Dr. Bian Zhaoxiang

Professor
Hong Kong Baptist University, Hong Kong

Highest Degree
Ph.D. in Integrated Chinese and Western Medicine from Guangzhou University of Traditional Chinese Medicine, China

My URL
https://livedna.org/86.10806

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Biography

Prof. Bian Zhaoxiang had been educated in Nanjing University of Traditional Chinese Medicine (TCM), Beijing University of Traditional Chinese Medicine and Pharmacology and Guangzhou University of TCM, and was conferred the Ph.D. degree in Integrated Chinese and Western Medicine in 1994. After graduation, he engaged in clinical and basic research in Digestive Diseases in Guangzhou University of TCM. Under the Quality Migrant Admission Scheme of HKSAR, he moved to Hong Kong Baptist University in 2001. Prof Bians research focuses mainly on the relationship between Psychological Stress and Digestive Diseases, especially focusing on the development and Recurrence of Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), and Colorectal Cancer. Major research topics involve: 1) Basic Mechanism of Visceral Hyperalgesia and Gastrointestinal Motility disorder and its Associated Depression; 2) Psychological Stress and Colorectal Cancer; 3) Clinical trial with Chinese medicine for Digestive Diseases, including IBS, IBD, functional Constipation and Colorectal Cancer; 4) New drug development based on Chinese Herbal Medicine and its active fraction for Digestive Diseases. He has been awarded second prize of National Science and Technology Award of China in 1999. Currently, Prof Bian serves as Director of Clinical Division, School of Chinese Medicine, and Associate Vice-President of HKBU.

Area of Interest:

Pharmacology and Toxicology
Psychological Stress
Colorectal Cancer
Drug Development
Chinese Herbal Medicine

Selected Publications

  1. Zhong, L.L., Z.X. Bian, J.H. Gu, X. Zhou, Y. Tian, J.C. Mao and X.J. Chen, 2013. Chinese herbal medicine (Zi shen qing) for mild-to-moderate systematic lupus erythematosus: A pilot prospective, single-blinded, randomized controlled study. Evidence Based Complementary Alternat. Med., Vol. 2013. 10.1155/2013/327245.
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  2. Cheng, C.W., S.F. Fu, Q.H. Zhou, T.X. Wu and H.C. Shang et al., 2013. Extending the CONSORT Statement to moxibustion. J. Integr. Med., 11: 54-63.
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  3. Cheng, C.W., A.O.L. Kwok, Z.X. Bian and D.M.W. Tse, 2013. A cross sectional study of constipation and laxatives use in advanced cancer patients: Insights for revision of current practice. Support Care Cancer, 21: 149-156.
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  4. Zhu, G.Y., B.C.K. Wong, L. Aiping, Z.X. Bian and G. Zhang et al., 2012. Alkylphenols from the roots of Ardisia brevicaulis induce g1 arrest and apoptosis through endoplasmic reticulum stress pathway in human non-small-cell lung cancer cells. Chem. Pharm. Bull., 60: 1029-1036.
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  5. Zhang, X., F.F.K. Choi, Y. Zhou, F.P. Leung and S. Tan et al., 2012. Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI- QTOF-MS-based metabonomics. FEBS J., 279: 2322-2338.
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  6. Tsang, S.W., M. Zhao, J. Wu, J.J.Y. Sung and Z.X. Bian, 2012. Nerve growth factor-mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation-induced visceral hypersensitivity in rats. Eur. J. Pain., 16: 463-472.
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  7. Tian, X.Y., W.T. Wong, N. Sayed, J. Luo and S.Y. Tsang et al., 2012. NaHS relaxes rat cerebral artery in vitro via inhibition of L-type voltage-sensitive Ca2+ channel. Pharmacol. Res., 65: 239-246.
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  8. Qin, H.Y., H.T. Xiao, J.C.Y. WU, B.M. Berman, J.J. Sung and Z.X. Bian, 2012. Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats World J. Gastroenterol., 18: 2481-2492.
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  9. Qin, H.Y., H.T. Xiao, F.P. Leung, J.C.Y. Wu and J.J.Y. Sung et al., 2012. JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced post-inflammatory irritable bowel syndrome rats through reducing colonic EC cell hyperplasia and serotonin availability. Evid. Based Complement. Altern. Med., Vol. 2012. 10.1155/2012/239638.
    CrossRef  |  Direct Link  |  

  10. Lu, A.P., Z.X. Bian and K.J. Chen, 2012. Bridging the traditional Chinese medicine pattern classification and biomedical disease diagnosis with systems biology. Chin. J. Integr. Med., 18: 883-890.
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  11. Cheng, C.W., A.O. Kwok, Z.X. Bian and D.M.W. Tse, 2012. The quintessence of traditional chinese medicine: Syndrome and Its distribution among advanced cancer patients with constipation. Evidence Based Complementary Alternat. Med., Vol.2012., 10.1155/2012/739642.
    CrossRef  |  Google  |  

  12. Bian, Z.X., S.L. Chen, C.W. Chung, J. Wang, H.T. Xiao and H.Y. Qin, 2012. Developing new drugs from annals of Chinese medicine. Acta Pharma. Sinica B, 2: 1-7.
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  13. Bian, Z.X., 2012. Novel insights about the mechanism of visceral hypersensitivity in maternally separated rats. Neurogastroent Motil., 24: 593-596.
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  14. Zeng, X.X., Z.X. Bian, T.X. Wu, S.F. Fu, E. Ziea and W.T. Woon, 2011. Traditional chinese medicine syndrome distribution in chronic hepatitis b populations: A systematic review. Am. J. Chin. Med., 39: 1061-1074.
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  15. Qin, H.Y., Wu, J.C., X.D. Tong , J.J.Y. Sung , H.X. Xu and Z.X. Bian, 2011. Systematic review of animal models of post-infectious/post inflammatory irritable. J. Gastroenterol., 46: 164-174.
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  16. Luo, J.L., H.Y. Qin, C.K. Wong, S.Y. Tsang, Y. Huang and Z.X. Bian, 2011. Enhanced excitability and down-regulated voltage-gated potassium channels in colonic drg neurons from neonatal maternal separation rats. J. Pain, 12: 600-609.
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  17. Lin, S.H., Z. Yang, X.J. Zhang, Z.X. Bian and Z.W. Cai, 2011. Hippocampal metabolomics reveals 2, 3, 7, 8-tetrachlorodibenzo -p-dioxin toxicity associated with ageing in SD rats. Talanta, 85: 1007-1012.

  18. Lau, Y.T., C.K. Wong, J. Luo, L.H. Leung, P.F. Tsang, Z.X. Bian and S.Y. Tsang, 2011. Effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers on the proliferation and cell cycle progression of embryonic stem cells. Pflugers Archiv Eur. J. Physiol., 461: 191-202.
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  19. Cheng, C.W., Z.X. Bian, L.X. Zhu, J.C. Wu and J.J. Sung, 2011. Efficacy of a Chinese herbal proprietary medicine (Hemp Seed Pill) for functional constipation. Am. J. Gastroenterol., 106: 120-129.
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  20. Bian, Z.X., and H.C. Shang, 2011. CONSORT 2010 statement: Updated guidelines for reporting parallel group randomized trials. Ann. Intern. Med., 154: 290-291.
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  21. Bian, Z.X., H.Y. Qin, S.L. Tian and S.D. Qi, 2011. Combined effect of early life stress and acute stress on colonic sensory and motor responses through serotonin pathways: Differences between proximal and distal colon in rats. Stress: Int. J. Biol. Stress, 14: 448-458.
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  22. Bian, Z.X. and Y.H. Chang, 2011. Revised STRICTA as a extending the CONSORT Statement: More items should be involved in the checklist. J. Altern. Complementary Med., 17: 97-98.
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  23. Zhang, X.J., F.P. Leung, W.W.L. Hsiao, S. Tan and S. Li et al., 2010. Proteome profiling of spinal cord and DRG in rats with TNBS-induced colitis. World J. Gastroenterol., 18: 2914-2928.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Zhang, M., F.P. Leung, Y. Huang and Z.X. Bian, 2010. Increased colonic motility in a rat model of irritable bowel syndrome is associated with up-regulation of L-type calcium channels in colonic smooth muscle cells. Neurogastroent Motil., 22: 162-170.
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  25. Wu, T., H. Shang, Z. Bian, J. Zhang, T. Li, Y. Li and B. Zhang, 2010. Recommendations for reporting adverse drug reactions and adverse events of traditional Chinese medicine. J. Evidence Based Med., 3: 11-17.
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  26. Wang ,L., X. Cui, L. Cheng, Q. Yuan and T. Li et al., 2010. Adverse events to Houttuynia injection: A systematic review. J. Evidence Based Med., 3: 168-176.
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  27. Qin, H.Y., J.L. Luo, S.D. Qi, H.X. Xu, J.J.Y. Sung and Z.X. Bian, 2010. Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon. Eur. J. Pharmacol., 647: 75-83.
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  28. Ng, S.Y., C.H. Chin, Y.T. Lau, J. Luo, C.K. Wong, Z.X. Bian and S.Y. Tsang, 2010. Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J. Cell. Physiol., 224: 165-177.
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  29. Cheng, C.W., W. Fan, S.G. Ko, L. Song and Z.X. Bian, 2010. Evidence-based management of herb-drug interaction in cancer chemotherapy. EXPLORE: J. Sci. Healing, 6: 324-329.
    CrossRef  |  

  30. Bian, Z.X., M. Zhang, Q.B. Han, H.X. Xu and J.J.Y. Sung, 2010. Analgesic effects of JCM-16021 on neonatal maternal separation-induced visceral pain in rats. World J. Gastroenterol., 16: 837-845.
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  31. Bian, Z.X., H.Y. Tian, L. Gao, H.C. Shang and T.X. Wu et al., 2010. Improving reporting of adverse events and adverse drug reactions following injections of Chinese materia medica. J. Evidance Based Med., 3: 5-10.
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  32. Bian, Z.X., H.C. Shang, T.X. Wu, Y.P. Li and B.L. Zhang, 2010. Review of adverse reactions to Chinese medicine injections. J. Evid. Based Med., 3: 88-94.

  33. Bian, Z.X. and T.X. Wu, 2010. Legislation for trial registration and data transparency. Trials, Vol. 11. .
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  34. Zhang, X.J., Z. Li, E.K.Y. Chung, H.Q. Zhang, H.X. Xu, J.J.Y. Sung and Z.X. Bian, 2009. Activation of extracellular signal- regulated protein kinase is associated with colorectal distension-induced spinal and supraspinal neuronal response and neonatal maternal separation-induced visceral hyperalgesia in rats. J. Mol. Neurosci., 37: 274-287.
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  35. Zhang, X.J., H.L. Chen, Z. Li, H.Q. Zhang, H.X. Xu, J.J.Y. Sung and Z.X. Bian, 2009. Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A1 receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway. Pharmacol. Biochem. Behav., 94: 88-97.
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  36. Wu, T., Y. Li, Z. Bian, G. Liu and D. Moher, 2009. Randomized trials published in some Chinese journals: How many are randomized? Trials, Vol. 10. 10.1186/1745-6215-10-46.
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  37. Qi, S.D., S.L. Tian, H.X. Xu, J.J.Y. Sung and Z.X. Bian, 2009. Quantification of luminally released serotonin in rat proximal colon by capillary electrophoresis with laser-induced fluorescence detection. Anal. Bioanal. Chem., 393: 2059-2066.
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  38. Li, Z., X.J. Zhang, H.X. Xu, J.J.Y. Sung and Z.X. Bian, 2009. Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats. Eur. J. Pharmacol., 606: 199-204.
    CrossRef  |  

  39. Chung, E.K.Y., Z.X. Bian, H.X. Xu and J.J.Y. Sung, 2009. Neonatal maternal separation increases brain-derived neurotrophic factor and tyrosine kinase receptor B expression in the descending pain modulatory system. Neurosignals, 17: 213-221.
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  40. Cheng, C.W., Z.X. Bian and T.X. Wu, 2009. Systematic review of Chinese herbal medicine for functional constipation. World J. Gastroenterol., 15: 4886-4895.
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  41. Chen, H.L., X.J. Zhang, S.D. Qi, H.X. Xu, J.J. Sung and Z.X. Bian, 2009. Simultaneous determination of glutamate and aspartate in rat periaqueductal gray matter microdialysates by capillary electrophoresis with laser-induced fluorescence. J. Chromatogr. B, 877: 3248-3252.
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  42. Bian, Z.X., Z. Li, Z.X. Huang, M. Zhang, H.L. Chen, H.X. Xu and J.J.Y. Sung, 2009. Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients. J. Gastroenterol., 44: 666-674.

  43. Zhang, X.J., Z. Li, W.M. Leung, L. Liu, H.X. Xu and Z.X. Bian, 2008. The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. J. Pain, 9: 497-505.
    CrossRef  |  PubMed  |  

  44. Cheng, C.W., Z.X. Bian, Y.P. Li, D. Moher and T.X. Wu et al., 2008. Transparently reporting adverse effects of traditional Chinese medicine interventions in randomized controlled trials. J. Chin. Integr. Med., 6: 881-886.
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  45. Cheng, C.W. and Z.X. Bian, 2008. How can apples be mixed with oranges? Explore: J. Sci. Healing, 4: 379-379.
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  46. Bian, Z.X., D. Moher, Y.P. Li, T.X. Wu and S. Dagenais et al., 2008. Precise reporting of traditional Chinese medicine interventions in randomized controlled trials. J. Chin. Integr. Med., 6: 641-667.
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  47. Bian, Z.X., D. Moher, Y.P. Li, T.X. Wu and S. Dagenais et al., 2008. Appropriately selecting and concisely reporting the outcome measures of randomized controlled trials of traditional Chinese medicine. J. Chin. Integr. Med., 6: 771-775.
    CrossRef  |  PubMed  |  Direct Link  |  

  48. Wu, T.X., Y.P. Li, Z.X. Bian, T.Q. Li and J. Li et al., 2007. Consolidated standards for reporting trials of traditional Chinese medicine (CONSORT for TCM) (For Solicitation of Comments). Chin. J. Evid-Based Med., 7: 625-630.
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  49. Chung, E.K., X.J. Zhang, H.X. Xu, J.J.Y. Sung and Z.X. Bian, 2007. Visceral hyperalgesia induced by neonatal maternal separation is associated with nerve growth factor-mediated central neuronal plasticity in rat spinal cord. Neuroscience, 149: 685-695.
    CrossRef  |  Direct Link  |  

  50. Tian, X.Y., Z.X. Bian, X.G. Hu, X.J. Zhang, L. Liu and H.Q. Zhang, 2006. Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway. Brain Res., 1088: 101-108.
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  51. Leung, K.S., Z.X. Bian, D. Moher, S. Dagenais and Y.P. Li et al., 2006. Improving the quality of randomized controlled trials in Chinese herbal medicine, part III: Quality control of Chinese herbal medicine used in randomized controlled trials. J. Chin. Integr. Med., 4: 225-232.
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  52. Bian, Z.X., Y.P. Li, D. Moher, S. Dagenais and L. Liu et al., 2006. Improving the quality of randomized controlled trials in Chinese herbal medicine, part I: Clinical trial design and methodology. J. Chin. Integr. Med., 4: 120-129.
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  53. Bian, Z.X., T.X. Wu, L. Liu, J.X. Miao, H.F. Wong, L. Song and J.J.Y. Sung, 2006. Effectiveness of the Chinese herbal formula TongXieYaoFang for irritable bowel syndrome: A systematic review. J. Altern. Comp. Med., 12: 401-407.
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  54. Bian, Z.X., G.S. Zhang, K.L. Wong, X.G. Hu, L. Liu, Z.J. Yang and M. Li, 2006. Inhibitory Effects of Magnolol on Distal Colon of Guinea Pig in Vitro. 29 Biol. Pharm. Bull.,: 790-795.
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  55. Bian, Z.X., D. Moher, S. Dagenais, Y.P. Li, L. Liu, T.X. Wu and J.X. Miao, 2006. Improving the quality of randomized controlled trials in Chinese herbal medicine, part II: Control group design. J. Chin. Integr. Med., 4: 130-136.
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  56. Bian, Z.X., D. Moher, S. Dagenais, Y.P. Li and T.X. Wu et al., 2006. Improving the quality of randomized controlled trials in Chinese herbal medicine, part IV: Applying a revised CONSORT checklist to measure reporting quality. J. Chin. Integr. Med., 4: 233-242.
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  57. Bian, Z.X., 2006. Stratification by sex and subgroup is necessary for RCT on IBS. Gut, 55: 743-744.
Member since February, 2016