Dr. Vivian Yvonne Shin

Research Scientist
The University of Hong Kong, Hong Kong

Highest Degree
Ph.D. in Pharmacology from The University of Hong Kong, Hong Kong

My URL
https://livedna.org/852.5956

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Area of Interest:

Biomedical Sciences
Cancer Science
Carcinogenesis
Digestion
Applied Pharmacology

Selected Publications

  1. Ng, E.K., R. Li, V.Y. Shin, H.C. Jin and C.P. Leung et al., 2013. Circulating microRNAs as specific biomarkers for breast cancer detection. PLoS One, Vol. 8. 10.1371/journal.pone.0053141.
    CrossRef  |  

  2. Chu, K.M., C.H. Cho and V.Y. Shin, 2013. Nicotine and gastrointestinal disorders: Its role in ulceration and cancer development. Curr. Pharm. Design, 19: 5-10.
    Direct Link  |  

  3. Wong, H.P., J.W. Ho, M.W. Koo, L. Yu and W.K. Wu et al., 2011. Effects of adrenaline in human colon adenocarcinoma HT-29 cells. Life Sci., 88: 1108-1112.
    CrossRef  |  PubMed  |  

  4. Shin, V.Y., H.C. Jin, E.K. Ng, C.H. Cho, W.K. Leung, J.J. Sung and K.M. Chu, 2011. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro. Cancer Sci., 102: 926-933.
    CrossRef  |  PubMed  |  

  5. Shin, V.Y., H.C. Jin, E.K. Ng, A.S. Cheng and W.W. Chong et al., 2011. NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors. Carcinogenesis, 32: 240-245.
    CrossRef  |  

  6. Ng, E.K.O., C.P.H. Leung, V.Y. Shin, C.L.P. Wong and E.S.K. Ma et al., 2011. Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients. PLoS One, Vol. 6. 10.1371/journal.pone.0022233.
    CrossRef  |  

  7. Lam, E.K.Y., X. Wang, V.Y. Shin, S. Zhang and H. Morrison et al., 2011. A microRNA contribution to aberrant Ras activation in gastric cancer. Am. J. Transl. Res., 3: 209-218.
    Direct Link  |  

  8. Shin, V.Y., H.C. Jin, E.K.O. Ng, J.J.Y. Sung, K.M. Chu and C.H. Cho, 2010. Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth. Cancer Lett., 292: 237-245.
    CrossRef  |  

  9. Liu, X., X. Wang, J. Zhang, E.K. Lam and V.Y. Shin et al., 2010. Warburg effect revisited: An epigenetic link between glycolysis and gastric carcinogenesis. Oncogene, 29: 442-450.
    PubMed  |  

  10. Wong, H.P., Z.J. Li, V.Y. Shin, E.K. Tai, W.K. Wu, L. Yu and C.H. Cho, 2009. Effects of cigarette smoking and restraint stress on human colon tumor growth in mice. Digestion, 80: 209-214.
    CrossRef  |  PubMed  |  

  11. Ng, E.K., W.W. Chong, H. Jin, E.K.Y. Lam and V.Y. Shin et al., 2009. Differential expression of microRNAs in plasma of colorectal cancer patients: A potential marker for colorectal cancer screening. Gut, 58: 1375-1381.
    CrossRef  |  

  12. Shin, V.Y., H.C. Jin, E.K. Ng, J. Yu, W.K. Leung, C.H. Cho and J.J. Sung, 2008. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. Toxicol. Applied Pharmacol., 233: 254-261.
    PubMed  |  

  13. Wu, W.K., P.T. Law, P.S. Wong, E.K. Lam and E.K. Tai et al., 2007. The shift of homeostasis from parenchymal regeneration to fibroproliferation induced by lipopolysaccharides-activated macrophages in gastric mucosal healing in vitro. Wound Repair Regen., 15: 221-226.
    PubMed  |  Direct Link  |  

  14. Shin, V.Y., W.K. Wu, P.S. Wong, E.K. Lam, E.K. Tai, M.W. Koo and C.H. Cho, 2007. Functional role of β-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol. Sci., 96: 21-29 .
    PubMed  |  Direct Link  |  

  15. Liu, E.S., Y.N. Ye, V.Y. Shin, W.K. Wu, B.C. Wong and C.H. Cho, 2007. Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice. Cancer Invest., 25: 750-757.
    CrossRef  |  Direct Link  |  

  16. Lam, E.K.Y., L. Yu, H.P.S. Wong, W.K.K. Wu and V.Y. Shin et al., 2007. Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats. Eur. J. Pharmacol., 565: 171-179.
    CrossRef  |  Direct Link  |  

  17. Yang, Y.H., W.K. Wu, E.K. Tai, H.P. Wong and E.K. Lam et al., 2006. The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats. J. Pharmacol. Exp. Ther., 318: 547-554.
    CrossRef  |  PubMed  |  

  18. Wu, W.K., V.Y. Shin, Y.N. Ye, H.P. Wong and F.Y. Huang et al., 2006. Heparin increases human gastric carcinoma cell growth. Anticancer Res., 26: 439-443.
    PubMed  |  

  19. Wu, W.K., G.R. Li, H.P. Wong, M.K. Hui and E.K. Tai et al., 2006. Involvement of Kv 1.1 and Nav1.5 in proliferation of gastric epithelial cells. J. Cell Physiol., 207: 437-444.
    CrossRef  |  Direct Link  |  

  20. Hui, M.K.C., W.K.K. Wu, V.Y. Shin, W.H.L. So and C.H. Cho, 2006. Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice. Int. J. Med. Sci., 3: 1-6.
    Direct Link  |  

  21. Ye, Y.N., W.K.K. Wu, V.Y. Shin, I.C. Bruce, B.C.Y. Wong and C.H. Cho, 2005. Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. Carcinogenesis, 26: 827-834 .
    CrossRef  |  PubMed  |  Direct Link  |  

  22. Ye, Y.N., W.K. Wu, V.Y. Shin and C.H. Cho, 2005. A mechanistic study of colon cancer growth promoted by cigarette smoke extract. Eur. J. Pharmacol., 519: 52-57.
    CrossRef  |  Direct Link  |  

  23. Wu, W.K., H.P. Wong, S.W. Luo, K. Chan and F.Y. Huang et al., 2005. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via β-adrenoceptors. Cancer Res., 65: 5272-5277.
    PubMed  |  

  24. Shin, V.Y., W.K. Wu, K.M. Chu, H.P. Wong and E.K. Lam et al., 2005. Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Mol. Cancer Res., 3: 607-615.
    PubMed  |  Direct Link  |  

  25. Shin, V.Y. and C.H. Cho, 2005. Nicotine and gastric cancer. Alcohol, 35: 259-264.
    PubMed  |  Direct Link  |  

  26. Luo, J.C., V.Y. Shin, Y.H. Yang, W.K. Wu and Y.N. Ye et al., 2005. Tumor necrosis factor-alpha stimulates gastric epithelial cell proliferation. Am. J. Physiol. Gastrointest. Liver Physiol., 288: G32-G38.
    PubMed  |  Direct Link  |  

  27. Liu, E.S., V.Y. Shin, Y.N. Ye, J.C. Luo, W.K. Wu and C.H. Cho, 2005. Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract. Eur. J. Pharmacol., 518: 47-55.
    CrossRef  |  Direct Link  |  

  28. Ye, Y.N., E.S. Liu, V.Y. Shin, W.K. Wu, J.C. Luo and C.H. Cho, 2004. Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src and 5-lipoxygenase-mediated signal pathway. J. Pharmacol. Exp. Ther., 308: 66-72.
    PubMed  |  Direct Link  |  

  29. Ye, Y.N., E.S. Liu, V.Y. Shin, W.K. Wu and C.H. Cho, 2004. The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. J. Pharmacol. Exp. Ther., 311: 123-130.
    PubMed  |  Direct Link  |  

  30. Ye, Y.N., E.S. Liu, V.Y. Shin, W.K. Wu and C.H. Cho, 2004. Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking. Toxicology, 203: 179-188.
    PubMed  |  Direct Link  |  

  31. Shin, V.Y., W.K. Wu, Y.N. Ye, W.H. So and Koo MW et al., 2004. Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. Carcinogenesis, 25: 2487-2495.
    PubMed  |  Direct Link  |  

  32. Shin, V.Y., W.H. So, E.S. Liu, Y.J. Wu, S.F. Pang and C.H. Cho, 2004. Anti-tumorigenic and pro-apoptotic effects of CKBM on gastric cancer growth in nude mice. Int. J. Med. Sci., 1: 137-145.
    Direct Link  |  

  33. Shin, V.Y., E.S. Liu, Y.N. Ye, M.W. Koo, K.M. Chu and C.H. Cho, 2004. A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells. Toxicol. Appl. Pharmacol., 195: 103-112.
    CrossRef  |  Direct Link  |  

  34. Luo, J.C., V.Y. Shin, E.S.L. Liu, Y.N. Ye, W.K.K. Wu, F.Y. Chang and C.H. Cho, 2004. Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs. Eur. J. Pharmacol., 485: 275-281.
    CrossRef  |  Direct Link  |  

  35. Ye, Y.N., H.L. So, E.S. Liu, V.Y. Shin and C.H. Cho, 2003. Effect of polysaccharides from Angelica sinensis on gastric ulcer healing. Life Sci., 72: 925-932.
    PubMed  |  Direct Link  |  

  36. Wang, H.Y., V.Y. Shin, S.Y. Leung, S.T. Yuen and C.H. Cho, 2003. Involvement of bcl-2 and caspase-3 in apoptosis induced by cigarette smoke extract in the gastric epithelial cell. Toxicol. Pathol., 31: 220-226.
    CrossRef  |  

  37. Shin, V.Y., H.Y. Wang, E.S. Liu, M.W. Koo and C.H. Cho, 2003. Differential effects of cigarette smoke extracts on cell proliferation in gastric and colon cells. Cancer Invest., 21: 200-207.
    PubMed  |  Direct Link  |  

  38. Luo, J.C., V.Y. Shin, E.S. Liu, W.H. So, Y.N. Ye, F.Y. Chang and C.H. Cho, 2003. Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats. J. Pharmacol. Exp. Ther., 307: 692-698.
    PubMed  |  Direct Link  |  

  39. Liu, E.S., Y.N. Ye, V.Y. Shin, S.T. Yuen, S.Y. Leung, B.C. Wong and C.H. Cho, 2003. Cigarette smoke exposure increases ulcerative colitis-associated colonic adenoma formation in mice. Carcinogenesis, 24: 1407-1413.
    CrossRef  |  

  40. Cho, C.H., K.K. Wu, S. Wu, T.M. Wong and W.H. So et al., 2003. Morphine as a drug for stress ulcer prevention and healing in the stomach. Eur. J. Pharmacol., 460: 177-182.
    PubMed  |  Direct Link  |  

  41. Wong, D., M.W. Koo, V.Y. Shin, E.S. Liu and C.H. Cho, 2002. Pathogenesis of nicotine treatment and its withdrawal on stress-induced gastric ulceration in rats. Eur. J. Pharmacol., 434: 81-86.
    CrossRef  |  Direct Link  |  

  42. Shin, V.Y., E.S. Liu, M.W. Koo, J.Y. Wang, H. Matsui and C.H. Cho, 2002. Cigarette smoke extracts delay wound healing in the stomach: involvement of polyamine synthesis. Exp. Biol. Med. (Maywood), 227: 114-124.
    PubMed  |  Direct Link  |  

  43. Shin, V.Y., E.S. Liu, M.W. Koo, J.C. Luo, W.H. So and C.H. Cho, 2002. Nicotine suppresses gastric wound repair via the inhibition of polyamine and K + channel expression. Eur. J. Pharmacol., 444: 115-121.
    CrossRef  |  Direct Link  |  

  44. Ye, Y.N., E.S. Liu, V.Y. Shin, M.W. Koo and Y. Li et al., 2001. A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line. Biochem. Pharmacol., 61: 1439-1448.
    CrossRef  |  PubMed  |  

  45. Wong, B.C., W.P. Wang, W.H. So, V.Y. Shin and W.M. Wong et al., 2001. Epidermal growth factor and its receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobacter pylori eradication. Aliment Pharmacol. Ther., 15: 1459-1465.
    PubMed  |  Direct Link  |  

  46. Li, Y., V.Y. Shin, C.Y. Cheuk, E.S. Liu and C.H. Cho, 2001. A 3.0-kDa low molecular weight heparin promotes gastric ulcer healing in rats. Aliment Pharmacol. Ther., 15: 2009-2017.
    PubMed  |  Direct Link  |  

  47. Guo, X., V.Y. Shin and C.H. Cho, 2001. Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases. Life Sci., 69: 3113-3119.
    PubMed  |  Direct Link  |  
Member since December, 2013