Dr. Da-Yong Shi

Research Scientist
Chinese Academy of Sciences, China

Highest Degree
Ph.D. in Chemistry from Chinese Academy of Sciences, China

My URL
https://livedna.org/86.10799

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Area of Interest:

Chemistry
Medicinal Chemistry
Marine Chemistry
Natural Product Chemistry
Chemical Synthesis

Selected Publications

  1. Wang, L.J., B. Jiang, N. Wu, S.Y. Wang and D. Shi, 2015. Natural and semisynthetic Protein Tyrosine Phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents. RSC Adv., 5: 48822-48834.
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  2. Shi, D., S. Guo, B. Jiang, C. Guo, T. Wang, L. Zhang and J. Li, 2013. HPN, a synthetic analogue of bromophenol from red alga Rhodomela confervoides: Synthesis and anti-diabetic effects in C57BL/KsJ-db/db mice. Mar. Drugs, 11: 350-362.
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  3. Jiang, B., S. Guo, D. Shi, C. Guo and T. Wang, 2013. Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice. Eur. J. Med. Chem., 64: 129-136.
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  4. Shi, D., J. Li, B. Jiang, S. Guo, H. Su and T. Wang, 2012. Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties. Bioorg. Med. Chem. Lett., 22: 2827-2832.
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  5. Jiang, B., D. Shi, Y. Cui and S. Guo, 2012. Design, synthesis and biological evaluation of bromophenol derivatives as protein tyrosine phosphatase 1B inhibitors. Archiv Pharmazie, 345: 444-453.
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  6. Shi, D., S. Guo and X. Fan, 2011. A new ketosteroid from red alga Acanthophora spicifera. Chin. J. Oceanol. Limnol., 29: 674-678.
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  7. Guo, S., J. Li, T. Li, D. Shi and L. Han, 2011. Synthesis of three bromophenols from red algae as PTP1B inhibitors. Chin. J. Oceanol. Limnol., 29: 68-74.
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  8. Cui, Y., D. Shi and Z. Hu, 2011. Synthesis and protein tyrosine phosphatase 1B inhibition activities of two new synthetic bromophenols and their methoxy derivatives. Chin. J. Oceanol. Limnol., 29: 1237-1242.
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  9. Shi, D., X. Li, J. Li, S. Guo, H. Su and X. Fan, 2010. Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor. Chin. J. Oceanol. Limnol., 28: 96-98.
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  10. Su, H., Z.H. Yuan, J. Li, S.J. Guo and L.P. Deng et al., 2009. Two new bromoindoles from red alga Laurencia similis. Chin. Chem. Lett., 20: 456-458.
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  11. Su, H., Z.H. Yuan, J. Li, S.J. Guo and L.P. Deng et al., 2009. Sesquiterpenes from the marine red alga Laurencia saitoi. Helvetica Chimica Acta, 92: 1291-1297.
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  12. Su, H., D.Y. Shi, J. Li, S.J. Guo, L.L. Li, Z.H. Yuan and X.B. Zhu, 2009. Sesquiterpenes from Laurencia similis. Molecules, 14: 1889-1897.
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  13. Shi, D., J. Li, S. Guo, H. Su and X. Fan, 2009. The antitumor effect of bromophenol derivatives in vitro and Leathesia nana extract in vivo. Chin. J. Oceanol. Limnol., 27: 277-282.
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  14. Shi, D., X. Fan, J. Sun, L. Han and J. Shi, 2008. Steroids from green alga Chaetomorpha basiretorsa Setchell. Chin. J. Oceanol. Limnol., 26: 415-418.
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  15. Shi, D., F. Xu, J. He, J. Shi, X. Fan and L. Han, 2008. Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell. Acta Oceanologica Sinica, 27: 147-151.
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  16. Li, J., S.J. Guo, H. Su, L.J. Han and D.Y. Shi, 2008. Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor. Chin. Chem. Lett., 19: 1290-1292.
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Member since September, 2015