. Int. J. Pharm., 415: 89-94.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Ha, N.S., T.T.D. Tran, P.H.L. Tran, J.B. Park and B.J. Lee, 2011. Dissolution-enhancing mechanism of alkalizers in poloxamer-based solid dispersions and physical mixtures containing poorly water-soluble valsartan. Chem. Pharm. Bull., 59: 844-850.
    CrossRef  |  PubMed  |  Direct Link  |  

  25. Yun, J., G.Y. Park, H.H. Kim, J. Lee and E.S. Lee et al., 2010. Physiochemical properties of binary pluronic systems for reversal of multi-drug resistant (MDR) cancers. J. Pharm. Inv., 40: 255-261.

  26. Yun, G., S.U. Choi, K.H. Park, Y.S. Rhee, B.J. Lee and J. Lee, 2010. Pharmaceutical devices for oral cavity-based local and systemic drug delivery. J. Pharm. Inv., 40: 113-118.

  27. Tran, T.T., P.H. Tran, J. Lim, J.B. Park, S.K. Choi and B.J. Lee, 2010. Physicochemical principles of controlled release solid dispersion containing a poorly water-soluble drug. Ther. Delivery, 1: 51-62.
    PubMed  |  

  28. Tran, T.T., P.H. Tran, H.G. Choi, H.K. Han and B.J. Lee, 2010. The roles of acidifiers in solid dispersions and physical mixtures. Int. J. Pharm., 384: 60-66.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Tran, P.H.L., T.T.D. Tran, K.H. Lee, D.J. Kim and B.J. Lee, 2010. Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with poor water solubility. Exp. Opinion Drug Delivery, 7: 647-661.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Rhee, Y.S., J. Lee, K.T. Oh, B.J. Lee and E.S. Park, 2010. Controlled-release pelletized dosage forms using the extrusion-spheronization process. J. Pharm. Inv., 40: 103-112.

  31. Rhee, Y.S., C.W. Park, T.O. Oh, J.Y. Kim and J.M. Ha et al., 2010. Effect of electrokinetic stabilizers on the physicochemical properties of propofol emulsions. Int. J. Pharm., 398: 21-27.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. Ren, S., T.T.D. Tran, P.H.L. Tran, Y.S. Rhee and B.J. Lee, 2010. Investigation of degradation mechanism of rabeprazole with solid state pharmaceutical excipients. J. Pharm. Inv., 40: 367-372.

  33. Qiang, F., B.J. Lee, I. Ha, K.W. Kang, E.R. Woo and H.K. Han, 2010. Effect of maceligan on the systemic exposure of paclitaxel: In vitro and In vivo evaluation. Eur. J. Pharm. Sci., 41: 226-231.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Park, J.B., J.S. Choi, S.C. Lee, H. Lee, B.J. Lee and C.Y. Kang, 2010. Physical properties of gelucire-based solid dispersions containing lacidipine and release profiles. J. Kor. Pharm. Sci., 40: 9-14.

  35. Lee, E.S., J.H. Kim, J. Yun, K.S. Lee, G.Y. Park, B.J. Lee and K.T. Oh, 2010. Functional polymers for drug delivery systems in Nanomedicines. J. Pharm. Inv., 40: 45-62.

  36. Cao, Q.R., J.H. Cui, J.B. Park, H.K. Han and J. Lee et al., 2010. Effect of food components and dosing times on the oral pharmacokinetics of nifedipine in rats. Int. J. Pharm., 396: 39-44.
    CrossRef  |  PubMed  |  Direct Link  |  

  37. Tran, T.T.D., P.H.L. Tran and B.J. Lee, 2009. Dissolution-modulating mechanism of alkalizers and polymers in a nanoemulsifying solid dispersion containing ionizable and poorly water-soluble drug. Eur. J. Pharmaceut. Biopharmaceut., 72: 83-90.
    CrossRef  |  PubMed  |  Direct Link  |  

  38. Tran, H.T.T., P.H.L. Tran, T.T.D. Tran, K.H. Lee and B.J. Lee, 2009. Preliminary imaging analysis for enhanced intestinal uptake of non-soluble polystyrene microspheres in the presence of oleic acid using rat intestine. J. Kor. Pharm. Sci., 39: 155-159.
    Direct Link  |  

  39. Tran, H.T.T., P.H.L. Tran and B.J. Lee, 2009. New findings on melatonin absorption and alterations by pharmaceutical excipients using the Ussing chamber technique with mounted rat gastrointestinal segments. Int. J. Pharm., 378: 9-16.
    CrossRef  |  PubMed  |  Direct Link  |  

  40. Qiang, F., B.J. Lee, W. Lee and H.K. Han, 2009. Pharmacokinetic drug Interaction between fexofenadine and fluvastatin mediated by organic anion-transporting polypeptides in rats. Eur. J. Pharm. Sci., 37: 413-417.
    CrossRef  |  PubMed  |  Direct Link  |  

  41. Kim, A.R., S.J. Lim and B.J. Lee, 2009. Metabolic inhibition and kinetics of raloxifene by pharmaceutical excipients in human liver microsomes. Int. J. Pharm., 368: 37-44.
    CrossRef  |  PubMed  |  Direct Link  |  

  42. Balakrishnan, P., B.J. Lee, D.H. Oh, J.O. Kim and Y.I. Lee et al., 2009. Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems. Int. J. Pharm., 374: 66-72.
    CrossRef  |  PubMed  |  Direct Link  |  

  43. Balakrishnan, P., B.J. Lee, D.H. Oh, J.O. Kim and M.J. Hong et al., 2009. Enhanced oral bioavailability of dexibuprofen by a novel solid Self-Emulsifying Drug Delivery System (SEDDS). Eur. J. Pharm. Biopharm., 72: 539-545.
    CrossRef  |  PubMed  |  Direct Link  |  

  44. Tran, P.H.L., H.T.T. Tran and B.J. Lee, 2008. Modulation of microenvironmental pH and crystallinity of ionizable telmisartan using alkalizers in solid dispersions for controlled release. J. Controlled Release, 129: 59-65.
    CrossRef  |  PubMed  |  Direct Link  |  

  45. Ren, S., M.J. Park, H. Sah and B.J. Lee, 2008. Effect of pharmaceutical excipients on aqueous stability of rabeprazole sodium. Int. J. Pharm., 350: 197-204.
    CrossRef  |  PubMed  |  Direct Link  |  

  46. Ren, S., M.J. Park, A. Kim and B.J. Lee, 2008. In vitro metabolic stability of moisture-sensitive rabeprazole in human liver microsomes and its modulation by pharmaceutical excipients. Arch. Pharm. Res., 31: 406-413.
    CrossRef  |  PubMed  |  Direct Link  |  

  47. Piao, Z.Z., M.K. Lee and B.J. Lee, 2008. Colonic release and reduced intestinal tissue damage of coated tablets containing naproxen inclusion complex. Int. J. Pharm., 350: 205-211.
    CrossRef  |  PubMed  |  Direct Link  |  

  48. Piao, Z.Z., E.S. Lee, Y.J. Choi and B.J. Lee, 2008. Controlled release of three nutrients from dual-layered coated compact pellets. J. Kor. Pharm. Sci., 38: 177-182.

  49. Piao, Z.Z., E.S. Lee, H.T.T. Tran and B.J. Lee, 2008. Improved analytical validation and pharmacokinetics of valsartan using HPLC with UV detection. Arch. Pharm. Res., 31: 1055-1059.
    CrossRef  |  PubMed  |  Direct Link  |  

  50. Cao, Q.R., E.S. Lee, Y.J. Choi, C.S. Cho and B.J. Lee, 2008. Rumen bypass and biodistribution of L-carnitine from dual-layered coated pellets in cows, In vitro and In vivo. Int. J. Pharm., 359: 87-93.
    CrossRef  |  PubMed  |  Direct Link  |  

  51. Park, M.J., S. Ren and B.J. Lee, 2007. In vitro and in vivo comparative study of itraconazole bioavailability when formulated in highly soluble self-emulsifying system and in solid dispersion. Biopharm. Drug Dispos., 28: 199-207.
    CrossRef  |  PubMed  |  Direct Link  |  

  52. Kim, T.W., H. Sah and B.J. Lee, 2007. Characterization of dual layered pellets for sustained release of poorly water-soluble drug. Chem. Pharm. Bull., 55: 975-979.
    CrossRef  |  PubMed  |  Direct Link  |  

  53. Kim, T.W., C.W. Ji, S.Y. Shim and B.J. Lee, 2007. Modified release of coated sugar spheres using drug-containing polymeric suspensions Arch. Pharm. Res., 30: 124-130.

  54. Kim, H., B.J. Lee and H. Sah, 2007. Reverse micelle-based microencapsulation of oxytetracycline hydrochloride into poly-d,l-lactide-co-glycolide microspheres. Drug Delivery, 14: 95-99.
    CrossRef  |  PubMed  |  Direct Link  |  

  55. Cui, J.H., Q.R. Cao and B.J. Lee, 2007. Enhanced delivery of bifidobacteria and fecal changes after multiple oral administrations of bifidobacteria-loaded alginate poly-l-lysine microparticles in human volunteers. Drug Delivery, 14: 265-271.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. Cao, Q.R., T.W. Kim and B.J. Lee, 2007. Photoimages and the release characteristics of lipophilic matrix tablets containing highly water-soluble potassium citrate with high drug loadings. Int. J. Pharm., 339: 19-24.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. Cao, Q.R., S. Ren, M.J. Park, Y.J. Choi and B.J. Lee, 2007. Determination of highly soluble L-carnitine in biological samples by reverse phase high performance liquid chromatography with fluorescent derivatization. Arch. Pharm. Res., 30: 1041-1046.
    CrossRef  |  PubMed  |  Direct Link  |  

  58. Shim, S.Y., C.W. Ji, H. Sah, E.S. Park and B.J. Lee, 2006. Characterization of itraconazole semisolid dosage forms prepared by hot melt technique. Arch. Pharm. Res., 29: 1055-1060.
    CrossRef  |  PubMed  |  Direct Link  |  

  59. Sah, H. and B.J. Lee, 2006. Development of new microencapsulation techniques useful for preparation of PLGA microspheres. Macromol. Rapid Commun., 27: 1845-1851.
    CrossRef  |  Direct Link  |  

  60. Cui, J.H., Q.R. Cao, Y.J. Choi, K.H. Lee and B.J. Lee, 2006. Effect of additives on the viability of Bifidobacteria loaded in alginate poly-l-lysine microparticles during the freeze-drying process Arch. Pharm. Res., 29: 707-711.
    CrossRef  |  PubMed  |  Direct Link  |  

  61. Kim, T.W., Q.R. Cao, S.Y. Han, O.K. Song, K.S. Sin, S.H. Kang and B.J. Lee, 2005. Bioequivalence of cefaclor monohydrate 250mg using an improved HPLC analytical method. Kor. J. Clin. Pharm., 15: 21-26.

  62. Kim, T.W., O.K. Song, Q.R. Cao, M.J. Park and S.H. Kang et al., 2005. Bioavailability of cefaclor capsules using an improved analytical method of cefaclor in human plasma. J. Kor. Pharm. Sci., 35: 117-122.

  63. Heo, M.Y., Z.Z. Piao, T.W. Kim, Q.R. Cao, A. Kim and B.J. Lee, 2005. Effect of solubilizing and microemulsifying excipients in polyethylene glycol 6000 solid dispersion on enhanced dissolution and bioavailability of ketoconazole. Arch. Pharm. Res., 28: 604-611.
    CrossRef  |  PubMed  |  Direct Link  |  

  64. Cao, Q.R., Y.W. Choi, J.H. Cui and B.J. Lee, 2005. Formulation, release characteristics and bioavailability of novel monolithic hydroxypropylmethylcellulose matrix tablets containing acetaminophen. J. Controlled Release, 108: 351-361.
    CrossRef  |  PubMed  |  Direct Link  |  

  65. Cao, Q.R., Y.W. Choi, J.H. Cui and B.J. Lee, 2005. Effect of solvents on physical properties and release characteristics of monolithic hydroxypropylmethylcellulose matrix granules and tablets. Arch. Pharm. Res., 28: 493-501.
    CrossRef  |  PubMed  |  Direct Link  |  

  66. Cao, Q.R., T.W. Kim, J.S. Choi and B.J. Lee, 2005. Circadian variations in the pharmacokinetics, tissue distribution and urinary excretion of nifedipine after a single oral administration to rats. Biopharm. Drug Disp., 26: 427-437.
    CrossRef  |  PubMed  |  Direct Link  |  

  67. Yong, C.S., C.H. Yang, J.D. Rhee, B.J. Lee and D.C. Kim et al., 2004. Enhanced rectal bioavailability of ibuprofen in rats by poloxamer 188 and menthol. Int. J. Pharm., 269: 169-176.
    CrossRef  |  PubMed  |  Direct Link  |  

  68. Phuong, N.T., B.J. Lee, J.K. Choi, J.S. Kang and K. Kwon, 2004. Enantioselective pharmacokinetics of carvedilol in human volunteers Arch. Pharm. Res., 27: 973-977.
    CrossRef  |  PubMed  |  Direct Link  |  

  69. Cao, Q.R., H.G. Choi, D.C. Kim and B.J. Lee, 2004. Release behavior and photo-image of nifedipine tablet coated with high viscosity grade hydroxypropylmethylcellulose: Effect of coating conditions. Int. J. Pharm., 274: 107-117.
    CrossRef  |  PubMed  |  Direct Link  |  

  70. Yong, C.S., S.H. Jung, J.D. Rhee, B.J. Lee and D.C. Kim et al., 2003. Improved solubility and in vitro dissolution of ibuprofen from poloxamer gel using eutectic mixture with menthol. Drug Delivery, 10: 179-183.
    CrossRef  |  PubMed  |  Direct Link  |  

  71. Kim, T.W., Q.R. Cao, C.Y. Choi and B.J. Lee, 2003. Physicochemical properties of polxamer-based gel containing capsaicin analog. J. Kor. Pharm. Sci., 33: 1-6.

  72. Cao, Q.R., T.W. Kim, C.Y. Choi, K.A. Kwon and B.J. Lee, 2003. Preparation and dissolution of PVP-based solid dispersion capsules containing solubilizers. J. Kor. Pharm. Sci., 33: 7-14.

  73. Kim, W.S., S.Y. Park, B.J. Lee, P.H. Kim and J.S. Goh, 2002. Effect of whey protein hydrolysates fractionated by molecular weight on the growth of Bifidobacterium bifidum Bb-11. Korean J. Food Sci. Animal Resour., 22: 59-65.

  74. Kim, T.W., C.Y. Choi, Q.R. Cao, K.A. Kwon and B.J. Lee, 2002. Dissolution profiles of solid dispersions containing poorly water-soluble drugs and solubilizing compositions. J. Kor. Pharm. Sci., 32: 191-197.

  75. Cui, J.H. and B.J. Lee, 2001. Preparation and physical characterization of alginate microparticles using air atomization method. Drug Dev. Ind. Pharm., 27: 309-319.
    CrossRef  |  PubMed  |  Direct Link  |  

  76. Choi, H.G., B.J. Lee, J.H. Han, K.M. Park and C.S. Yong et al., 2001. Terfenadine B-cyclodextrin inclusion complex with antihistaminic activity enhancement. Drug Dev. Ind. Pharm., 27: 857-862.
    CrossRef  |  PubMed  |  Direct Link  |  

  77. Cui, J.H., J.S. Koh, P.H. Kim, S.H. Choi and B.J. Lee, 2000. Survival and stability of bifidobacteria loaded in alginate poly-l-lysine microparticles. Int. J. Pharm., 210: 51-59.
    CrossRef  |  PubMed  |  Direct Link  |  

  78. Cui, J., J.M. Shim, J.S. Lee and B.J. Lee, 2000. Gastric acid resistance of lactobacilli and bifidobacteria in commercial drink and liquid yohurts. Kor. J. Microbiol., 36: 161-165.

  79. Lee, B.J., S.G. Ryu and J.H. Cui, 1999. Formulation and release characteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin. Drug Dev. Ind. Pharm., 25: 493-501.
    CrossRef  |  PubMed  |  Direct Link  |  

  80. Lee, B.J., S.G. Ryu and J.H. Cui, 1999. Controlled release of dual drug-loaded hydroxypropyl methylcellulose matrix tablet using drug-containing polymeric coatings. Int. J. Pharm., 188: 71-80.
    CrossRef  |  PubMed  |  Direct Link  |  

  81. Lee, B.J., J. Cui, O.S. Park, J.S. Goh, T.S. Ahn and S. Yong, 1999. Park stability and gastric acid resistence of lactobacilli and bifidobacteria in commercial yohurts. Kor. J. Microbiol., 35: 89-93.

  82. Lee, B.J., H. Jung, J. Cui and S.H. Kim, 1999. Diffusional behaviors of the fabricated polymeric films containing various excipients. J. Kor. Pharm. Sci., 29: 185-191.

  83. Lee, B.J., G.H. Min and J.H. Cui, 1999. Correlation of drug solubility with trapping efficiency and release characteristics of alginate beads. Pharm. Pharmacol. Commun., 5: 85-89.
    CrossRef  |  Direct Link  |  

  84. Ko, E.J., J.S. Koh, B.J. Lee, S.H. Choi and P.H. Kim, 1999. Bifidobacterium bifidum exhibits a lipopolysaccharide-like mitogenic activity for murine B lymphocytes. J. Dairy Sci., 82: 1869-1876.
    CrossRef  |  PubMed  |  Direct Link  |  

  85. Choi, J.S., C.K. Kim and B.J. Lee, 1999. Administration-time differences in the pharmacokinetics of gentamicin intravenously delivered to human beings. Chronobiol. Int., 16: 821-829.
    CrossRef  |  PubMed  |  Direct Link  |  

  86. Lee, B.J., J.S. Choe and C.K. Kim, 1998. Preparation and characterization of melatonin-loaded stearyl alcohol microspheres. J. Microencapsulation, 15: 775-787.
    CrossRef  |  PubMed  |  Direct Link  |  

  87. Lee, B.J., J.H. Cui, K.A. Parrott, J.W. Ayres and R.L. Sack, 1998. Percutaneous absorption and model membrane variations of melatonin in aqueous-based propylene glycol and 2-hydroxypropyl-β-cyclodextrin vehicles. Arch. Pharm. Res., 21: 503-507.
    CrossRef  |  PubMed  |  Direct Link  |  

  88. Lee, B.J., J,H. Cui, T.W. Kim and M.Y. Heo and C.K. Kim, 1998. Biphasic release characteristics of dual drug-loaded alginate beads. Arch. Pharm. Res., 21: 645-650.
    CrossRef  |  PubMed  |  Direct Link  |  

  89. Kim, W.S., J.W. Choi, S.Y. Park, B.J. Lee, P.H. Kim, S.H. Choi and J.S. Goh, 1998. Effects of casein hydrolysates fractionated by molecular weight on the growth of Bifidobaceria bifidum Bb-11. Kor. J. Dairy Sci., 20: 123-132.

  90. Choi, S.H., W.H. Kwon, J.S. Goh, B.J. Lee and P.H. Kim, 1998. Comparative study on biochemical and molecular genetical methods for identification of species and strains of Bifidobaceria. Kor. J. Dairy Sci., 20: 261-272.

  91. Choi, H.G., J.H. Jung, J.M. Ryu, M.K. Lee, I.S. Kim, B.J. Lee and C.K. Kim, 1998. Effect of additives on the physical properties of acetaminophen liquid suppository. Yakhak Hoeji, 42: 290-295.

  92. Lee, B.J., T.S. Lee, B.J. Cha, S.H. Kim and W.B. Kim, 1997. Percutaneous absorption and histopathology of a poloxamer-based formulation of capsaicin analog. Int. J. Pharm., 159: 105-114.
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  93. Lee, B.J., S.G. Ryu, H.G. Choi, C.K. Kim, K.A. Parrott, J.W. Ayres and R.L. Sack, 1997. Batch variation and pharmacokinetics of oral sustained release melatonin-loaded sugar spheres in human subjects. Arch. Pharm. Res., 20: 555-559.
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  94. Lee, B.J., H.G. Choi, C.K. Kim, K.A. Parrott, J.W. Ayres and R.L. Sack, 1997. Solubility and stability of melatonin in propylene glycol and 2-hydroxypropyl-β-cyclodextrin vehicles. Arch. Pharm. Res., 20: 560-565.
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  95. Kim, T.W., B.J. Lee, H.G. Choi, C.K. Kim, H.J. Shin and J.W. KIm, 1997. Pharmacokinetics of ethanol after oral administration of aspartate-containing compositions. J. Kor. Pharm. Sci., 27: 181-187.

  96. Shin, S.I., B.J. Lee, T.S. Lee, B.U. Heo and S.G. Ryu, 1996. Sustained release matrix tablet containing sodium alginate and excipients. J. Kor. Pharm. Sci., 26: 187-192.

  97. Lee, B.J., K.A. Parrott and J.W. Ayres, 1996. Development and characterization of an oral controlled-release delivery system for melatonin. Drug Dev. Ind. Pharm., 22: 269-274.
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  98. Lee, B.J., G.H. Min and T.W. Kim, 1996. Preparation and in vitro release of melatonin-loaded multivalent cationic alginate beads. Arch. Pharm. Res., 19: 280-285.
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  99. Lee, B.J. and G.H. Min, 1996. Oral controlled release of melatonin using polymer-reinforced and coated alginate beads. Int. J. Pharm., 144: 37-46.
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  100. Lee, B.J., K.A. Parrott, J.W. Ayres and R.L. Sack, 1995. Design and evaluation of an oral controlled release delivery system for melatonin in human subjects. Int. J. Pharm., 124: 119-127.
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  101. Lee, B.J. and T.S. Lee, 1995. Enhancement of dissolution rate of poorly water-soluble drug using solid dispersion and inclusion complex. J. Kor. Pharm. Sci., 25: 31-36.

  102. Lee, B.J. and J.R. Lee, 1995. Enhancement of solubility and dissolution rate of poorly water-soluble naproxen by complexation with 2-hydroxypropyl-β-cyclodextrin. Arch. Pharm. Res., 18: 22-26.
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  103. Lee, B.J. and G.H. Min, 1995. Preparation and release characteristics of polymer-reinforced and coated alginate beads. Arch. Pharm. Res., 18: 183-188.
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  104. Kim, C.K. and B.J. Lee, 1995. Effects of exercise on the physiological changes of Korean cyclists. J. Kor. Pharm. Sci., 25: 95-100.

  105. Kim, C.K. and B.J. Lee, 1995. Comparative study on the absorption of water after oral administration of various sports drinking beverages to rabbits. J. Kor. Pharm. Sci., 25: 1-7.

  106. Lee, B.J., K.A. Parrott, J.W. Ayres and R.L. Sack, 1994. Preliminary evaluation of transdermal delivery of melatonin in human subjects. Res. Commun. Mol. Pathol. Pharmacol., 85: 337-346.
    PubMed  |  

  107. Kim, C.K., M.K. Lee, J.H. Han and B.J. Lee, 1994. Pharmacokinetics and tissue distribution of methotrexate after intravenous injection of differently charged liposome-entrapped methotrexate to rats. Int. J. Pharm., 108: 21-29.
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  108. Chong-Kook, K., C. Jae-Yoon, Y. Yong-Sang, G. Jae-Phil, C. Han-Gona, K.J. Yang and L. Beom-Jin, 1994. Preparation and evaluation of a dry elixir for the enhancement of the dissolution rate of poorly water-soluble drugs. Int. J. Pharm., 106: 25-32.
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  109. Kim, C.K., S.K. Lee and B.J. Lee, 1993. Preparation and evaluation of temperature sensitive liposomes containing adriamycin and cytarabine. Arch. Pharm. Res., 16: 129-133.
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  110. Kim, C.K., H.S. Kim, B.J. Lee and J.H. Han, 1991. Effect of bovine serum albumin on the stability of methotrexate-encapsulated liposomes. Arch. Pharm. Res., 14: 336-341.
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  111. Kim, C.K. and B.J. Lee, 1988. The absorption of water from the isolated small intestine of the rat. Yakhak Hoeji, 32: 194-197.

  112. Kim, C.K. and B.J. Lee, 1987. Effect of salts on the entrapment of calf thymus DNA into liposomes. Arch. Pharm. Res., 10: 110-114.
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