Dr. Lili Zhu
Associate ProfessorEast China University of Science and Technology, China
Highest Degree
Ph.D. in Pharmacy from Chinese Academy of Sciences, China
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Biography
Dr. Lili Zhu is currently working as Associate Professor at School of Pharmacy, East China University of Science and Technology, China. Her area of research focused on Structural Biology. Using X-ray diffraction method to obtain the structure of biologically important macromolecules (Proteins, Nucleic Acid and their Complexes), another area of our research is high-throughput screening of small inhibitors through molecular-based assays and cell-based assays. She has published 11 articles in journals as author/co-author.
Area of Interest:
Selected Publications
- Zhu, J., L. Han, Y. Diao, X. Ren and M. Xu et al., 2015. Design, synthesis, x-ray crystallographic analysis and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase. J. Med. Chem., 58: 1123-1139.
CrossRef | Direct Link | - Wang, L., S. Zhang, J. Zhu, L. Zhu and X. Liu et al., 2014. Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening. Bioorg. Med. Chem. Lett., 24: 1261-1264.
CrossRef | Direct Link | - Yu, X., X. Zhao, L. Zhu, C. Zou and X. Liu et al., 2013. Discovery of novel inhibitors for human farnesyltransferase (hFTase) via structure-based virtual screening. Med. Chem. Commun., 4: 962-971.
CrossRef | Direct Link | - Xu, M., J. Zhu, Y. Diao, H. Zhou and X. Ren et al., 2013. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J. Med. Chem., 56: 7911-7924.
CrossRef | Direct Link | - Wang, L., C. Yang, W. Lu, L. Liu and R. Gao et al., 2013. Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening. Bioorg. Med. Chem. Lett., 23: 3496-3499.
CrossRef | Direct Link | - Song, Y., H. Jin, X. Liu, L. Zhu, J. Huang and H. Li, 2013. Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening. Bioorg. Med. Chem. Lett., 23: 2078-2082.
CrossRef | Direct Link | - Cui, K., W. Lu, L. Zhu, X. Shen and J. Huang, 2013. Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity. Biochem. Biophys. Res. Commun., 435: 289-294.
CrossRef | Direct Link | - Cao, X., J. Jiang, S. Zhang, L. Zhu and J. Zou et al., 2013. Discovery of natural estrogen receptor modulators with structure-based virtual screening. Bioorg. Med. Chem. Lett., 23: 3329-3333.
CrossRef | Direct Link | - Zhu, L., S. George, M.F.Schmidt, S.I. Al-Gharabli, J. Rademann and R. Hilgenfeld, 2011. Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Res., 92: 204-216.
CrossRef | Direct Link | - Zhu, L., C. Yuan, Z. Chen, W. Wang and M. Huang, 2010. Expression, purification and characterization of recombinant Jerdonitin, a P-II class snake venom metalloproteinase comprising metalloproteinase and disintegrin domains. Toxicon, 55: 375-380.
CrossRef | Direct Link | - Zhu, L., F. Yang, L. Chen, E.J. Meehan and M. Huang, 2008. A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography. J. Struct. Biol., 162: 40-49.
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