Dr. Huaxi Xu

Professor
Jiangsu University, China

Highest Degree
Ph.D. in Regeneration and Advanced Medical Science from Gifu University, Gifu, Japan

My URL
https://livedna.org/86.10160

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Biography

Dr. Huaxi Xu is a Professor, Vice President of Jiangsu University. He is a PhD Supervisor, the Pace Setter of the Provincial Key Academic Discipline of Clinical Examination Diagnosis and enjoys the State Council Special Allowance, Director of Institute of Clinical Laboratory Medicine Academic Leader of Qinglan Project of Jiangsu province. He is the executive member of Chinese Society of Immunology (the deputy chairman of the Jiangsu Society of Immunology), the executive member of Chinese Society of Microbiology, Vice Chief Member of Jiangsu Society of Microbiology and Immunology of Chinese Medical Association and Member of the Ministry of Public Health Guiding Committee of College Medical Textbook Construction. Besides, he is the eEditor-in-chief of Journal of Jiangsu University (Medicine Edition), Member of the editing board of Shiyong Laonian Yixue and Chinese Pharmacological Bulletin. He has supervised 18 doctoral candidates and more than 20 masters degree candidates. He is author and coauthor of more than 60 journals papers.

Area of Interest:

Biomedical Sciences
Immunology
Microbiology
Autoimmune Diseases
Food Nutrition

Selected Publications

  1. Zhang, Y., H. Yang, P.A. Barnie, P. Yang and Z. Su et al., 2014. The expression of toll-like receptor 8 and its relationship with VEGF and Bcl-2 in cervical cancer. Int. J. Med. Sci., 11: 608-613.
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  2. Xue, Y., Y. Yang, Z. Su, P.A. Barnie and D. Zheng et al., 2014. Local delivery of T-bet shRNA reduces inflammation in collagen II-induced arthritis via downregulation of IFN-γ and IL-17. Mol. Med. Rep., 9: 899-903.
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  3. Xu, X., H. Zhu, T. Wang, Y. Sun and P. Ni et al., 2014. Exogenous high-mobility group box 1 inhibits apoptosis and promotes the proliferation of lewis cells via RAGE/TLR4-dependent signal pathways. Scand. J. Immunol., 79: 386-394.
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  4. Xia, S., X. Li, L. Cheng, M. Han and M. Zhang et al., 2014. Chronic intake of high fish oil diet induces myeloid-derived suppressor cells to promote tumor growth. Cancer Immunol. Immunother., 63: 663-673.
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  5. Xia, S., M. Han, X. Li, L. Cheng and Y. Qiang et al., 2014. Dietary fish oil exacerbates concanavalin A induced hepatitis through promoting hepatocyte apoptosis and altering immune cell populations. J. Toxicol. Sci., 39: 179-190.
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  6. Su, Z., Y. Sun, H. Zhu, Y. Liu and X. Lin et al., 2014. Th17 cell expansion in gastric cancer may contribute to cancer development and metastasis. Immunol. Res., 58: 118-124.
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  7. Jiao, Z., W. Wang, S. Hua, M. Liu and H. Wang et al., 2014. Blockade of Notch signaling ameliorates murine collagen-induced arthritis via suppressing Th1 and Th17 cell responses. Am. J. Pathol., 184: 1085-1093.
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  8. Chen, Y., J. Tian, X. Tian, X. Tang and K. Rui et al., 2014. Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cells. PLoS ONE, Vol. 9. 10.1371/journal.pone.0092450.
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  9. Bie, Q., P. Zhang, Z. Su, D. Zheng and X. Ying et al., 2014. Polarization of ILC2s in peripheral blood might contribute to immunosuppressive microenvironment in patients with gastric cancer. J. Immunol. Res. 10.1155/2014/923135.
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  10. Barnie, P.A., P. Zhang, P. Lu, X. Chen, Z. Su, S. Wang and H. Xu, 2014. CpG-oligodeoxynucleotides suppress the proliferation of A549 lung adenocarcinoma cells via toll-like receptor 9 signaling and upregulation of Runt-related transcription factor 3 expression. Biomed. Rep., 2: 374-377.
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  11. Wang, Y., D. Zheng, M. Wei, J. Ma and Y. Yu et al., 2013. Over-expression of calpastatin aggravates cardiotoxicity induced by doxorubicin. Cardiovasc. Res., 98: 381-390.
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  12. Tian, J., J. Ma, K. Ma, H. Guo and S.E. Baidoo et al., 2013. β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells. Eur. J. Immunol., 43: 1220-1230.
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  13. Tang, X., X. Tian, Y. Zhang, W. Wu and J. Tian et al., 2013. Correlation between the frequency of Th17 cell and the expression of microRNA-206 in patients with dermatomyositis. Clin. Dev. Immunol. 10.1155/2013/345347.
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  14. Su, Z., S.S. Shotorbani, X. Jiang, R. Ma, H. Shen, F. Kong and H. Xu, 2013. A method of experimental rheumatoid arthritis induction using collagen type II isolated from chicken sternal cartilage. Mol. Med. Rep., 8: 113-117.
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  15. Sheng, X., H. Zhang, Q. Xia, S. Xu, H. Xu and X. Huang, 2013. Mig-14 plays an important role in influencing gene expression of Salmonella enterica serovar Typhi, which contributes to cell invasion under hyperosmotic conditions. Res. Microbiol., 164: 903-912.
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  16. Gu, Y., P. Yang, Q. Shao, X. Liu and S. Xia et al., 2013. Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues. Oncol. Lett., 5: 452-458.
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  17. Dadzie, I., S. Xu, B. Ni, X. Zhang and H. Zhang et al., 2013. Identification and characterization of a cis-encoded antisense RNA associated with the replication process of Salmonella enterica serovar Typhi. PLoS ONE, Vol. 8. 10.1371/journal.pone.0061308.
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  18. Zhang, H., B. Ni, X. Zhao, I. Dadzie and H. Du et al., 2012. Fis is essential for the stability of linear plasmid pBSSB1 and affects the motility of Salmonella enterica serovar Typhi. PLoS ONE, Vol. 7. 10.1371/journal.pone.0037462.
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  19. Wang, W., S. Shao, Z. Jiao, M. Guo, H. Xu and S. Wang, 2012. The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol. Int., 32: 887-893.
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  20. Wang, K., Z. Su, Y. Zhao, S.S. Shotorbani and Z. Jiao et al., 2012. Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA). Rheumatol. Int., 32: 2331-2338.
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  21. Gong, Y., H.X. Xu, M. Lin and Y. Gu, 2012. An iatrogenic complication of internal jugular vein catheterization for hemodialysis. Irish J. Med. Sci., 181: 135-137.
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  22. Gong, Y., H. Xu, Z. Xu, F. Zhang and C. Hao et al., 2012. Comparison of prognostic value of two kinds of severity scoring systems for hospital mortality prediction of elderly patients with acute kidney injury. Aging Clin. Exp. Res., 24: 74-78.
    PubMed  |  Direct Link  |  

  23. Zhou, D., S.B. Levery, F.F. Hsu, P.G. Wang and S. Teneberg et al., 2011. Immunologic mapping of glycomes: Implications for cancer diagnosis and therapy. Front. Biosci. (Scholar Edn.), 3: 1520-1532.
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  24. Wang, M., Z. Luo, H. Du, S. Xu and B. Ni et al., 2011. Molecular characterization of a functional type VI secretion system in Salmonella enterica serovar Typhi. Curr. Microbiol., 63: 22-31.
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  25. Tong, J., C. Liu, P. Summanen, H. Xu and S.M. Finegold, 2011. Application of quantitative real-time PCR for rapid identification of Bacteroides fragilis group and related organisms in human wound samples. Anaerobe, 17: 64-68.
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  26. Tian, J., J. Ma, S. Wang, J. Yan and J. Chen et al., 2011. Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation. Cell. Immunol., 270: 183-187.
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  27. Sun, X., H. Cai, H. Qian, W. Zhu, Y. Yan, H. Xu and W. Xu, 2011. Mesenchymal stem cells isolated from human uterine cervix cancer tissues. Cell Biol. Int., 35: 119-123.
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  28. Su, Z., C. Sun, C. Zhou, Y. Liu and H. Zhu et al., 2011. HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion. Eur. J. Immunol., 41: 3586-3595.
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  29. Shotorbani, S.S., Z.L. Su and H.X. Xu, 2011. Toll-like receptors are potential therapeutic targets in rheumatoid arthritis. World J. Biol. Chem., 2: 167-172.
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  30. Ma, J., S. Wang, B. Ma, C. Mao and J. Tong et al., 2011. Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma. Cancer Lett., 301: 142-150.
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  31. Du, H., X. Sheng, H. Zhang, X. Zou and B. Ni et al., 2011. RpoE may promote flagellar gene expression in Salmonella enterica serovar Typhi under hyperosmotic stress. Curr. Microbiol., 62: 492-500.
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  32. Chen, J., Z. Su, Y. Liu, S. Sandoghchian, D. Zheng, S. Wang and H. Xu, 2011. Herbaspirillum species: A potential pathogenic bacteria isolated from acute lymphoblastic leukemia patient. Curr. Microbiol., 62: 331-333.
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  33. Che, L.L., D.S. Xiao, H.X. Xu and L. Lu, 2011. Changes of iron stores and duodenal transepithelial iron transfer during regular exercise in rats. Biol. Trace Elem. Res., 143: 1044-1053.
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  34. Zhang, H., L. Ma, M. Turner, H. Xu, X. Zheng, Y. Dong and S. Jiang, 2010. Salicylic acid enhances biocontrol efficacy of Rhodotorula glutinis against postharvest Rhizopus rot of strawberries and the possible mechanisms involved. Food Chem., 122: 577-583.
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  35. Yang, P., G. Qiu, S. Wang, Z. Su and J. Chen et al., 2010. The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers. Int. J. Immunogenet., 37: 111-115.
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  36. Yang, M., L. Sun, S. Wang, K.H. Ko and H. Xu et al., 2010. Cutting edge: Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J. Immunol., 184: 3321-3325.
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  37. Tong, J., C. Liu, P.H. Summanen, H. Xu and S.M. Finegold, 2010. Corynebacterium pyruviciproducens sp. nov., a pyruvic acid producer. Int. J. Syst. Evol. Microbiol., 60: 1135-1140.
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  38. Su, Z., F. Kong, S. Wang, J. Chen and R. Yin et al., 2010. The rag locus of Porphyromonas gingivalis might arise from Bacteroides via horizontal gene transfer. Eur. J. Clin. Microbiol. Infect. Dis., 29: 429-437.
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  39. Shi, Y., H. Wang, Z. Su, J. Chen and Y. Xue et al., 2010. Differentiation imbalance of Th1/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto's thyroiditis. Scand. J. Immunol., 72: 250-255.
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  40. Mao, L.X., B. Wu, W.X. Bao, F.A. Han and L. Xu et al., 2010. Epidemiology of hand, foot and mouth disease and genotype characterization of Enterovirus 71 in Jiangsu, China. J. Clin. Virol., 49: 100-104.
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  41. Hu, J., H. Fan, D. Liu, S. Zhang, F. Zhang and H. Xu, 2010. DNMT3B promoter polymorphism and risk of gastric cancer. Dig. Dis. Sci., 55: 1011-1016.
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  42. Cui, D., S. Wang, Y. Chen, J. Tong and J. Ma et al., 2010. An isoleucine-zipper motif enhances costimulation of human soluble trimeric GITR ligand. Cell. Mol. Immunol., 7: 316-322.
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  43. Zou, X., X. Huang, S. Xu, L. Zhou and X. Sheng et al., 2009. Identification of a fljA gene on a linear plasmid as the repressor gene of fliC in Salmonella enterica serovar Typhi. Microbiol. Immunol., 53: 191-197.
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  44. Zhang, H., L. Ma, M. Turner, H. Xu, Y. Dong and S. Jiang, 2009. Methyl jasmonate enhances biocontrol efficacy of Rhodotorula glutinis to postharvest blue mold decay of pears. Food Chem., 117: 621-626.
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  45. Xu, H., Z. Su, S. Wang, X. Dai and J. Chen et al., 2009. Four novel resistance integron gene-cassette occurrences in bacterial isolates from Zhenjiang, China. Curr. Microbiol., 59: 113-117.
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  46. Wu, C., S. Wang, F. Wang, Q. Chen and S. Peng et al., 2009. Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia. Clin. Exp. Immunol., 158: 199-204.
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  47. Lo, C.K., Q.L. Lam, M. Yang, K.H. Ko and L. Sun et al., 2009. Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow. Cell. Mol. Immunol., 6: 353-360.
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  48. Gong, Y., N. Chen, F.Q. Wang, Z.H. Wang and H.X. Xu, 2009. Serum proteome alteration of severe sepsis in the treatment of continuous renal replacement therapy. Nephrol. Dial. Transplant., 24: 3108-3114.
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  49. Chen, J., Z. Su, Y. Liu, S. Wang and X. Dai et al., 2009. Identification and characterization of class 1 integrons among Pseudomonas aeruginosa isolates from patients in Zhenjiang, China. Int. J. Infect. Dis., 13: 717-721.
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  50. Yang, M., S. Wang, S. Wang, J. Ma and X. Xu et al., 2008. Tat-mediated intracellular delivery of T-bet protein into THP-1 cells can induce Th1-type response. Immunol. Investigat., 37: 97-111.
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  51. Xu, S., H. Zhang, X. Sheng, H. Xu and X. Huang, 2008. Transcriptional expression of fljB: z66, a flagellin gene located on a novel linear plasmid of Salmonella enterica serovar Typhi under environmental stresses. N. Microbiol., 31: 241-247.
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  52. Wang, S.Y., M. Yang, X.P. Xu, G.F. Qiu and J. Ma et al., 2008. Intranasal delivery of T-bet modulates the profile of helper T cell immune responses in experimental asthma. J. Investigat. Allergol. Clin. Immunol., 18: 357-365.
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  53. Su, Z., X. Dai, J. Chen, F. Kong and H. Wang et al., 2008. The blaCTX-M-1 gene located in a novel complex class I integron bearing an ISCR1 element in Escherichia coli isolates from Zhenjiang, China. J. Antimicrob. Chemother., 62: 1150-1151.
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  54. Mao, C., S. Wang, Q. Jiang, J. Tong and J. Ma et al., 2008. Increased CD4CD25+FOXP3+ regulatory T Cells in cancer patients from conversion of CD4+CD25- T cells through tumor-derived factors. Onkologie, 31: 243-248.
    PubMed  |  

  55. Lo, C.K.C., Q.L.K. Lam, L. Sun, S. Wang and K.H. Ko et al., 2008. Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin‐17 production. Arthritis Rheumatism, 58: 2700-2711.
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  56. Xu, S., X. Huang, H. Xu and C. Zhang, 2007. Improved prediction of coreceptor usage and phenotype of HIV-1 based on combined features of V3 loop sequence using random forest. J. Microbiol., 45: 441-446.
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  57. Su, Z., H. Xu and J. Chen, 2007. Avian influenza: Should China be alarmed? Yonsei Med. J., 48: 586-594.
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  58. Wang, S., H. Xu, Y. Wang, J. Ma and C. Mao et al., 2006. Regulatory T cells induced by rAAV carrying the forkhead boxP3gene prevent autoimmune thyroiditis in mice. Int. J. Mol. Med., 18: 1193-1199.
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  59. Su, Z., H. Xu, C. Zhang, S. Shao and L. Li et al., 2006. Mutations in Helicobacter pylori porD and oorD genes may contribute to furazolidone resistance. Croat. Med. J., 47: 410-415.
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  60. Huang, X., H. Xu, M.M. Sha, L. Zhao and K. Ohkusu et al., 2006. Virulence-defective strains of Salmonella enterica serovar Typhi as candidates for education at level 2 facilities. Microbiol. Immunol., 50: 273-279.
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Member since August, 2015